Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding
Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffery Van Deusen
Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1254-1262; DOI: https://doi.org/10.1124/jpet.104.079319
Xingrong Liu
Bill J. Smith
Cuiping Chen
Ernesto Callegari
Stacey L. Becker
Xi Chen
Julie Cianfrogna
Angela C. Doran
Shawn D. Doran
John P. Gibbs
Natilie Hosea
Jianhua Liu
Frederick R. Nelson
Mark A. Szewc

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In this issue
Journal of Pharmacology and Experimental Therapeutics
Vol. 377, Issue 2
1 May 2021
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding
Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffery Van Deusen
Journal of Pharmacology and Experimental Therapeutics June 1, 2005, 313 (3) 1254-1262; DOI: https://doi.org/10.1124/jpet.104.079319
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding
Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffery Van Deusen
Journal of Pharmacology and Experimental Therapeutics June 1, 2005, 313 (3) 1254-1262; DOI: https://doi.org/10.1124/jpet.104.079319
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