Journal of Pharmacology and Experimental Therapeutics: 316 (1)

January 01, 2006; Volume 316,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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The Role of Protein Kinase C Isoforms in Modulating Injury and Repair of the Intestinal Barrier
A. Farhadi, A. Keshavarzian, Z. Ranjbaran, J. Z. Fields and A. Banan

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 1-7; DOI: https://doi.org/10.1124/jpet.105.085449

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Evaluation of Tributyrin Lipid Emulsion with Affinity to Low-Density Lipoprotein: Pharmacokinetics in Adult Male Wistar Rats and Cellular Activity on Caco-2 and HepG2 Cell Lines
Jie Su, Li He, Ningning Zhang and Paul C. Ho

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 62-70; DOI: https://doi.org/10.1124/jpet.105.090464
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Sexually Dimorphic Regulation of Hepatic Isoforms of Human Cytochrome P450 by Growth Hormone
Ravindra N. Dhir, Wojciech Dworakowski, Chellappagounder Thangavel and Bernard H. Shapiro

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 87-94; DOI: https://doi.org/10.1124/jpet.105.093773
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The Dual Actions of Morin (3,5,7,2′,4′-Pentahydroxyflavone) as a Hypouricemic Agent: Uricosuric Effect and Xanthine Oxidase Inhibitory Activity
Zhifeng Yu, Wing Ping Fong and Christopher H. K. Cheng

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 169-175; DOI: https://doi.org/10.1124/jpet.105.092684
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Preparation of a Claudin-Targeting Molecule Using a C-Terminal Fragment of Clostridium perfringens Enterotoxin
Chiaki Ebihara, Masuo Kondoh, Naoki Hasuike, Motoki Harada, Hiroyuki Mizuguchi, Yasuhiko Horiguchi, Makiko Fujii and Yoshiteru Watanabe

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 255-260; DOI: https://doi.org/10.1124/jpet.105.093351
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Inactivation of CYP2A6 and CYP2A13 during Nicotine Metabolism
Linda B. von Weymarn, Kathryn M. Brown and Sharon E. Murphy

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 295-303; DOI: https://doi.org/10.1124/jpet.105.091306
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The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions
R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan, Emily A. Gaman, J. Brian Houston and Larry M. Tremaine

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 336-348; DOI: https://doi.org/10.1124/jpet.105.093229
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The Impact of Plasma Protein Binding on the Renal Transport of Organic Anions
Daniel A. J. Bow, Jennifer L. Perry, John D. Simon and John B. Pritchard

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 349-355; DOI: https://doi.org/10.1124/jpet.105.093070
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A Biosynthetic Pathway Generating 12-Hydroxy-5,8,14-eicosatrienoic Acid from Arachidonic Acid Is Active in Mouse Skin Microsomes
Liping Du, Valery Yermalitsky, David L. Hachey, Setti G. Jagadeesh, John R. Falck and Diane S. Keeney

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 371-379; DOI: https://doi.org/10.1124/jpet.105.093922

BEHAVIORAL PHARMACOLOGY

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Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
William A. Carlezon, Cécile Béguin, Jennifer A. DiNieri, Michael H. Baumann, Michele R. Richards, Mark S. Todtenkopf, Richard B. Rothman, Zhongze Ma, David Y.-W. Lee and Bruce M. Cohen

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 440-447; DOI: https://doi.org/10.1124/jpet.105.092304

CARDIOVASCULAR

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YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid through Suppression of Expressions and Activities of Matrix Metalloproteinases 2 and 9
Yi-Nan Liu, Shiow-Lin Pan, Chieh-Yu Peng, Jih-Hwa Guh, Dong-Ming Huang, Ya-Ling Chang, Chun-Hung Lin, Hui-Chen Pai, Sheng-Chu Kuo, Fang-Yu Lee and Che-Ming Teng

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 35-41; DOI: https://doi.org/10.1124/jpet.105.090563
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Increased Superoxide Anion Production by Interleukin-1β Impairs Nitric Oxide-Mediated Relaxation in Resistance Arteries
Francesc Jiménez-Altayó, Ana M. Briones, Jesús Giraldo, Anna M. Planas, Mercedes Salaices and Elisabet Vila

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 42-52; DOI: https://doi.org/10.1124/jpet.105.088435
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Pressor Responses to Ephedrine Are Mediated by a Direct Mechanism in the Rat
John T. Liles, Paul A. Dabisch, Keith E. Hude, Leena Pradhan, Kurt J. Varner, Johnny R. Porter, Alissa R. Hicks, Conni Corll, Syed R. Baber and Philip J. Kadowitz

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 95-105; DOI: https://doi.org/10.1124/jpet.105.090035
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Hyperlipidemia Attenuates the Infarct Size-Limiting Effect of Ischemic Preconditioning: Role of Matrix Metalloproteinase-2 Inhibition
Zoltán Giricz, Manoj M. Lalu, Csaba Csonka, Péter Bencsik, Richard Schulz and Péter Ferdinandy

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 154-161; DOI: https://doi.org/10.1124/jpet.105.091140
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The Amiodarone Derivative KB130015 [2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] Induces an Na⁺-Dependent Increase of [Ca²⁺] in Ventricular Myocytes
Virginie Bito, Dieter Dauwe, Fons Verdonck, Kanigula Mubagwa and Karin R. Sipido

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 162-168; DOI: https://doi.org/10.1124/jpet.105.092221
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Dosing Time-Dependent Effect of Temocapril on the Mortality of Stroke-Prone Spontaneously Hypertensive Rats
Masahiko Nozawa, Koh-ichi Sugimoto, Masami Ohmori, Hitoshi Ando and Akio Fujimura

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 176-181; DOI: https://doi.org/10.1124/jpet.105.092080
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Bepridil, an Antiarrhythmic Drug, Opens Mitochondrial K_ATP Channels, Blocks Sarcolemmal K_ATP Channels, and Confers Cardioprotection
Toshiaki Sato, Alexandre D. T. Costa, Tomoaki Saito, Takehiko Ogura, Hideyuki Ishida, Keith D. Garlid and Haruaki Nakaya

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 182-188; DOI: https://doi.org/10.1124/jpet.105.094029
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Blockade of Electron Transport before Cardiac Ischemia with the Reversible Inhibitor Amobarbital Protects Rat Heart Mitochondria
Qun Chen, Charles L. Hoppel and Edward J. Lesnefsky

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 200-207; DOI: https://doi.org/10.1124/jpet.105.091702
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Chronic Ethanol Consumption Enhances Phenylephrine-Induced Contraction in the Isolated Rat Aorta
Carlos R. Tirapelli, Johny Al-Khoury, Ghassan Bkaily, Pedro D'Orléans-Juste, Vera L. Lanchote, Sergio A. Uyemura and Ana M. de Oliveira

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 233-241; DOI: https://doi.org/10.1124/jpet.105.092999
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A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor γ Agonist Reverses Endothelial Dysfunction in Diabetic (db/db^-/-) Mice
Andrew G. Howarth, William B. Wiehler, Malarvannan Pannirselvam, Yanfen Jiang, Joel P. Berger, David Severson, Todd J. Anderson and Chris R. Triggle

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 364-370; DOI: https://doi.org/10.1124/jpet.105.086397
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Multiple Cellular Electrophysiological Effects of a Novel Antiarrhythmic Furoquinoline Derivative HA-7 [N-Benzyl-7-methoxy-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-dione] in Guinea Pig Cardiac Preparations
Gwo-Jyh Chang, Ming-Jai Su, Sheng-Chu Kuo, Tsung-Ping Lin and Ying-Shiung Lee

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 380-391; DOI: https://doi.org/10.1124/jpet.105.092106
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Induction of β₃-Adrenergic Receptor Functional Expression following Chronic Stimulation with Noradrenaline in Neonatal Rat Cardiomyocytes
Renée Germack and John M. Dickenson

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 392-402; DOI: https://doi.org/10.1124/jpet.105.090597
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ARD-353 [4-((2R,5S)-4-(R)-(4-Diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic Acid], A Novel Nonpeptide δ Receptor Agonist, Reduces Myocardial Infarct Size without Central Effects
Michael. J. Watson, Jonathon D. S. Holt, Scott J. O'Neill, Ke Wei, William Pendergast, Garrett J. Gross, Peter J. Gengo and Kwen-Jen Chang

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 423-430; DOI: https://doi.org/10.1124/jpet.105.092742

CELLULAR AND MOLECULAR

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Nitric Oxide-Donating Aspirin Inhibits Colon Cancer Cell Growth via Mitogen-Activated Protein Kinase Activation
Thomas R. Hundley and Basil Rigas

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 25-34; DOI: https://doi.org/10.1124/jpet.105.091363
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HIV Protease Inhibitors: Suppression of Insulin Secretion by Inhibition of Voltage-Dependent K⁺ Currents and Anion Currents
Yvonne Neye, Martina Düfer, Gisela Drews and Peter Krippeit-Drews

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 106-112; DOI: https://doi.org/10.1124/jpet.105.090589
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Molecular Mechanisms for Large Conductance Ca²⁺-Activated K⁺ Channel Activation by a Novel Opener, 12,14-Dichlorodehydroabietic Acid
Kazuho Sakamoto, Taro Nonomura, Susumu Ohya, Katsuhiko Muraki, Tomohiko Ohwada and Yuji Imaizumi

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 144-153; DOI: https://doi.org/10.1124/jpet.105.093856
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3-O-Acetyl-11-keto-boswellic Acid Decreases Basal Intracellular Ca²⁺ Levels and Inhibits Agonist-Induced Ca²⁺ Mobilization and Mitogen-Activated Protein Kinase Activation in Human Monocytic Cells
Daniel Poeckel, Lars Tausch, Sven George, Johann Jauch and Oliver Werz

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 224-232; DOI: https://doi.org/10.1124/jpet.105.089466
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Niemann-Pick C1 Protein Facilitates the Efflux of the Anticancer Drug Daunorubicin from Cells According to a Novel Vesicle-Mediated Pathway
Yuping Gong, Muralikrishna Duvvuri, Michael B. Duncan, Jian Liu and Jeffrey P. Krise

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 242-247; DOI: https://doi.org/10.1124/jpet.105.089482
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Constitutive Activity and Inverse Agonism at the M₂ Muscarinic Acetylcholine Receptor
Carl P. Nelson, Stefan R. Nahorski and R. A. John Challiss

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 279-288; DOI: https://doi.org/10.1124/jpet.105.094383
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Proline 326 in the C Terminus of Murine CX3CR1 Prevents G-Protein and Phosphatidylinositol 3-Kinase-Dependent Stimulation of Akt and Extracellular Signal-Regulated Kinase in Chinese Hamster Ovary Cells
Christopher N. Davis and Jeffrey K. Harrison

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 356-363; DOI: https://doi.org/10.1124/jpet.105.093039
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Erythropoietin Receptor Signal Transduction Requires Protein Geranylgeranylation
Sumaya N. Hamadmad, Matthew K. Henry and Raymond J. Hohl

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 403-409; DOI: https://doi.org/10.1124/jpet.105.092510
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The Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibitor PD184352 (CI-1040) Selectively Induces Apoptosis in Malignant Schwannoma Cell Lines
Raymond R. Mattingly, Janice M. Kraniak, Joshua T. Dilworth, Patricia Mathieu, Beverly Bealmear, James E. Nowak, Joyce A. Benjamins, Michael A. Tainsky and John J. Reiners

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 456-465; DOI: https://doi.org/10.1124/jpet.105.091454

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Hpr6 (Heme-1 Domain Protein) Regulates the Susceptibility of Cancer Cells to Chemotherapeutic Drugs
Gerard Crudden, Rachel E. Chitti and Rolf J. Craven

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 448-455; DOI: https://doi.org/10.1124/jpet.105.094631

ENDOCRINE AND DIABETES

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Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor Improves Glucose Homeostasis in ob/ob Mice: Molecular Characterization in Liver and Muscle
Oksana Kaidanovich-Beilin and Hagit Eldar-Finkelman

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 17-24; DOI: https://doi.org/10.1124/jpet.105.090266

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Expression and Response to Angiotensin-Converting Enzyme Inhibition of Matrix Metalloproteinases 2 and 9 in Renal Glomerular Damage in Young Transgenic Rats with Renin-Dependent Hypertension
Juliane Bolbrinker, Snezana Markovic, Markus Wehland, Wynand B. W. H. Melenhorst, Harry van Goor and Reinhold Kreutz

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 8-16; DOI: https://doi.org/10.1124/jpet.105.093112
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Evidence That Hydrogen Sulfide Exerts Antinociceptive Effects in the Gastrointestinal Tract by Activating K_ATP Channels
Eleonora Distrutti, Luca Sediari, Andrea Mencarelli, Barbara Renga, Stefano Orlandi, Elisabetta Antonelli, Fiorenza Roviezzo, Antonio Morelli, Giuseppe Cirino, John L. Wallace and Stefano Fiorucci

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 325-335; DOI: https://doi.org/10.1124/jpet.105.091595
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Energy Homeostasis and Gastric Emptying in Ghrelin Knockout Mice
B. De Smet, I. Depoortere, D. Moechars, Q. Swennen, B. Moreaux, K. Cryns, J. Tack, J. Buyse, B. Coulie and T. L. Peeters

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 431-439; DOI: https://doi.org/10.1124/jpet.105.091504

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Activation of the Adenosine A₃ Receptor in RAW 264.7 Cells Inhibits Lipopolysaccharide-Stimulated Tumor Necrosis Factor-α Release by Reducing Calcium-Dependent Activation of Nuclear Factor-κB and Extracellular Signal-Regulated Kinase 1/2
Lynn Martin, Sandeep C. Pingle, Daniel M. Hallam, Leonard P. Rybak and Vickram Ramkumar

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 71-78; DOI: https://doi.org/10.1124/jpet.105.091868
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Inhibition of Inducible Nitric-Oxide Synthase Expression by (5R)-5-Hydroxytriptolide in Interferon-γ- and Bacterial Lipopolysaccharide-Stimulated Macrophages
Ru Zhou, Shen-Xi Zheng, Wei Tang, Pei-Lan He, Xiao-Yu Li, Yi-Fu Yang, Yuan-Chao Li, Jian-Guo Geng and Jian-Ping Zuo

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 121-128; DOI: https://doi.org/10.1124/jpet.105.093179
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Antiexudative Effects of Opioids and Expression of κ- and δ- Opioid Receptors during Intestinal Inflammation in Mice: Involvement of Nitric Oxide
Natalia Jiménez, Margarita M. Puig and Olga Pol

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 261-270; DOI: https://doi.org/10.1124/jpet.105.091991
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Blockade of Nuclear Factor-κB Signaling Pathway and Anti-Inflammatory Activity of Cardamomin, a Chalcone Analog from Alpinia conchigera
Jeong-Hyung Lee, Haeng Sun Jung, Phan Minh Giang, Xuejun Jin, Sangku Lee, Phan Tong Son, Dongho Lee, Young-Soo Hong, Kyeong Lee and Jung Joon Lee

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 271-278; DOI: https://doi.org/10.1124/jpet.105.092486

NEUROPHARMACOLOGY

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Evaluation of Drug Penetration into the Brain: A Double Study by in Vivo Imaging with Positron Emission Tomography and Using an in Vitro Model of the Human Blood-Brain Barrier
Véronique Josserand, Hélène Pélerin, Béatrice de Bruin, Benoît Jego, Bertrand Kuhnast, Françoise Hinnen, Frédéric Ducongé, Raphaël Boisgard, Frédéric Beuvon, Francine Chassoux, Catherine Daumas-Duport, Eric Ezan, Frédéric Dollé, Aloïse Mabondzo and Bertrand Tavitian

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 79-86; DOI: https://doi.org/10.1124/jpet.105.089102
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Dopamine-Mediated Disinhibition in the CA1 Region of Rat Hippocampus via D₃ Receptor Activation
Hana Hammad and John J. Wagner

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 113-120; DOI: https://doi.org/10.1124/jpet.105.091579
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Characterization of Prejunctional Serotonin Receptors Modulating [³H]Acetylcholine Release in the Human Detrusor
Gianluigi D'Agostino, Anna M. Condino, Paola Gallinari, Gian P. Franceschetti and Marcello Tonini

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 129-135; DOI: https://doi.org/10.1124/jpet.105.092551
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Targeted Antioxidative and Neuroprotective Properties of the Dopamine Agonist Pramipexole and Its Nondopaminergic Enantiomer SND919CL2x [(+)2-Amino-4,5,6,7-tetrahydro-6-lpropylamino-benzathiazole Dihydrochloride]
R. Danzeisen, B. Schwalenstoecker, F. Gillardon, E. Buerger, V. Krzykalla, K. Klinder, L. Schild, B. Hengerer, A. C. Ludolph, C. Dorner-Ciossek and L. Kussmaul

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 189-199; DOI: https://doi.org/10.1124/jpet.105.092312
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Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: Basal Release
Robert I. Westphalen and Hugh C. Hemmings

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 208-215; DOI: https://doi.org/10.1124/jpet.105.090647
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Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: 4-Aminopyridine-Evoked Release
Robert I. Westphalen and Hugh C. Hemmings

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 216-223; DOI: https://doi.org/10.1124/jpet.105.090662
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Tobacco Smoke Chemicals Attenuate Brain-to-Blood Potassium Transport Mediated by the Na,K,2Cl-Cotransporter during Hypoxia-Reoxygenation
Jennifer R. Paulson, Karen E. Roder, Ghia McAfee, David D. Allen, Cornelis J. Van der Schyf and Thomas J. Abbruscato

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 248-254; DOI: https://doi.org/10.1124/jpet.105.090738
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Ketamine Produces Lasting Disruptions in Encoding of Sensory Stimuli
Christina R. Maxwell, Richard S. Ehrlichman, Yuling Liang, Danielle Trief, Stephen J. Kanes, Jonathan Karp and Steven J. Siegel

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 315-324; DOI: https://doi.org/10.1124/jpet.105.091199
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TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABA_A Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates
John R. Atack, Keith A. Wafford, Spencer J. Tye, Susan M. Cook, Bindi Sohal, Andrew Pike, Cyrille Sur, David Melillo, Linda Bristow, Fran Bromidge, Ian Ragan, Julie Kerby, Les Street, Robert Carling, José L. Castro, Paul Whiting, Gerard R. Dawson and Ruth M. McKernan

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 410-422; DOI: https://doi.org/10.1124/jpet.105.089920
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Systemic and Intrathecal Effects of a Novel Series of Phospholipase A₂ Inhibitors on Hyperalgesia and Spinal Prostaglandin E₂ Release
Tony L. Yaksh, George Kokotos, Camilla I. Svensson, Daren Stephens, Christoforos G. Kokotos, Bethany Fitzsimmons, Dimitra Hadjipavlou-Litina, Xiao-Ying Hua and Edward A. Dennis

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 466-475; DOI: https://doi.org/10.1124/jpet.105.091686

TOXICOLOGY

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Neurotoxicity of Ecstasy Metabolites in Rat Cortical Neurons, and Influence of Hyperthermia
João Paulo Capela, Andreas Meisel, Artur Reis Abreu, Paula Sério Branco, Luísa Maria Ferreira, Ana Maria Lobo, Fernando Remião, Maria Lurdes Bastos and Félix Carvalho

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 53-61; DOI: https://doi.org/10.1124/jpet.105.092577
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Deltamethrin, a Pyrethroid Insecticide, Is a Potent Inducer for the Activity-Dependent Gene Expression of Brain-Derived Neurotrophic Factor in Neurons
Lisa Imamura, Makoto Yasuda, Kozue Kuramitsu, Daichi Hara, Akiko Tabuchi and Masaaki Tsuda

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 136-143; DOI: https://doi.org/10.1124/jpet.105.092478
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4,4′-Methylenedianiline-Induced Hepatotoxicity Is Modified by N-Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat
Xiaoyan Zhang, Jason C. Lambert, Mark A. Doll, Jason M. Walraven, Gavin E. Arteel and David W. Hein

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 289-294; DOI: https://doi.org/10.1124/jpet.105.093302
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Arsenic Trioxide Induces Apoptosis of Human Monocytes during Macrophagic Differentiation through Nuclear Factor-κB-Related Survival Pathway Down-Regulation
Anthony Lemarie, Claudie Morzadec, Delphine Mérino, Olivier Micheau, Olivier Fardel and Laurent Vernhet

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 304-314; DOI: https://doi.org/10.1124/jpet.105.092874

LETTERS TO THE EDITOR

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Comments on “Isobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles”
J. Ignacio Lorenzo and Paula Sánchez-Marín

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 476-478; DOI: https://doi.org/10.1124/jpet.105.095091
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Response to Comments on “Isobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles”
Ronald J. Tallarida

Journal of Pharmacology and Experimental Therapeutics January 2006, 316 (1) 479; DOI: https://doi.org/10.1124/jpet.105.096198

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

LETTERS TO THE EDITOR

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