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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2005; Volume 314,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Can Claims, Misleading Information, and Manufacturing Issues Regarding Dietary Supplements Be Improved in the United States?
    James E. Gibson and David A. Taylor
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 939-944; DOI: https://doi.org/10.1124/jpet.105.085712

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Identification of the Hepatic Efflux Transporters of Organic Anions Using Double-Transfected Madin-Darby Canine Kidney II Cells Expressing Human Organic Anion-Transporting Polypeptide 1B1 (OATP1B1)/Multidrug Resistance-Associated Protein 2, OATP1B1/Multidrug Resistance 1, and OATP1B1/Breast Cancer Resistance Protein
    Soichiro Matsushima, Kazuya Maeda, Chihiro Kondo, Masaru Hirano, Makoto Sasaki, Hiroshi Suzuki and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1059-1067; DOI: https://doi.org/10.1124/jpet.105.085589
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    Delineation of Human Peptide Transporter 1 (hPepT1)-Mediated Uptake and Transport of Substrates with Varying Transporter Affinities Utilizing Stably Transfected hPepT1/Madin-Darby Canine Kidney Clones and Caco-2 Cells
    Rajinder K. Bhardwaj, Dea Herrera-Ruiz, Patrick J. Sinko, Olafur S. Gudmundsson and Gregory Knipp
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1093-1100; DOI: https://doi.org/10.1124/jpet.105.087148
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    Development of Polyethylene Glycol-Conjugated Poly-S-Nitrosated Serum Albumin, a Novel S-Nitrosothiol for Prolonged Delivery of Nitric Oxide in the Blood Circulation in Vivo
    Hidemasa Katsumi, Makiya Nishikawa, Fumiyoshi Yamashita and Mitsuru Hashida
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1117-1124; DOI: https://doi.org/10.1124/jpet.105.087429

BEHAVIORAL PHARMACOLOGY

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    Morphine Side Effects in β-Arrestin 2 Knockout Mice
    Kirsten M. Raehal, Julia K. L. Walker and Laura M. Bohn
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1195-1201; DOI: https://doi.org/10.1124/jpet.105.087254

CARDIOVASCULAR

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    Mitogen-Activated Protein Kinase Phosphorylation in the Rostral Ventrolateral Medulla Plays a Key Role in Imidazoline (I1)-Receptor-Mediated Hypotension
    Jian Zhang and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 945-952; DOI: https://doi.org/10.1124/jpet.105.087510
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    (+)-Norfenfluramine-Induced Arterial Contraction Is Not Dependent on Endogenous 5-Hydroxytryptamine or 5-Hydroxytryptamine Transporter
    Wei Ni, Claudia S. Wilhelm, Michael Bader, Dennis L. Murphy, Keith Lookingland and Stephanie W. Watts
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 953-960; DOI: https://doi.org/10.1124/jpet.105.087080
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    Effects of Cocaine on Nitric Oxide Production in Bovine Coronary Artery Endothelial Cells
    Jiale He, Shumei Yang and Lubo Zhang
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 980-986; DOI: https://doi.org/10.1124/jpet.105.087452
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    Mechanism of the Vascular Angiotensin II/α2-Adrenoceptor Interaction
    Edwin K. Jackson, Liping Gao and Chongxue Zhu
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1109-1116; DOI: https://doi.org/10.1124/jpet.105.086074
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    Soy Isoflavones Improve Endothelial Function in Spontaneously Hypertensive Rats in an Estrogen-Independent Manner: Role of Nitric-Oxide Synthase, Superoxide, and Cyclooxygenase Metabolites
    Rocío Vera, Milagros Galisteo, Inmaculada Concepción Villar, Manuel Sánchez, Antonio Zarzuelo, Francisco Pérez-Vizcaíno and Juan Duarte
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1300-1309; DOI: https://doi.org/10.1124/jpet.105.085530
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    Mechanism of Fatty Acids Induced Suppression of Cardiovascular Reflexes in Rats
    Hossam A. Shaltout and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1328-1337; DOI: https://doi.org/10.1124/jpet.105.086314
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    Pretreatment with d-myo-Inositol Trisphosphate Reduces Infarct Size in Rabbit Hearts: Role of Inositol Trisphosphate Receptors and Gap Junctions in Triggering Protection
    Karin Przyklenk, Michelle Maynard, Chad E. Darling and Peter Whittaker
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1386-1392; DOI: https://doi.org/10.1124/jpet.105.087742

CELLULAR AND MOLECULAR

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    Modulation of Ca2+ Channels by Opioid Receptor-Like 1 Receptors Natively Expressed in Rat Stellate Ganglion Neurons Innervating Cardiac Muscle
    Victor Ruiz-Velasco, Henry L. Puhl, Brad C. Fuller and Andrew D. Sumner
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 987-994; DOI: https://doi.org/10.1124/jpet.105.089284
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    Delineation of Myotoxicity Induced by 3-Hydroxy-3-methylglutaryl CoA Reductase Inhibitors in Human Skeletal Muscle Cells
    Julia Sacher, Lukas Weigl, Martin Werner, Csaba Szegedi and Martin Hohenegger
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1032-1041; DOI: https://doi.org/10.1124/jpet.105.086462
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    Effects of Dinucleoside Polyphosphates on Trabecular Meshwork Cells and Aqueous Humor Outflow Facility
    David Soto, Jesús Pintor, Assumpta Peral, Arcadi Gual and Xavier Gasull
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1042-1051; DOI: https://doi.org/10.1124/jpet.105.085274
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    The Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Cross-Talk with Hepatic Nuclear Factor 4α to Synergistically Activate the Human CYP2C9 Promoter
    Yuping Chen, Grace Kissling, Masahiko Negishi and Joyce A. Goldstein
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1125-1133; DOI: https://doi.org/10.1124/jpet.105.087072
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    Inhibition of the A-Type K+ Channels of Dorsal Root Ganglion Neurons by the Long-Duration Anesthetic Butamben
    D. L. B. Winkelman, C. L. Beck, D. L. Ypey and M. E. O'Leary
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1177-1186; DOI: https://doi.org/10.1124/jpet.105.087759
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    Scalaradial Inhibition of Epidermal Growth Factor Receptor-Mediated Akt Phosphorylation Is Independent of Secretory Phospholipase A2
    Yili Xie, Lunhua Liu, Xiaochun Huang, Yuewei Guo and Liguang Lou
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1210-1217; DOI: https://doi.org/10.1124/jpet.105.086520
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    Osthole-Mediated Cell Differentiation through Bone Morphogenetic Protein-2/p38 and Extracellular Signal-Regulated Kinase 1/2 Pathway in Human Osteoblast Cells
    Po-Lin Kuo, Ya-Ling Hsu, Cheng-Hsiung Chang and Jiunn-Kae Chang
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1290-1299; DOI: https://doi.org/10.1124/jpet.105.085092
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    Evaluation of Histamine H1-, H2-, and H3-Receptor Ligands at the Human Histamine H4 Receptor: Identification of 4-Methylhistamine as the First Potent and Selective H4 Receptor Agonist
    Herman D. Lim, Richard M. van Rijn, Ping Ling, Remko A. Bakker, Robin L. Thurmond and Rob Leurs
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1310-1321; DOI: https://doi.org/10.1124/jpet.105.087965

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) Acts via Phosphatidylinositol 3-Kinase-Independent Pathways to Inhibit Cell Proliferation via Mammalian Target of Rapamycin (mTOR)- and Non-mTOR-Dependent Mechanisms
    Arnold S. Kristof, Gustavo Pacheco-Rodriguez, Bruno Schremmer and Joel Moss
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1134-1143; DOI: https://doi.org/10.1124/jpet.105.083550
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    In Vitro Synergy and Enhanced Murine Brain Penetration of Saquinavir Coadministered with Mefloquine
    Andrew Owen, Omar Janneh, Ruben C. Hartkoorn, Becky Chandler, Patrick G. Bray, Phillip Martin, Stephen A. Ward, C. Anthony Hart, Saye H. Khoo and David J. Back
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1202-1209; DOI: https://doi.org/10.1124/jpet.105.086272

ENDOCRINE AND REPRODUCTIVE

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    Role of Protein Kinase C-Ras-MAPK p44/42 in Ethanol and Transforming Growth Factor-β3-Induced Basic Fibroblast Growth Factor Release from Folliculostellate Cells
    Kirti Chaturvedi and Dipak K. Sarkar
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1346-1352; DOI: https://doi.org/10.1124/jpet.105.088302

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Inhibitors of Prostaglandin Transport and Metabolism Augment Protease-Activated Receptor-2-Mediated Increases in Prostaglandin E2 Levels and Smooth Muscle Relaxation in Mouse Isolated Trachea
    Peter J. Henry, Angela D'Aprile, Glenn Self, Tracy Hong and Tracy S. Mann
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 995-1001; DOI: https://doi.org/10.1124/jpet.105.086124
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    Proliferative Signaling by Store-Operated Calcium Channels Opposes Colon Cancer Cell Cytostasis Induced by Bacterial Enterotoxins
    Shiva Kazerounian, Giovanni M. Pitari, Fawad J. Shah, Glen S. Frick, Muniswamy Madesh, Inez Ruiz-Stewart, Stephanie Schulz, Gyorgy Hajnóczky and Scott A. Waldman
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1013-1022; DOI: https://doi.org/10.1124/jpet.105.089052
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    Protection against Cisplatin-Induced Toxicities by N-Acetylcysteine and Sodium Thiosulfate as Assessed at the Molecular, Cellular, and in Vivo Levels
    D. Thomas Dickey, Y. Jeffrey Wu, Leslie L. Muldoon and Edward A. Neuwelt
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1052-1058; DOI: https://doi.org/10.1124/jpet.105.087601
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    A Novel, Long-Acting Agonist of Glucose-Dependent Insulinotropic Polypeptide Suitable for Once-Daily Administration in Type 2 Diabetes
    Nigel Irwin, Brian D. Green, Mark H. Mooney, Brett Greer, Patrick Harriott, Clifford J. Bailey, Victor A. Gault, Finbarr P. M. O'Harte and Peter R. Flatt
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1187-1194; DOI: https://doi.org/10.1124/jpet.105.086082
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    Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation
    Hon-Wai Koon, Dezheng Zhao, Yanai Zhan, Simos Simeonidis, Mary P. Moyer and Charalabos Pothoulakis
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1393-1400; DOI: https://doi.org/10.1124/jpet.105.088013

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Non-CpG-Containing Antisense 2′-Methoxyethyl Oligonucleotides Activate a Proinflammatory Response Independent of Toll-Like Receptor 9 or Myeloid Differentiation Factor 88
    Joseph J. Senn, Sebastien Burel and Scott P. Henry
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 972-979; DOI: https://doi.org/10.1124/jpet.105.084004
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    Oral Delivery and Gastrointestinal Absorption of Soluble Glucans Stimulate Increased Resistance to Infectious Challenge
    Peter J. Rice, Elizabeth L. Adams, Tammy Ozment-Skelton, Andres J. Gonzalez, Matthew P. Goldman, Brent E. Lockhart, Luke A. Barker, Kevin F. Breuel, Warren K. DePonti, John H. Kalbfleisch, Harry E. Ensley, Gordon D. Brown, Siamon Gordon and David L. Williams
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1079-1086; DOI: https://doi.org/10.1124/jpet.105.085415
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    Endogenous Aminopeptidase N Decreases the Potency of Peptide Agonists and Antagonists of the Kinin B1 Receptors in the Rabbit Aorta
    Jean-Philippe Fortin, Lajos Gera, Johanne Bouthillier, John M. Stewart, Albert Adam and François Marceau
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1169-1176; DOI: https://doi.org/10.1124/jpet.105.088799
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    Neutrophil Adherence to Bladder Microvascular Endothelial Cells following Platelet-Activating Factor Acetylhydrolase Inhibition
    Suzanne M. Vinson, Alice Rickard, Jan S. Ryerse and Jane McHowat
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1241-1247; DOI: https://doi.org/10.1124/jpet.105.085365

NEUROPHARMACOLOGY

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    Pharmacological Implications of Two Distinct Mechanisms of Interaction of Memantine with N-Methyl-d-aspartate-Gated Channels
    Huei-Sheng Vincent Chen and Stuart A. Lipton
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 961-971; DOI: https://doi.org/10.1124/jpet.105.085142
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    (±)-3,4-Methylenedioxymethamphetamine Administration to Rats Does Not Decrease Levels of the Serotonin Transporter Protein or Alter Its Distribution between Endosomes and the Plasma Membrane
    Xiaoying Wang, Michael H. Baumann, Heng Xu, Marisela Morales and Richard B. Rothman
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1002-1012; DOI: https://doi.org/10.1124/jpet.105.088476
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    Divergent Pharmacological Activity of Novel Marine-Derived Excitatory Amino Acids on Glutamate Receptors
    James M. Sanders, Koichi Ito, Luca Settimo, Olli T. Pentikäinen, Muneo Shoji, Makoto Sasaki, Mark S. Johnson, Ryuichi Sakai and Geoffrey T. Swanson
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1068-1078; DOI: https://doi.org/10.1124/jpet.105.086389
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    Age-Dependent Methamphetamine-Induced Alterations in Vesicular Monoamine Transporter-2 Function: Implications for Neurotoxicity
    Jannine G. Truong, Diana G. Wilkins, Jakub Baudys, Dennis J. Crouch, Kamisha L. Johnson-Davis, James W. Gibb, Glen R. Hanson and Annette E. Fleckenstein
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1087-1092; DOI: https://doi.org/10.1124/jpet.105.085951
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    Antianalgesia: Stereoselective Action of dextro-Morphine over levo-Morphine on Glia in the Mouse Spinal Cord
    Hsiang-En Wu, Jonathan Thompson, Han-Sen Sun, Maia Terashvili and Leon F. Tseng
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1101-1108; DOI: https://doi.org/10.1124/jpet.105.087130
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    Contributions of the Mitogen-Activated Protein Kinase and Protein Kinase C Cascades in Spatial Learning and Memory Mediated by the Nucleus Accumbens
    Lily Alvarez-Jaimes, Mara Feliciano-Rivera, Marjorie Centeno-González and Carmen S. Maldonado-Vlaar
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1144-1157; DOI: https://doi.org/10.1124/jpet.105.086140
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    Pharmacodynamic and Pharmacokinetic Studies of Agmatine after Spinal Administration in the Mouse
    John C. Roberts, Brent M. Grocholski, Kelley F. Kitto and Carolyn A. Fairbanks
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1226-1233; DOI: https://doi.org/10.1124/jpet.105.086173
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    The Role of Central and Peripheral μ Opioid Receptors in Inflammatory Pain and Edema: A Study Using Morphine and DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic Acid)
    Garth T. Whiteside, Jamie M. Boulet and Katharine Walker
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1234-1240; DOI: https://doi.org/10.1124/jpet.105.088351
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    Sumanirole, a Highly Dopamine D2-Selective Receptor Agonist: In Vitro and in Vivo Pharmacological Characterization and Efficacy in Animal Models of Parkinson's Disease
    Robert B. McCall, Keith J. Lookingland, Paul J. Bédard and Rita M. Huff
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1248-1256; DOI: https://doi.org/10.1124/jpet.105.084202
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    The Effects of a Selective Dopamine D2 Receptor Agonist on Behavioral and Pathological Outcome in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Squirrel Monkeys
    Diane T. Stephenson, Martin D. Meglasson, Mark A. Connell, Mary A. Childs, Eva Hajos-Korcsok and Marina E. Emborg
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1257-1266; DOI: https://doi.org/10.1124/jpet.105.087379
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    Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties
    L. E. Schechter, D. L. Smith, S. Rosenzweig-Lipson, S. J. Sukoff, L. A. Dawson, K. Marquis, D. Jones, M. Piesla, T. Andree, S. Nawoschik, J. A. Harder, M. D. Womack, J. Buccafusco, A. V. Terry, B. Hoebel, P. Rada, M. Kelly, M. Abou-Gharbia, J. E. Barrett and W. Childers
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1274-1289; DOI: https://doi.org/10.1124/jpet.105.086363
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    Hypocretin-1 (Orexin-A) Facilitates Inhibitory and Diminishes Excitatory Synaptic Pathways to Cardiac Vagal Neurons in the Nucleus Ambiguus
    Olga Dergacheva, Xin Wang, Zheng-Gui Huang, Evguenia Bouairi, Christopher Stephens, Chistopher Gorini and David Mendelowitz
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1322-1327; DOI: https://doi.org/10.1124/jpet.105.086421
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    Tertiapin-Q Blocks Recombinant and Native Large Conductance K+ Channels in a Use-Dependent Manner
    Refik Kanjhan, Elizabeth J. Coulson, David J. Adams and Mark C. Bellingham
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1353-1361; DOI: https://doi.org/10.1124/jpet.105.085928
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    Resting and Evoked Spinal Substance P Release during Chronic Intrathecal Morphine Infusion: Parallels with Tolerance and Dependence
    Guibao Gu, Ichiro Kondo, Xiao-Ying Hua and Tony L. Yaksh
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1362-1369; DOI: https://doi.org/10.1124/jpet.105.087718
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    Inhibition of High Voltage-Activated Calcium Channels by Spider Toxin PnTx3-6
    Luciene B. Vieira, Christopher Kushmerick, Michael E. Hildebrand, Esperanza Garcia, Antony Stea, Marta N. Cordeiro, Michael Richardson, Marcus Vinicius Gomez and Terrance P. Snutch
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1370-1377; DOI: https://doi.org/10.1124/jpet.105.087023
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    5-Iodoresiniferatoxin Evokes Hypothermia in Mice and Is a Partial Transient Receptor Potential Vanilloid 1 Agonist in Vitro
    Isao Shimizu, Tohko Iida, Nobuhiko Horiuchi and Michael J. Caterina
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1378-1385; DOI: https://doi.org/10.1124/jpet.105.084277

TOXICOLOGY

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    Coagulation-Mediated Hypoxia and Neutrophil-Dependent Hepatic Injury in Rats Given Lipopolysaccharide and Ranitidine
    James P. Luyendyk, Patrick J. Shaw, Christopher D. Green, Jane F. Maddox, Patricia E. Ganey and Robert A. Roth
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1023-1031; DOI: https://doi.org/10.1124/jpet.105.087981
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    Transport of N-Acetylcysteine S-Conjugates of Methylmercury in Madin-Darby Canine Kidney Cells Stably Transfected with Human Isoform of Organic Anion Transporter 1
    Rudolfs K. Zalups and Sarfaraz Ahmad
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1158-1168; DOI: https://doi.org/10.1124/jpet.105.086645
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    Hypersensitivity of HIV-1-Infected Cells to Reactive Sulfonamide Metabolites Correlated to Expression of the HIV-1 Viral Protein Tat
    Jacqueline Arp, Michael J. Rieder, Brad Urquhart, David Freeman, M. Jane Tucker, Adriana Krizova, David Lehmann and Gregory A. Dekaban
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1218-1225; DOI: https://doi.org/10.1124/jpet.105.085050
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    3,4-Methylenedioxymethamphetamine (Ecstasy) Activates Skeletal Muscle Nicotinic Acetylcholine Receptors
    Werner Klingler, James J. A. Heffron, Karin Jurkat-Rott, Grainne O'Sullivan, Andreas Alt, Friedrich Schlesinger, Johannes Bufler and Frank Lehmann-Horn
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1267-1273; DOI: https://doi.org/10.1124/jpet.105.086629
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    Up-Regulation of Uncoupling Protein 2 by Cyanide Is Linked with Cytotoxicity in Mesencephalic Cells
    Krishnan Prabhakaran, Li Li, Edward M. Mills, Joseph L. Borowitz and Gary E. Isom
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1338-1345; DOI: https://doi.org/10.1124/jpet.105.088625

LETTERS TO THE EDITOR

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    Comments on “Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells”
    Hartmut Jaeschke
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1401-1402; DOI: https://doi.org/10.1124/jpet.105.089821
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    Response: Comments on “Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells”
    George E. N. Kass
    Journal of Pharmacology and Experimental Therapeutics September 2005, 314 (3) 1403-1404; DOI: https://doi.org/10.1124/jpet.105.090548
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Journal of Pharmacology and Experimental Therapeutics: 314 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 314, Issue 3
1 Sep 2005
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • LETTERS TO THE EDITOR
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

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