Abstract
1. Lithium, sodium and potassium salicylates were given to physically normal individuals on a weighed diet containing 2500 calories, ⅓ gram of protein per pound and 2000 cc. of fluid. The dose of salicyl was 6 mgm. per pound of body weight, three times a day.
2. An increase of 10 per cent in the total urinary nitrogen, total sulphur, total sulphate, and inorganic sulphate followed the administration of these drugs. The uric acid excretion was increased 30 per cent.
3. The increase in the total nitrogen excretion occurred immediately when the sodium salt was given, but was delayed for two days when the potassium salt was used.
4. The excretion of uric acid was promptest after the lithium salt was given followed by sodium and potassium in the order named.
Footnotes
- Received September 29, 1927.
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