Journal of Pharmacology and Experimental Therapeutics: 321 (1)

April 01, 2007; Volume 321,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Therapeutic Potential of Phosphatidylinositol 3-Kinase Inhibitors in Inflammatory Respiratory Disease
Kazuhiro Ito, Gaetano Caramori and Ian M. Adcock

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 1-8; DOI: https://doi.org/10.1124/jpet.106.111674

BEHAVIORAL PHARMACOLOGY

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Circadian-Dependent Learning and Memory Enhancement in Nociceptin Receptor-Deficient Mice with a Novel KUROBOX Apparatus Using Stress-Free Positive Cue Task
Jun Nagai, Mamoru Kurokawa, Hiroshi Takeshima, Brigitte L. Kieffer and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 195-201; DOI: https://doi.org/10.1124/jpet.106.115121
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Thienorphine: Receptor Binding and Behavioral Effects in Rhesus Monkeys
Jun-Xu Li, Ginger L. Becker, John R. Traynor, Ze-Hui Gong and Charles P. France

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 227-236; DOI: https://doi.org/10.1124/jpet.106.113290
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Effects of Muscarinic M₁ Receptor Blockade on Cocaine-Induced Elevations of Brain Dopamine Levels and Locomotor Behavior in Rats
Gianluigi Tanda, Aaron L. Ebbs, Theresa A. Kopajtic, Lyn M. Elias, Bettye L. Campbell, Amy H. Newman and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 334-344; DOI: https://doi.org/10.1124/jpet.106.118067
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Preclinical Investigation of the Topical Administration of Phenserine: Transdermal Flux, Cholinesterase Inhibition, and Cognitive Efficacy
Tadanobu Utsuki, Nao Uchimura, Mitsuru Irikura, Hiroshi Moriuchi, Harold W. Holloway, Qian-Sheng Yu, Edward L. Spangler, Jacek Mamczarz, Donald K. Ingram, Tetsumi Irie and Nigel H. Greig

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 353-361; DOI: https://doi.org/10.1124/jpet.106.118000
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The Endogenous Cannabinoid Anandamide Produces δ-9-Tetrahydrocannabinol-Like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by Inhibition of Anandamide Transport
Marcello Solinas, Gianluigi Tanda, Zuzana Justinova, Carrie E. Wertheim, Sevil Yasar, Daniele Piomelli, Subramanian K. Vadivel, Alexandros Makriyannis and Steven R. Goldberg

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 370-380; DOI: https://doi.org/10.1124/jpet.106.114124

CARDIOVASCULAR

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The Glycocalyx Protects Erythrocyte-Bound Tissue-Type Plasminogen Activator from Enzymatic Inhibition
Kumkum Ganguly, Juan-Carlos Murciano, Randal Westrick, John Leferovich, Douglas B. Cines and Vladimir R. Muzykantov

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 158-164; DOI: https://doi.org/10.1124/jpet.106.114405
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Chronic Activation of Peroxisome Proliferator-Activated Receptor-α with Fenofibrate Prevents Alterations in Cardiac Metabolic Phenotype without Changing the Onset of Decompensation in Pacing-Induced Heart Failure
Volodymyr Labinskyy, Michelle Bellomo, Margaret P. Chandler, Martin E. Young, Vincenzo Lionetti, Khaled Qanud, Federico Bigazzi, Tiziana Sampietro, William C. Stanley and Fabio A. Recchia

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 165-171; DOI: https://doi.org/10.1124/jpet.106.116871
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A Comparison between Ranolazine and CVT-4325, a Novel Inhibitor of Fatty Acid Oxidation, on Cardiac Metabolism and Left Ventricular Function in Rat Isolated Perfused Heart during Ischemia and Reperfusion
Peipei Wang, Heather Fraser, Steven G. Lloyd, Jeffrey J. McVeigh, Luiz Belardinelli and John C. Chatham

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 213-220; DOI: https://doi.org/10.1124/jpet.106.115519
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A Comparison between the Cardiovascular Actions of Urocortin 1 and Urocortin 2 (Stresscopin-Related Peptide) in Conscious Rats
S. M. Gardiner, J. E. March, P. A. Kemp and T. Bennett

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 221-226; DOI: https://doi.org/10.1124/jpet.106.116962
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Losartan Reduces the Increased Participation of Cyclooxygenase-2-Derived Products in Vascular Responses of Hypertensive Rats
Yolanda Álvarez, José V. Pérez-Girón, Raquel Hernanz, Ana M. Briones, Ana García-Redondo, Amada Beltrán, María J. Alonso and Mercedes Salaices

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 381-388; DOI: https://doi.org/10.1124/jpet.106.115287
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Hypoxic Induction of Receptor Activity-Modifying Protein 2 Alters Regulation of Pulmonary Endothelin-1 by Adrenomedullin: Induction under Normoxia Versus Inhibition under Hypoxia
Thomas Dschietzig, Christoph Richter, Louay Asswad, Gert Baumann and Karl Stangl

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 409-419; DOI: https://doi.org/10.1124/jpet.106.114298

CELLULAR AND MOLECULAR

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Activation of Vascular Endothelial Growth Factor through Reactive Oxygen Species Mediates 20-Hydroxyeicosatetraenoic Acid-Induced Endothelial Cell Proliferation
Austin M. Guo, Ali S. Arbab, John R. Falck, Ping Chen, Paul A. Edwards, Richard J. Roman and A. Guillermo Scicli

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 18-27; DOI: https://doi.org/10.1124/jpet.106.115360
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Extracellular Signal-Regulated Kinase 1/2-Mediated Transcriptional Regulation of G-Protein-Coupled Receptor Kinase 3 Expression in Neuronal Cells
Samina Salim, Kelly M. Standifer and Douglas C. Eikenburg

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 51-59; DOI: https://doi.org/10.1124/jpet.106.116921
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Base Excision Repair Proteins Are Required for Integrin-Mediated Suppression of Bleomycin-Induced DNA Breakage in Murine Lung Endothelial Cells
Jane L. Rose, Kevin C. Reeves, Rostislav I. Likhotvorik and Dale G. Hoyt

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 318-326; DOI: https://doi.org/10.1124/jpet.106.113498

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Preclinical Pharmacokinetic and Pharmacodynamic Evaluation of Metronomic and Conventional Temozolomide Dosing Regimens
Qingyu Zhou, Ping Guo, Xiaomin Wang, Silpa Nuthalapati and James M. Gallo

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 265-275; DOI: https://doi.org/10.1124/jpet.106.118265
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STI-571 (Imatinib Mesylate) Enhances the Apoptotic Efficacy of Pyrrolo-1,5-Benzoxazepine-6, a Novel Microtubule-Targeting Agent, in Both STI-571-Sensitive and -Resistant Bcr-Abl-Positive Human Chronic Myeloid Leukemia Cells
Lisa M. Greene, Liam Kelly, Valeria Onnis, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 288-297; DOI: https://doi.org/10.1124/jpet.106.116640

ENDOCRINE AND DIABETES

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The Dual Peroxisome Proliferator-Activated Receptor α/γ Activator Muraglitazar Prevents the Natural Progression of Diabetes in db/db Mice
Effie Tozzo, Randolph Ponticiello, JoAnn Swartz, Dennis Farrelly, Rachel Zebo, Gustav Welzel, Donald Egan, Lori Kunselman, Andrew Peters, Liqun Gu, Michele French, Sean Chen, Pratik Devasthale, Evan Janovitz, Ada Staal, Thomas Harrity, Rene Belder, Peter T. Cheng, Jean Whaley, Simeon Taylor and Narayanan Hariharan

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 107-115; DOI: https://doi.org/10.1124/jpet.106.115337
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Antilipolytic Activity of a Novel Partial A₁ Adenosine Receptor Agonist Devoid of Cardiovascular Effects: Comparison with Nicotinic Acid
Arvinder K. Dhalla, Melissa Santikul, Michelle Smith, Mei-Yee Wong, John C. Shryock and Luiz Belardinelli

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 327-333; DOI: https://doi.org/10.1124/jpet.106.114421

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Effects of the Protein Kinase Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic Diseases
Ragini Vittal, Hengmin Zhang, MeiLan K. Han, Bethany B. Moore, Jeffrey C. Horowitz and Victor J. Thannickal

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 35-44; DOI: https://doi.org/10.1124/jpet.106.113407
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Regulation of Oxidant-Induced Intestinal Permeability by Metalloprotease-Dependent Epidermal Growth Factor Receptor Signaling
C. B. Forsyth, A. Banan, A. Farhadi, J. Z. Fields, Y. Tang, M. Shaikh, L. J. Zhang, P. A. Engen and A. Keshavarzian

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 84-97; DOI: https://doi.org/10.1124/jpet.106.113019
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Carbon Monoxide-Mediated Activation of Large-Conductance Calcium-Activated Potassium Channels Contributes to Mesenteric Vasodilatation in Cirrhotic Rats
Massimo Bolognesi, David Sacerdoti, Anna Piva, Marco Di Pascoli, Francesca Zampieri, Santina Quarta, Roberto Motterlini, Paolo Angeli, Carlo Merkel and Angelo Gatta

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 187-194; DOI: https://doi.org/10.1124/jpet.106.116665
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Characterization of the Uptake of Organic Anion Transporter (OAT) 1 and OAT3 Substrates by Human Kidney Slices
Yoshitane Nozaki, Hiroyuki Kusuhara, Tsunenori Kondo, Maki Hasegawa, Yoshiyuki Shiroyanagi, Hayakazu Nakazawa, Teruo Okano and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 362-369; DOI: https://doi.org/10.1124/jpet.106.113076

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Inhibition of Lipopolysaccharide-Induced Prostaglandin E₂ Production and Inflammation by the Na⁺/H⁺ Exchanger Inhibitors
Fumitaka Kamachi, Hyun Seung Ban, Noriyasu Hirasawa and Kazuo Ohuchi

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 345-352; DOI: https://doi.org/10.1124/jpet.106.116251

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Binding of Inhibitory Fatty Acids Is Responsible for the Enhancement of UDP-Glucuronosyltransferase 2B7 Activity by Albumin: Implications for in Vitro-in Vivo Extrapolation
Andrew Rowland, Paraskevi Gaganis, David J. Elliot, Peter I. Mackenzie, Kathleen M. Knights and John O. Miners

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 137-147; DOI: https://doi.org/10.1124/jpet.106.118216
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Differential Modulation of Sodium- and Chloride-Dependent Opioid Peptide Transport System by Small Nonopioid Peptides and Free Amino Acids
Seiji Miyauchi, Elangovan Gopal, Santosh V. Thakkar, Satoshi Ichikawa, Puttur D. Prasad and Vadivel Ganapathy

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 257-264; DOI: https://doi.org/10.1124/jpet.106.116806
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The Inactivation of Cytochrome P450 3A5 by 17α-Ethynylestradiol Is Cytochrome b₅-Dependent: Metabolic Activation of the Ethynyl Moiety Leads to the Formation of Glutathione Conjugates, a Heme Adduct, and Covalent Binding to the Apoprotein
Hsia-lien Lin and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 276-287; DOI: https://doi.org/10.1124/jpet.106.117861
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Enantiomeric Metabolic Interactions and Stereoselective Human Methadone Metabolism
Rheem A. Totah, Kyle E. Allen, Pamela Sheffels, Dale Whittington and Evan D. Kharasch

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 389-399; DOI: https://doi.org/10.1124/jpet.106.117580
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A Metabolic Screening Study of Trichostatin A (TSA) and TSA-Like Histone Deacetylase Inhibitors in Rat and Human Primary Hepatocyte Cultures
G. Elaut, G. Laus, E. Alexandre, L. Richert, P. Bachellier, D. Tourwé, V. Rogiers and T. Vanhaecke

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 400-408; DOI: https://doi.org/10.1124/jpet.106.116202

NEUROPHARMACOLOGY

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Intensity-Dependent Activation of Extracellular Signal-Regulated Protein Kinase 5 in Sensory Neurons Contributes to Pain Hypersensitivity
Toshiyuki Mizushima, Koichi Obata, Hirokazu Katsura, Jun Sakurai, Kimiko Kobayashi, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Takashi Mashimo and Koichi Noguchi

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 28-34; DOI: https://doi.org/10.1124/jpet.106.116749
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Astrocyte Glycogen Sustains Neuronal Activity during Hypoglycemia: Studies with the Glycogen Phosphorylase Inhibitor CP-316,819 ([R-R*,S*]-5-Chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)
Sang Won Suh, Jennifer P. Bergher, Christopher M. Anderson, Judith L. Treadway, Keld Fosgerau and Raymond A. Swanson

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 45-50; DOI: https://doi.org/10.1124/jpet.106.115550
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Aberrant Synaptic Activation of N-Methyl-d-aspartate Receptors Underlies Ethanol Withdrawal Hyperexcitability
Adam W. Hendricson, Regina E. Maldve, Armando G. Salinas, Jonathan W. Theile, Tao A. Zhang, Laurea M. Diaz and Richard A. Morrisett

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 60-72; DOI: https://doi.org/10.1124/jpet.106.111419
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Activation by Zonisamide, a Newer Antiepileptic Drug, of Large-Conductance Calcium-Activated Potassium Channel in Differentiated Hippocampal Neuron-Derived H19-7 Cells
Chin-Wei Huang, Chao-Ching Huang and Sheng-Nan Wu

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 98-106; DOI: https://doi.org/10.1124/jpet.106.116954
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Rhesus Monkey Trace Amine-Associated Receptor 1 Signaling: Enhancement by Monoamine Transporters and Attenuation by the D2 Autoreceptor in Vitro
Zhihua Xie, Susan V. Westmoreland, Mary E. Bahn, Guo-Lin Chen, Hong Yang, Eric J. Vallender, Wei-Dong Yao, Bertha K. Madras and Gregory M. Miller

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 116-127; DOI: https://doi.org/10.1124/jpet.106.116863
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Trace Amine-Associated Receptor 1 Is a Modulator of the Dopamine Transporter
Zhihua Xie and Gregory M. Miller

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 128-136; DOI: https://doi.org/10.1124/jpet.106.117382
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Antidepressants Increase Glial Cell Line-Derived Neurotrophic Factor Production through Monoamine-Independent Activation of Protein Tyrosine Kinase and Extracellular Signal-Regulated Kinase in Glial Cells
Kazue Hisaoka, Minoru Takebayashi, Mami Tsuchioka, Natsuko Maeda, Yoshihiro Nakata and Shigeto Yamawaki

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 148-157; DOI: https://doi.org/10.1124/jpet.106.116558
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GABA_B Receptor-Positive Modulation-Induced Blockade of the Rewarding Properties of Nicotine Is Associated with a Reduction in Nucleus Accumbens ΔFosB Accumulation
Cedric Mombereau, Loic Lhuillier, Klemens Kaupmann and John F. Cryan

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 172-177; DOI: https://doi.org/10.1124/jpet.106.116228
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Trace Amine-Associated Receptor 1 Displays Species-Dependent Stereoselectivity for Isomers of Methamphetamine, Amphetamine, and Para-Hydroxyamphetamine
E. A. Reese, J. R. Bunzow, S. Arttamangkul, M. S. Sonders and D. K. Grandy

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 178-186; DOI: https://doi.org/10.1124/jpet.106.115402
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Efficacy of the MCHR1 Antagonist N-[3-(1-{[4-(3,4-Difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in Mouse Models of Anxiety and Depression following Acute and Chronic Administration Is Independent of Hippocampal Neurogenesis
D. J. David, K. C. Klemenhagen, K. A. Holick, M. D. Saxe, I. Mendez, L. Santarelli, D. A. Craig, H. Zhong, C. J. Swanson, L. G. Hegde, X. I. Ping, D. Dong, M. R. Marzabadi, C. P. Gerald and R. Hen

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 237-248; DOI: https://doi.org/10.1124/jpet.106.109678
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Protective Effect of Sulforaphane against Dopaminergic Cell Death
Ji Man Han, Yong Jin Lee, So Yeon Lee, Eun Mee Kim, Younghye Moon, Ha Won Kim and Onyou Hwang

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 249-256; DOI: https://doi.org/10.1124/jpet.106.110866
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Identification of Amino Acid Determinants of Dopamine 2 Receptor Synthetic Agonist Function
Munya A. Al-Fulaij, Yong Ren, Martin Beinborn and Alan S. Kopin

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 298-307; DOI: https://doi.org/10.1124/jpet.106.116384
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Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039)
Linda M. Rorick-Kehn, Bryan G. Johnson, Jennifer L. Burkey, Rebecca A. Wright, David O. Calligaro, Gerard J. Marek, Eric S. Nisenbaum, John T. Catlow, Ann E. Kingston, Deborah D. Giera, Marc F. Herin, James A. Monn, David L. McKinzie and Darryle D. Schoepp

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 308-317; DOI: https://doi.org/10.1124/jpet.106.110809

TOXICOLOGY

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A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition
Jun Gu, Chong-Sheng Chen, Yuan Wei, Cheng Fang, Fang Xie, Kurunthachalam Kannan, Weizhu Yang, David J. Waxman and Xinxin Ding

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 9-17; DOI: https://doi.org/10.1124/jpet.106.118240
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Inhibition of Acrolein-Induced Apoptosis by the Antioxidant N-Acetylcysteine
André Tanel and Diana A. Averill-Bates

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 73-83; DOI: https://doi.org/10.1124/jpet.106.114678
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Bifunctional Alkylating Agent-Induced p53 and Nonclassical Nuclear Factor κB Responses and Cell Death Are Altered by Caffeic Acid Phenethyl Ester: A Potential Role for Antioxidant/Electrophilic Response-Element Signaling
Gary D. Minsavage and James F. Dillman

Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 202-212; DOI: https://doi.org/10.1124/jpet.106.116145

Errata

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Correction to “A Potent Immunomodulatory Compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole Acetic Acid, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice”
Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 420;
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Correction to “Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats”
Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 421;
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Correction to “Modulation of Pro- and Antiapoptotic Molecules in Double-Positive (CD4⁺CD8⁺) Thymocytes following Dexamethasone Treatment”
Journal of Pharmacology and Experimental Therapeutics April 2007, 321 (1) 422;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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