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Research ArticleNEUROPHARMACOLOGY

Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels

L. E. O'Dell and L. H. Parsons
Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 711-719; DOI: https://doi.org/10.1124/jpet.104.069278
L. E. O'Dell
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L. H. Parsons
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Abstract

Previous work has demonstrated that peripheral serotonin1B (5-HT1B) receptor agonist administration facilitates the behavioral and neurochemical effects of cocaine. This study used dual probe microdialysis to investigate whether activation of serotonin1B (5-HT1B) receptors in the ventral tegmental area (VTA) alters the ability of peripherally administered cocaine to elevate dopamine (DA) levels in the ipsilateral nucleus accumbens (NAcc) of drug-naive Wistar rats. Intra-VTA administration of the selective 5-HT1B agonist 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrolo [3,2-b]pyridin-5-one dihydrochloride (CP 93,129) by reverse dialysis produced a dose-dependent (30 and 100 μM) potentiation of cocaine-induced (10 mg/kg i.p.) increases in NAcc DA efflux and concurrent cocaine-induced decreases in VTA GABA efflux. There was no effect of either local CP 93,129 or peripheral cocaine on VTA glutamate efflux. Intra-VTA administration of the 5-HT1A/7 receptor agonist 8-hydroxy-2-dipropylaminotetralin (8-OH-DPAT; 100 μM) did not alter cocaine-induced alterations in NAcc DA or VTA GABA, suggesting that the effects of CP 93,129 were not mediated through 5-HT1A receptors. Moreover, the effects of intra-VTA CP 93,129 (100 μM) on both cocaine-induced increases in NAcc DA levels and cocaine-induced decreases in VTA GABA levels were reversed by coadministration of the selective 5-HT1B receptor antagonist 3-[3-(dimethylamine)propyl]-4-hydroxy-N-[4-(4-pyridinyl] phenyl] benzamide dihydrochloride (GR 55562; 300 μM). In the absence of cocaine, intra-VTA CP 93,139 produced an increase in NAcc DA and decrease in VTA GABA levels. However, intra-VTA GR 55562 alone had no effect on any of our neurochemical measures. These findings indicate that activation of VTA 5-HT1B receptors potentiates cocaine-induced increases in NAcc DA levels by enhancing the ability of cocaine to decrease VTA GABA efflux.

Footnotes

  • Financial support for this research was provided by National Institute on Drug Abuse Grant DA-11004. This manuscript is publication 16483-NP from The Scripps Research Institute.

  • doi:10.1124/jpet.104.069278.

  • ABBREVIATIONS: DA, dopamine; VTA, ventral tegmental area; NAcc, nucleus accumbens; 5-HT, 5-hydroxytryptamine (serotonin); GLU, glutamatel; aCSF, artificial cerebral spinal fluid; 8-OH-DPAT, 8-hydroxy-2-dipropylaminotetralin; CP 93,129, 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrolo [3,2-b]pyridin-5-one dihydrochloride; GR 55562, 3-[3-(dimethylamine)propyl]-4-hydroxy-N-[4-(4-pyridinyl] phenyl] benzamide dihydrochloride.

    • Received March 30, 2004.
    • Accepted June 28, 2004.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 311 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 311, Issue 2
1 Nov 2004
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Research ArticleNEUROPHARMACOLOGY

Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels

L. E. O'Dell and L. H. Parsons
Journal of Pharmacology and Experimental Therapeutics November 1, 2004, 311 (2) 711-719; DOI: https://doi.org/10.1124/jpet.104.069278

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Research ArticleNEUROPHARMACOLOGY

Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels

L. E. O'Dell and L. H. Parsons
Journal of Pharmacology and Experimental Therapeutics November 1, 2004, 311 (2) 711-719; DOI: https://doi.org/10.1124/jpet.104.069278
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