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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2005; Volume 315,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to “Keep in Mind”
    Jay T. Goodwin and David E. Clark
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 477-483; DOI: https://doi.org/10.1124/jpet.104.075705

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Interaction with Blood Components Plays a Crucial Role in Asialoglycoprotein Receptor-Mediated in Vivo Gene Transfer by Galactosylated Lipoplex
    Shintaro Fumoto, Shigeru Kawakami, Kosuke Shigeta, Yuriko Higuchi, Fumiyoshi Yamashita and Mitsuru Hashida
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 484-493; DOI: https://doi.org/10.1124/jpet.105.089516
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    Human U251 Glioma Cell Proliferation Is Suppressed by HET0016 [N-Hydroxy-N′-(4-butyl-2-methylphenyl)formamidine], a Selective Inhibitor of CYP4A
    Meng Guo, Richard J. Roman, John R. Falck, Paul A. Edwards and A. Guillermo Scicli
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 526-533; DOI: https://doi.org/10.1124/jpet.105.088567
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    Synthetic Pyrrole-Imidazole Polyamide Inhibits Expression of the Human Transforming Growth Factor-β1 Gene
    Yu-Mu Lai, Noboru Fukuda, Takahiro Ueno, Hiroyuki Matsuda, Satoshi Saito, Koichi Matsumoto, Hirohito Ayame, Toshikazu Bando, Hiroshi Sugiyama, Hideo Mugishima and Kazuo Serie
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 571-575; DOI: https://doi.org/10.1124/jpet.105.089086
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    Coformulated N-Octanoyl-glucosylceramide Improves Cellular Delivery and Cytotoxicity of Liposomal Doxorubicin
    Robert Jan Veldman, Gerben A. Koning, Albert van Hell, Shuraila Zerp, Stefan R. Vink, Gert Storm, Marcel Verheij and Wim J. van Blitterswijk
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 704-710; DOI: https://doi.org/10.1124/jpet.105.087486
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    Pharmacoproteomic Effects of Isoniazid, Ethambutol, and N-Geranyl-N′-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv
    Lee Jia, Lori Coward, Gregory S. Gorman, Patricia E. Noker and Joseph E. Tomaszewski
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 905-911; DOI: https://doi.org/10.1124/jpet.105.087817

CARDIOVASCULAR

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    The Effect of Dipyridamole on Vascular Cell-Derived Reactive Oxygen Species
    Subrata Chakrabarti, Olga Vitseva, David Iyu, Sonia Varghese and Jane E. Freedman
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 494-500; DOI: https://doi.org/10.1124/jpet.105.089987
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    Effects of Phytoestrogens Genistein and Daidzein on Prostacyclin Production by Human Endothelial Cells
    Carlos Hermenegildo, Pilar J. Oviedo, Miguel Angel García-Pérez, Juan J. Tarín and Antonio Cano
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 722-728; DOI: https://doi.org/10.1124/jpet.105.090456
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    Donitriptan Decreases Jugular Venous Oxygen Saturation in Rats in the Absence of Cranial Vasoconstriction: An Overlooked Mechanism of Antimigraine Action?
    Robert Létienne, Jean-Christophe Blanchet, Estelle Sole, Gareth W. John and Bruno Le Grand
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 849-857; DOI: https://doi.org/10.1124/jpet.105.090159
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    DAF-FM (4-Amino-5-methylamino-2′,7′-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and l-Sepiapterin
    Jan-Zhong Sheng, Dianna Wang and Andrew P. Braun
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 931-940; DOI: https://doi.org/10.1124/jpet.105.087932

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    A New ATP-Sensitive Potassium Channel Opener Protects the Kidney from Hypertensive Damage in Spontaneously Hypertensive Rats
    Hao Xue, Ying-Li Zhang, Guo-Shu Liu and Hai Wang
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 501-509; DOI: https://doi.org/10.1124/jpet.105.089722
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    Signal Transduction for Proteinase-Activated Receptor-2-Triggered Prostaglandin E2 Formation in Human Lung Epithelial Cells
    Naoyuki Kawao, Mami Nagataki, Keita Nagasawa, Satoko Kubo, Kelly Cushing, Tetsuyuki Wada, Fumiko Sekiguchi, Seiji Ichida, Morley D. Hollenberg, Wallace K. MacNaughton, Hiroyuki Nishikawa and Atsufumi Kawabata
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 576-589; DOI: https://doi.org/10.1124/jpet.105.089490
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    DPI-221 [4-((α-S)-α-((2S,5R)-2,5-Dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: A Novel Nonpeptide δ Receptor Agonist Producing Increased Micturition Interval in Normal Rats
    Jonathon D. S. Holt, Michael J. Watson, Jane P. Chang, Scott J. O'Neill, Ke Wei, William Pendergast, Peter J. Gengo and Kwen-Jen Chang
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 601-608; DOI: https://doi.org/10.1124/jpet.105.090498
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    Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells
    Huiling Liu, Abulkhair M. Mamoon and Jerry M. Farley, Sr.
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 729-739; DOI: https://doi.org/10.1124/jpet.105.088542
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    Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity
    Sylvia Notenboom, David S. Miller, Leon H. Kuik, Paul Smits, Frans G. M. Russel and Rosalinde Masereeuw
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 912-920; DOI: https://doi.org/10.1124/jpet.105.089094
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    The Effects of Extracellular Purines and Pyrimidines on Human Airway Smooth Muscle Cells
    Vasanthi Govindaraju, James G. Martin, Karim Maghni, Pasquale Ferraro and Marie-Claire Michoud
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 941-948; DOI: https://doi.org/10.1124/jpet.105.089698

CELLULAR AND MOLECULAR

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    In Vitro Evaluation of the Angiostatic Potential of Drugs Using an Endothelialized Tissue-Engineered Connective Tissue
    Pierre-Luc Tremblay, François Berthod, Lucie Germain and François A. Auger
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 510-516; DOI: https://doi.org/10.1124/jpet.105.089524
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    Impairment of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Intravenous General Anesthetic Propofol
    Luisa P. Cacheaux, Norbert Topf, Gareth R. Tibbs, Ulrich R. Schaefer, Roberto Levi, Neil L. Harrison, Geoffrey W. Abbott and Peter A. Goldstein
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 517-525; DOI: https://doi.org/10.1124/jpet.105.091801
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    Differential Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by Interferon γ in Mast Cells and Epithelial Cells
    Marianna Kulka, Rene Dery, Drew Nahirney, Marek Duszyk and A. Dean Befus
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 563-570; DOI: https://doi.org/10.1124/jpet.105.087528
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    Prevention of the Ultraviolet B-Mediated Skin Photoaging by a Nuclear Factor κB Inhibitor, Parthenolide
    Kiyotaka Tanaka, Junichi Hasegawa, Kaori Asamitsu and Takashi Okamoto
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 624-630; DOI: https://doi.org/10.1124/jpet.105.088674
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    Transcriptional Regulation of Activating Transcription Factor 3 Involves the Early Growth Response-1 Gene
    Frank G. Bottone, Yuseok Moon, Brenda Alston-Mills and Thomas E. Eling
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 668-677; DOI: https://doi.org/10.1124/jpet.105.089607
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    Fibrotic Lung Fibroblasts Show Blunted Inhibition by cAMP Due to Deficient cAMP Response Element-Binding Protein Phosphorylation
    Xiaoqiu Liu, Shu Qiang Sun and Rennolds S. Ostrom
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 678-687; DOI: https://doi.org/10.1124/jpet.105.090324
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    Analysis of Allosterism in Functional Assays
    Frederick J. Ehlert
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 740-754; DOI: https://doi.org/10.1124/jpet.105.090886
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    Curcumin Suppresses Interleukin 1β-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways
    Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 788-795; DOI: https://doi.org/10.1124/jpet.105.084434
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    Inhibition of Autoantigen Expression by (-)-Epigallocatechin-3-gallate (the Major Constituent of Green Tea) in Normal Human Cells
    Stephen Hsu, Douglas P. Dickinson, Haiyan Qin, Carol Lapp, David Lapp, James Borke, Douglas S. Walsh, Wendy B. Bollag, Hubert Stöppler, Tetsuya Yamamoto, Tokio Osaki and George Schuster
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 805-811; DOI: https://doi.org/10.1124/jpet.105.090399
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    Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors
    Jennifer L. Shoemaker, Michael B. Ruckle, Philip R. Mayeux and Paul L. Prather
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 828-838; DOI: https://doi.org/10.1124/jpet.105.089474
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    Characterization of Isoprenaline- and Salmeterol-Stimulated Interactions between β2-Adrenoceptors and β-Arrestin 2 Using β-Galactosidase Complementation in C2C12 Cells
    Alison A. Carter and Stephen J. Hill
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 839-848; DOI: https://doi.org/10.1124/jpet.105.088914
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    Evans Blue Is a Specific Antagonist of the Human Epithelial Na+ Channel δ-Subunit
    Hisao Yamamura, Shinya Ugawa, Takashi Ueda and Shoichi Shimada
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 965-969; DOI: https://doi.org/10.1124/jpet.105.092775

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Functional Characterization of Rat Organic Anion Transporter 5 (Slc22a19) at the Apical Membrane of Renal Proximal Tubules
    Naohiko Anzai, Promsuk Jutabha, Atsushi Enomoto, Hirokazu Yokoyama, Hiroshi Nonoguchi, Taku Hirata, Katsuko Shiraya, Xin He, Seok Ho Cha, Michio Takeda, Hiroki Miyazaki, Takeshi Sakata, Kimio Tomita, Takashi Igarashi, Yoshikatsu Kanai and Hitoshi Endou
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 534-544; DOI: https://doi.org/10.1124/jpet.105.088583
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    Enantiomer/Enantiomer Interactions between the S- and R- Isomers of Omeprazole in Human Cytochrome P450 Enzymes: Major Role of CYP2C19 and CYP3A4
    Xue-Qing Li, Lars Weidolf, Roger Simonsson and Tommy B. Andersson
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 777-787; DOI: https://doi.org/10.1124/jpet.105.090928
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    Functional Analysis of Organic Cation Transporter 3 Expressed in Human Placenta
    Ryoko Sata, Hisakazu Ohtani, Masayuki Tsujimoto, Hideyasu Murakami, Noriko Koyabu, Takanori Nakamura, Takeshi Uchiumi, Michihiko Kuwano, Hideaki Nagata, Kiyomi Tsukimori, Hitoo Nakano and Yasufumi Sawada
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 888-895; DOI: https://doi.org/10.1124/jpet.105.086827

NEUROPHARMACOLOGY

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    RETRACTION: Human Expanded Polyglutamine Androgen Receptor Mutants in Neurodegeneration as a Novel Ligand Target
    Takashi Furutani, Ken-ichi Takeyama, Masahiko Tanabe, Hiroshi Koutoku, Saya Ito, Nobuaki Taniguchi, Eriko Suzuki, Masafumi Kudoh, Masayuki Shibasaki, Hisataka Shikama and Shigeaki Kato
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 545-552; DOI: https://doi.org/10.1124/jpet.105.087643
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    The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems
    Michael S. Cowen, Elvan Djouma and Andrew J. Lawrence
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 590-600; DOI: https://doi.org/10.1124/jpet.105.090449
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    Prolonged Increase in the Sensitivity of the Posterior Ventral Tegmental Area to the Reinforcing Effects of Ethanol following Repeated Exposure to Cycles of Ethanol Access and Deprivation
    Zachary A. Rodd, Richard L. Bell, Victoria K. McQueen, Michelle R. Davids, Cathleen C. Hsu, James M. Murphy, Ting-Kai Li, Lawrence Lumeng and William J. McBride
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 648-657; DOI: https://doi.org/10.1124/jpet.105.084350
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    Methyllycaconitine Prevents Methamphetamine-Induced Effects in Mouse Striatum: Involvement of α7 Nicotinic Receptors
    Elena Escubedo, Carlos Chipana, Mónica Pérez-Sánchez, Jordi Camarasa and David Pubill
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 658-667; DOI: https://doi.org/10.1124/jpet.105.089748
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    Effect of Morphine on Deep Dorsal Horn Projection Neurons Depends on Spinal GABAergic and Glycinergic Tone: Implications for Reduced Opioid Effect in Neuropathic Pain
    Yan-Ping Chen, Shao-Rui Chen and Hui-Lin Pan
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 696-703; DOI: https://doi.org/10.1124/jpet.105.091314
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    Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity
    Richard H. P. Porter, Georg Jaeschke, Will Spooren, Theresa M. Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira, Andreas Mühlemann, Silvia Gatti, Vincent Mutel and Pari Malherbe
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 711-721; DOI: https://doi.org/10.1124/jpet.105.089839
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    Subnanomolar Concentrations of Thrombin Enhance the Volume-Sensitive Efflux of Taurine from Human 1321N1 Astrocytoma Cells
    Tooba A. Cheema, Caroline E. Ward and Stephen K. Fisher
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 755-763; DOI: https://doi.org/10.1124/jpet.105.090787
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    General Anesthetic-Induced Channel Gating Enhancement of 5-Hydroxytryptamine Type 3 Receptors Depends on Receptor Subunit Composition
    Ken Solt, Renna J. Stevens, Paul A. Davies and Douglas E. Raines
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 771-776; DOI: https://doi.org/10.1124/jpet.105.090621
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    Nicotine Regulates DARPP-32 (Dopamine- and cAMP-Regulated Phosphoprotein of 32 kDa) Phosphorylation at Multiple Sites in Neostriatal Neurons
    Miho Hamada, Joseph P. Hendrick, Gregory R. Ryan, Mahomi Kuroiwa, Hideho Higashi, Masatoshi Tanaka, Angus C. Nairn, Paul Greengard and Akinori Nishi
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 872-878; DOI: https://doi.org/10.1124/jpet.105.090852
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    Glycyl-Glutamine, an Endogenous β-Endorphin-Derived Peptide, Inhibits Morphine-Induced Conditioned Place Preference, Tolerance, Dependence, and Withdrawal
    Sinan Cavun, Gökhan Göktalay and William R. Millington
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 949-958; DOI: https://doi.org/10.1124/jpet.105.091553
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    Calcium-Acting Drugs Modulate Expression and Development of Chronic Tolerance to Nicotine-Induced Antinociception in Mice
    M. I. Damaj
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 959-964; DOI: https://doi.org/10.1124/jpet.105.092460

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Anti-Inflammatory Effects of Inhibiting the Amine Oxidase Activity of Semicarbazide-Sensitive Amine Oxidase
    Luisa M. Salter-Cid, Eric Wang, Anne M. O'Rourke, Andrew Miller, Hongfeng Gao, Li Huang, Arnie Garcia and Matthew D. Linnik
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 553-562; DOI: https://doi.org/10.1124/jpet.105.089649
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    Nociceptive Effect of Subcutaneously Injected Interleukin-12 Is Mediated by Endothelin (ET) Acting on ETB Receptors in Rats
    Waldiceu A. Verri, Rodrigo O. Molina, Ieda R. S. Schivo, Thiago M. Cunha, Carlos A. Parada, Stephen Poole, Sérgio H. Ferreira and Fernando Q. Cunha
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 609-615; DOI: https://doi.org/10.1124/jpet.105.089409
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    MEN16132, a Novel Potent and Selective Nonpeptide Kinin B2 Receptor Antagonist: In Vivo Activity on Bradykinin-Induced Bronchoconstriction and Nasal Mucosa Microvascular Leakage in Anesthetized Guinea Pigs
    Claudio Valenti, Cecilia Cialdai, Sandro Giuliani, Alessandro Lecci, Manuela Tramontana, Stefania Meini, Laura Quartara and Carlo Alberto Maggi
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 616-623; DOI: https://doi.org/10.1124/jpet.105.088252
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    Indirect CB2 Receptor and Mediator-Dependent Stimulation of Human Whole-Blood Neutrophils by Exogenous and Endogenous Cannabinoids
    Birgit Kraft and Hans G. Kress
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 641-647; DOI: https://doi.org/10.1124/jpet.105.084269
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    Prostaglandin E2 Enhances Neurotrophin-4 Production via EP3 Receptor in Human Keratinocytes
    Naoko Kanda, Satsuki Koike and Shinichi Watanabe
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 796-804; DOI: https://doi.org/10.1124/jpet.105.091645
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    Gender Differences in the Endotoxin-Induced Inflammatory and Vascular Responses: Potential Role of Poly(ADP-ribose) Polymerase Activation
    Jon G. Mabley, Eszter M. Horváth, Kanneganti G. K. Murthy, Zsuzsanna Zsengellér, Anne Vaslin, Rita Benkő, Márk Kollai and Csaba Szabó
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 812-820; DOI: https://doi.org/10.1124/jpet.105.090480

BEHAVIORAL PHARMACOLOGY

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    Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3α-Diphenylmethoxytropane Analogs
    Vera C. Campbell, Theresa A. Kopajtic, Amy Hauck Newman and Jonathan L. Katz
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 631-640; DOI: https://doi.org/10.1124/jpet.105.090829
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    Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice
    Kentarou Ushijima, Hiromi Sakaguchi, Yuki Sato, Hideto To, Satoru Koyanagi, Shun Higuchi and Shigehiro Ohdo
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 764-770; DOI: https://doi.org/10.1124/jpet.105.088849
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    Characterization of a Novel Bivalent Morphinan Possessing κ Agonist and μ Agonist/Antagonist Properties
    Jennifer L. Mathews, Xuemei Peng, Wennan Xiong, Ao Zhang, S. Stevens Negus, John L. Neumeyer and Jean M. Bidlack
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 821-827; DOI: https://doi.org/10.1124/jpet.105.084343
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    Effect of GABA Agonists and GABA-A Receptor Modulators on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rats
    Andrew C. Barrett, S. Stevens Negus, Nancy K. Mello and S. Barak Caine
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 858-871; DOI: https://doi.org/10.1124/jpet.105.086033
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    Despite Similar Anxiolytic Potential, the 5-Hydroxytryptamine 2C Receptor Antagonist SB-242084 [6-Chloro-5-methyl-1-[2-(2-methylpyrid-3-yloxy)-pyrid-5-yl Carbamoyl] Indoline] and Chlordiazepoxide Produced Differential Effects on Electroencephalogram Power Spectra
    Sandor Kantor, Rita Jakus, Eszter Molnar, Norbert Gyongyosi, Attila Toth, Laszlo Detari and Gyorgy Bagdy
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 921-930; DOI: https://doi.org/10.1124/jpet.105.086413

ENDOCRINE AND DIABETES

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    Acute and Chronic Effects of the Incretin Enhancer Vildagliptin in Insulin-Resistant Rats
    B. F. Burkey, X. Li, L. Bolognese, B. Balkan, M. Mone, M. Russell, T. E. Hughes and P. R. Wang
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 688-695; DOI: https://doi.org/10.1124/jpet.105.087064

TOXICOLOGY

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    Peroxynitrite-Induced Mitochondrial and Endonuclease-Mediated Nuclear DNA Damage in Acetaminophen Hepatotoxicity
    Cathleen Cover, Abdellah Mansouri, Tamara R. Knight, Mary Lynn Bajt, John J. Lemasters, Dominique Pessayre and Hartmut Jaeschke
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 879-887; DOI: https://doi.org/10.1124/jpet.105.088898
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    Handling of the Homocysteine S-Conjugate of Methylmercury by Renal Epithelial Cells: Role of Organic Anion Transporter 1 and Amino Acid Transporters
    Rudolfs K. Zalups and Sarfaraz Ahmad
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 896-904; DOI: https://doi.org/10.1124/jpet.105.090530

Erratum

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    Corrections to “Heme-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic α-Subunit of the Eukaryotic Initiation Factor Kinase?”
    Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 970;
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Journal of Pharmacology and Experimental Therapeutics: 315 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 315, Issue 2
1 Nov 2005
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  • PERSPECTIVES IN PHARMACOLOGY
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • CARDIOVASCULAR
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • CELLULAR AND MOLECULAR
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • NEUROPHARMACOLOGY
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • BEHAVIORAL PHARMACOLOGY
  • ENDOCRINE AND DIABETES
  • TOXICOLOGY
  • Erratum
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