Journal of Pharmacology and Experimental Therapeutics: 315 (2)

November 01, 2005; Volume 315,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to “Keep in Mind”
Jay T. Goodwin and David E. Clark

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 477-483; DOI: https://doi.org/10.1124/jpet.104.075705

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Interaction with Blood Components Plays a Crucial Role in Asialoglycoprotein Receptor-Mediated in Vivo Gene Transfer by Galactosylated Lipoplex
Shintaro Fumoto, Shigeru Kawakami, Kosuke Shigeta, Yuriko Higuchi, Fumiyoshi Yamashita and Mitsuru Hashida

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 484-493; DOI: https://doi.org/10.1124/jpet.105.089516
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Human U251 Glioma Cell Proliferation Is Suppressed by HET0016 [N-Hydroxy-N′-(4-butyl-2-methylphenyl)formamidine], a Selective Inhibitor of CYP4A
Meng Guo, Richard J. Roman, John R. Falck, Paul A. Edwards and A. Guillermo Scicli

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 526-533; DOI: https://doi.org/10.1124/jpet.105.088567
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Synthetic Pyrrole-Imidazole Polyamide Inhibits Expression of the Human Transforming Growth Factor-β1 Gene
Yu-Mu Lai, Noboru Fukuda, Takahiro Ueno, Hiroyuki Matsuda, Satoshi Saito, Koichi Matsumoto, Hirohito Ayame, Toshikazu Bando, Hiroshi Sugiyama, Hideo Mugishima and Kazuo Serie

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 571-575; DOI: https://doi.org/10.1124/jpet.105.089086
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Coformulated N-Octanoyl-glucosylceramide Improves Cellular Delivery and Cytotoxicity of Liposomal Doxorubicin
Robert Jan Veldman, Gerben A. Koning, Albert van Hell, Shuraila Zerp, Stefan R. Vink, Gert Storm, Marcel Verheij and Wim J. van Blitterswijk

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 704-710; DOI: https://doi.org/10.1124/jpet.105.087486
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Pharmacoproteomic Effects of Isoniazid, Ethambutol, and N-Geranyl-N′-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv
Lee Jia, Lori Coward, Gregory S. Gorman, Patricia E. Noker and Joseph E. Tomaszewski

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 905-911; DOI: https://doi.org/10.1124/jpet.105.087817

CARDIOVASCULAR

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The Effect of Dipyridamole on Vascular Cell-Derived Reactive Oxygen Species
Subrata Chakrabarti, Olga Vitseva, David Iyu, Sonia Varghese and Jane E. Freedman

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 494-500; DOI: https://doi.org/10.1124/jpet.105.089987
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Effects of Phytoestrogens Genistein and Daidzein on Prostacyclin Production by Human Endothelial Cells
Carlos Hermenegildo, Pilar J. Oviedo, Miguel Angel García-Pérez, Juan J. Tarín and Antonio Cano

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 722-728; DOI: https://doi.org/10.1124/jpet.105.090456
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Donitriptan Decreases Jugular Venous Oxygen Saturation in Rats in the Absence of Cranial Vasoconstriction: An Overlooked Mechanism of Antimigraine Action?
Robert Létienne, Jean-Christophe Blanchet, Estelle Sole, Gareth W. John and Bruno Le Grand

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 849-857; DOI: https://doi.org/10.1124/jpet.105.090159
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DAF-FM (4-Amino-5-methylamino-2′,7′-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and l-Sepiapterin
Jan-Zhong Sheng, Dianna Wang and Andrew P. Braun

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 931-940; DOI: https://doi.org/10.1124/jpet.105.087932

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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A New ATP-Sensitive Potassium Channel Opener Protects the Kidney from Hypertensive Damage in Spontaneously Hypertensive Rats
Hao Xue, Ying-Li Zhang, Guo-Shu Liu and Hai Wang

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 501-509; DOI: https://doi.org/10.1124/jpet.105.089722
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Signal Transduction for Proteinase-Activated Receptor-2-Triggered Prostaglandin E₂ Formation in Human Lung Epithelial Cells
Naoyuki Kawao, Mami Nagataki, Keita Nagasawa, Satoko Kubo, Kelly Cushing, Tetsuyuki Wada, Fumiko Sekiguchi, Seiji Ichida, Morley D. Hollenberg, Wallace K. MacNaughton, Hiroyuki Nishikawa and Atsufumi Kawabata

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 576-589; DOI: https://doi.org/10.1124/jpet.105.089490
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DPI-221 [4-((α-S)-α-((2S,5R)-2,5-Dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: A Novel Nonpeptide δ Receptor Agonist Producing Increased Micturition Interval in Normal Rats
Jonathon D. S. Holt, Michael J. Watson, Jane P. Chang, Scott J. O'Neill, Ke Wei, William Pendergast, Peter J. Gengo and Kwen-Jen Chang

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 601-608; DOI: https://doi.org/10.1124/jpet.105.090498
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Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells
Huiling Liu, Abulkhair M. Mamoon and Jerry M. Farley, Sr.

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 729-739; DOI: https://doi.org/10.1124/jpet.105.088542
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Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity
Sylvia Notenboom, David S. Miller, Leon H. Kuik, Paul Smits, Frans G. M. Russel and Rosalinde Masereeuw

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 912-920; DOI: https://doi.org/10.1124/jpet.105.089094
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The Effects of Extracellular Purines and Pyrimidines on Human Airway Smooth Muscle Cells
Vasanthi Govindaraju, James G. Martin, Karim Maghni, Pasquale Ferraro and Marie-Claire Michoud

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 941-948; DOI: https://doi.org/10.1124/jpet.105.089698

CELLULAR AND MOLECULAR

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In Vitro Evaluation of the Angiostatic Potential of Drugs Using an Endothelialized Tissue-Engineered Connective Tissue
Pierre-Luc Tremblay, François Berthod, Lucie Germain and François A. Auger

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 510-516; DOI: https://doi.org/10.1124/jpet.105.089524
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Impairment of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Intravenous General Anesthetic Propofol
Luisa P. Cacheaux, Norbert Topf, Gareth R. Tibbs, Ulrich R. Schaefer, Roberto Levi, Neil L. Harrison, Geoffrey W. Abbott and Peter A. Goldstein

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 517-525; DOI: https://doi.org/10.1124/jpet.105.091801
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Differential Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by Interferon γ in Mast Cells and Epithelial Cells
Marianna Kulka, Rene Dery, Drew Nahirney, Marek Duszyk and A. Dean Befus

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 563-570; DOI: https://doi.org/10.1124/jpet.105.087528
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Prevention of the Ultraviolet B-Mediated Skin Photoaging by a Nuclear Factor κB Inhibitor, Parthenolide
Kiyotaka Tanaka, Junichi Hasegawa, Kaori Asamitsu and Takashi Okamoto

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 624-630; DOI: https://doi.org/10.1124/jpet.105.088674
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Transcriptional Regulation of Activating Transcription Factor 3 Involves the Early Growth Response-1 Gene
Frank G. Bottone, Yuseok Moon, Brenda Alston-Mills and Thomas E. Eling

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 668-677; DOI: https://doi.org/10.1124/jpet.105.089607
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Fibrotic Lung Fibroblasts Show Blunted Inhibition by cAMP Due to Deficient cAMP Response Element-Binding Protein Phosphorylation
Xiaoqiu Liu, Shu Qiang Sun and Rennolds S. Ostrom

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 678-687; DOI: https://doi.org/10.1124/jpet.105.090324
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Analysis of Allosterism in Functional Assays
Frederick J. Ehlert

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 740-754; DOI: https://doi.org/10.1124/jpet.105.090886
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Curcumin Suppresses Interleukin 1β-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways
Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 788-795; DOI: https://doi.org/10.1124/jpet.105.084434
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Inhibition of Autoantigen Expression by (-)-Epigallocatechin-3-gallate (the Major Constituent of Green Tea) in Normal Human Cells
Stephen Hsu, Douglas P. Dickinson, Haiyan Qin, Carol Lapp, David Lapp, James Borke, Douglas S. Walsh, Wendy B. Bollag, Hubert Stöppler, Tetsuya Yamamoto, Tokio Osaki and George Schuster

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 805-811; DOI: https://doi.org/10.1124/jpet.105.090399
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Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors
Jennifer L. Shoemaker, Michael B. Ruckle, Philip R. Mayeux and Paul L. Prather

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 828-838; DOI: https://doi.org/10.1124/jpet.105.089474
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Characterization of Isoprenaline- and Salmeterol-Stimulated Interactions between β₂-Adrenoceptors and β-Arrestin 2 Using β-Galactosidase Complementation in C2C12 Cells
Alison A. Carter and Stephen J. Hill

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 839-848; DOI: https://doi.org/10.1124/jpet.105.088914
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Evans Blue Is a Specific Antagonist of the Human Epithelial Na⁺ Channel δ-Subunit
Hisao Yamamura, Shinya Ugawa, Takashi Ueda and Shoichi Shimada

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 965-969; DOI: https://doi.org/10.1124/jpet.105.092775

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Functional Characterization of Rat Organic Anion Transporter 5 (Slc22a19) at the Apical Membrane of Renal Proximal Tubules
Naohiko Anzai, Promsuk Jutabha, Atsushi Enomoto, Hirokazu Yokoyama, Hiroshi Nonoguchi, Taku Hirata, Katsuko Shiraya, Xin He, Seok Ho Cha, Michio Takeda, Hiroki Miyazaki, Takeshi Sakata, Kimio Tomita, Takashi Igarashi, Yoshikatsu Kanai and Hitoshi Endou

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 534-544; DOI: https://doi.org/10.1124/jpet.105.088583
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Enantiomer/Enantiomer Interactions between the S- and R- Isomers of Omeprazole in Human Cytochrome P450 Enzymes: Major Role of CYP2C19 and CYP3A4
Xue-Qing Li, Lars Weidolf, Roger Simonsson and Tommy B. Andersson

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 777-787; DOI: https://doi.org/10.1124/jpet.105.090928
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Functional Analysis of Organic Cation Transporter 3 Expressed in Human Placenta
Ryoko Sata, Hisakazu Ohtani, Masayuki Tsujimoto, Hideyasu Murakami, Noriko Koyabu, Takanori Nakamura, Takeshi Uchiumi, Michihiko Kuwano, Hideaki Nagata, Kiyomi Tsukimori, Hitoo Nakano and Yasufumi Sawada

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 888-895; DOI: https://doi.org/10.1124/jpet.105.086827

NEUROPHARMACOLOGY

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RETRACTION: Human Expanded Polyglutamine Androgen Receptor Mutants in Neurodegeneration as a Novel Ligand Target
Takashi Furutani, Ken-ichi Takeyama, Masahiko Tanabe, Hiroshi Koutoku, Saya Ito, Nobuaki Taniguchi, Eriko Suzuki, Masafumi Kudoh, Masayuki Shibasaki, Hisataka Shikama and Shigeaki Kato

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 545-552; DOI: https://doi.org/10.1124/jpet.105.087643
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The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems
Michael S. Cowen, Elvan Djouma and Andrew J. Lawrence

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 590-600; DOI: https://doi.org/10.1124/jpet.105.090449
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Prolonged Increase in the Sensitivity of the Posterior Ventral Tegmental Area to the Reinforcing Effects of Ethanol following Repeated Exposure to Cycles of Ethanol Access and Deprivation
Zachary A. Rodd, Richard L. Bell, Victoria K. McQueen, Michelle R. Davids, Cathleen C. Hsu, James M. Murphy, Ting-Kai Li, Lawrence Lumeng and William J. McBride

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 648-657; DOI: https://doi.org/10.1124/jpet.105.084350
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Methyllycaconitine Prevents Methamphetamine-Induced Effects in Mouse Striatum: Involvement of α7 Nicotinic Receptors
Elena Escubedo, Carlos Chipana, Mónica Pérez-Sánchez, Jordi Camarasa and David Pubill

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 658-667; DOI: https://doi.org/10.1124/jpet.105.089748
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Effect of Morphine on Deep Dorsal Horn Projection Neurons Depends on Spinal GABAergic and Glycinergic Tone: Implications for Reduced Opioid Effect in Neuropathic Pain
Yan-Ping Chen, Shao-Rui Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 696-703; DOI: https://doi.org/10.1124/jpet.105.091314
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Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity
Richard H. P. Porter, Georg Jaeschke, Will Spooren, Theresa M. Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira, Andreas Mühlemann, Silvia Gatti, Vincent Mutel and Pari Malherbe

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 711-721; DOI: https://doi.org/10.1124/jpet.105.089839
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Subnanomolar Concentrations of Thrombin Enhance the Volume-Sensitive Efflux of Taurine from Human 1321N1 Astrocytoma Cells
Tooba A. Cheema, Caroline E. Ward and Stephen K. Fisher

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 755-763; DOI: https://doi.org/10.1124/jpet.105.090787
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General Anesthetic-Induced Channel Gating Enhancement of 5-Hydroxytryptamine Type 3 Receptors Depends on Receptor Subunit Composition
Ken Solt, Renna J. Stevens, Paul A. Davies and Douglas E. Raines

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 771-776; DOI: https://doi.org/10.1124/jpet.105.090621
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Nicotine Regulates DARPP-32 (Dopamine- and cAMP-Regulated Phosphoprotein of 32 kDa) Phosphorylation at Multiple Sites in Neostriatal Neurons
Miho Hamada, Joseph P. Hendrick, Gregory R. Ryan, Mahomi Kuroiwa, Hideho Higashi, Masatoshi Tanaka, Angus C. Nairn, Paul Greengard and Akinori Nishi

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 872-878; DOI: https://doi.org/10.1124/jpet.105.090852
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Glycyl-Glutamine, an Endogenous β-Endorphin-Derived Peptide, Inhibits Morphine-Induced Conditioned Place Preference, Tolerance, Dependence, and Withdrawal
Sinan Cavun, Gökhan Göktalay and William R. Millington

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 949-958; DOI: https://doi.org/10.1124/jpet.105.091553
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Calcium-Acting Drugs Modulate Expression and Development of Chronic Tolerance to Nicotine-Induced Antinociception in Mice
M. I. Damaj

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 959-964; DOI: https://doi.org/10.1124/jpet.105.092460

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Anti-Inflammatory Effects of Inhibiting the Amine Oxidase Activity of Semicarbazide-Sensitive Amine Oxidase
Luisa M. Salter-Cid, Eric Wang, Anne M. O'Rourke, Andrew Miller, Hongfeng Gao, Li Huang, Arnie Garcia and Matthew D. Linnik

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 553-562; DOI: https://doi.org/10.1124/jpet.105.089649
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Nociceptive Effect of Subcutaneously Injected Interleukin-12 Is Mediated by Endothelin (ET) Acting on ET_B Receptors in Rats
Waldiceu A. Verri, Rodrigo O. Molina, Ieda R. S. Schivo, Thiago M. Cunha, Carlos A. Parada, Stephen Poole, Sérgio H. Ferreira and Fernando Q. Cunha

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 609-615; DOI: https://doi.org/10.1124/jpet.105.089409
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MEN16132, a Novel Potent and Selective Nonpeptide Kinin B₂ Receptor Antagonist: In Vivo Activity on Bradykinin-Induced Bronchoconstriction and Nasal Mucosa Microvascular Leakage in Anesthetized Guinea Pigs
Claudio Valenti, Cecilia Cialdai, Sandro Giuliani, Alessandro Lecci, Manuela Tramontana, Stefania Meini, Laura Quartara and Carlo Alberto Maggi

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 616-623; DOI: https://doi.org/10.1124/jpet.105.088252
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Indirect CB₂ Receptor and Mediator-Dependent Stimulation of Human Whole-Blood Neutrophils by Exogenous and Endogenous Cannabinoids
Birgit Kraft and Hans G. Kress

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 641-647; DOI: https://doi.org/10.1124/jpet.105.084269
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Prostaglandin E₂ Enhances Neurotrophin-4 Production via EP3 Receptor in Human Keratinocytes
Naoko Kanda, Satsuki Koike and Shinichi Watanabe

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 796-804; DOI: https://doi.org/10.1124/jpet.105.091645
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Gender Differences in the Endotoxin-Induced Inflammatory and Vascular Responses: Potential Role of Poly(ADP-ribose) Polymerase Activation
Jon G. Mabley, Eszter M. Horváth, Kanneganti G. K. Murthy, Zsuzsanna Zsengellér, Anne Vaslin, Rita Benkő, Márk Kollai and Csaba Szabó

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 812-820; DOI: https://doi.org/10.1124/jpet.105.090480

BEHAVIORAL PHARMACOLOGY

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Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3α-Diphenylmethoxytropane Analogs
Vera C. Campbell, Theresa A. Kopajtic, Amy Hauck Newman and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 631-640; DOI: https://doi.org/10.1124/jpet.105.090829
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Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice
Kentarou Ushijima, Hiromi Sakaguchi, Yuki Sato, Hideto To, Satoru Koyanagi, Shun Higuchi and Shigehiro Ohdo

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 764-770; DOI: https://doi.org/10.1124/jpet.105.088849
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Characterization of a Novel Bivalent Morphinan Possessing κ Agonist and μ Agonist/Antagonist Properties
Jennifer L. Mathews, Xuemei Peng, Wennan Xiong, Ao Zhang, S. Stevens Negus, John L. Neumeyer and Jean M. Bidlack

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 821-827; DOI: https://doi.org/10.1124/jpet.105.084343
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Effect of GABA Agonists and GABA-A Receptor Modulators on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rats
Andrew C. Barrett, S. Stevens Negus, Nancy K. Mello and S. Barak Caine

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 858-871; DOI: https://doi.org/10.1124/jpet.105.086033
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Despite Similar Anxiolytic Potential, the 5-Hydroxytryptamine 2C Receptor Antagonist SB-242084 [6-Chloro-5-methyl-1-[2-(2-methylpyrid-3-yloxy)-pyrid-5-yl Carbamoyl] Indoline] and Chlordiazepoxide Produced Differential Effects on Electroencephalogram Power Spectra
Sandor Kantor, Rita Jakus, Eszter Molnar, Norbert Gyongyosi, Attila Toth, Laszlo Detari and Gyorgy Bagdy

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 921-930; DOI: https://doi.org/10.1124/jpet.105.086413

ENDOCRINE AND DIABETES

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Acute and Chronic Effects of the Incretin Enhancer Vildagliptin in Insulin-Resistant Rats
B. F. Burkey, X. Li, L. Bolognese, B. Balkan, M. Mone, M. Russell, T. E. Hughes and P. R. Wang

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 688-695; DOI: https://doi.org/10.1124/jpet.105.087064

TOXICOLOGY

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Peroxynitrite-Induced Mitochondrial and Endonuclease-Mediated Nuclear DNA Damage in Acetaminophen Hepatotoxicity
Cathleen Cover, Abdellah Mansouri, Tamara R. Knight, Mary Lynn Bajt, John J. Lemasters, Dominique Pessayre and Hartmut Jaeschke

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 879-887; DOI: https://doi.org/10.1124/jpet.105.088898
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Handling of the Homocysteine S-Conjugate of Methylmercury by Renal Epithelial Cells: Role of Organic Anion Transporter 1 and Amino Acid Transporters
Rudolfs K. Zalups and Sarfaraz Ahmad

Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 896-904; DOI: https://doi.org/10.1124/jpet.105.090530

Erratum

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Corrections to “Heme-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic α-Subunit of the Eukaryotic Initiation Factor Kinase?”
Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 970;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

CARDIOVASCULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

CELLULAR AND MOLECULAR

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

NEUROPHARMACOLOGY

INFLAMMATION AND IMMUNOPHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

ENDOCRINE AND DIABETES

TOXICOLOGY

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