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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2005; Volume 312,Issue 1

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Investigation of Efflux Transport of Dehydroepiandrosterone Sulfate and Mitoxantrone at the Mouse Blood-Brain Barrier: A Minor Role of Breast Cancer Resistance Protein
    Young-Joo Lee, Hiroyuki Kusuhara, Johan W. Jonker, Alfred H. Schinkel and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 44-52; DOI: https://doi.org/10.1124/jpet.104.073320
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    H+-Dependent Transport Mechanism of Nateglinide in the Brush-Border Membrane of the Rat Intestine
    Shirou Itagaki, Yoshitaka Saito, Sayaka Kubo, Yukio Otsuka, Yuta Yamamoto, Masaki Kobayashi, Takeshi Hirano and Ken Iseki
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 77-82; DOI: https://doi.org/10.1124/jpet.104.074021
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    Human Breast Cancer Resistance Protein: Interactions with Steroid Drugs, Hormones, the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and Transport of Cimetidine
    Petr Pavek, Gracia Merino, Els Wagenaar, Ellen Bolscher, Martina Novotna, Johan W. Jonker and Alfred H. Schinkel
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 144-152; DOI: https://doi.org/10.1124/jpet.104.073916
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    Novel Organic Cation Transporter 2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells
    Erik Rytting and Kenneth L. Audus
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 192-198; DOI: https://doi.org/10.1124/jpet.104.072363
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    The Impact of ΔG on the Oral Bioavailability of Low Bioavailable Therapeutic Agents
    Noha N. Salama, Alessio Fasano, Manjusha Thakar and Natalie D. Eddington
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 199-205; DOI: https://doi.org/10.1124/jpet.104.073205
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    Up-Regulation of P-Glycoprotein Expression in Small Intestine under Chronic Serotonin-Depleted Conditions in Rats
    Hideo Hiraoka, Naoji Kimura, Yumiko Furukawa, Ken-ichi Ogawara, Toshikiro Kimura and Kazutaka Higaki
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 248-255; DOI: https://doi.org/10.1124/jpet.104.071290
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    Protease-Activated Receptor-2 (PAR-2)-Related Peptides Induce Tear Secretion in Rats: Involvement of PAR-2 and Non-PAR-2 Mechanisms
    Hiroyuki Nishikawa, Kenzo Kawai, Makoto Tanaka, Hiroya Ohtani, Shuichi Tanaka, Chizuko Kitagawa, Minoru Nishida, Tomoyuki Abe, Hiromasa Araki and Atusufumi Kawabata
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 324-331; DOI: https://doi.org/10.1124/jpet.104.072074

BEHAVIORAL PHARMACOLOGY

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    Assessment of the Relative Reinforcing Strength of Cocaine in Socially Housed Monkeys Using a Choice Procedure
    Paul W. Czoty, Ciara McCabe and Michael A. Nader
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 96-102; DOI: https://doi.org/10.1124/jpet.104.073411
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    GABAB Receptor Antagonist-Mediated Antidepressant-Like Behavior Is Serotonin-Dependent
    David A. Slattery, Sandrine Desrayaud and John F. Cryan
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 290-296; DOI: https://doi.org/10.1124/jpet.104.073536

CARDIOVASCULAR

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    Dynamic Beat-to-Beat Modeling of the QT-RR Interval Relationship: Analysis of QT Prolongation during Alterations of Autonomic State versus Human Ether a-go-go-Related Gene Inhibition
    Anthony A. Fossa, Todd Wisialowski, Anthony Magnano, Eric Wolfgang, Roxanne Winslow, William Gorczyca, Kimberly Crimin and David L. Raunig
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 1-11; DOI: https://doi.org/10.1124/jpet.104.073288
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    Effects of Rapamycin on Cardiac and Skeletal Muscle Contraction and Crossbridge Cycling
    Brenda Schoffstall, Aya Kataoka, Amanda Clark and P. Bryant Chase
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 12-18; DOI: https://doi.org/10.1124/jpet.104.073445
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    Inhibition of Phenylephrine-Induced Cardiomyocyte Hypertrophy by Activation of Multiple Adenosine Receptor Subtypes
    Xiaohong Tracey Gan, Venkatesh Rajapurohitam, James V. Haist, Peter Chidiac, Michael A. Cook and Morris Karmazyn
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 27-34; DOI: https://doi.org/10.1124/jpet.104.073122
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    Regional Hemodynamic Actions of Selective Corticotropin-Releasing Factor Type 2 Receptor Ligands in Conscious Rats
    Sheila M. Gardiner, Julie E. March, Philip A. Kemp, Anthony P. Davenport, Katherine E. Wiley and Terence Bennett
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 53-60; DOI: https://doi.org/10.1124/jpet.104.075259
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    Inhibition of Na+-K+ Pump and L-Type Ca2+ Channel by Glibenclamide in Guinea Pig Ventricular Myocytes
    So-Young Lee and Chin O. Lee
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 61-68; DOI: https://doi.org/10.1124/jpet.104.074369
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    Cocaine Induces Apoptosis in Fetal Rat Myocardial Cells through the p38 Mitogen-Activated Protein Kinase and Mitochondrial/Cytochrome c Pathways
    Guohu Li, Yuhui Xiao and Lubo Zhang
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 112-119; DOI: https://doi.org/10.1124/jpet.104.073494
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    Antiplatelet Activity of J78 (2-Chloro-3-[2′-bromo, 4′-fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an Antithrombotic Agent, Is Mediated by Thromboxane (TX) A2 Receptor Blockade with TXA2 Synthase Inhibition and Suppression of Cytosolic Ca2+ Mobilization
    Yong-Ri Jin, Mi-Ra Cho, Chung-Kyu Ryu, Jin-Ho Chung, Dong-Yeon Yuk, Jin-Tae Hong, Kyung-Sup Lee, Jung-Jin Lee, Mi-Yea Lee, Yong Lim and Yeo-Pyo Yun
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 214-219; DOI: https://doi.org/10.1124/jpet.104.073718
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    Attentuation of Cardiac Stunning by Losartan in a Cellular Model of Ischemia and Reperfusion Is Accompanied by Increased Sarcoplasmic Reticulum Ca2+ Stores and Prevention of Cytosolic Ca2+ Elevation
    William E. Louch, Gregory R. Ferrier and Susan E. Howlett
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 238-247; DOI: https://doi.org/10.1124/jpet.104.072769
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    Hemodynamic Effects of Phosphodiesterase 5 and Angiotensin-Converting Enzyme Inhibition Alone or in Combination in Conscious SHR
    S. M. Gardiner, J. E. March, P. A. Kemp, S. A. Ballard, E. Hawkeswood, B. Hughes and T. Bennett
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 265-271; DOI: https://doi.org/10.1124/jpet.104.071993
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    Histamine H3-Receptor-Induced Attenuation of Norepinephrine Exocytosis: A Decreased Protein Kinase A Activity Mediates a Reduction in Intracellular Calcium
    Nahid Seyedi, Christina J. Mackins, Takuji Machida, Alicia C. Reid, Randi B. Silver and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 272-280; DOI: https://doi.org/10.1124/jpet.104.072504
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    Glucagon-Like Peptide-1 Limits Myocardial Stunning following Brief Coronary Occlusion and Reperfusion in Conscious Canines
    Lazaros A. Nikolaidis, Aaron Doverspike, Teresa Hentosz, Lee Zourelias, You-Tang Shen, Dariush Elahi and Richard P. Shannon
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 303-308; DOI: https://doi.org/10.1124/jpet.104.073890
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    Pentamidine-Induced Long QT Syndrome and Block of hERG Trafficking
    Yuri A. Kuryshev, Eckhard Ficker, Lu Wang, Peter Hawryluk, Adrienne T. Dennis, Barbara A. Wible, Arthur M. Brown, Jiesheng Kang, Xiao-Liang Chen, Kaoru Sawamura, William Reynolds and David Rampe
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 316-323; DOI: https://doi.org/10.1124/jpet.104.073692

CELLULAR AND MOLECULAR

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    Pharmacological Characterization of Relaxin-3/INSL7 Receptors GPCR135 and GPCR142 from Different Mammalian Species
    Jingcai Chen, Chester Kuei, Steven W. Sutton, Pascal Bonaventure, Diane Nepomuceno, Elo Eriste, Rannar Sillard, Timothy W. Lovenberg and Changlu Liu
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 83-95; DOI: https://doi.org/10.1124/jpet.104.073486
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    C75 [4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic Acid] Activates Carnitine Palmitoyltransferase-1 in Isolated Mitochondria and Intact Cells without Displacement of Bound Malonyl CoA
    Nengyu Yang, Joanne S. Kays, Tiffanie R. Skillman, Lorri Burris, Thomas W. Seng and Craig Hammond
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 127-133; DOI: https://doi.org/10.1124/jpet.104.074104
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    Ligand-Dependent Coactivation of the Human Bile Acid Receptor FXR by the Peroxisome Proliferator-Activated Receptor γ Coactivator-1α
    Rajesh S. Savkur, Jeffrey S. Thomas, Kelli S. Bramlett, Yunling Gao, Laura F. Michael and Thomas P. Burris
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 170-178; DOI: https://doi.org/10.1124/jpet.104.072124
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    Superagonism at the Human Somatostatin Receptor Subtype 4
    Mia Engström, Jussi Tomperi, Kamel El-Darwish, Mikaela Åhman, Juha-Matti Savola and Siegfried Wurster
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 332-338; DOI: https://doi.org/10.1124/jpet.104.075531
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    Regulation of M2 Muscarinic Acetylcholine Receptor Expression and Signaling by Prolonged Exposure to Allosteric Modulators
    Lauren T. May, Yvonne Lin, Patrick M. Sexton and Arthur Christopoulos
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 382-390; DOI: https://doi.org/10.1124/jpet.104.073767
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    Hydrogen Peroxide-Induced Extracellular Signal-Regulated Kinase Activation in Cultured Feline Ileal Smooth Muscle Cells
    Hyun Ju Song, Tai Sang Lee, Ji Hoon Jeong, Young Sil Min, Chang Yell Shin and Uy Dong Sohn
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 391-398; DOI: https://doi.org/10.1124/jpet.104.074401

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Effect of Cell Cycle Inhibition on Cisplatin-Induced Cytotoxicity
    Melissa L. Fishel, David R. Newell, Roger J. Griffin, Richard Davison, Lan-Zhen Wang, Nicola J. Curtin, Eleanor G. Zuhowski, Kristen Kasza, Merrill J. Egorin, Robert C. Moschel and M. Eileen Dolan
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 206-213; DOI: https://doi.org/10.1124/jpet.104.073924
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    Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A)
    P. Heffeter, M. Pongratz, E. Steiner, P. Chiba, M. A. Jakupec, L. Elbling, B. Marian, W. Körner, F. Sevelda, M. Micksche, B. K. Keppler and W. Berger
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 281-289; DOI: https://doi.org/10.1124/jpet.104.073395
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    Retinoic Acid Down-Regulates Aldehyde Dehydrogenase and Increases Cytotoxicity of 4-Hydroperoxycyclophosphamide and Acetaldehyde
    Jan S. Moreb, Amir Gabr, Govind R. Vartikar, Santosh Gowda, James R. Zucali and Dagmara Mohuczy
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 339-345; DOI: https://doi.org/10.1124/jpet.104.072496
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    Impact of the Cyclooxygenase System on Doxorubicin-Induced Functional Multidrug Resistance 1 Overexpression and Doxorubicin Sensitivity in Acute Myeloid Leukemic HL-60 Cells
    Ulrike Puhlmann, Christina Ziemann, Gudrun Ruedell, Hagen Vorwerk, Dirk Schaefer, Claudia Langebrake, Peter Schuermann, Ursula Creutzig and Dirk Reinhardt
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 346-354; DOI: https://doi.org/10.1124/jpet.104.071571

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Prolyl Endopeptidase-Mediated Destruction of T Cell Epitopes in Whole Gluten: Chemical and Immunological Characterization
    Thomas Marti, Øyvind Molberg, Qing Li, Gary M. Gray, Chaitan Khosla and Ludvig M. Sollid
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 19-26; DOI: https://doi.org/10.1124/jpet.104.073312
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    Selective Reversal of Hyperglycemia-Evoked Gastric Myoelectric Dysrhythmias by Nitrergic Stimulation in Healthy Humans
    Radoslav Coleski, Sutep Gonlachanvit, Chung Owyang and William L. Hasler
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 103-111; DOI: https://doi.org/10.1124/jpet.104.072868
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    Endothelial Nitric Oxide Contributes to the Renal Protective Effects of Ischemic Preconditioning
    Hiroshi Yamasowa, Satoko Shimizu, Takao Inoue, Masanori Takaoka and Yasuo Matsumura
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 153-159; DOI: https://doi.org/10.1124/jpet.104.074427
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    Ozone Exposure in Vivo and Formation of Biologically Active Oxysterols in the Lung
    Melissa K. Pulfer, Christian Taube, Erwin Gelfand and Robert C. Murphy
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 256-264; DOI: https://doi.org/10.1124/jpet.104.073437

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Peroxisome Proliferation-Activated Receptor (PPAR)γ Is Not Necessary for Synthetic PPARγ Agonist Inhibition of Inducible Nitric-Oxide Synthase and Nitric Oxide
    Michelle B. Crosby, John L. Svenson, John Zhang, Christopher J. Nicol, Frank J. Gonzalez and Gary S. Gilkeson
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 69-76; DOI: https://doi.org/10.1124/jpet.104.074005
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    Methylenedioxymethamphetamine Suppresses Production of the Proinflammatory Cytokine Tumor Necrosis Factor-α Independent of a β-Adrenoceptor-Mediated Increase in Interleukin-10
    Thomas J. Connor, Andrew Harkin and John P. Kelly
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 134-143; DOI: https://doi.org/10.1124/jpet.104.073023
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    Andrographolide Interferes with T Cell Activation and Reduces Experimental Autoimmune Encephalomyelitis in the Mouse
    Mirentxu I. Iruretagoyena, Jaime A. Tobar, Pablo A. González, Sofía E. Sepúlveda, Claudio A. Figueroa, Rafael A. Burgos, Juan L. Hancke and Alexis M. Kalergis
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 366-372; DOI: https://doi.org/10.1124/jpet.104.072512
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    Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation
    Patricia L. Podolin, James F. Callahan, Brian J. Bolognese, Yue H. Li, Karey Carlson, T. Gregg Davis, Geoff W. Mellor, Christopher Evans and Amy K. Roshak
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 373-381; DOI: https://doi.org/10.1124/jpet.104.074484

NEUROPHARMACOLOGY

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    Distinct Roles of Group III Metabotropic Glutamate Receptors in Control of Nociception and Dorsal Horn Neurons in Normal and Nerve-Injured Rats
    Shao-Rui Chen and Hui-Lin Pan
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 120-126; DOI: https://doi.org/10.1124/jpet.104.073817
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    Lobeline Attenuates Methamphetamine-Induced Changes in Vesicular Monoamine Transporter 2 Immunoreactivity and Monoamine Depletions in the Striatum
    David J. Eyerman and Bryan K. Yamamoto
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 160-169; DOI: https://doi.org/10.1124/jpet.104.072264
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    The Importance of Brainstem Cholinergic Neurons in the Pressor Response to Cocaine
    Jerry J. Buccafusco, Jerry A. Davis, Laura C. Shuster, Christopher J. Buccafusco and Mahanandeeshwar Gattu
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 179-191; DOI: https://doi.org/10.1124/jpet.104.073619
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    Comparison of Pharmacological Activities of Three Distinct κ Ligands (Salvinorin A, TRK-820 and 3FLB) on κ Opioid Receptors in Vitro and Their Antipruritic and Antinociceptive Activities in Vivo
    Yulin Wang, Kang Tang, Saadet Inan, Daniel Siebert, Ulrike Holzgrabe, David Y.W. Lee, Peng Huang, Jian-Guo Li, Alan Cowan and Lee-Yuan Liu-Chen
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 220-230; DOI: https://doi.org/10.1124/jpet.104.073668
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    Effect of Novel α-Conotoxins on Nicotine-Stimulated [3H]Dopamine Release from Rat Striatal Synaptosomes
    Layla Azam and J. Michael McIntosh
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 231-237; DOI: https://doi.org/10.1124/jpet.104.071456
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    Clozapine Protection against Gestational Cocaine-Induced Neurochemical Abnormalities
    Elena Yablonsky-Alter, Eleonora Gashi, Theodore I. Lidsky, Hoau-Yan Wang and Shailesh P. Banerjee
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 297-302; DOI: https://doi.org/10.1124/jpet.104.074062
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    Using [11C]Diprenorphine to Image Opioid Receptor Occupancy by Methadone in Opioid Addiction: Clinical and Preclinical Studies
    Jan K. Melichar, Susan P. Hume, Tim M. Williams, Mark R. C. Daglish, Lindsay G. Taylor, Rabia Ahmad, Andrea L. Malizia, David J. Brooks, Judith S. Myles, Anne Lingford-Hughes and David J. Nutt
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 309-315; DOI: https://doi.org/10.1124/jpet.104.072686
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    Pharmacological and Toxicological Evaluation of 2-Fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a Ligand for Imaging Cerebral Nicotinic Acetylcholine Receptors with Positron Emission Tomography
    D. Bruce Vaupel, Srihari R. Tella, David L. Huso, Valentine O. Wagner, Alexey G. Mukhin, Svetlana I. Chefer, Andrew G. Horti, Edythe D. London, Andrei O. Koren and Alane S. Kimes
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 355-365; DOI: https://doi.org/10.1124/jpet.104.073999
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    Lack of Specific Amyloid-β(1-42) Suppression by Nonsteroidal Anti-Inflammatory Drugs in Young, Plaque-Free Tg2576 Mice and in Guinea Pig Neuronal Cultures
    Thomas A. Lanz, Gregory J. Fici and Kalpana M. Merchant
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 399-406; DOI: https://doi.org/10.1124/jpet.104.073965
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    Facilitation of the Purinergic Contractile Response of the Guinea Pig Vas Deferens by Sodium Orthovanadate
    Latchezar D. Todorov, Svetlana T. Mihaylova-Todorova, Sophie M. Choe and David P. Westfall
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 407-416; DOI: https://doi.org/10.1124/jpet.104.072991

TOXICOLOGY

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    Transgenic Mice with a Hypomorphic NADPH-Cytochrome P450 Reductase Gene: Effects on Development, Reproduction, and Microsomal Cytochrome P450
    Lin Wu, Jun Gu, Huadong Cui, Qing-Yu Zhang, Melissa Behr, Cheng Fang, Yan Weng, Kerri Kluetzman, Pamela J. Swiatek, Weizhu Yang, Laurence Kaminsky and Xinxin Ding
    Journal of Pharmacology and Experimental Therapeutics January 2005, 312 (1) 35-43; DOI: https://doi.org/10.1124/jpet.104.073353
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Journal of Pharmacology and Experimental Therapeutics: 312 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 312, Issue 1
1 Jan 2005
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  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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