Journal of Pharmacology and Experimental Therapeutics: 313 (1)

April 01, 2005; Volume 313,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Ligand Discovery Using Small Molecule Microarrays
Xuezhong G. He, Guillermo Gerona-Navarro and Samie R. Jaffrey

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 1-7; DOI: https://doi.org/10.1124/jpet.104.076943

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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The Grapefruit Juice Effect Is Not Limited to Cytochrome P450 (P450) 3A4: Evidence for Bergamottin-Dependent Inactivation, Heme Destruction, and Covalent Binding to Protein in P450s 2B6 and 3A5
Hsia-lien Lin, Ute M. Kent and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 154-164; DOI: https://doi.org/10.1124/jpet.104.079608
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Efflux of Depsipeptide FK228 (FR901228, NSC-630176) Is Mediated by P-Glycoprotein and Multidrug Resistance-Associated Protein 1
Jim J. Xiao, Amy B. Foraker, Peter W. Swaan, Shujun Liu, Ying Huang, Zunyan Dai, Jiyun Chen, Wolfgang Sadée, John Byrd, Guido Marcucci and Kenneth K. Chan

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 268-276; DOI: https://doi.org/10.1124/jpet.104.072033
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Recombinant CYP3A4^*17 Is Defective in Metabolizing the Hypertensive Drug Nifedipine, and the CYP3A4^*17 Allele May Occur on the Same Chromosome as CYP3A5^*3, Representing a New Putative Defective CYP3A Haplotype
Su-Jun Lee, Douglas A. Bell, Sherry J. Coulter, Burhan Ghanayem and Joyce A. Goldstein

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 302-309; DOI: https://doi.org/10.1124/jpet.104.078758
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Lymphatic Absorption Is the Primary Contributor to the Systemic Availability of Epoetin Alfa following Subcutaneous Administration to Sheep
Danielle N. McLennan, Christopher J. H. Porter, Glenn A. Edwards, Steven W. Martin, Anne C. Heatherington and Susan A. Charman

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 345-351; DOI: https://doi.org/10.1124/jpet.104.078790

BEHAVIORAL PHARMACOLOGY

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Intracranial Self-Administration of Cocaine within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons
Zachary A. Rodd, Richard L. Bell, Kelly A. Kuc, Ying Zhang, James M. Murphy and William J. McBride

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 134-145; DOI: https://doi.org/10.1124/jpet.104.075952
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Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats
Charles D. Cook and Michael D. Nickerson

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 449-459; DOI: https://doi.org/10.1124/jpet.104.077792

CARDIOVASCULAR

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Vascular Dysfunction of Venous Bypass Conduits Is Mediated by Reactive Oxygen Species in Diabetes: Role of Endothelin-1
Adviye Ergul, Jeanette Schultz Johansen, Catherine Strømhaug, Alex K. Harris, Jimmie Hutchinson, Amany Tawfik, Ali Rahimi, Edward Rhim, Bryan Wells, R. William Caldwell and Mark P. Anstadt

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 70-77; DOI: https://doi.org/10.1124/jpet.104.078105
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Bradykinin Down-Regulates, Whereas Arginine Analogs Up-Regulates, Endothelial Nitric-Oxide Synthase Expression in Coronary Endothelial Cells
N. D. Vaziri, Y. Ding, Z. Ni and C. H. Barton

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 121-126; DOI: https://doi.org/10.1124/jpet.104.076497
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Electrophysiological Effects of Prucalopride, a Novel Enterokinetic Agent, on Isolated Atrial Myocytes from Patients Treated with β-Adrenoceptor Antagonists
Davide Pau, Antony J. Workman, Kathleen A. Kane and Andrew C. Rankin

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 146-153; DOI: https://doi.org/10.1124/jpet.104.076869
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Modulation of Sarcoplasmic Reticulum Function by Na⁺/K⁺ Pump Inhibitors with Different Toxicity: Digoxin and PST2744 [(E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride]
Marcella Rocchetti, Alessandra Besana, Gaspare Mostacciuolo, Rosella Micheletti, Patrizia Ferrari, Sandor Sarkozi, Csaba Szegedi, Istvan Jona and Antonio Zaza

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 207-215; DOI: https://doi.org/10.1124/jpet.104.077933
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In Vitro and in Vivo Pharmacological Characterization of BM-613 [N-n-Pentyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a Novel Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist
Julien Hanson, Stephanie Rolin, Denis Reynaud, Na Qiao, Leanne P. Kelley, Helen M. Reid, François Valentin, John Tippins, B. Therese Kinsella, Bernard Masereel, Cecil Pace-Asciak, Bernard Pirotte and Jean-Michel Dogné

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 293-301; DOI: https://doi.org/10.1124/jpet.104.079301
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Acute and Chronic Captopril, but Not Prazosin or Nifedipine, Normalize Alterations in Adrenergic Intracellular Ca²⁺ Handling Observed in the Mesenteric Arterial Tree of Spontaneously Hypertensive Rats
R. Miquel, R. Gisbert, E. Serna, F. Perez-Vizcaino, E. Anselmi, M. A. Noguera, M. D. Ivorra and M. P. D'Ocon

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 359-367; DOI: https://doi.org/10.1124/jpet.104.078725
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Phenylpropanolamine Constricts Mouse and Human Blood Vessels by Preferentially Activating α2-Adrenoceptors
Nicholas A. Flavahan

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 432-439; DOI: https://doi.org/10.1124/jpet.104.076653

CELLULAR AND MOLECULAR

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Heterodimerization with β₂-Adrenergic Receptors Promotes Surface Expression and Functional Activity of α_1D-Adrenergic Receptors
Michelle A. Uberti, Chris Hague, Heide Oller, Kenneth P. Minneman and Randy A. Hall

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 16-23; DOI: https://doi.org/10.1124/jpet.104.079541
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A Novel Benzodiazepine Selectively Inhibits Keratinocyte Proliferation and Reduces Retinoid-Induced Epidermal Hyperplasia in Organ-Cultured Human Skin
James Varani, Narasimharao Bhagavathula, Kamalakar C. Nerusu, Hilary Sherzer, Kevin Fay, Anthony E. Boitano, Gary D. Glick, Kent Johnson, Sewon Kang and Anthony W. Opipari

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 56-63; DOI: https://doi.org/10.1124/jpet.104.075929
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A Highly Conserved Glycine within Linker I and the Extreme C Terminus of G Protein α Subunits Interact Cooperatively in Switching G Protein-Coupled Receptor-to-Effector Specificity
Evi Kostenis, Lene Martini, James Ellis, Maria Waldhoer, Arne Heydorn, Mette M. Rosenkilde, Pia K. Norregaard, Rasmus Jorgensen, Jennifer L. Whistler and Graeme Milligan

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 78-87; DOI: https://doi.org/10.1124/jpet.104.080424
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Suramin Disrupts Receptor-G Protein Coupling by Blocking Association of G Protein α and βγ Subunits
Wen-Cheng Chung and John C. Kermode

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 191-198; DOI: https://doi.org/10.1124/jpet.104.078311
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Antagonist Efficacy in MORS196L Mutant Is Affected by the Interaction between Transmembrane Domains of the Opioid Receptor
Patricia A. Claude-Geppert, Jiahui Liu, Jonathan Solberg, Laurie J. Erickson-Herbrandson, Horace H. Loh and Ping-Yee Law

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 216-226; DOI: https://doi.org/10.1124/jpet.104.076505
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BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties
Svetlana Tertyshnikova, Ronald J. Knox, Mary Jane Plym, George Thalody, Corinne Griffin, Torben Neelands, David G. Harden, Laura Signor, David Weaver, Robert A. Myers and Nicholas J. Lodge

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 250-259; DOI: https://doi.org/10.1124/jpet.104.078592
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Inhibition of Tumor Growth, Angiogenesis, and Tumor Cell Proliferation by a Small Molecule Inhibitor of c-Jun N-terminal Kinase
Bruce W. Ennis, Kimberly E. Fultz, Kent A. Smith, John K. Westwick, Dan Zhu, Michael Boluro-Ajayi, Graham K. Bilter and Bernd Stein

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 325-332; DOI: https://doi.org/10.1124/jpet.104.078873
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Asiatic Acid, a Triterpene, Induces Apoptosis and Cell Cycle Arrest through Activation of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways in Human Breast Cancer Cells
Ya-Ling Hsu, Po-Lin Kuo, Liang-Tzung Lin and Chun-Ching Lin

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 333-344; DOI: https://doi.org/10.1124/jpet.104.078808
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The M₂ Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder
Frederick J. Ehlert, Michael T. Griffin, Diane M. Abe, Tran H. Vo, Makoto M. Taketo, Toshiya Manabe and Minoru Matsui

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 368-378; DOI: https://doi.org/10.1124/jpet.104.077909

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Trimers of N-Alkylglycines Are Potent Modulators of the Multidrug Resistance Phenotype
Maria J. Abad-Merin, Nuria Cortés, Isabel Masip, Enrique Pérez-Payá, José A. Ferragut, Angel Messeguer and Antonio Ferrer-Montiel

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 112-120; DOI: https://doi.org/10.1124/jpet.104.078014
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Free Exchange across Cells, and Echistatin-Sensitive Membrane Target for the Metastasis Inhibitor NAMI-A (Imidazolium trans-Imidazole Dimethyl Sulfoxide Tetrachlororuthenate) on KB Tumor Cells
F. Frausin, V. Scarcia, M. Cocchietto, A. Furlani, B. Serli, E. Alessio and G. Sava

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 227-233; DOI: https://doi.org/10.1124/jpet.104.078352

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Mechanisms of Interleukin-4 Effects on Calcium Signaling in Airway Smooth Muscle Cells
Michael F. Ethier, Erika Cappelluti and J. Mark Madison

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 127-133; DOI: https://doi.org/10.1124/jpet.104.079343
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Proximal Tubular Toxicity of Ochratoxin A Is Amplified by Simultaneous Inhibition of the Extracellular Signal-Regulated Kinases 1/2
C. Sauvant, H. Holzinger and M. Gekle

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 234-241; DOI: https://doi.org/10.1124/jpet.104.079475
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Does Cyclic AMP Mediate Rat Urinary Bladder Relaxation by Isoproterenol?
Elfaridah P. Frazier, Marie-Jeanne Mathy, Stephan L. M. Peters and Martin C. Michel

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 260-267; DOI: https://doi.org/10.1124/jpet.104.077768
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Involvement of Mast Cells in Adenosine-Mediated Bronchoconstriction and Inflammation in an Allergic Mouse Model
Peter J. Oldenburg and S. Jamal Mustafa

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 319-324; DOI: https://doi.org/10.1124/jpet.104.071720
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Protection of Pirfenidone against an Early Phase of Oleic Acid-Induced Acute Lung Injury in Rats
Shuang Mei, Wei Yao, Yuanjue Zhu and Jinyuan Zhao

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 379-388; DOI: https://doi.org/10.1124/jpet.104.078030
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Requirement of Intact Adenosine A₁ Receptors for the Diuretic and Natriuretic Action of the Methylxanthines Theophylline and Caffeine
Timo Rieg, Hannah Steigele, Jurgen Schnermann, Kerstin Richter, Hartmut Osswald and Volker Vallon

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 403-409; DOI: https://doi.org/10.1124/jpet.104.080432

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Therapeutic Dosing with Anti-Interleukin-13 Monoclonal Antibody Inhibits Asthma Progression in Mice
Gaoyun Yang, Li Li, Amy Volk, Eva Emmell, Ted Petley, Jill Giles-Komar, Patricia Rafferty, Mani Lakshminarayanan, Don E. Griswold, Peter J. Bugelski and Anuk M. Das

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 8-15; DOI: https://doi.org/10.1124/jpet.104.076133
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Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats
Tamaki Yamada, Atsushi Kuno, Kumiko Ogawa, Mingxi Tang, Kazuhiko Masuda, Soichi Nakamura, Tomoaki Ando, Tetsu Okamoto, Hirotaka Ohara, Tomoyuki Nomura, Takashi Joh, Tomoyuki Shirai and Makoto Itoh

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 36-45; DOI: https://doi.org/10.1124/jpet.104.077883
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Effects of Prostaglandin D₂, 15-Deoxy-Δ^12,14-prostaglandin J₂, and Selective DP₁ and DP₂ Receptor Agonists on Pulmonary Infiltration of Eosinophils in Brown Norway Rats
Wagdi Almishri, Chantal Cossette, Joshua Rokach, James G. Martin, Qutayba Hamid and William S. Powell

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 64-69; DOI: https://doi.org/10.1124/jpet.104.079079
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Significance of Cyclooxygenase-2 Induced via p38 Mitogen-Activated Protein Kinase in Mechanical Stimulus-Induced Peritoneal Adhesion in Mice
Jun Katada, Hitomi Saito and Akira Ohashi

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 286-292; DOI: https://doi.org/10.1124/jpet.104.078717
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Mechanisms Involved in the Enhancement of Allergic Airways Neutrophil Influx by Permanent C-Fiber Degeneration in Rats
Carla F. Franco-Penteado, Ivani A. De Souza, Enilton A. Camargo, Simone A. Teixeira, Marcelo N. Muscara, Gilberto De Nucci and Edson Antunes

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 440-448; DOI: https://doi.org/10.1124/jpet.104.078147

NEUROPHARMACOLOGY

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High-Affinity Epibatidine Binding of Functional, Human α7-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed de Novo in Human SH-EP1 Cells
Jian-Hong Peng, John D. Fryer, Raymond S. Hurst, Katherine M. Schroeder, Andrew A. George, Steven Morrissy, Vincent E. Groppi, Sherry S. Leonard and Ronald J. Lukas

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 24-35; DOI: https://doi.org/10.1124/jpet.104.079004
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Involvement of Protein Kinase A in Cannabinoid Receptor-Mediated Protection from Oxidative Neuronal Injury
Sun Hee Kim, Seok Joon Won, Xiao Ou Mao, Kunlin Jin and David A. Greenberg

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 88-94; DOI: https://doi.org/10.1124/jpet.104.079509
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Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H₃ Receptor Antagonist with Drug-Like Properties
Timothy A. Esbenshade, Gerard B. Fox, Kathleen M. Krueger, Thomas R. Miller, Chae Hee Kang, Lynne I. Denny, David G. Witte, Betty B. Yao, Liping Pan, Jill Wetter, Kennan Marsh, Youssef L. Bennani, Marlon D. Cowart, James P. Sullivan and Arthur A. Hancock

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 165-175; DOI: https://doi.org/10.1124/jpet.104.078303
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Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H₃ Receptor Antagonist
Gerard B. Fox, Timothy A. Esbenshade, Jia Bao Pan, Richard J. Radek, Kathleen M. Krueger, Betty B. Yao, Kaitlin E. Browman, Michael J. Buckley, Michael E. Ballard, Victoria A. Komater, Holly Miner, Min Zhang, Ramin Faghih, Lynne E. Rueter, R. Scott Bitner, Karla U. Drescher, Jill Wetter, Kennan Marsh, Martine Lemaire, Roger D. Porsolt, Youssef L. Bennani, James P. Sullivan, Marlon D. Cowart, Michael W. Decker and Arthur A. Hancock

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 176-190; DOI: https://doi.org/10.1124/jpet.104.078402
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A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
Gene G. Kinney, Julie A. O'Brien, Wei Lemaire, Maryann Burno, Denise J. Bickel, Michelle K. Clements, Tsing-Bau Chen, David D. Wisnoski, Craig W. Lindsley, Philip R. Tiller, Sheri Smith, Marlene A. Jacobson, Cyrille Sur, Mark E. Duggan, Douglas J. Pettibone, P. Jeffrey Conn and David L. Williams

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 199-206; DOI: https://doi.org/10.1124/jpet.104.079244
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Somatostatin-Induced Activation and Up-Regulation of N-Methyl-d-aspartate Receptor Function: Mediation through Calmodulin-Dependent Protein Kinase II, Phospholipase C, Protein Kinase C, and Tyrosine Kinase in Hippocampal Noradrenergic Nerve Endings
Anna Pittaluga, Marco Feligioni, Fabio Longordo, Marica Arvigo and Maurizio Raiteri

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 242-249; DOI: https://doi.org/10.1124/jpet.104.079590
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Positive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Modulators Have Different Impact on Synaptic Transmission in the Thalamus and Hippocampus
Yan-Fang Xia, Markus Kessler and Amy C. Arai

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 277-285; DOI: https://doi.org/10.1124/jpet.104.078196
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Antinociceptive Properties of Mixture of α-Amyrin and β-Amyrin Triterpenes: Evidence for Participation of Protein Kinase C and Protein Kinase A Pathways
Michel F. Otuki, Juliano Ferreira, Fabiana V. Lima, Cristiane Meyre-Silva, Ângela Malheiros, Luciane A. Muller, Graziela S. Cani, Adair R. S. Santos, Rosendo A. Yunes and João B. Calixto

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 310-318; DOI: https://doi.org/10.1124/jpet.104.071779
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Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation
Darren Fegley, Silvana Gaetani, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia and Daniele Piomelli

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 352-358; DOI: https://doi.org/10.1124/jpet.104.078980
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The Dorsal Raphe Nucleus as a Site of Action of the Antinociceptive and Behavioral Effects of the α4 Nicotinic Receptor Agonist Epibatidine
Giovanni Cucchiaro, Nayla Chaijale and Kathryn G. Commons

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 389-394; DOI: https://doi.org/10.1124/jpet.104.079368
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Metabotropic Glutamate Receptor mGlu5 Is a Mediator of Appetite and Energy Balance in Rats and Mice
Margaret J. Bradbury, Una Campbell, Darlene Giracello, Deborah Chapman, Chris King, Lida Tehrani, Nicholas D. P. Cosford, Jeff Anderson, Mark A. Varney and Alison M. Strack

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 395-402; DOI: https://doi.org/10.1124/jpet.104.076406
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Inverse Agonism and Neutral Antagonism at Wild-Type and Constitutively Active Mutant Delta Opioid Receptors
P. Tryoen-Tóth, F. M. Décaillot, D. Filliol, K. Befort, L. H. Lazarus, P. W. Schiller, H. Schmidhammer and B. L. Kieffer

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 410-421; DOI: https://doi.org/10.1124/jpet.104.077321
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Induction Patterns of Transcription Factors of the Nur Family (Nurr1, Nur77, and Nor-1) by Typical and Atypical Antipsychotics in the Mouse Brain: Implication for Their Mechanism of Action
Jérôme Maheux, Isabelle Éthier, Claude Rouillard and Daniel Lévesque

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 460-473; DOI: https://doi.org/10.1124/jpet.104.080184
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AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties
Narender R. Gavva, Rami Tamir, Yusheng Qu, Lana Klionsky, T. J. Zhang, David Immke, Judy Wang, Dawn Zhu, Todd W. Vanderah, Frank Porreca, Elizabeth M. Doherty, Mark H. Norman, Kenneth D. Wild, Anthony W. Bannon, Jean-Claude Louis and James J. S. Treanor

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 474-484; DOI: https://doi.org/10.1124/jpet.104.079855

TOXICOLOGY

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Protein Kinase Cδ Is a Key Downstream Mediator of Manganese-Induced Apoptosis in Dopaminergic Neuronal Cells
Calivarathan Latchoumycandane, Vellareddy Anantharam, Masashi Kitazawa, Yongjie Yang, Arthi Kanthasamy and Anumantha G. Kanthasamy

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 46-55; DOI: https://doi.org/10.1124/jpet.104.078469
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1,1-Dichloroethylene-Induced Mitochondrial Damage Precedes Apoptotic Cell Death of Bronchiolar Epithelial Cells in Murine Lung
Erik J. Martin and Poh-Gek Forkert

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 95-103; DOI: https://doi.org/10.1124/jpet.104.079392
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Role for Membrane Fluidity in Ethanol-Induced Oxidative Stress of Primary Rat Hepatocytes
Odile Sergent, Manuella Pereira, Corinne Belhomme, Martine Chevanne, Laurence Huc and Dominique Lagadic-Gossmann

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 104-111; DOI: https://doi.org/10.1124/jpet.104.078634
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Serotonergic Neurotoxic Metabolites of Ecstasy Identified in Rat Brain
Douglas C. Jones, Christine Duvauchelle, Aiko Ikegami, Christopher M. Olsen, Serrine S. Lau, Rafael de la Torre and Terrence J. Monks

Journal of Pharmacology and Experimental Therapeutics April 2005, 313 (1) 422-431; DOI: https://doi.org/10.1124/jpet.104.077628

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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