Abstract
1. Intravenous injection of histamine phosphate (0.25 mgm.) in the cat produces a great increase in the blood flow through the submaxillary gland, with chorda tympani and sympathetic nerves cut. The same effect is observed in dogs with 1 mgm. of histamine phosphate.
2. Intravenous injection of a small dose of pilocarpine 0.25 mgm. in a cat and 1 mgm. in a dog produces a moderate increase of blood flow through the submaxillary gland of both animals.
3. Injection of histamine following pilocarpine in a cat causes a diminution in the blood flow through the submaxillary gland. The same reversal effect of pilocarpine on histamine can be evoked in the dog, but with much larger doses of pilocarpine.
4. Atropine restores the vaso-dilator action of histamine both in a cat and a dog, but to a lesser degree than originally.
Footnotes
- Received June 23, 1927.
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