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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Jonathan D. Urban, William P. Clarke, Mark von Zastrow, David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M. Sexton, Keith J. Miller, Michael Spedding and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 1-13; DOI: https://doi.org/10.1124/jpet.106.104463
Jonathan D. Urban
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William P. Clarke
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Mark von Zastrow
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David E. Nichols
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Brian Kobilka
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Harel Weinstein
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Jonathan A. Javitch
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Bryan L. Roth
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Arthur Christopoulos
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Patrick M. Sexton
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Keith J. Miller
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Michael Spedding
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Richard B. Mailman
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Article Information

vol. 320 no. 1 1-13
DOI 
https://doi.org/10.1124/jpet.106.104463
PubMed 
16803859

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 11, 2006
  • Accepted June 23, 2006
  • Published online December 20, 2006.

Article Versions

  • Earlier version (June 27, 2006 - 06:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jonathan D. Urban,
  2. William P. Clarke,
  3. Mark von Zastrow,
  4. David E. Nichols,
  5. Brian Kobilka,
  6. Harel Weinstein,
  7. Jonathan A. Javitch,
  8. Bryan L. Roth,
  9. Arthur Christopoulos,
  10. Patrick M. Sexton,
  11. Keith J. Miller,
  12. Michael Spedding and
  13. Richard B. Mailman
  1. Curriculum in Toxicology (J.D.U., R.B.M.) and Departments of Pharmacology, Psychiatry Medicinal Chemistry (B.L.R., R.B.M.), and Neurology (R.B.M.), University of North Carolina, Chapel Hill, North Carolina; Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas (W.P.C.); Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, California (M.v.Z); Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana (D.E.N.); Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, California (B.K.); Department of Physiology and Biophysics, and Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York (H.W.); Center for Molecular Recognition, and Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York (J.A.J.); Department of Pharmacology, Monash University, Clayton, Victoria, Australia (A.C., P.M.S.); Obesity Department, Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, New Jersey (K.J.M.); and Institute de Recherches Servier, Suresnes, France (M.S.)
  1. Address correspondence to:
    Dr. Richard B. Mailman, CB 7160, 7011 NC Neurosciences Hospital, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7160. E-mail: richard_mailman{at}med.unc.edu
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Journal of Pharmacology and Experimental Therapeutics: 382 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 382, Issue 2
1 Aug 2022
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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Jonathan D. Urban, William P. Clarke, Mark von Zastrow, David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M. Sexton, Keith J. Miller, Michael Spedding and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics January 1, 2007, 320 (1) 1-13; DOI: https://doi.org/10.1124/jpet.106.104463

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Research ArticlePERSPECTIVES IN PHARMACOLOGY

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Jonathan D. Urban, William P. Clarke, Mark von Zastrow, David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M. Sexton, Keith J. Miller, Michael Spedding and Richard B. Mailman
Journal of Pharmacology and Experimental Therapeutics January 1, 2007, 320 (1) 1-13; DOI: https://doi.org/10.1124/jpet.106.104463
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  • Article
    • Abstract
    • Receptor Pharmacology for the New Millennium
    • Examples of Functional Selectivity
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