Journal of Pharmacology and Experimental Therapeutics: 317 (1)

April 01, 2006; Volume 317,Issue 1

EDITOR'S NOTE

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Editor's Note Regarding “Protective Mechanisms of a Metalloporhyrinic Peroxynitrite Decomposition Catalyst, WW85, in Rat Cardiac Transplants”
Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 462;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Modeling Glucocorticoid-Mediated Fetal Lung Maturation: I. Temporal Patterns of Corticosteroids in Rat Pregnancy
Mahesh N. Samtani, Nancy A. Pyszczynski, Debra C. DuBois, Richard R. Almon and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 117-126; DOI: https://doi.org/10.1124/jpet.105.095851
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Modeling Glucocorticoid-Mediated Fetal Lung Maturation: II. Temporal Patterns of Gene Expression in Fetal Rat Lung
Mahesh N. Samtani, Nancy A. Pyszczynski, Debra C. DuBois, Richard R. Almon and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 127-138; DOI: https://doi.org/10.1124/jpet.105.095869
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Inhibition of E-Cadherin-Mediated Homotypic Adhesion of Caco-2 Cells: A Novel Evaluation Assay for Peptide Activities in Modulating Cell-Cell Adhesion
Naoki Kobayashi, Atsutoshi Ikesue, Sumit Majumdar and Teruna J. Siahaan

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 309-316; DOI: https://doi.org/10.1124/jpet.105.097535

BEHAVIORAL PHARMACOLOGY

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Peripherally Mediated Antinociception of the μ-Opioid Receptor Agonist 2-[(4,5α-Epoxy-3-hydroxy-14β-methoxy-17-methylmorphinan-6β-yl)amino]acetic Acid (HS-731) after Subcutaneous and Oral Administration in Rats with Carrageenan-Induced Hindpaw Inflammation
Indre Bileviciute-Ljungar, Mariana Spetea, Yan Guo, Johannes Schütz, Petra Windisch and Helmut Schmidhammer

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 220-227; DOI: https://doi.org/10.1124/jpet.105.096032
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Inhibition of Neprilysin by Infusion of Thiorphan into the Hippocampus Causes an Accumulation of Amyloid β and Impairment of Learning and Memory
Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda and Toshitaka Nabeshima

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 334-340; DOI: https://doi.org/10.1124/jpet.105.095687
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Metabolic Transformation Plays a Primary Role in the Psychostimulant-Like Discriminative-Stimulus Effects of Selegiline [(R)-(–)-Deprenyl]
Sevil Yasar, Zuzana Justinova, Sun-Hee Lee, Roman Stefanski, Steven R. Goldberg and Gianluigi Tanda

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 387-394; DOI: https://doi.org/10.1124/jpet.105.096263
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Discriminative Stimulus Effects of γ-Hydroxybutyrate: Role of Training Dose
Wouter Koek, Weibin Chen, Susan L. Mercer, Andrew Coop and Charles P. France

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 409-417; DOI: https://doi.org/10.1124/jpet.105.096909

CARDIOVASCULAR

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Induction of Renal 20-Hydroxyeicosatetraenoic Acid by Clofibrate Attenuates High-Fat Diet-Induced Hypertension in Rats
Yiqiang Zhou, Hui Huang, Hsin-Hsin Chang, Juan Du, Jing Feng Wu, Cong-Yi Wang and Mong-Heng Wang

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 11-18; DOI: https://doi.org/10.1124/jpet.105.095356
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Peroxisome Proliferator-Activated Receptor γ Down-Regulates Receptor for Advanced Glycation End Products and Inhibits Smooth Muscle Cell Proliferation in a Diabetic and Nondiabetic Rat Carotid Artery Injury Model
Kai Wang, Zhongmin Zhou, Ming Zhang, Liming Fan, Farhad Forudi, Xiaorong Zhou, Wu Qu, A. Michael Lincoff, Ann Marie Schmidt, Eric J. Topol and Marc S. Penn

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 37-43; DOI: https://doi.org/10.1124/jpet.105.095125
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Alteration in Erythropoietin-Induced Cardioprotective Signaling by Postinfarct Ventricular Remodeling
Takayuki Miki, Tetsuji Miura, Toshiyuki Yano, Akari Takahashi, Jun Sakamoto, Masaya Tanno, Hironori Kobayashi, Yoshihiro Ikeda, Masahiro Nishihara, Kazuyuki Naitoh, Katsuhiko Ohori and Kazuaki Shimamoto

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 68-75; DOI: https://doi.org/10.1124/jpet.105.095745
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Inhibition of Phosphodiesterase 5 Selectively Reverses Nitrate Tolerance in the Venous Circulation
Jeffery D. MacPherson, Timothy D. Gillespie, Heather A. Dunkerley, Donald H. Maurice and Brian M. Bennett

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 188-195; DOI: https://doi.org/10.1124/jpet.105.094763
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Rotigaptide (ZP123) Prevents Spontaneous Ventricular Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs
James K. Hennan, Robert E. Swillo, Gwen A. Morgan, James C. Keith, Robert G. Schaub, Robert P. Smith, Hal S. Feldman, Ketil Haugan, Joel Kantrowitz, Phil J. Wang, Aqel Abu-Qare, John Butera, Bjarne D. Larsen and David L. Crandall

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 236-243; DOI: https://doi.org/10.1124/jpet.105.096933
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Molecular Mechanisms Underlying Rat Mesenteric Artery Vasorelaxation Induced by the Nitric Oxide-Independent Soluble Guanylyl Cyclase Stimulators BAY 41-2272 [5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole]
Cleber E. Teixeira, Fernanda B. M. Priviero and R. Clinton Webb

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 258-266; DOI: https://doi.org/10.1124/jpet.105.095752
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K_v Channels Contribute to Nitric Oxide- and Atrial Natriuretic Peptide-Induced Relaxation of a Rat Conduit Artery
Yoshio Tanaka, Guanghua Tang, Kei Takizawa, Kazuoki Otsuka, Mansoureh Eghbali, Min Song, Kazuhide Nishimaru, Koki Shigenobu, Katsuo Koike, Enrico Stefani and Ligia Toro

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 341-354; DOI: https://doi.org/10.1124/jpet.105.096115
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Lysophosphatidylcholine Potentiates Phenylephrine Responses in Rat Mesenteric Arterial Bed through Modulation of Thromboxane A₂
Rui Zhang, Brian Rodrigues and Kathleen M. MacLeod

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 355-361; DOI: https://doi.org/10.1124/jpet.105.097964
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Pitavastatin Effect on ATP Binding Cassette A1-Mediated Lipid Efflux from Macrophages: Evidence for Liver X Receptor (LXR)-Dependent and LXR-Independent Mechanisms of Activation by cAMP
Ilaria Zanotti, Francesco Potì, Elda Favari, Knut R. Steffensen, Jan-Åke Gustafsson and Franco Bernini

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 395-401; DOI: https://doi.org/10.1124/jpet.105.093930
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Further Characterization of the Time-Dependent Vascular Effects of Δ⁹-Tetrahydrocannabinol
Saoirse E. O'Sullivan, David A. Kendall and Michael D. Randall

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 428-438; DOI: https://doi.org/10.1124/jpet.105.095828

CELLULAR AND MOLECULAR

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Induction of Adenosine A₁ Receptor Expression by Pertussis Toxin via an Adenosine 5′-Diphosphate Ribosylation-Independent Pathway
Sarvesh Jajoo, Debashree Mukherjea, Sandeep Pingle, Yuko Sekino and Vickram Ramkumar

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 1-10; DOI: https://doi.org/10.1124/jpet.105.096255
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Probing Ligand-Specific Histamine H₁- and H₂-Receptor Conformations with N^G-Acylated Imidazolylpropylguanidines
Sheng-Xue Xie, Prasanta Ghorai, Qi-Zhuang Ye, Armin Buschauer and Roland Seifert

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 139-146; DOI: https://doi.org/10.1124/jpet.105.097923
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Resistance to the Antineoplastic Agent Gallium Nitrate Results in Marked Alterations in Intracellular Iron and Gallium Trafficking: Identification of Novel Intermediates
Neil P. Davies, Yohan Suryo Rahmanto, Christopher R. Chitambar and Des R. Richardson

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 153-162; DOI: https://doi.org/10.1124/jpet.105.099044
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Glycogen Synthase Kinase-3 Phosphorylation, T-Cell Factor Signaling Activation, and Cell Morphology Change following Stimulation of Thromboxane Receptor α
Weili Yan and Hsin-Hsiung Tai

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 267-274; DOI: https://doi.org/10.1124/jpet.105.096826

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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9L Gliosarcoma Cell Proliferation and Tumor Growth in Rats Are Suppressed by N-Hydroxy-N′-(4-butyl-2-methylphenol) Formamidine (HET0016), a Selective Inhibitor of CYP4A
Meng Guo, Richard J. Roman, Joseph D. Fenstermacher, Stephen L. Brown, John R. Falck, Ali S. Arbab, Paul A. Edwards and A. Guillermo Scicli

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 97-108; DOI: https://doi.org/10.1124/jpet.105.097782
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Inhibition of B16 Melanoma Metastases with the Ruthenium Complex Imidazolium trans-Imidazoledimethylsulfoxide-tetrachlororuthenate and Down-Regulation of Tumor Cell Invasion
B. Gava, S. Zorzet, P. Spessotto, M. Cocchietto and G. Sava

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 284-291; DOI: https://doi.org/10.1124/jpet.105.095141

ENDOCRINE AND DIABETES

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Preclinical Pharmacology of a Nonsteroidal Ligand for Androgen Receptor-Mediated Imaging of Prostate Cancer
Jun Yang, Casey E. Bohl, Vipin A. Nair, Suni M. Mustafa, Seoung Soo Hong, Duane D. Miller and James T. Dalton

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 402-408; DOI: https://doi.org/10.1124/jpet.105.094334

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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3H-1,2-Dithiole-3-thione Targets Nuclear Factor κB to Block Expression of Inducible Nitric-Oxide Synthase, Prevents Hypotension, and Improves Survival in Endotoxemic Rats
Asok R. Karuri, Yong Huang, Sridevi Bodreddigari, Carrie Hayes Sutter, Bill D. Roebuck, Thomas W. Kensler and Thomas R. Sutter

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 61-67; DOI: https://doi.org/10.1124/jpet.105.096396
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Noninvasive Mapping of Reactive Oxygen Species by in Vivo Electron Spin Resonance Spectroscopy in Indomethacin-Induced Gastric Ulcers in Rats
Hideo Utsumi, Keiji Yasukawa, Tetsuhiro Soeda, Ken-ichi Yamada, Ryota Shigemi, Takashi Yao and Masazumi Tsuneyoshi

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 228-235; DOI: https://doi.org/10.1124/jpet.105.095166
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Talniflumate Increases Survival in a Cystic Fibrosis Mouse Model of Distal Intestinal Obstructive Syndrome
Nancy M. Walker, Janet E. Simpson, Roy C. Levitt, Kathryn T. Boyle and Lane L. Clarke

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 275-283; DOI: https://doi.org/10.1124/jpet.105.094847
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Oxysterol 22(R)-Hydroxycholesterol Induces the Expression of the Bile Salt Export Pump through Nuclear Receptor Farsenoid X Receptor but Not Liver X Receptor
Ruitang Deng, Dongfang Yang, Jian Yang and Bingfang Yan

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 317-325; DOI: https://doi.org/10.1124/jpet.105.097758
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The Role of Prostaglandin E Receptor-Dependent Signaling via cAMP in Mdr1b Gene Activation in Primary Rat Hepatocyte Cultures
Christina Ziemann, Armin Riecke, Gudrun Rüdell, Elke Oetjen, Hans J. Steinfelder, Christian Lass, Georg F. Kahl and Karen I. Hirsch-Ernst

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 378-386; DOI: https://doi.org/10.1124/jpet.105.094193
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Ava[l-Pro⁹,N-MeLeu10] Substance P(7-11) (GR 73632) and Sar⁹, Met(O₂)¹¹ Increase Distention-Induced Peristalsis through Activation of Neurokinin-1 Receptors on Smooth Muscle and Interstitial Cells of Cajal
Florentine Nieuwmeyer, Jing Ye and Jan D. Huizinga

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 439-445; DOI: https://doi.org/10.1124/jpet.105.094920
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Tonic Nociceptinergic Inputs to Neurons in the Hypothalamic Paraventricular Nucleus Contribute to Sympathetic Vasomotor Tone and Water and Electrolyte Homeostasis in Conscious Rats
Zbigniew K. Krowicki and Daniel R. Kapusta

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 446-453; DOI: https://doi.org/10.1124/jpet.105.094441

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Vascular Adhesion Protein-1 Plays an Important Role in Postischemic Inflammation and Neuropathology in Diabetic, Estrogen-Treated Ovariectomized Female Rats Subjected to Transient Forebrain Ischemia
Hao-Liang Xu, Luisa Salter-Cid, Matthew D. Linnik, Eric Y. Wang, Chanannait Paisansathan and Dale A. Pelligrino

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 19-29; DOI: https://doi.org/10.1124/jpet.105.096958
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Anti-Inflammatory Activity in Vitro and in Vivo of the Protein Farnesyltransferase Inhibitor Tipifarnib
Xiaohua Xue, Kuei-Tai A. Lai, Jing-Feng Huang, Yin Gu, Lars Karlsson and Anne Fourie

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 53-60; DOI: https://doi.org/10.1124/jpet.105.095976
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Adenosine Inhibits Tumor Necrosis Factor-α Release from Mouse Peritoneal Macrophages via A_2A and A_2B but Not the A₃ Adenosine Receptor
Laura M. Kreckler, Tina C. Wan, Zhi-Dong Ge and John A. Auchampach

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 172-180; DOI: https://doi.org/10.1124/jpet.105.096016
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In Vivo Characterization of the Novel Imidazopyridine BYK191023 [2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a Potent and Highly Selective Inhibitor of Inducible Nitric-Oxide Synthase
Martin D. Lehner, Degenhard Marx, Rainer Boer, Andreas Strub, Christian Hesslinger, Manfrid Eltze, Wolf-Rüdiger Ulrich, Frank Schwoebel, Ralph Theo Schermuly and Johannes Barsig

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 181-187; DOI: https://doi.org/10.1124/jpet.105.098673
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A Novel, Selective, and Orally Available Antagonist for CC Chemokine Receptor 3
Tatsuaki Morokata, Keiko Suzuki, Yohei Masunaga, Katsunari Taguchi, Koichiro Morihira, Ippei Sato, Masahiro Fujii, Satoko Takizawa, Yuichi Torii, Naoyoshi Yamamoto, Masayuki Kaneko, Toshimitsu Yamada, Koichiro Takahashi and Yasuaki Shimizu

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 244-250; DOI: https://doi.org/10.1124/jpet.105.097048
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Discovery of a Dual-Function Peptide That Combines Aminopeptidase N Inhibition and Kinin B₁ Receptor Antagonism
Lajos Gera, Jean-Philippe Fortin, Albert Adam, John M. Stewart and François Marceau

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 300-308; DOI: https://doi.org/10.1124/jpet.105.095661
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In Vitro and in Vivo Anti-Inflammatory Activity of a Seed Preparation Containing Phenethylisothiocyanate
Moul Dey, David Ribnicky, Anvar G. Kurmukov and Ilya Raskin

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 326-333; DOI: https://doi.org/10.1124/jpet.105.096511

NEUROPHARMACOLOGY

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Effect of Subchronic Treatment of Memantine, Galantamine, and Nicotine in the Brain of Tg2576 (APPswe) Transgenic Mice
Christina Unger, Marie M. Svedberg, Wen-Feng Yu, Monika M. Hedberg and Agneta Nordberg

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 30-36; DOI: https://doi.org/10.1124/jpet.105.098566
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Reciprocal Interaction of Serotonin and Neuronal Activity in Regulation of cAMP-Responsive Element-Dependent Gene Expression
Melissa A. Mahgoub, Yildirim Sara, Ege T. Kavalali and Lisa M. Monteggia

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 88-96; DOI: https://doi.org/10.1124/jpet.105.097097
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Cell Death Mechanism and Protective Effect of Erythropoietin after Focal Ischemia in the Whisker-Barrel Cortex of Neonatal Rats
Ling Wei, Byung H. Han, Ying Li, Christine L. Keogh, David M. Holtzman and Shan Ping Yu

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 109-116; DOI: https://doi.org/10.1124/jpet.105.094391
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Pharmacological Characterization of (E)-N-(4-Fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl)nortropane (LBT-999) as a Highly Promising Fluorinated Ligand for the Dopamine Transporter
Sylvie Chalon, Hakan Hall, Wadad Saba, Lucette Garreau, Frédéric Dollé, Christer Halldin, Patrick Emond, Michel Bottlaender, Jean-Bernard Deloye, Julie Helfenbein, Jean-Claude Madelmont, Sylvie Bodard, Zoïa Mincheva, Jean-Claude Besnard and Denis Guilloteau

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 147-152; DOI: https://doi.org/10.1124/jpet.105.096792
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Hypocretin (Orexin) Receptor Subtypes Differentially Enhance Acetylcholine Release and Activate G Protein Subtypes in Rat Pontine Reticular Formation
René Bernard, Ralph Lydic and Helen A. Baghdoyan

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 163-171; DOI: https://doi.org/10.1124/jpet.105.097071
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Differential Effects of Cocaine on Firing Rate and Pattern of Dopamine Neurons: Role of α₁ Receptors and Comparison with l-Dopa and Apomorphine
Yan Zhou, Bejamin S. Bunney and Wei-Xing Shi

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 196-201; DOI: https://doi.org/10.1124/jpet.105.094045
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Modeling Drug- and System-Related Changes in Body Temperature: Application to Clomethiazole-Induced Hypothermia, Long-Lasting Tolerance Development, and Circadian Rhythm in Rats
Sandra A. G. Visser, Björn Sällström, Tomas Forsberg, Lambertus A. Peletier and Johan Gabrielsson

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 209-219; DOI: https://doi.org/10.1124/jpet.105.095224
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Fatty Acid Amide Hydrolase (–/–) Mice Exhibit an Increased Sensitivity to the Disruptive Effects of Anandamide or Oleamide in a Working Memory Water Maze Task
Stephen A. Varvel, Benjamin F. Cravatt, April E. Engram and Aron H. Lichtman

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 251-257; DOI: https://doi.org/10.1124/jpet.105.095059
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KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor, Is a Direct Extracellular Blocker of Voltage-Gated Potassium Channels
Saman Rezazadeh, Thomas W. Claydon and David Fedida

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 292-299; DOI: https://doi.org/10.1124/jpet.105.097618
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Possible Involvement of Dynorphin A-(1–17) Release via μ₁-Opioid Receptors in Spinal Antinociception by Endomorphin-2
Hirokazu Mizoguchi, Hiroyuki Watanabe, Takafumi Hayashi, Wataru Sakurada, Toshiki Sawai, Tsutomu Fujimura, Tsukasa Sakurada and Shinobu Sakurada

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 362-368; DOI: https://doi.org/10.1124/jpet.105.098293
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Indiplon Is a High-Affinity Positive Allosteric Modulator with Selectivity for α1 Subunit-Containing GABA_A Receptors
Robert E. Petroski, Jordan E. Pomeroy, Ronnie Das, Heath Bowman, Weidong Yang, Adele P. Chen and Alan C. Foster

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 369-377; DOI: https://doi.org/10.1124/jpet.105.096701
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Cocaine-Amphetamine-Regulated Transcript Expression in the Rat Nucleus Accumbens Is Regulated by Adenylyl Cyclase and the Cyclic Adenosine 5′-Monophosphate/Protein Kinase A Second Messenger System
Douglas C. Jones and Michael J. Kuhar

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 454-461; DOI: https://doi.org/10.1124/jpet.105.096123

TOXICOLOGY

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S-Adenosyl-l-methionine Attenuates Hepatotoxicity Induced by Agonistic Jo2 Fas Antibody following CYP2E1 Induction in Mice
Xiaodong Wang and Arthur I. Cederbaum

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 44-52; DOI: https://doi.org/10.1124/jpet.105.098004
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Microarray Analysis of Mouse Ear Tissue Exposed to Bis-(2-chloroethyl) Sulfide: Gene Expression Profiles Correlate with Treatment Efficacy and An Established Clinical Endpoint
James F. Dillman, Alison I. Hege, Christopher S. Phillips, Linda D. Orzolek, Albert J. Sylvester, Carol Bossone, Claudia Henemyre-Harris, Robyn C. Kiser, Young W. Choi, John J. Schlager and Carol L. Sabourin

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 76-87; DOI: https://doi.org/10.1124/jpet.105.097014
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Ubiquitin-Dependent Degradation of p53 Protein Despite Phosphorylation at Its N Terminus by Acetaminophen
Yun-Sik Lee, Jie Wan, Bong-Jo Kim, Myung-Ae Bae and Byoung J. Song

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 202-208; DOI: https://doi.org/10.1124/jpet.105.096719
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Inorganic Mercury and Methylmercury Inhibit the Ca_v3.1 Channel Expressed in Human Embryonic Kidney 293 Cells by Different Mechanisms
Bohumila Tarabová, Martina Kurejová, Zdena Sulová, Melinda Drabová and L'ubica Lacinová

Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 418-427; DOI: https://doi.org/10.1124/jpet.105.095463

Erratum

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Correction to “The Chemoprotective Agent N-Acetylcysteine Blocks Cisplatin-Induced Apoptosis through Caspase Signaling Pathway”
Journal of Pharmacology and Experimental Therapeutics April 2006, 317 (1) 463;

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Table of Contents

EDITOR'S NOTE

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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