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Research ArticleINFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells

Danyi Wen, Yuhua Nong, Jennifer G. Morgan, Pranoti Gangurde, Andrew Bielecki, Jennifer DaSilva, Marie Keaveney, Hong Cheng, Chris Fraser, Lisa Schopf, Michael Hepperle, Geraldine Harriman, Bruce D. Jaffee, Timothy D. Ocain and Yajun Xu
Journal of Pharmacology and Experimental Therapeutics June 2006, 317 (3) 989-1001; DOI: https://doi.org/10.1124/jpet.105.097584
Danyi Wen
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Yuhua Nong
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Jennifer G. Morgan
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Pranoti Gangurde
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Andrew Bielecki
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Jennifer DaSilva
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Marie Keaveney
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Hong Cheng
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Chris Fraser
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Lisa Schopf
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Michael Hepperle
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Geraldine Harriman
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Bruce D. Jaffee
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Timothy D. Ocain
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Yajun Xu
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Article Information

vol. 317 no. 3 989-1001
DOI 
https://doi.org/10.1124/jpet.105.097584
PubMed 
16525037

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 25, 2005
  • Accepted March 6, 2006
  • Published online May 18, 2006.

Article Versions

  • Earlier version (March 8, 2006 - 11:12).
  • Earlier version (March 8, 2006 - 11:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Danyi Wen,
  2. Yuhua Nong,
  3. Jennifer G. Morgan,
  4. Pranoti Gangurde,
  5. Andrew Bielecki,
  6. Jennifer DaSilva,
  7. Marie Keaveney,
  8. Hong Cheng,
  9. Chris Fraser,
  10. Lisa Schopf,
  11. Michael Hepperle,
  12. Geraldine Harriman,
  13. Bruce D. Jaffee,
  14. Timothy D. Ocain and
  15. Yajun Xu
  1. Departments of Inflammation and Discovery Technologies, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts
  1. Address correspondence to:
    Danyi Wen, Inflammation Department, Millennium Pharmaceuticals, Inc., 35 Landsdowne Street, Cambridge, MA 02139. E-mail: wen{at}mpi.com
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Journal of Pharmacology and Experimental Therapeutics: 385 (3)
Journal of Pharmacology and Experimental Therapeutics
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1 Jun 2023
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Research ArticleINFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells

Danyi Wen, Yuhua Nong, Jennifer G. Morgan, Pranoti Gangurde, Andrew Bielecki, Jennifer DaSilva, Marie Keaveney, Hong Cheng, Chris Fraser, Lisa Schopf, Michael Hepperle, Geraldine Harriman, Bruce D. Jaffee, Timothy D. Ocain and Yajun Xu
Journal of Pharmacology and Experimental Therapeutics June 1, 2006, 317 (3) 989-1001; DOI: https://doi.org/10.1124/jpet.105.097584

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Research ArticleINFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells

Danyi Wen, Yuhua Nong, Jennifer G. Morgan, Pranoti Gangurde, Andrew Bielecki, Jennifer DaSilva, Marie Keaveney, Hong Cheng, Chris Fraser, Lisa Schopf, Michael Hepperle, Geraldine Harriman, Bruce D. Jaffee, Timothy D. Ocain and Yajun Xu
Journal of Pharmacology and Experimental Therapeutics June 1, 2006, 317 (3) 989-1001; DOI: https://doi.org/10.1124/jpet.105.097584
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