Journal of Pharmacology and Experimental Therapeutics: 316 (3)

March 01, 2006; Volume 316,Issue 3

NEUROPHARMACOLOGY

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Elevation of Endocannabinoid Levels in the Ventrolateral Periaqueductal Grey through Inhibition of Fatty Acid Amide Hydrolase Affects Descending Nociceptive Pathways via Both Cannabinoid Receptor Type 1 and Transient Receptor Potential Vanilloid Type-1 Receptors
Sabatino Maione, Tiziana Bisogno, Vito de Novellis, Enza Palazzo, Luigia Cristino, Marta Valenti, Stefania Petrosino, Vittorio Guglielmotti, Francesco Rossi and Vincenzo Di Marzo

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 969-982; DOI: https://doi.org/10.1124/jpet.105.093286
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Cumulative Activation of Akt and Consequent Inhibition of Glycogen Synthase Kinase-3 by Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor-1 in Cultured Hippocampal Neurons
Nadine N. Johnson-Farley, Tatyana Travkina and Daniel S. Cowen

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1062-1069; DOI: https://doi.org/10.1124/jpet.105.094433
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Ex Vivo Imaging of Fatty Acid Amide Hydrolase Activity and Its Inhibition in the Mouse Brain
Sherrye T. Glaser, S. John Gatley and Andrew N. Gifford

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1088-1097; DOI: https://doi.org/10.1124/jpet.105.094748
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TrkAd5: A Novel Therapeutic Agent for Treatment of Inflammatory Pain and Asthma
Judy J. Watson, Mark S. Fahey, Edwin van den Worm, Ferdi Engels, Frans P. Nijkamp, Paul Stroemer, Steve McMahon, Shelley J. Allen and David Dawbarn

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1122-1129; DOI: https://doi.org/10.1124/jpet.105.095844
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Advantages for Transdermal over Oral Oxybutynin to Treat Overactive Bladder: Muscarinic Receptor Binding, Plasma Drug Concentration, and Salivary Secretion
Tomomi Oki, Ayako Toma-Okura and Shizuo Yamada

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1137-1145; DOI: https://doi.org/10.1124/jpet.105.094508
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Brain Cholesterol Synthesis in Mice Is Affected by High Dose of Simvastatin but Not of Pravastatin
Karin M. Thelen, Katharina M. Rentsch, Ursula Gutteck, Maura Heverin, Maria Olin, Ulla Andersson, Arnold von Eckardstein, Ingemar Björkhem and Dieter Lütjohann

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1146-1152; DOI: https://doi.org/10.1124/jpet.105.094136
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An Inverse Agonist Selective for α5 Subunit-Containing GABA_A Receptors Enhances Cognition
G. R. Dawson, K. A. Maubach, N. Collinson, M. Cobain, B. J. Everitt, A. M. MacLeod, H. I. Choudhury, L. M. McDonald, G. Pillai, W. Rycroft, A. J. Smith, F. Sternfeld, F. D. Tattersall, K. A. Wafford, D. S. Reynolds, G. R. Seabrook and J. R. Atack

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1335-1345; DOI: https://doi.org/10.1124/jpet.105.092320
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Pharmacological Characterization of Agonists at δ-Containing GABA_A Receptors: Functional Selectivity for Extrasynaptic Receptors Is Dependent on the Absence of γ₂
Signe í Stórustovu and Bjarke Ebert

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1351-1359; DOI: https://doi.org/10.1124/jpet.105.092403
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The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol
Cecilia M. Borghese, Signe í Stórustovu, Bjarke Ebert, Murray B. Herd, Delia Belelli, Jeremy J. Lambert, George Marshall, Keith A. Wafford and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1360-1368; DOI: https://doi.org/10.1124/jpet.105.092452

CELLULAR AND MOLECULAR

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A Trimeric Anti-HER2/neu ScFv and Tumor Necrosis Factor-α Fusion Protein Induces HER2/neu Signaling and Facilitates Repair of Injured Epithelia
Tzu-Hsuan Huang and Sherie L. Morrison

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 983-991; DOI: https://doi.org/10.1124/jpet.105.095513
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Glibenclamide-Induced Apoptosis Is Specifically Enhanced by Expression of the Sulfonylurea Receptor Isoform SUR1 but Not by Expression of SUR2B or the Mutant SUR1(M1289T)
Annette Hambrock, Claudia Bernardo de Oliveira Franz, Sabrina Hiller and Hartmut Osswald

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1031-1037; DOI: https://doi.org/10.1124/jpet.105.097501
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Linopirdine Modulates Calcium Signaling and Stimulus-Secretion Coupling in Adrenal Chromaffin Cells by Targeting M-Type K⁺ Channels and Nicotinic Acetylcholine Receptors
Elvira V. Dzhura, Wenjuan He and Kevin P. M. Currie

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1165-1174; DOI: https://doi.org/10.1124/jpet.105.095570
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R(+)-Methanandamide and Other Cannabinoids Induce the Expression of Cyclooxygenase-2 and Matrix Metalloproteinases in Human Nonpigmented Ciliary Epithelial Cells
Susanne Rösch, Robert Ramer, Kay Brune and Burkhard Hinz

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1219-1228; DOI: https://doi.org/10.1124/jpet.105.092858
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Identification of the Insulin Signaling Cascade in the Regulation of Alpha-Class Glutathione S-Transferase Expression in Primary Cultured Rat Hepatocytes
Sang K. Kim, Mohamed A. Abdelmegeed and Raymond F. Novak

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1255-1261; DOI: https://doi.org/10.1124/jpet.105.096065
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Differential Efficacies of Somatostatin Receptor Agonists for G-Protein Activation and Desensitization of Somatostatin Receptor Subtype 4-Mediated Responses
Mia Engström, Juha-Matti Savola and Siegfried Wurster

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1262-1268; DOI: https://doi.org/10.1124/jpet.105.094128
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Growth Hormone Determines Sexual Dimorphism of Hepatic Cytochrome P450 3A4 Expression in Transgenic Mice
Connie Cheung, Ai-Ming Yu, Chong-Sheng Chen, Kristopher W. Krausz, Linda G. Byrd, Lionel Feigenbaum, Robert J. Edwards, David J. Waxman and Frank J. Gonzalez

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1328-1334; DOI: https://doi.org/10.1124/jpet.105.094367
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Identification of a New Class of Prostaglandin Transporter Inhibitors and Characterization of Their Biological Effects on Prostaglandin E₂ Transport
Yuling Chi, Sonya M. Khersonsky, Young-Tae Chang and Victor L. Schuster

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1346-1350; DOI: https://doi.org/10.1124/jpet.105.091975
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Traditional Chinese Medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) Activate Pregnane X Receptor and Increase Warfarin Clearance in Rats
Ying Mu, Jinnan Zhang, Shimin Zhang, Hong-Hao Zhou, David Toma, Songrong Ren, Leaf Huang, Maria Yaramus, Andrew Baum, Raman Venkataramanan and Wen Xie

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1369-1377; DOI: https://doi.org/10.1124/jpet.105.094342

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Molecular Targeting of BCL2 and BCLXL Proteins by Synthetic BCL2 Homology 3 Domain Peptide Enhances the Efficacy of Chemotherapy
Sonia S. Dharap, Pooja Chandna, Yang Wang, Jayant J. Khandare, Bo Qiu, Stanley Stein and Tamara Minko

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 992-998; DOI: https://doi.org/10.1124/jpet.105.094243

CARDIOVASCULAR

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Erythropoietin, Modified to Not Stimulate Red Blood Cell Production, Retains Its Cardioprotective Properties
Chanil Moon, Melissa Krawczyk, Doojin Paik, Thomas Coleman, Michael Brines, Magdalena Juhaszova, Steven J. Sollott, Edward G. Lakatta and Mark I. Talan

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 999-1005; DOI: https://doi.org/10.1124/jpet.105.094854
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Estrogen Receptor α Mediates Acute Potassium Channel Stimulation in Human Coronary Artery Smooth Muscle Cells
Guichun Han, Xiuping Yu, Luo Lu, Shuyi Li, Handong Ma, Shu Zhu, Xiuyun Cui and Richard E. White

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1025-1030; DOI: https://doi.org/10.1124/jpet.105.093542
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Comparative Evaluation of HERG Currents and QT Intervals following Challenge with Suspected Torsadogenic and Nontorsadogenic Drugs
Alexander N. Katchman, John Koerner, Toshimasa Tosaka, Raymond L. Woosley and Steven N. Ebert

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1098-1106; DOI: https://doi.org/10.1124/jpet.105.093393
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The Effect of NCX4016 [2-Acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl Ester] on the Consequences of Ischemia and Reperfusion in the Streptozotocin Diabetic Rat
S. G. Burke, C. L. Wainwright, I. Vojnovic, T. Warner, D. G. Watson and B. L. Furman

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1107-1114; DOI: https://doi.org/10.1124/jpet.105.096339
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The Urotensin-II Receptor Antagonist Palosuran Improves Pancreatic and Renal Function in Diabetic Rats
Martine Clozel, Patrick Hess, Changbin Qiu, Shuang-Shuang Ding and Markus Rey

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1115-1121; DOI: https://doi.org/10.1124/jpet.105.094821
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Fibrin Affinity of Erythrocyte-Coupled Tissue-Type Plasminogen Activators Endures Hemodynamic Forces and Enhances Fibrinolysis in Vivo
Kumkum Ganguly, Mukul S. Goel, Tatyana Krasik, Khalil Bdeir, Scott L. Diamond, Douglas B. Cines, Vladimir R. Muzykantov and Juan-Carlos Murciano

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1130-1136; DOI: https://doi.org/10.1124/jpet.105.093450
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Angiotensin I-Converting Enzyme Inhibitors Block Protein Kinase Cϵ by Activating Bradykinin B₁ Receptors in Human Endothelial Cells
Sinisa Stanisavljevic, Tatjana Ignjatovic, Peter A. Deddish, Viktor Brovkovych, Kai Zhang, Ervin G. Erdös and Randal A. Skidgel

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1153-1158; DOI: https://doi.org/10.1124/jpet.105.093849
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Differential Expression of Components of the Cardiomyocyte Adrenomedullin/Intermedin Receptor System following Blood Pressure Reduction in Nitric Oxide-Deficient Hypertension
YouYou Zhao, David Bell, Lisa R. Smith, Li Zhao, Adrian B. Devine, Eugene M. McHenry, D. Paul Nicholls and Barbara J. McDermott

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1269-1281; DOI: https://doi.org/10.1124/jpet.105.092783

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Immunomodulatory Effects of Etanercept in an Experimental Model of Spinal Cord Injury
Tiziana Genovese, Emanuela Mazzon, Concetta Crisafulli, Rosanna Di Paola, Carmelo Muià, Placido Bramanti and Salvatore Cuzzocrea

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1006-1016; DOI: https://doi.org/10.1124/jpet.105.097188
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Therapeutic Promise of Proteinase-Activated Receptor-2 Antagonism in Joint Inflammation
Elizabeth B. Kelso, John C. Lockhart, Todd Hembrough, Lynette Dunning, Robin Plevin, Morley D. Hollenberg, Christian P. Sommerhoff, John S. McLean and William R. Ferrell

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1017-1024; DOI: https://doi.org/10.1124/jpet.105.093807
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The Phase 2 Enzyme Inducers Ethacrynic Acid, DL-Sulforaphane, and Oltipraz Inhibit Lipopolysaccharide-Induced High-Mobility Group Box 1 Secretion by RAW 264.7 Cells
Meaghan E. Killeen, Joshua A. Englert, Donna Beer Stolz, Mingchen Song, Yusheng Han, Russell L. Delude, John A. Kellum and Mitchell P. Fink

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1070-1079; DOI: https://doi.org/10.1124/jpet.105.092841
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S-Adenosyl-l-homocysteine Hydrolase Inactivation Curtails Ovalbumin-Induced Immune Responses
Yun-Feng Fu, Jun-Xia Wang, Yang Zhao, Yang Yang, Wei Tang, Jia Ni, Yi-Na Zhu, Ru Zhou, Pei-Lan He, Chuan Li, Xiao-Yu Li, Yi-Fu Yang, Brian R. Lawson and Jian-Ping Zuo

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1229-1237; DOI: https://doi.org/10.1124/jpet.105.093369
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Second-Generation Inhibitors Demonstrate the Involvement of p38 Mitogen-Activated Protein Kinase in Post-Transcriptional Modulation of Inflammatory Mediator Production in Human and Rodent Airways
Mark A. Birrell, Sissie Wong, Kerryn McCluskie, Matthew C. Catley, Elizabeth L. Hardaker, Saleem Haj-Yahia and Maria G. Belvisi

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1318-1327; DOI: https://doi.org/10.1124/jpet.105.093310

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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RETRACTION: Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury
Atsushi Nakajima, Kyoko Ueda, Masanori Takaoka, Yoshiko Yoshimi and Yasuo Matsumura

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1038-1046; DOI: https://doi.org/10.1124/jpet.105.092049
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Effects of Calcium Channel Blockade on Angiotensin II-Induced Peritubular Ischemia in Rats
Naoki Kondo, Hideyasu Kiyomoto, Tokunori Yamamoto, Akira Miyatake, Guang-Ping Sun, Matlubur Rahman, Hirofumi Hitomi, Kumiko Moriwaki, Taiga Hara, Shoji Kimura, Youichi Abe, Masakazu Kohno and Akira Nishiyama

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1047-1052; DOI: https://doi.org/10.1124/jpet.105.095331
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Metformin Prevents Endotoxin-Induced Liver Injury after Partial Hepatectomy
Ina Bergheim, James P. Luyendyk, Chad Steele, Gilandra K. Russell, Luping Guo, Robert A. Roth and Gavin E. Arteel

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1053-1061; DOI: https://doi.org/10.1124/jpet.105.092122
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Pharmacologic Characterization of Intrinsic Mechanisms Controlling Tone and Relaxation of Porcine Lower Esophageal Sphincter
Ricard Farré, Mariona Aulí, Begoña Lecea, Emma Martínez and Pere Clavé

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1238-1248; DOI: https://doi.org/10.1124/jpet.105.094482
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Superoxide Dismutase Mimetic Preserves the Glomerular Capillary Permeability Barrier to Protein
Pu Duann, Prasun K. Datta, Cynthia Pan, Jeffrey B. Blumberg, Mukut Sharma and Elias A. Lianos

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1249-1254; DOI: https://doi.org/10.1124/jpet.105.092957

TOXICOLOGY

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Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils
Jeffrey F. Waring, Michael J. Liguori, James P. Luyendyk, Jane F. Maddox, Patricia E. Ganey, Robert F. Stachlewitz, Colin North, Eric A. G. Blomme and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1080-1087; DOI: https://doi.org/10.1124/jpet.105.096347
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Modulation of Expression of Rat Mitochondrial 2-Oxoglutarate Carrier in NRK-52E Cells Alters Mitochondrial Transport and Accumulation of Glutathione and Susceptibility to Chemically Induced Apoptosis
Feng Xu, David A. Putt, Larry H. Matherly and Lawrence H. Lash

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1175-1186; DOI: https://doi.org/10.1124/jpet.105.094599
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Relationship between Temperature, Dopaminergic Neurotoxicity, and Plasma Drug Concentrations in Methamphetamine-Treated Squirrel Monkeys
Jie Yuan, George Hatzidimitriou, Pranav Suthar, Melanie Mueller, Una McCann and George Ricaurte

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1210-1218; DOI: https://doi.org/10.1124/jpet.105.096503

ENDOCRINE AND DIABETES

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A Model of Controlled Acute Hyperglycemia in Rats: Effects of Insulin and Glucagon-Like Peptide-1 Analog
Joy K. Saha, Jinqi Xia, Steven K. Engle, Yun-Fei Chen, Wolfgang Glaesner and Joseph A. Jakubowski

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1159-1164; DOI: https://doi.org/10.1124/jpet.105.093534

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Is the Monkey an Appropriate Animal Model to Examine Drug-Drug Interactions Involving Renal Clearance? Effect of Probenecid on the Renal Elimination of H₂ Receptor Antagonists
Harunobu Tahara, Hiroyuki Kusuhara, Michihiro Chida, Eiichi Fuse and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1187-1194; DOI: https://doi.org/10.1124/jpet.105.094052
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Changes in Pharmacokinetics of Anti-HIV Protease Inhibitors during Pregnancy: The Role of CYP3A and P-glycoprotein
Anita A. Mathias, Lillian Maggio-Price, Yurong Lai, Anshul Gupta and Jashvant D. Unadkat

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1202-1209; DOI: https://doi.org/10.1124/jpet.105.095406
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Improving the in Vitro Prediction of in Vivo Central Nervous System Penetration: Integrating Permeability, P-glycoprotein Efflux, and Free Fractions in Blood and Brain
Scott G. Summerfield, Alexander J. Stevens, Leanne Cutler, Maria del Carmen Osuna, Beverley Hammond, Sac-Pham Tang, Ann Hersey, David J. Spalding and Phil Jeffrey

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1282-1290; DOI: https://doi.org/10.1124/jpet.105.092916
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Tibolone Metabolism in Human Liver Is Catalyzed by 3α/3β-Hydroxysteroid Dehydrogenase Activities of the Four Isoforms of the Aldo-Keto Reductase (AKR)1C Subfamily
Stephan Steckelbroeck, Busola Oyesanmi, Yi Jin, Seon-Hwa Lee, Helenius J. Kloosterboer and Trevor M. Penning

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1300-1309; DOI: https://doi.org/10.1124/jpet.105.091587
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Developmental Expression of Aryl, Estrogen, and Hydroxysteroid Sulfotransferases in Pre- and Postnatal Human Liver
Zhengbo Duanmu, Amy Weckle, Sevasti B. Koukouritaki, Ronald N. Hines, Josie L. Falany, Charles N. Falany, Thomas A. Kocarek and Melissa Runge-Morris

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1310-1317; DOI: https://doi.org/10.1124/jpet.105.093633

BEHAVIORAL PHARMACOLOGY

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Comparison of the Antinociceptive Response to Morphine and Morphine-Like Compounds in Male and Female Sprague-Dawley Rats
Elizabeth M. Peckham and John R. Traynor

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1195-1201; DOI: https://doi.org/10.1124/jpet.105.094276
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Comparative Cue Generalization Profiles of L-838, 417, SL651498, Zolpidem, CL218,872, Ocinaplon, Bretazenil, Zopiclone, and Various Benzodiazepines in Chlordiazepoxide and Zolpidem Drug Discrimination
N. R. Mirza, R. J. Rodgers and L. S. Mathiasen

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1291-1299; DOI: https://doi.org/10.1124/jpet.105.094003
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Do Subtype-Selective γ-Aminobutyric Acid_A Receptor Modulators Have a Reduced Propensity to Induce Physical Dependence in Mice?
N. R. Mirza and E. Ø. Nielsen

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1378-1385; DOI: https://doi.org/10.1124/jpet.105.094474

LETTERS TO THE EDITOR

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Comments on “Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems”
Kari T. Kivistö

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1386; DOI: https://doi.org/10.1124/jpet.105.099333
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Response to Comments on “Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems”
Yvonne Y. Lau, Hideaki Okochi, Yong Huang and Leslie Z. Benet

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1387; DOI: https://doi.org/10.1124/jpet.105.099473

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Table of Contents

NEUROPHARMACOLOGY

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

CARDIOVASCULAR

INFLAMMATION AND IMMUNOPHARMACOLOGY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

TOXICOLOGY

ENDOCRINE AND DIABETES

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

LETTERS TO THE EDITOR

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