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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan, Emily A. Gaman, J. Brian Houston and Larry M. Tremaine
Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 336-348; DOI: https://doi.org/10.1124/jpet.105.093229
R. Scott Obach
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Robert L. Walsky
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Karthik Venkatakrishnan
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Emily A. Gaman
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J. Brian Houston
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Larry M. Tremaine
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Article Information

vol. 316 no. 1 336-348
DOI 
https://doi.org/10.1124/jpet.105.093229
PubMed 
16192315

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 25, 2005
  • Accepted September 27, 2005
  • Published online December 21, 2005.

Article Versions

  • Earlier version (September 28, 2005 - 08:01).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. R. Scott Obach,
  2. Robert L. Walsky,
  3. Karthik Venkatakrishnan,
  4. Emily A. Gaman,
  5. J. Brian Houston and
  6. Larry M. Tremaine
  1. Pharmacokinetics, Dynamics, and Drug Metabolism (R.S.O., R.L.W., E.A.G., L.M.T.) and Clinical Pharmacokinetics and Pharmacodynamics (K.V.), Pfizer, Inc., Groton, Connecticut; and School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (J.B.H.)
  1. Address correspondence to:
    Dr. R. Scott Obach, Pfizer Global Research and Development, Groton Laboratories, MS4088, Groton, CT 06340. E-mail: r.scott.obach{at}pfizer.com
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Journal of Pharmacology and Experimental Therapeutics: 316 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 316, Issue 1
1 Jan 2006
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan, Emily A. Gaman, J. Brian Houston and Larry M. Tremaine
Journal of Pharmacology and Experimental Therapeutics January 1, 2006, 316 (1) 336-348; DOI: https://doi.org/10.1124/jpet.105.093229

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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan, Emily A. Gaman, J. Brian Houston and Larry M. Tremaine
Journal of Pharmacology and Experimental Therapeutics January 1, 2006, 316 (1) 336-348; DOI: https://doi.org/10.1124/jpet.105.093229
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