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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

A Species Difference in the Transport Activities of H2 Receptor Antagonists by Rat and Human Renal Organic Anion and Cation Transporters

Harunobu Tahara, Hiroyuki Kusuhara, Hitoshi Endou, Hermann Koepsell, Tomoki Imaoka, Eiichi Fuse and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics October 2005, 315 (1) 337-345; DOI: https://doi.org/10.1124/jpet.105.088104

Article Information

vol. 315 no. 1 337-345
DOI 
https://doi.org/10.1124/jpet.105.088104
PubMed 
16006492
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 17, 2005
  • Accepted July 6, 2005
  • Published online September 19, 2005.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Harunobu Tahara,
  2. Hiroyuki Kusuhara,
  3. Hitoshi Endou,
  4. Hermann Koepsell,
  5. Tomoki Imaoka,
  6. Eiichi Fuse and
  7. Yuichi Sugiyama
  1. Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan (H.T., H.Ku., T.I., Y.S.); Kyowa Hakko Kogyo Co., Ltd., Drug Development Research Laboratories Pharmaceutical Research Institute, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan (H.T., E.F.); Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan (H.E.); and Institut für Anatomie und Zellbiologie, Universitaeät Würzburg, Würzburg, Germany (H.Ko.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

A Species Difference in the Transport Activities of H2 Receptor Antagonists by Rat and Human Renal Organic Anion and Cation Transporters

Harunobu Tahara, Hiroyuki Kusuhara, Hitoshi Endou, Hermann Koepsell, Tomoki Imaoka, Eiichi Fuse and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics October 1, 2005, 315 (1) 337-345; DOI: https://doi.org/10.1124/jpet.105.088104
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