The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

Pharmacokinetics, Dynamics, and Drug Metabolism (R.S.O., R.L.W., E.A.G., L.M.T.) and Clinical Pharmacokinetics and Pharmacodynamics (K.V.), Pfizer, Inc., Groton, Connecticut; and School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (J.B.H.)

Address correspondence to:
Dr. R. Scott Obach, Pfizer Global Research and Development, Groton Laboratories, MS4088, Groton, CT 06340. E-mail: r.scott.obach{at}pfizer.com

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