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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems

Yvonne Y. Lau, Hideaki Okochi, Yong Huang and Leslie Z. Benet
Journal of Pharmacology and Experimental Therapeutics February 2006, 316 (2) 762-771; DOI: https://doi.org/10.1124/jpet.105.093088

Article Information

vol. 316 no. 2 762-771
DOI 
https://doi.org/10.1124/jpet.105.093088
PubMed 
16258024
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 23, 2005
  • Accepted October 27, 2005
  • Published online January 20, 2006.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yvonne Y. Lau,
  2. Hideaki Okochi,
  3. Yong Huang and
  4. Leslie Z. Benet
  1. Department of Biopharmaceutical Sciences, University of California, San Francisco, California
  1. Address correspondence to:
    Dr. Leslie Z. Benet, Professor, Department of Biopharmaceutical Sciences, 533 Parnassus, Room U-68, University of California, San Francisco, San Francisco, CA 94143-0446. E-mail: benet{at}itsa.ucsf.edu
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems

Yvonne Y. Lau, Hideaki Okochi, Yong Huang and Leslie Z. Benet
Journal of Pharmacology and Experimental Therapeutics February 1, 2006, 316 (2) 762-771; DOI: https://doi.org/10.1124/jpet.105.093088
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