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Research ArticlePERSPECTIVES IN PHARMACOLOGY

In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to “Keep in Mind”

Jay T. Goodwin and David E. Clark
Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 477-483; DOI: https://doi.org/10.1124/jpet.104.075705
Jay T. Goodwin
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David E. Clark
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Article Information

vol. 315 no. 2 477-483
DOI 
https://doi.org/10.1124/jpet.104.075705
PubMed 
15919767

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 18, 2005
  • Accepted May 24, 2005
  • Published online October 19, 2005.

Article Versions

  • Earlier version (May 26, 2005 - 11:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jay T. Goodwin and
  2. David E. Clark
  1. ADMETRx, Inc., Kalamazoo, Michigan (J.T.G.); and Argenta Discovery Ltd., Harlow, Essex, United Kingdom (D.E.C.)
  1. Address correspondence to:
    Dr. Jay T. Goodwin, ADMETRx, Inc., 4717 Campus Drive, Suite 600, Kalamazoo, MI 49008. E-mail: jtgoodwin{at}admetrx.com
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Journal of Pharmacology and Experimental Therapeutics: 376 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 2
1 Feb 2021
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Research ArticlePERSPECTIVES IN PHARMACOLOGY

In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to “Keep in Mind”

Jay T. Goodwin and David E. Clark
Journal of Pharmacology and Experimental Therapeutics November 1, 2005, 315 (2) 477-483; DOI: https://doi.org/10.1124/jpet.104.075705

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Research ArticlePERSPECTIVES IN PHARMACOLOGY

In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to “Keep in Mind”

Jay T. Goodwin and David E. Clark
Journal of Pharmacology and Experimental Therapeutics November 1, 2005, 315 (2) 477-483; DOI: https://doi.org/10.1124/jpet.104.075705
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  • Article
    • Abstract
    • Determinants of BBB Penetration
    • How Is BBB Permeation Measured?
    • Why Predict BBB Permeation?
    • A Bit of History
    • The State of the Art
    • Some Success Stories
    • Current Issues and Future Directions
    • Concluding Remarks
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