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Research ArticleENDOCRINE AND REPRODUCTIVE

Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes

Peer B. Jacobson, Thomas W. von Geldern, Lars Öhman, Marie Österland, Jiahong Wang, Bradley Zinker, Denise Wilcox, Phong T. Nguyen, Amanda Mika, Steven Fung, Thomas Fey, Annika Goos-Nilsson, Marlena Grynfarb, Tomas Barkhem, Kennan Marsh, David W. A. Beno, Bach Nga-Nguyen, Philip R. Kym, James T. Link, Noah Tu, Dale S. Edgerton, Alan Cherrington, Suad Efendic, Benjamin C. Lane and Terry J. Opgenorth
Journal of Pharmacology and Experimental Therapeutics July 2005, 314 (1) 191-200; DOI: https://doi.org/10.1124/jpet.104.081257
Peer B. Jacobson
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Thomas W. von Geldern
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Lars Öhman
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Marie Österland
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Jiahong Wang
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Bradley Zinker
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Denise Wilcox
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Phong T. Nguyen
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Amanda Mika
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Steven Fung
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Thomas Fey
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Annika Goos-Nilsson
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Marlena Grynfarb
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Tomas Barkhem
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Kennan Marsh
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David W. A. Beno
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Bach Nga-Nguyen
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Philip R. Kym
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James T. Link
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Noah Tu
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Dale S. Edgerton
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Alan Cherrington
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Suad Efendic
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Benjamin C. Lane
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Terry J. Opgenorth
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Article Information

vol. 314 no. 1 191-200
DOI 
https://doi.org/10.1124/jpet.104.081257
PubMed 
15784656

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 24, 2004
  • Accepted March 21, 2005
  • Published online June 16, 2005.

Article Versions

  • Earlier version (March 22, 2005 - 08:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Peer B. Jacobson,
  2. Thomas W. von Geldern,
  3. Lars Öhman,
  4. Marie Österland,
  5. Jiahong Wang,
  6. Bradley Zinker,
  7. Denise Wilcox,
  8. Phong T. Nguyen,
  9. Amanda Mika,
  10. Steven Fung,
  11. Thomas Fey,
  12. Annika Goos-Nilsson,
  13. Marlena Grynfarb,
  14. Tomas Barkhem,
  15. Kennan Marsh,
  16. David W. A. Beno,
  17. Bach Nga-Nguyen,
  18. Philip R. Kym,
  19. James T. Link,
  20. Noah Tu,
  21. Dale S. Edgerton,
  22. Alan Cherrington,
  23. Suad Efendic,
  24. Benjamin C. Lane and
  25. Terry J. Opgenorth
  1. Abbott Laboratories, Chicago, Illinois (P.B.J., T.W.v.G., J.W., B.Z., D.W., P.T.N., A.M., S.F., T.F., K.M., D.W.A.B., B.N.-N., P.R.K., J.T.L., N.T., B.C.L., T.J.O.); Karo Bio, Huddinge, Sweden (L.Ö., M.Ö., A.G.-N., M.G., T.B.); Vanderbilt University, Nashville, Tennessee (D.S.E., A.C.); and Karolinska Institute, Stockholm, Sweden (S.E.)
  1. Address correspondence to:
    Dr. Peer B. Jacobson, Department of Metabolic Disease Research, Abbott Laboratories, R47M, AP10-111, 100 Abbott Park Rd., Abbott Park, IL 60064. E-mail: peer.b.jacobson{at}abbott.com
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Journal of Pharmacology and Experimental Therapeutics: 377 (2)
Journal of Pharmacology and Experimental Therapeutics
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Research ArticleENDOCRINE AND REPRODUCTIVE

Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes

Peer B. Jacobson, Thomas W. von Geldern, Lars Öhman, Marie Österland, Jiahong Wang, Bradley Zinker, Denise Wilcox, Phong T. Nguyen, Amanda Mika, Steven Fung, Thomas Fey, Annika Goos-Nilsson, Marlena Grynfarb, Tomas Barkhem, Kennan Marsh, David W. A. Beno, Bach Nga-Nguyen, Philip R. Kym, James T. Link, Noah Tu, Dale S. Edgerton, Alan Cherrington, Suad Efendic, Benjamin C. Lane and Terry J. Opgenorth
Journal of Pharmacology and Experimental Therapeutics July 1, 2005, 314 (1) 191-200; DOI: https://doi.org/10.1124/jpet.104.081257

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Research ArticleENDOCRINE AND REPRODUCTIVE

Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes

Peer B. Jacobson, Thomas W. von Geldern, Lars Öhman, Marie Österland, Jiahong Wang, Bradley Zinker, Denise Wilcox, Phong T. Nguyen, Amanda Mika, Steven Fung, Thomas Fey, Annika Goos-Nilsson, Marlena Grynfarb, Tomas Barkhem, Kennan Marsh, David W. A. Beno, Bach Nga-Nguyen, Philip R. Kym, James T. Link, Noah Tu, Dale S. Edgerton, Alan Cherrington, Suad Efendic, Benjamin C. Lane and Terry J. Opgenorth
Journal of Pharmacology and Experimental Therapeutics July 1, 2005, 314 (1) 191-200; DOI: https://doi.org/10.1124/jpet.104.081257
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