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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2006; Volume 319,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Preclinical Assessment of Candidate Analgesic Drugs: Recent Advances and Future Challenges
    S. S. Negus, T. W. Vanderah, M. R. Brandt, E. J. Bilsky, L. Becerra and D. Borsook
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 507-514; DOI: https://doi.org/10.1124/jpet.106.106377

BEHAVIORAL PHARMACOLOGY

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    Effect of Duration and Pattern of Chronic Ethanol Exposure on Tolerance to the Discriminative Stimulus Effects of Ethanol in C57BL/6J Mice
    Howard C. Becker and Alicia M. Baros
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 871-878; DOI: https://doi.org/10.1124/jpet.106.108795
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    The Dopamine Agonist Piribedil with L-DOPA Improves Attentional Dysfunction: Relevance for Parkinson's Disease
    Nathalie Turle-Lorenzo, Béatrice Maurin, Carole Puma, Claire Chezaubernard, Philippe Morain, Christelle Baunez, André Nieoullon and Marianne Amalric
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 914-923; DOI: https://doi.org/10.1124/jpet.106.109207

CARDIOVASCULAR

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    Fibroblast Growth Factor-2 Mediates Angiotensin-Converting Enzyme Inhibitor-Induced Angiogenesis in Coronary Endothelium
    Sandra Donnini, Raffaella Solito, Antonio Giachetti, Harris J. Granger, Marina Ziche and Lucia Morbidelli
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 515-522; DOI: https://doi.org/10.1124/jpet.106.108803
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    Soluble Guanylyl Cyclase Activation Promotes Angiogenesis
    Anastasia Pyriochou, Dimitris Beis, Vasiliki Koika, Christos Potytarchou, Evangelia Papadimitriou, Zongmin Zhou and Andreas Papapetropoulos
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 663-671; DOI: https://doi.org/10.1124/jpet.106.108878
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    Role of Myocardial Nitric Oxide in Diabetic Ischemia-Reperfusion Dysfunction: Studies in Mice with Myocyte-Specific Overexpression of Endothelial Nitric-Oxide Synthase
    Beatriz Pozo-Navas, Heike Stessel, Gerald Wölkart and Friedrich Brunner
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 729-738; DOI: https://doi.org/10.1124/jpet.106.107854
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    Pharmacological Characterization of Novel α-Calcitonin Gene-Related Peptide (CGRP) Receptor Peptide Antagonists That Are Selective for Human CGRP Receptors
    Christopher K. Taylor, D. David Smith, Martin Hulce and Peter W. Abel
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 749-757; DOI: https://doi.org/10.1124/jpet.106.108316
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    The Serotonin 5-Hydroxytryptaphan1A Receptor Agonist, (+)8-Hydroxy-2-(di-n-propylamino)-tetralin, Stimulates Sympathetic-Dependent Increases in Venous Tone during Hypovolemic Shock
    Ruslan Tiniakov and Karie E. Scrogin
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 776-782; DOI: https://doi.org/10.1124/jpet.106.108944
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    Enhanced Thromboxane Receptor-Mediated Responses and Impaired Endothelium-Dependent Relaxation in Human Corpus Cavernosum from Diabetic Impotent Men: Role of Protein Kinase C Activity
    Javier Angulo, Pedro Cuevas, Argentina Fernández, Antonio Allona, Ignacio Moncada, Antonio Martín-Morales, José María La Fuente and Iñigo Sáenz de Tejada
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 783-789; DOI: https://doi.org/10.1124/jpet.106.108597
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    Properties of a Time-Dependent Potassium Current in Pig Atrium: Evidence for a Role of Kv1.5 in Repolarization
    Joachim R. Ehrlich, Christin Hoche, Pierre Coutu, Christiane Metz-Weidmann, Werner Dittrich, Stefan H. Hohnloser, Stanley Nattel and Heinz Gögelein
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 898-906; DOI: https://doi.org/10.1124/jpet.106.110080

CELLULAR AND MOLECULAR

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    Valproic Acid Inhibits Invasiveness in Bladder Cancer but Not in Prostate Cancer Cells
    Chien-Lun Chen, Jennifer Sung, Michael Cohen, Wasim H. Chowdhury, Markus D. Sachs, Ying Li, Yegappan Lakshmanan, Benjamin Y. M. Yung, Shawn E. Lupold and Ronald Rodriguez
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 533-542; DOI: https://doi.org/10.1124/jpet.106.106658
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    Busulfan Selectively Induces Cellular Senescence but Not Apoptosis in WI38 Fibroblasts via a p53-Independent but Extracellular Signal-Regulated Kinase-p38 Mitogen-Activated Protein Kinase-Dependent Mechanism
    Virginia Probin, Yong Wang, Aiping Bai and Daohong Zhou
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 551-560; DOI: https://doi.org/10.1124/jpet.106.107771
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    Nitric Oxide Production by the Vacuolar-Type (H+)-ATPase Inhibitors Bafilomycin A1 and Concanamycin A and Its Possible Role in Apoptosis in RAW 264.7 Cells
    JangJa Hong, Yasuhiro Nakano, Aya Yokomakura, Kenji Ishihara, Soonjoo Kim, Young-Sook Kang and Kazuo Ohuchi
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 672-681; DOI: https://doi.org/10.1124/jpet.106.109280
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    Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists
    Terry Kenakin, Stephen Jenkinson and Christian Watson
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 710-723; DOI: https://doi.org/10.1124/jpet.106.107375
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    Tethered Yohimbine Analogs as Selective Human α2C-Adrenergic Receptor Ligands
    Supriya A. Bavadekar, Guoyi Ma, Suni M. Mustafa, Bob M. Moore, Duane D. Miller and Dennis R. Feller
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 739-748; DOI: https://doi.org/10.1124/jpet.106.105981
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    Voltage-Gated K+ Channel Block by Catechol Derivatives: Defining Nonselective and Selective Pharmacophores
    Vicenta Salvador-Recatala, Yonjung Kim, Elena Zaks-Makhina and Edwin S. Levitan
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 758-764; DOI: https://doi.org/10.1124/jpet.106.107607
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    Ligands Regulate Cell Surface Level of the Human κ Opioid Receptor by Activation-Induced Down-Regulation and Pharmacological Chaperone-Mediated Enhancement: Differential Effects of Nonpeptide and Peptide Agonists
    Yong Chen, Chongguang Chen, Yulin Wang and Lee-Yuan Liu-Chen
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 765-775; DOI: https://doi.org/10.1124/jpet.106.107987
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    Modulation of Pro- and Antiapoptotic Molecules in Double-Positive (CD4+CD8+) Thymocytes following Dexamethasone Treatment
    Rodolfo Bianchini, Giuseppe Nocentini, Ludovic Tibor Krausz, Katia Fettucciari, Stefano Coaccioli, Simona Ronchetti and Carlo Riccardi
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 887-897; DOI: https://doi.org/10.1124/jpet.106.108480
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    Mallotoxin Is a Novel Human Ether-a-go-go-Related Gene (hERG) Potassium Channel Activator
    Haoyu Zeng, Irina M. Lozinskaya, Zuojun Lin, Robert N. Willette, David P. Brooks and Xiaoping Xu
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 957-962; DOI: https://doi.org/10.1124/jpet.106.110593
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    Prostanoid Receptors Regulate the Volume-Sensitive Efflux of Osmolytes from Murine Fibroblasts via a Cyclic AMP-Dependent Mechanism
    Anne M. Heacock, Daniel J. Foster and Stephen K. Fisher
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 963-971; DOI: https://doi.org/10.1124/jpet.106.109496

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Photochemical Internalization of Therapeutic Macromolecular Agents: A Novel Strategy to Kill Multidrug-Resistant Cancer Cells
    Pål K. Selbo, Anette Weyergang, Anette Bonsted, Stephen G. Bown and Kristian Berg
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 604-612; DOI: https://doi.org/10.1124/jpet.106.109165

ENDOCRINE AND DIABETES

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    Transport within the Interstitial Space, Rather Than Membrane Permeability, Determines Norepinephrine Recovery in Microdialysis
    H. Alec Ross, Petra J. van Gurp, Jacques J. Willemsen, Jacques W. M. Lenders, Cees J. Tack and Fred C. G. J. Sweep
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 840-846; DOI: https://doi.org/10.1124/jpet.106.109710

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    The New Low Calcemic Vitamin D Analog 22-Ene-25-Oxa-Vitamin D Prominently Ameliorates T Helper Cell Type 1-Mediated Colitis in Mice
    Carolin Daniel, Heinfried H. Radeke, Nico A. Sartory, Nadine Zahn, Ulrich Zuegel, Andreas Steinmeyer and Jürgen Stein
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 622-631; DOI: https://doi.org/10.1124/jpet.106.107599
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    Renoprotective Effects of l-Carnosine on Ischemia/Reperfusion-Induced Renal Injury in Rats
    Hayato Kurata, Toshihide Fujii, Hidenobu Tsutsui, Tomoaki Katayama, Mamoru Ohkita, Masanori Takaoka, Nobuo Tsuruoka, Yoshinobu Kiso, Yukihiro Ohno, Yoshihide Fujisawa, Takatoshi Shokoji, Akira Nishiyama, Youichi Abe and Yasuo Matsumura
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 640-647; DOI: https://doi.org/10.1124/jpet.106.110122
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    Role of Cyclooxygenase Isoforms and Nitric-Oxide Synthase in the Modulation of Tracheal Motor Responsiveness in Normal and Antigen-Sensitized Guinea Pigs
    Paola Nieri, Cinzia Martinelli, Corrado Blandizzi, Nunzia Bernardini, Rosamiria Greco, Chiara Ippolito, Mario Del Tacca and Maria Cristina Breschi
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 648-656; DOI: https://doi.org/10.1124/jpet.106.102475
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    Melatonin Treatment Reverts Age-Related Changes in Guinea Pig Gallbladder Neuromuscular Transmission and Contractility
    Pedro J. Gomez-Pinilla, Cristina Camello-Almaraz, Rosario Moreno, Pedro J. Camello and María J. Pozo
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 847-856; DOI: https://doi.org/10.1124/jpet.106.109256
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    Identification of Bombesin Receptor Subtype-Specific Ligands: Effect of N-Methyl Scanning, Truncation, Substitution, and Evaluation of Putative Reported Selective Ligands
    Samuel A. Mantey, Nieves Gonzalez, Michael Schumann, Tapas K. Pradhan, Lin Shen, David H. Coy and Robert T. Jensen
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 980-989; DOI: https://doi.org/10.1124/jpet.106.107011

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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    Effect of Transforming Growth Factor-β Receptor I Kinase Inhibitor 2,4-Disubstituted Pteridine (SD-208) in Chronic Allergic Airway Inflammation and Remodeling
    Sum Yee Leung, Akio Niimi, Alistair Noble, Timothy Oates, Alison S. Williams, Satyanarayana Medicherla, Andrew A. Protter and Kian Fan Chung
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 586-594; DOI: https://doi.org/10.1124/jpet.106.109314
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    A Reversible S-Adenosyl-l-Homocysteine Hydrolase Inhibitor Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting T Cell Activation
    Yun-Feng Fu, Yi-Na Zhu, Jia Ni, Xiang-Gen Zhong, Wei Tang, Yu-Dan Re, Li-Ping Shi, Jin Wan, Yi-Fu Yang, Chong Yuan, Fa-Jun Nan, Brian R. Lawson and Jian-Ping Zuo
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 799-808; DOI: https://doi.org/10.1124/jpet.106.107185
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    Aspirin and Salicylate Suppress Polymorphonuclear Apoptosis Delay Mediated by Proinflammatory Stimuli
    Soledad Negrotto, Elisa Malaver, María Eugenia Alvarez, Natalia Pacienza, Lina Paola D'Atri, Roberto Gabriel Pozner, Ricardo Martín Gómez and Mirta Schattner
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 972-979; DOI: https://doi.org/10.1124/jpet.106.109389

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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    Variability of CYP2J2 Expression in Human Fetal Tissues
    Andrea Gaedigk, Darren W. Baker, Rheem A. Totah, Roger Gaedigk, Robin E. Pearce, Carrie A. Vyhlidal, Darryl C. Zeldin and J. Steven Leeder
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 523-532; DOI: https://doi.org/10.1124/jpet.106.109215
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    Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches
    Elisabet Gullberg, Åsa V. Keita, Sa'ad Y. Salim, Margaretha Andersson, Karin D. Caldwell, Johan D. Söderholm and Per Artursson
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 632-639; DOI: https://doi.org/10.1124/jpet.106.107847
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    Nuclear Trafficking of a Gadolinium Conjugate in Nude Mice Xenografted with Human LN-229 Glioma
    Stefan Heckl and Ulrich Vogel
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 657-662; DOI: https://doi.org/10.1124/jpet.106.109868
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    Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α
    Masahiro Itoh, Miki Nakajima, Eriko Higashi, Ryoko Yoshida, Kiyoshi Nagata, Yasushi Yamazoe and Tsuyoshi Yokoi
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 693-702; DOI: https://doi.org/10.1124/jpet.106.107573
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    N-Acetyltransferase (Nat) 1 and 2 Expression in Nat2 Knockout Mice
    Jennifer A. Loehle, Valerie Cornish, Larissa Wakefield, Mark A. Doll, Jason R. Neale, Yu Zang, Edith Sim and David W. Hein
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 724-728; DOI: https://doi.org/10.1124/jpet.106.108662
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    Molecular Determinants in the Transport of a Bile Acid-Derived Diagnostic Agent in Tumoral and Nontumoral Cell Lines of Human Liver
    Antonin Libra, Cristina Fernetti, Vito Lorusso, Massimo Visigalli, Pier Lucio Anelli, Frantisek Staud, Claudio Tiribelli and Lorella Pascolo
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 809-817; DOI: https://doi.org/10.1124/jpet.106.106591
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    Increased Estrogen Sulfation of Estradiol 17β-D-Glucuronide in Metastatic Tumor Rat Livers
    Huadong Sun, Lichuan Liu and K. Sandy Pang
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 818-831; DOI: https://doi.org/10.1124/jpet.106.108860
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    Elucidating the Effect of Final-Day Dosing of Rifampin in Induction Studies on Hepatic Drug Disposition and Metabolism
    Justine L. Lam, Sarah B. Shugarts, Hideaki Okochi and Leslie Z. Benet
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 864-870; DOI: https://doi.org/10.1124/jpet.106.108282
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    Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)
    Atsushi Yonezawa, Satohiro Masuda, Sachiko Yokoo, Toshiya Katsura and Ken-ichi Inui
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 879-886; DOI: https://doi.org/10.1124/jpet.106.110346
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    Effects of Trimethoprim on the Clearance of Apricitabine, a Deoxycytidine Analog Reverse Transcriptase Inhibitor, and Lamivudine in the Isolated Perfused Rat Kidney
    Tomoko Nakatani-Freshwater, Mariana Babayeva, Aruna Dontabhaktuni and David R. Taft
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 941-947; DOI: https://doi.org/10.1124/jpet.106.108522

NEUROPHARMACOLOGY

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    A Nonfeminizing Estrogen Analog Protects against Ethanol Withdrawal Toxicity in Immortalized Hippocampal Cells
    Marianna E. Jung, Andrew M. Wilson and James W. Simpkins
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 543-550; DOI: https://doi.org/10.1124/jpet.106.103630
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    Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro
    Bertha K. Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J. Spencer, Ali A. Bonab, Gregory M. Miller and Alan J. Fischman
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 561-569; DOI: https://doi.org/10.1124/jpet.106.106583
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    Dopamine Transporter (DAT) Inhibitors Alleviate Specific Parkinsonian Deficits in Monkeys: Association with DAT Occupancy in Vivo
    Bertha K. Madras, Michele A. Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C. Meltzer, David R. Elmaleh, Eli Livni, Ali A. Bonab and Alan J. Fischman
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 570-585; DOI: https://doi.org/10.1124/jpet.106.105312
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    Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) 38 and PACAP4–6 Are Neuroprotective through Inhibition of NADPH Oxidase: Potent Regulators of Microglia-Mediated Oxidative Stress
    Sufen Yang, Jun Yang, Zhengqin Yang, Posee Chen, Alison Fraser, Wei Zhang, Hao Pang, Xi Gao, Belinda Wilson, Jau-Shyong Hong and Michelle L. Block
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 595-603; DOI: https://doi.org/10.1124/jpet.106.102236
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    Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of the Respiratory-Depressant Effect of Buprenorphine and Fentanyl in Rats
    Ashraf Yassen, Jingmin Kan, Erik Olofsen, Ernst Suidgeest, Albert Dahan and Meindert Danhof
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 682-692; DOI: https://doi.org/10.1124/jpet.106.107953
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    The Mechanism of Carbamazepine Aggravation of Absence Seizures
    Lige Liu, Thomas Zheng, Margaret J. Morris, Charlott Wallengren, Alison L. Clarke, Christopher A. Reid, Steven Petrou and Terence J. O'Brien
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 790-798; DOI: https://doi.org/10.1124/jpet.106.104968
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    Effects of Glycogen Synthase Kinase 3β and Cyclin-Dependent Kinase 5 Inhibitors on Morphine-Induced Analgesia and Tolerance in Rats
    Jan Rodriguez Parkitna, Ilona Obara, Agnieszka Wawrzczak-Bargiela, Wioletta Makuch, Barbara Przewlocka and Ryszard Przewlocki
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 832-839; DOI: https://doi.org/10.1124/jpet.106.107581
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    Effects of Prenatal Ethanol Exposure on the Excitability of Ventral Tegmental Area Dopamine Neurons in Vitro
    Jue Wang, Samir Haj-Dahmane and Roh-Yu Shen
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 857-863; DOI: https://doi.org/10.1124/jpet.106.109041
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    Functional Selectivity of NK1 Receptor Signaling: Peptide Agonists Can Preferentially Produce Receptor Activation or Desensitization
    Mark A. Simmons
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 907-913; DOI: https://doi.org/10.1124/jpet.106.109512
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    Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139
    Thomas A. Lanz, Michael J. Karmilowicz, Kathleen M. Wood, Nikolay Pozdnyakov, Ping Du, Mary A. Piotrowski, Tracy M. Brown, Charles E. Nolan, Karl E. G. Richter, James E. Finley, Qing Fei, Charles F. Ebbinghaus, Yuhpyng L. Chen, Douglas K. Spracklin, Barbara Tate, Kieran F. Geoghegan, Lit-Fui Lau, David D. Auperin and Joel B. Schachter
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 924-933; DOI: https://doi.org/10.1124/jpet.106.110700

TOXICOLOGY

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    Depletion of Glutathione Induces 4-Hydroxynonenal Protein Adducts and Hydroxyurea Teratogenicity in the Organogenesis Stage Mouse Embryo
    Jin Yan and Barbara F. Hales
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 613-621; DOI: https://doi.org/10.1124/jpet.106.109850
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    Levels of 4-Hydroxynonenal and Malondialdehyde Are Increased in Brain of Human Chronic Users of Methamphetamine
    Paul S. Fitzmaurice, Junchao Tong, Mehrdad Yazdanpanah, Peter P. Liu, Kathryn S. Kalasinsky and Stephen J. Kish
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 703-709; DOI: https://doi.org/10.1124/jpet.106.109173
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    Calcineurin Activation Is Not Necessary for Doxorubicin-Induced Hypertrophy in H9c2 Embryonic Rat Cardiac Cells: Involvement of the Phosphoinositide 3-Kinase-Akt Pathway
    Kevyn E. Merten, Youchun Jiang, Wenke Feng and Y. James Kang
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 934-940; DOI: https://doi.org/10.1124/jpet.106.108845
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    System B0,+ and the Transport of Thiol-S-Conjugates of Methylmercury
    Christy C. Bridges and Rudolfs K. Zalups
    Journal of Pharmacology and Experimental Therapeutics November 2006, 319 (2) 948-956; DOI: https://doi.org/10.1124/jpet.106.109371
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Journal of Pharmacology and Experimental Therapeutics: 319 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 319, Issue 2
1 Nov 2006
  • Table of Contents
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  • PERSPECTIVES IN PHARMACOLOGY
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND DIABETES
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
  • METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

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