Journal of Pharmacology and Experimental Therapeutics: 313 (3)

June 01, 2005; Volume 313,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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The Evolution of in Vitro Fertilization: Integration of Pharmacology, Technology, and Clinical Care
Eve C. Feinberg, Jason G. Bromer and William H. Catherino

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 935-942; DOI: https://doi.org/10.1124/jpet.104.080051

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Hydrolysis of Capecitabine to 5′-Deoxy-5-fluorocytidine by Human Carboxylesterases and Inhibition by Loperamide
S. K. Quinney, S. P. Sanghani, W. I. Davis, T. D. Hurley, Z. Sun, D. J. Murry and W. F. Bosron

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1011-1016; DOI: https://doi.org/10.1124/jpet.104.081265
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Modulation of Metoprolol Pharmacokinetics and Hemodynamics by Diphenhydramine Coadministration during Exercise Testing in Healthy Premenopausal Women
Ashish Sharma, Philippe Pibarot, Sylvie Pilote, Jean G. Dumesnil, Marie Arsenault, Pierre Maxime Bélanger, Bernd Meibohm and Bettina A. Hamelin

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1172-1181; DOI: https://doi.org/10.1124/jpet.104.081109
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Renal Clearance of γ-Hydroxybutyric Acid in Rats: Increasing Renal Elimination as a Detoxification Strategy
Marilyn E. Morris, Ke Hu and Qi Wang

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1194-1202; DOI: https://doi.org/10.1124/jpet.105.083253
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Relative Bioavailability of Calcium from Calcium Formate, Calcium Citrate, and Calcium Carbonate
Robert P. Hanzlik, Stephen C. Fowler and Daniel H. Fisher

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1217-1222; DOI: https://doi.org/10.1124/jpet.104.081893
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Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding
Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffery Van Deusen

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1254-1262; DOI: https://doi.org/10.1124/jpet.104.079319
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UDP Glucuronosyltransferase (UGT) 1A6 Pharmacogenetics: I. Identification of Polymorphisms in the 5′-Regulatory and Exon 1 Regions, and Association with Human Liver UGT1A6 Gene Expression and Glucuronidation
Soundararajan Krishnaswamy, Qin Hao, Abdul Al-Rohaimi, Leah M. Hesse, Lisa L. von Moltke, David J. Greenblatt and Michael H. Court

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1331-1339; DOI: https://doi.org/10.1124/jpet.104.081950
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UDP Glucuronosyltransferase (UGT) 1A6 Pharmacogenetics: II. Functional Impact of the Three Most Common Nonsynonymous UGT1A6 Polymorphisms (S7A, T181A, and R184S)
Soundararajan Krishnaswamy, Qin Hao, Abdul Al-Rohaimi, Leah M. Hesse, Lisa L. von Moltke, David J. Greenblatt and Michael H. Court

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1340-1346; DOI: https://doi.org/10.1124/jpet.104.081968

BEHAVIORAL PHARMACOLOGY

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Contribution of GABA_A Receptor Subtypes to the Anxiolytic-Like, Motor, and Discriminative Stimulus Effects of Benzodiazepines: Studies with the Functionally Selective Ligand SL651498 [6-Fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one]
Stephanie C. Licata, Donna M. Platt, James M. Cook, P. V. V. Srirama Sarma, Guy Griebel and James K. Rowlett

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1118-1125; DOI: https://doi.org/10.1124/jpet.104.081612
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In Vivo Characterization of 6β-Naltrexol, an Opioid Ligand with Less Inverse Agonist Activity Compared with Naltrexone and Naloxone in Opioid-Dependent Mice
Kirsten M. Raehal, John J. Lowery, Castigliano M. Bhamidipati, Ryan M. Paolino, Jennifer R. Blair, Danxin Wang, Wolfgang Sadée and Edward J. Bilsky

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1150-1162; DOI: https://doi.org/10.1124/jpet.104.082966
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Place Conditioning and Locomotor Effects of N-Substituted, 4′,4′′-Difluorobenztropine Analogs in Rats
Su-Min Li, Amy Hauck Newman and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1223-1230; DOI: https://doi.org/10.1124/jpet.105.084541
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Novel γ-Hydroxybutyric Acid (GHB) Analogs Share Some, but Not All, of the Behavioral Effects of GHB and GABA_B Receptor Agonists
Lawrence P. Carter, Huifang Wu, Weibin Chen, Marilyn M. Matthews, Ashok K. Mehta, R. Jason Hernandez, Jennifer A. Thomson, Maharaj K. Ticku, Andrew Coop, Wouter Koek and Charles P. France

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1314-1323; DOI: https://doi.org/10.1124/jpet.104.077578

CARDIOVASCULAR

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Intact Actin Filaments Are Required for Cytosolic Phospholipase A₂ Translocation but Not for Its Activation by Norepinephrine in Vascular Smooth Muscle Cells
Soghra Fatima, Fariborz A. Yaghini, Zoran Pavicevic, Shailaja Kalyankrishna, Nauzanene Jafari, Elizabeth Luong, Anne Estes and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1017-1026; DOI: https://doi.org/10.1124/jpet.104.081992
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N,N,N′,N′-Tetrakis(2-pyridylmethyl)-ethylenediamine Improves Myocardial Protection against Ischemia by Modulation of Intracellular Ca²+ Homeostasis
Yelena A. Shmist, Roman Kamburg, Gal Ophir, Alex Kozak, Vladimir Shneyvays, Yori J. Appelbaum and Asher Shainberg

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1046-1057; DOI: https://doi.org/10.1124/jpet.104.081281
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The Acute Estrogenic Dilation of Rat Aorta Is Mediated Solely by Selective Estrogen Receptor-α Agonists and Is Abolished by Estrogen Deprivation
Chiara Bolego, Andrea Cignarella, Paola Sanvito, Valeria Pelosi, Fabio Pellegatta, Lina Puglisi and Christian Pinna

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1203-1208; DOI: https://doi.org/10.1124/jpet.104.082867
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Opposing Roles of Endothelial and Smooth Muscle Phosphatidylinositol 3-Kinase in Vasoconstriction: Effects of Rho-Kinase and Hypertension
Klaudia Budzyn, Philip D. Marley and Christopher G. Sobey

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1248-1253; DOI: https://doi.org/10.1124/jpet.104.082784
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Differential Effects of 20-Hydroxyeicosatetraenoic Acid on Intrarenal Blood Flow in the Rat
Adebayo O. Oyekan

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1289-1295; DOI: https://doi.org/10.1124/jpet.104.080218

CELLULAR AND MOLECULAR

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θ Isoform of Protein Kinase C Alters Barrier Function in Intestinal Epithelium through Modulation of Distinct Claudin Isotypes: A Novel Mechanism for Regulation of Permeability
A. Banan, L. J. Zhang, M. Shaikh, J. Z. Fields, S. Choudhary, C. B. Forsyth, A. Farhadi and A. Keshavarzian

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 962-982; DOI: https://doi.org/10.1124/jpet.105.083428
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Differential Agonist-Mediated Internalization of the Human 5-Hydroxytryptamine 7 Receptor Isoforms
Chris R. Guthrie, Aaron T. Murray, Allyn A. Franklin and Mark W. Hamblin

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1003-1010; DOI: https://doi.org/10.1124/jpet.104.081919
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Insulin Receptor-Protein Kinase C-γ Signaling Mediates Inhibition of Hypoxia-Induced Necrosis of Cortical Neurons
Wakako Hamabe, Ryousuke Fujita and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1027-1034; DOI: https://doi.org/10.1124/jpet.104.082735
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Angiotensin II Attenuates Synaptic GABA Release and Excites Paraventricular-Rostral Ventrolateral Medulla Output Neurons
De-Pei Li and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1035-1045; DOI: https://doi.org/10.1124/jpet.104.082495
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Site of Action of β-Ligands at the Human β1-Adrenoceptor
Jillian G. Baker

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1163-1171; DOI: https://doi.org/10.1124/jpet.104.082875
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Functional Selectivity of Melanocortin 4 Receptor Peptide and Nonpeptide Agonists: Evidence for Ligand-Specific Conformational States
Sarah A. Nickolls, Beth Fleck, Sam R. J. Hoare and Rich A. Maki

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1281-1288; DOI: https://doi.org/10.1124/jpet.105.083337
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Neurokinin-1 Receptor Resensitization Precedes Receptor Recycling
V. J. Bennett, S. A. Perrine and M. A. Simmons

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1347-1354; DOI: https://doi.org/10.1124/jpet.104.079954
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Desensitization of the Human Motilin Receptor by Motilides
Leen Thielemans, Inge Depoortere, Jason Perret, Patrick Robberecht, Yaoquan Liu, Theo Thijs, Chris Carreras, Emmanuel Burgeon and Theo L. Peeters

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1397-1405; DOI: https://doi.org/10.1124/jpet.104.081497
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Mediation of Highly Concentrative Uptake of Pregabalin by L-Type Amino Acid Transport in Chinese Hamster Ovary and Caco-2 Cells
T. Z. Su, M. R. Feng and M. L. Weber

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1406-1415; DOI: https://doi.org/10.1124/jpet.104.082255

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Inhibition of Gene Markers of Fibrosis with a Novel Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase in Puromycin-Induced Nephritis
Eugene T. Grygielko, William M. Martin, Christopher Tweed, Peter Thornton, John Harling, David P. Brooks and Nicholas J. Laping

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 943-951; DOI: https://doi.org/10.1124/jpet.104.082099
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Long-Term Treatment of Bile Duct-Ligated Rats with Rapamycin (Sirolimus) Significantly Attenuates Liver Fibrosis: Analysis of the Underlying Mechanisms
Erwin Biecker, Andrea De Gottardi, Markus Neef, Matthias Unternährer, Vreni Schneider, Monika Ledermann, Hans Sägesser, Sidney Shaw and Jürg Reichen

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 952-961; DOI: https://doi.org/10.1124/jpet.104.079616
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Cholinergic Stimulation of Amylase Secretion from Pancreatic Acinar Cells Studied with Muscarinic Acetylcholine Receptor Mutant Mice
Dinesh Gautam, Sung-Jun Han, Thomas S. Heard, Yinghong Cui, Georgina Miller, Lanh Bloodworth and Jürgen Wess

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 995-1002; DOI: https://doi.org/10.1124/jpet.105.084855
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Demonstration of a Specific Site of Covalent Labeling of the Human Motilin Receptor Using a Biologically Active Photolabile Motilin Analog
Bunzo Matsuura, Maoqing Dong, Bernard Coulie, Delia I. Pinon and Laurence J. Miller

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1101-1108; DOI: https://doi.org/10.1124/jpet.104.081562
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Regulation of Human Hepatocytes by P2Y Receptors: Control of Glycogen Phosphorylase, Ca²⁺, and Mitogen-Activated Protein Kinases
C. Jane Dixon, Pamela J. White, John F. Hall, Shaun Kingston and Michael R. Boarder

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1305-1313; DOI: https://doi.org/10.1124/jpet.104.082743

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Infection-Induced Kinin B₁ Receptors in Human Pulmonary Fibroblasts: Role of Intact Pathogens and p38 Mitogen-Activated Protein Kinase-Dependent Signaling
Stephen B. Phagoo, Krisanavane Reddi, Bertrand J. Silvallana, L. M. Fredrik Leeb-Lundberg and David Warburton

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1231-1238; DOI: https://doi.org/10.1124/jpet.104.083030
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Pharmacological Characterization of CXC Chemokine Receptor 3 Ligands and a Small Molecule Antagonist
Christopher E. Heise, Anil Pahuja, Sarah C. Hudson, Monica S. Mistry, Amy L. Putnam, Molly M. Gross, Peter A. Gottlieb, Warren S. Wade, Mehrak Kiankarimi, David Schwarz, Paul Crowe, Albert Zlotnik and David G. Alleva

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1263-1271; DOI: https://doi.org/10.1124/jpet.105.083683
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Potentiation of des-Arg⁹-Kallidin-Induced Vasoconstrictor Responses by Metallopeptidase Inhibition in Isolated Human Umbilical Artery
Facundo Germán Pelorosso, Paula Tamara Brodsky, Camila Lidia Zold and Rodolfo Pedro Rothlin

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1355-1360; DOI: https://doi.org/10.1124/jpet.105.083063
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A Novel Effect for Annexin 1-Derived Peptide Ac2-26: Reduction of Allergic Inflammation in the Rat
Christianne Bandeira-Melo, André Gustavo C. Bonavita, Bruno L. Diaz, Patricia M. R. e Silva, Vinícius F. Carvalho, Peter J. Jose, Roderick J. Flower, Mauro Perretti and Marco A. Martins

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1416-1422; DOI: https://doi.org/10.1124/jpet.104.080473

NEUROPHARMACOLOGY

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Primate Trace Amine Receptor 1 Modulation by the Dopamine Transporter
Gregory M. Miller, Christopher D. Verrico, Amy Jassen, Martha Konar, Hong Yang, Helen Panas, Mary Bahn, Ryan Johnson and Bertha K. Madras

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 983-994; DOI: https://doi.org/10.1124/jpet.105.084459
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Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding Pocket
Leo Kinarsky, Bihua Feng, Donald A. Skifter, Richard M. Morley, Simon Sherman, David E. Jane and Daniel T. Monaghan

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1066-1074; DOI: https://doi.org/10.1124/jpet.104.082990
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Delivery of β-Galactosidase to Mouse Brain via the Blood-Brain Barrier Transferrin Receptor
Yun Zhang and William M. Pardridge

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1075-1081; DOI: https://doi.org/10.1124/jpet.104.082974
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Subcellular Alterations of Protein Kinase C Isozymes in the Rat Brain after Organophosphate Poisoning
Eugenia Bloch-Shilderman, Tamar Kadar, Aharon Levy, Rita Sahar, Ishai Rabinovitz and Eran Gilat

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1082-1089; DOI: https://doi.org/10.1124/jpet.105.083469
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Stilbazulenyl Nitrone, a Second-Generation Azulenyl Nitrone Antioxidant, Confers Enduring Neuroprotection in Experimental Focal Cerebral Ischemia in the Rat: Neurobehavior, Histopathology, and Pharmacokinetics
James J. Ley, Alexey Vigdorchik, Ludmila Belayev, Weizhao Zhao, Raul Busto, Larissa Khoutorova, David A. Becker and Myron D. Ginsberg

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1090-1100; DOI: https://doi.org/10.1124/jpet.105.083386
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Endothelin (ET)-1-Induced Inhibition of ATP Release from PC-12 Cells Is Mediated by the ET_B Receptor: Differential Response to ET-1 on ATP, Neuropeptide Y, and Dopamine Levels
A. Gardner, T. C. Westfall and H. Macarthur

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1109-1117; DOI: https://doi.org/10.1124/jpet.104.081075
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Effects of Chronic Infusion of a GABA_A Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig
Catherine M. Gliddon, Cynthia L. Darlington and Paul F. Smith

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1126-1135; DOI: https://doi.org/10.1124/jpet.104.082172
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Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effect of Buprenorphine and Fentanyl in Rats: Role of Receptor Equilibration Kinetics
Ashraf Yassen, Erik Olofsen, Albert Dahan and Meindert Danhof

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1136-1149; DOI: https://doi.org/10.1124/jpet.104.082560
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Cross-Sensitization to Morphine in Cocaine-Sensitized Rats: Behavioral Assessments Correlate with Enhanced Responding of Ventral Pallidal Neurons to Morphine and Glutamate, with Diminished Effects of GABA
J. McDaid, J. E. Dallimore, A. R. Mackie, A. L. Mickiewicz and T. C. Napier

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1182-1193; DOI: https://doi.org/10.1124/jpet.105.084038
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Comparison of the Antinociceptive Profiles of Gabapentin and 3-Methylgabapentin in Rat Models of Acute and Persistent Pain: Implications for Mechanism of Action
M. O. Urban, K. Ren, K. T. Park, B. Campbell, N. Anker, B. Stearns, J. Aiyar, M. Belley, C. Cohen and L. Bristow

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1209-1216; DOI: https://doi.org/10.1124/jpet.104.081778
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Transcriptional and Translational Regulation of Glial Activation by Morphine in a Rodent Model of Neuropathic Pain
V. L. Tawfik, M. L. LaCroix-Fralish, N. Nutile-McMenemy and J. A. DeLeo

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1239-1247; DOI: https://doi.org/10.1124/jpet.104.082420
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Additive Effects of Endogenous Cannabinoid Anandamide and Ethanol on α₇-Nicotinic Acetylcholine Receptor-Mediated Responses in Xenopus Oocytes
Murat Oz, Shelley N. Jackson, Amina S. Woods, Marisela Morales and Li Zhang

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1272-1280; DOI: https://doi.org/10.1124/jpet.104.081315
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Group III Metabotropic Glutamate-Receptor-Mediated Modulation of Excitatory Transmission in Rodent Substantia Nigra Pars Compacta Dopamine Neurons
Ornella Valenti, Guido Mannaioni, Guy R. Seabrook, P. Jeffrey Conn and Michael J. Marino

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1296-1304; DOI: https://doi.org/10.1124/jpet.104.080481
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5-Hydroxytryptamine 1A Receptors in the Paraventricular Nucleus of the Hypothalamus Mediate Oxytocin and Adrenocorticotropin Hormone Release and Some Behavioral Components of the Serotonin Syndrome
Patrick Osei-Owusu, Amy James, James Crane and Karie E. Scrogin

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1324-1330; DOI: https://doi.org/10.1124/jpet.104.082073
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Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration
Richard B. Rothman, Bruce E. Blough, William L. Woolverton, Karen G. Anderson, S. Stevens Negus, Nancy K. Mello, Bryan L. Roth and Michael H. Baumann

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1361-1369; DOI: https://doi.org/10.1124/jpet.104.082503
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Pharmacokinetic Analysis of the Blood-Brain Barrier Transport of ¹²⁵I-Amyloid β Protein 40 in Wild-Type and Alzheimer's Disease Transgenic Mice (APP,PS1) and Its Implications for Amyloid Plaque Formation
Karunya K. Kandimalla, Geoffry L. Curran, Silvina S. Holasek, Emily J. Gilles, Thomas M. Wengenack and Joseph F. Poduslo

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1370-1378; DOI: https://doi.org/10.1124/jpet.104.081901
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Effects of the N-Methyl-d-aspartate Receptor Antagonist Perzinfotel [EAA-090; [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic Acid] on Chemically Induced Thermal Hypersensitivity
Michael R. Brandt, Terri A. Cummons, Lisa Potestio, Stacey J. Sukoff and Sharon Rosenzweig-Lipson

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1379-1386; DOI: https://doi.org/10.1124/jpet.105.084467
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σ Receptor Activation Blocks Potassium Channels and Depresses Neuroexcitability in Rat Intracardiac Neurons
Hongling Zhang and Javier Cuevas

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1387-1396; DOI: https://doi.org/10.1124/jpet.105.084152

TOXICOLOGY

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Characterization of the T-Cell Response in a Patient with Phenindione Hypersensitivity
Dean J. Naisbitt, John Farrell, Peter J. Chamberlain, Josephine E. Hopkins, Neil G. Berry, Munir Pirmohamed and B. Kevin Park

Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1058-1065; DOI: https://doi.org/10.1124/jpet.105.083758

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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