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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic Modeling in Sandwich-Cultured Rat Hepatocytes

Ryan Z. Turncliff, Keith A. Hoffmaster, J. Cory Kalvass, Gary M. Pollack and Kim L. R. Brouwer
Journal of Pharmacology and Experimental Therapeutics August 2006, 318 (2) 881-889; DOI: https://doi.org/10.1124/jpet.106.102616

Article Information

vol. 318 no. 2 881-889
DOI 
https://doi.org/10.1124/jpet.106.102616
PubMed 
16690724
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 15, 2006
  • Accepted May 9, 2006
  • Published online July 13, 2006.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ryan Z. Turncliff,
  2. Keith A. Hoffmaster,
  3. J. Cory Kalvass,
  4. Gary M. Pollack and
  5. Kim L. R. Brouwer
  1. School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (R.Z.T., J.C.K., G.M.P., K.L.R.B.); and Pfizer Research Technology Center, Cambridge, Massachusetts (K.A.H.)
  1. Address correspondence to:
    Dr. Kim L. R. Brouwer, School of Pharmacy, Kerr Hall, CB #7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360. E-mail: kbrouwer{at}unc.edu
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Research ArticleMETABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic Modeling in Sandwich-Cultured Rat Hepatocytes

Ryan Z. Turncliff, Keith A. Hoffmaster, J. Cory Kalvass, Gary M. Pollack and Kim L. R. Brouwer
Journal of Pharmacology and Experimental Therapeutics August 1, 2006, 318 (2) 881-889; DOI: https://doi.org/10.1124/jpet.106.102616
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