Journal of Pharmacology and Experimental Therapeutics: 320 (1)

January 01, 2007; Volume 320,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Jonathan D. Urban, William P. Clarke, Mark von Zastrow, David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M. Sexton, Keith J. Miller, Michael Spedding and Richard B. Mailman

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 1-13; DOI: https://doi.org/10.1124/jpet.106.104463

BEHAVIORAL PHARMACOLOGY

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Inflammation-Induced Reduction of Spontaneous Activity by Adjuvant: A Novel Model to Study the Effect of Analgesics in Rats
David J. Matson, Daniel C. Broom, Susan R. Carson, James Baldassari, John Kehne and Daniel N. Cortright

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 194-201; DOI: https://doi.org/10.1124/jpet.106.109736
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Effects of Salvinorin A, a κ-Opioid Hallucinogen, on a Neuroendocrine Biomarker Assay in Nonhuman Primates with High κ-Receptor Homology to Humans
Eduardo R. Butelman, Marek Mandau, Kevin Tidgewell, Thomas E. Prisinzano, Vadim Yuferov and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 300-306; DOI: https://doi.org/10.1124/jpet.106.112417
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Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats
P. E. Alele and L. L. Devaud

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 427-436; DOI: https://doi.org/10.1124/jpet.106.107896
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WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-Octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A Novel 5-Hydroxytryptamine 2C Receptor-Selective Agonist with Preclinical Antipsychotic-Like Activity
Karen L. Marquis, Annmarie L. Sabb, Sheree F. Logue, Julie A. Brennan, Michael J. Piesla, Tom A. Comery, Steven M. Grauer, Charles R. Ashby, Huy Q. Nguyen, Lee A. Dawson, James E. Barrett, Gary Stack, Herbert Y. Meltzer, Boyd L. Harrison and Sharon Rosenzweig-Lipson

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 486-496; DOI: https://doi.org/10.1124/jpet.106.106989

CARDIOVASCULAR

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Distinct K_ATP Channels Mediate the Antihypertrophic Effects of Adenosine Receptor Activation in Neonatal Rat Ventricular Myocytes
Ying Xia, Sabzali Javadov, Tracey X. Gan, Theresa Pang, Michael A. Cook and Morris Karmazyn

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 14-21; DOI: https://doi.org/10.1124/jpet.106.110494
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Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities
Chris Doe, Ross Bentley, David J. Behm, Robert Lafferty, Robert Stavenger, David Jung, Mark Bamford, Terry Panchal, Eugene Grygielko, Lois L. Wright, Gary K. Smith, Zunxuan Chen, Christine Webb, Sanjay Khandekar, Tracey Yi, Robert Kirkpatrick, Edward Dul, Larry Jolivette, Joseph P. Marino, Robert Willette, Dennis Lee and Erding Hu

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 89-98; DOI: https://doi.org/10.1124/jpet.106.110635
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Licofelone, a Balanced Inhibitor of Cyclooxygenase and 5-Lipoxygenase, Reduces Inflammation in a Rabbit Model of Atherosclerosis
Cristina Vidal, Almudena Gómez-Hernández, Eva Sánchez-Galán, Alejandro González, Luis Ortega, Juan Antonio Gómez-Gerique, José Tuñón and Jesús Egido

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 108-116; DOI: https://doi.org/10.1124/jpet.106.110361
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Cyclooxygenase, p38 Mitogen-Activated Protein Kinase (MAPK), Extracellular Signal-Regulated Kinase MAPK, Rho Kinase, and Src Mediate Hydrogen Peroxide-Induced Contraction of Rat Thoracic Aorta and Vena Cava
Keshari Thakali, Lauren Davenport, Gregory D. Fink and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 236-243; DOI: https://doi.org/10.1124/jpet.106.110650
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The Nitric Oxide-Donating Pravastatin Derivative, NCX 6550 [(1S-[1α(βS*, δS*), 2α, 6α, 8β-(R*), 8aα]]-1,2,6,7,8,8a-Hexahydro-β, δ, 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic Acid 4-(Nitrooxy)butyl Ester)], Reduces Splenocyte Adhesion and Reactive Oxygen Species Generation in Normal and Atherosclerotic Mice
G. Dever, C. M. Spickett, S. Kennedy, C. Rush, G. Tennant, A. Monopoli and C. L. Wainwright

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 419-426; DOI: https://doi.org/10.1124/jpet.106.109298

CELLULAR AND MOLECULAR

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Comparative Studies of Anthraquinone- and Anthracene-Tetraamines as Blockers of N-Methyl-d-aspartate Receptors
Lihua Jin, Hiromi Sugiyama, Miki Takigawa, Daisuke Katagiri, Hideyuki Tomitori, Kazuhiro Nishimura, Navneet Kaur, Otto Phanstiel, Mariko Kitajima, Hiromitsu Takayama, Tadashi Okawara, Keith Williams, Keiko Kashiwagi and Kazuei Igarashi

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 47-55; DOI: https://doi.org/10.1124/jpet.106.110528
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Complete Inhibition of P-glycoprotein by Simultaneous Treatment with a Distinct Class of Modulators and the UIC2 Monoclonal Antibody
Katalin Goda, Ferenc Fenyvesi, Zsolt Bacsó, Henrietta Nagy, Teréz Márián, Attila Megyeri, Zoltán Krasznai, István Juhász, Miklós Vecsernyés and Gábor Szabó

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 81-88; DOI: https://doi.org/10.1124/jpet.106.110155
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A Comparison of the Antagonist Affinities for the G_i- and G_s-Coupled States of the Human Adenosine A1-Receptor
Jillian G. Baker and Stephen J. Hill

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 218-228; DOI: https://doi.org/10.1124/jpet.106.113589
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Mechanisms Linking Adenosine A₁ Receptors and Extracellular Signal-Regulated Kinase 1/2 Activation in Human Trabecular Meshwork Cells
S. Husain, T. W. Shearer and C. E. Crosson

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 258-265; DOI: https://doi.org/10.1124/jpet.106.110981
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Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes
Michelle L. Halls, Ross A. D. Bathgate and Roger J. Summers

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 281-290; DOI: https://doi.org/10.1124/jpet.106.113225
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Inhibition of Human Preadipocyte Proteasomal Activity by HIV Protease Inhibitors or Specific Inhibitor Lactacystin Leads to a Defect in Adipogenesis, Which Involves Matrix Metalloproteinase-9
Sandra De Barros, Alexia Zakaroff-Girard, Max Lafontan, Jean Galitzky and Virginie Bourlier

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 291-299; DOI: https://doi.org/10.1124/jpet.106.111849
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Ca²⁺-Calmodulin and Janus Kinase 2 Are Required for Activation of Sodium-Proton Exchange by the G_i-Coupled 5-Hydroxytryptamine_1a Receptor
Justin H. Turner, Maria N. Garnovskaya, Sonya D. Coaxum, Tamara M. Vlasova, Margarita Yakutovich, David M. Lefler and John R. Raymond

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 314-322; DOI: https://doi.org/10.1124/jpet.106.112581
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Lack of the Aryl Hydrocarbon Receptor Leads to Impaired Activation of AKT/Protein Kinase B and Enhanced Sensitivity to Apoptosis Induced via the Intrinsic Pathway
Ran Wu, Li Zhang, Martin S. Hoagland and Hollie I. Swanson

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 448-457; DOI: https://doi.org/10.1124/jpet.106.111773

ENDOCRINE AND DIABETES

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Desoxyrhaponticin (3,5-Dihydroxy-4′-methoxystilbene 3-O-β-d-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies
Jian Mei Li, Chun Tao Che, Clara B. S. Lau, Po Sing Leung and Christopher H. K. Cheng

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 38-46; DOI: https://doi.org/10.1124/jpet.106.111526
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Sergliflozin, a Novel Selective Inhibitor of Low-Affinity Sodium Glucose Cotransporter (SGLT2), Validates the Critical Role of SGLT2 in Renal Glucose Reabsorption and Modulates Plasma Glucose Level
Kenji Katsuno, Yoshikazu Fujimori, Yukiko Takemura, Masahiro Hiratochi, Fumiaki Itoh, Yoshimitsu Komatsu, Hideki Fujikura and Masayuki Isaji

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 323-330; DOI: https://doi.org/10.1124/jpet.106.110296
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Nicotinamide Reverses Neurological and Neurovascular Deficits in Streptozotocin Diabetic Rats
M. J. Stevens, F. Li, V. R. Drel, O. I. Abatan, H. Kim, D. Burnett, D. Larkin and I. G. Obrosova

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 458-464; DOI: https://doi.org/10.1124/jpet.106.109702
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The Thyroid Disruptor 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)-Ethane Appears to Be an Uncompetitive Inverse Agonist for the Thyrotropin Receptor
Mario Rossi, Antonio Dimida, Maria Teresa Dell'anno, Maria Letizia Trincavelli, Patrizia Agretti, Franco Giorgi, Giovanni U. Corsini, Aldo Pinchera, Paolo Vitti, Massimo Tonacchera and Roberto Maggio

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 465-474; DOI: https://doi.org/10.1124/jpet.106.113613

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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The Prevention of Colitis by E Prostanoid Receptor 4 Agonist through Enhancement of Epithelium Survival and Regeneration
Guang-Liang Jiang, Amelia Nieves, Wha Bin Im, David W. Old, Danny T. Dinh and Larry Wheeler

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 22-28; DOI: https://doi.org/10.1124/jpet.106.111146
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The Extracellular cAMP-Adenosine Pathway Significantly Contributes to the in Vivo Production of Adenosine
Edwin K. Jackson, Zaichuan Mi and Raghvendra K. Dubey

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 117-123; DOI: https://doi.org/10.1124/jpet.106.112748
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The Nuclear Receptor Constitutively Active/Androstane Receptor Regulates Type 1 Deiodinase and Thyroid Hormone Activity in the Regenerating Mouse Liver
Eric S. Tien, Kenji Matsui, Rick Moore and Masahiko Negishi

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 307-313; DOI: https://doi.org/10.1124/jpet.106.112706

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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A p38α Selective Mitogen-Activated Protein Kinase Inhibitor Prevents Periodontal Bone Loss
Keith L. Kirkwood, Fei Li, Jill E. Rogers, Jodie Otremba, Derek D. Coatney, Jaclynn M. Kreider, Nisha J. D'Silva, Sarvajit Chakravarty, Sundeep Dugar, Linda S. Higgins, Andrew A. Protter and Satyanarayana Medicherla

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 56-63; DOI: https://doi.org/10.1124/jpet.106.112466
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Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D₂ and 11-Methylene-PGD₂ on Human Eosinophils and Basophils
Chantal Cossette, Sinead E. Walsh, Seongjin Kim, Gue-Jae Lee, John A. Lawson, Sophie Bellone, Joshua Rokach and William S. Powell

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 173-179; DOI: https://doi.org/10.1124/jpet.106.111062

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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The Contribution of Intestinal UDP-Glucuronosyltransferases in Modulating 7-Ethyl-10-hydroxy-camptothecin (SN-38)-Induced Gastrointestinal Toxicity in Rats
Melanie N. Tallman, Kristini K. Miles, Fay K. Kessler, Judith N. Nielsen, Xianbin Tian, Joseph K. Ritter and Philip C. Smith

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 29-37; DOI: https://doi.org/10.1124/jpet.106.110924
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Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers
Stephanie R. Faucette, Tong-Cun Zhang, Rick Moore, Tatsuya Sueyoshi, Curtis J. Omiecinski, Edward L. LeCluyse, Masahiko Negishi and Hongbing Wang

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 72-80; DOI: https://doi.org/10.1124/jpet.106.112136
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Marked Strain Differences in the Pharmacokinetics of an α₄β₁ Integrin Antagonist, 4-[1-[3-Chloro-4-[N-(2-methylphenyl)-ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]-methoxybenzoic Acid (D01-4582), in Sprague-Dawley Rats Are Associated with Albumin Genetic Polymorphism
Takashi Ito, Masayuki Takahashi, Kenichi Sudo and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 124-132; DOI: https://doi.org/10.1124/jpet.106.111948
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Bias in Estimation of Transporter Kinetic Parameters from Overexpression Systems: Interplay of Transporter Expression Level and Substrate Affinity
Anand Balakrishnan, Naissan Hussainzada, Pablo Gonzalez, Marival Bermejo, Peter W. Swaan and James E. Polli

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 133-144; DOI: https://doi.org/10.1124/jpet.106.107433
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Concentration-Dependent Mode of Interaction of Angiotensin II Receptor Blockers with Uric Acid Transporter
Takashi Iwanaga, Masanobu Sato, Tomoji Maeda, Toshio Ogihara and Ikumi Tamai

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 211-217; DOI: https://doi.org/10.1124/jpet.106.112755
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Interaction of Nonsteroidal Anti-Inflammatory Drugs with Multidrug Resistance Protein (MRP) 2/ABCC2- and MRP4/ABCC4-Mediated Methotrexate Transport
Azza A. K. El-Sheikh, Jeroen J. M. W. van den Heuvel, Jan B. Koenderink and Frans G. M. Russel

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 229-235; DOI: https://doi.org/10.1124/jpet.106.110379
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Identification and Functional Analysis of Common Human Flavin-Containing Monooxygenase 3 Genetic Variants
Sevasti B. Koukouritaki, Mark T. Poch, Marilyn C. Henderson, Lisbeth K. Siddens, Sharon K. Krueger, Jonathan E. VanDyke, David E. Williams, Nicholas M. Pajewski, Tao Wang and Ronald N. Hines

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 266-273; DOI: https://doi.org/10.1124/jpet.106.112268
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Valproic Acid Is Not a Substrate for P-glycoprotein or Multidrug Resistance Proteins 1 and 2 in a Number of in Vitro and in Vivo Transport Assays
Steffen Baltes, Maren Fedrowitz, Carlos Luna Tortós, Heidrun Potschka and Wolfgang Löscher

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 331-343; DOI: https://doi.org/10.1124/jpet.106.102491
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Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse
Ahmed A. Othman, Shariq A. Syed, Amy H. Newman and Natalie D. Eddington

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 344-353; DOI: https://doi.org/10.1124/jpet.106.111245

NEUROPHARMACOLOGY

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Cannabinoid (CB₁) Receptor Activation Inhibits Trigeminovascular Neurons
Simon Akerman, Philip R. Holland and Peter J. Goadsby

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 64-71; DOI: https://doi.org/10.1124/jpet.106.106971
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A Chimeric Human/Murine Anticocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Mice
Andrew B. Norman, Michael R. Tabet, Mantana K. Norman, William R. Buesing, Amadeo J. Pesce and William J. Ball

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 145-153; DOI: https://doi.org/10.1124/jpet.106.111781
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Anticonvulsants for Nerve Agent-Induced Seizures: The Influence of the Therapeutic Dose of Atropine
Tsung-Ming Shih, Tami C. Rowland and John H. McDonough

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 154-161; DOI: https://doi.org/10.1124/jpet.106.111252
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4-Aminopyridine Prevents the Conformational Changes Associated with P/C-Type Inactivation in Shaker Channels
Thomas W. Claydon, Moni Vaid, Saman Rezazadeh, Steven J. Kehl and David Fedida

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 162-172; DOI: https://doi.org/10.1124/jpet.106.110411
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Extended Access to Nicotine Self-Administration Leads to Dependence: Circadian Measures, Withdrawal Measures, and Extinction Behavior in Rats
Laura E. O'Dell, Scott A. Chen, Ron T. Smith, Sheila E. Specio, Robert L. Balster, Neil E. Paterson, Athina Markou, Eric P. Zorrilla and George F. Koob

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 180-193; DOI: https://doi.org/10.1124/jpet.106.105270
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Protein Kinase A Activation Down-Regulates, Whereas Extracellular Signal-Regulated Kinase Activation Up-Regulates σ-1 Receptors in B-104 Cells: Implication for Neuroplasticity
Gianfrancesco Cormaci, Tomohisa Mori, Teruo Hayashi and Tsung-Ping Su

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 202-210; DOI: https://doi.org/10.1124/jpet.106.108415
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Nicotinic Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Activation in the Spinal Cord
M. I. Damaj

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 244-249; DOI: https://doi.org/10.1124/jpet.106.111336
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Inhibition of Nicotine Metabolism by Methoxysalen: Pharmacokinetic and Pharmacological Studies in Mice
M. I. Damaj, E. C. K. Siu, E. M. Sellers, R. F. Tyndale and B. R. Martin

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 250-257; DOI: https://doi.org/10.1124/jpet.106.111237
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Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Na_v1.8 Than in TTX-Sensitive Na⁺ Channels
Andreas Leffler, Anne Reiprich, Durga P. Mohapatra and Carla Nau

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 354-364; DOI: https://doi.org/10.1124/jpet.106.109025
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BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H₃ Receptor: Preclinical Pharmacology
X. Ligneau, D. Perrin, L. Landais, J.-C. Camelin, T. P. G. Calmels, I. Berrebi-Bertrand, J.-M. Lecomte, R. Parmentier, C. Anaclet, J.-S. Lin, V. Bertaina-Anglade, C. Drieu la Rochelle, F. d'Aniello, A. Rouleau, F. Gbahou, J.-M. Arrang, C. R. Ganellin, H. Stark, W. Schunack and J.-C. Schwartz

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 365-375; DOI: https://doi.org/10.1124/jpet.106.111039
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D₂-Like Dopamine Receptors Depolarize Dorsal Raphe Serotonin Neurons through the Activation of Nonselective Cationic Conductance
Teresa K. Aman, Roh-Yu Shen and Samir Haj-Dahmane

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 376-385; DOI: https://doi.org/10.1124/jpet.106.111690
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The Experimental Alzheimer's Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid-β Peptide Levels in Cell Culture and Mice
Debomoy K. Lahiri, DeMao Chen, Bryan Maloney, Harold W. Holloway, Qian-sheng Yu, Tada Utsuki, Tony Giordano, Kumar Sambamurti and Nigel H. Greig

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 386-396; DOI: https://doi.org/10.1124/jpet.106.112102
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Selective Activation of Group III Metabotropic Glutamate Receptors by l-(+)-2-Amino-4-phosphonobutryic Acid Protects the Nigrostriatal System against 6-Hydroxydopamine Toxicity in Vivo
Anthony C. Vernon, Virginia Zbarsky, Krishna P. Datla, David T. Dexter and Martin J. Croucher

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 397-409; DOI: https://doi.org/10.1124/jpet.106.108159
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Two Protein Trafficking Processes at Motor Nerve Endings Unveiled by Botulinum Neurotoxin E
Gary Lawrence, Jiafu Wang, C. K. N. Kwo Chion, K. Roger Aoki and J. Oliver Dolly

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 410-418; DOI: https://doi.org/10.1124/jpet.106.108829
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Group III Metabotropic Glutamate Receptor Agonists Selectively Suppress Excitatory Synaptic Currents in the Rat Prefrontal Cortex Induced by 5-Hydroxytryptamine_2A Receptor Activation
Ce Zhang and Gerard J. Marek

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 437-447; DOI: https://doi.org/10.1124/jpet.106.107490
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Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1
David B. Wainscott, Sheila P. Little, Tinggui Yin, Yuan Tu, Vincent P. Rocco, John X. He and David L. Nelson

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 475-485; DOI: https://doi.org/10.1124/jpet.106.112532

TOXICOLOGY

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Comparison of S-Adenosyl-l-methionine and N-Acetylcysteine Protective Effects on Acetaminophen Hepatic Toxicity
Marcus V. Terneus, K. Kelley Kiningham, A. Betts Carpenter, Sarah B. Sullivan and Monica A. Valentovic

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 99-107; DOI: https://doi.org/10.1124/jpet.106.111872
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Roles of Norepinephrine, Free Fatty Acids, Thyroid Status, and Skeletal Muscle Uncoupling Protein 3 Expression in Sympathomimetic-Induced Thermogenesis
Jon E. Sprague, Xianmei Yang, Joni Sommers, Tracy L. Gilman and Edward M. Mills

Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 274-280; DOI: https://doi.org/10.1124/jpet.106.107755

Errata

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Correction to “In Vitro Metabolism of (Nitroxy)butyl Ester Nitric Oxide-Releasing Compounds: Comparison with Glyceryl Trinitrate”
Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 497;
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Correction to “NAP Enhances Neurodevelopment of Newborn E-Deficient Mice Subjected to Hypoxia”
Journal of Pharmacology and Experimental Therapeutics January 2007, 320 (1) 498;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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