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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding

Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffery Van Deusen
Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1254-1262; DOI: https://doi.org/10.1124/jpet.104.079319
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding

Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffery Van Deusen
Journal of Pharmacology and Experimental Therapeutics June 1, 2005, 313 (3) 1254-1262; DOI: https://doi.org/10.1124/jpet.104.079319
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