Journal of Pharmacology and Experimental Therapeutics: 311 (2)

November 01, 2004; Volume 311,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation
Stephen C. Heinrichs and George F. Koob

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 427-440; DOI: https://doi.org/10.1124/jpet.103.052092

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Plasma Membrane Localization of Multidrug Resistance-Associated Protein Homologs in Brain Capillary Endothelial Cells
Yan Zhang, John D. Schuetz, William F. Elmquist and Donald W. Miller

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 449-455; DOI: https://doi.org/10.1124/jpet.104.068528
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The Role of Advanced Glycation in Reduced Organic Cation Transport Associated with Experimental Diabetes
Merlin C. Thomas, Christos Tikellis, Phillip Kantharidis, Wendy C. Burns, Mark E. Cooper and Josephine M. Forbes

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 456-466; DOI: https://doi.org/10.1124/jpet.104.070672
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Differential Multidrug Resistance-Associated Protein 1 through 6 Isoform Expression and Function in Human Intestinal Epithelial Caco-2 Cells
Hannah M. Prime-Chapman, Richard A. Fearn, Anne E. Cooper, Vanessa Moore and Barry H. Hirst

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 476-484; DOI: https://doi.org/10.1124/jpet.104.068775
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β-Adrenergic Blockade Affects Initial Drug Distribution Due to Decreased Cardiac Output and Altered Blood Flow Distribution
Michael J. Avram, Tom C. Krejcie, Thomas K. Henthorn and Claus U. Niemann

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 617-624; DOI: https://doi.org/10.1124/jpet.104.070094
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Pharmacokinetics of Novel Dipeptide Ester Prodrugs of Acyclovir after Oral Administration: Intestinal Absorption and Liver Metabolism
Banmeet S. Anand, Suresh Katragadda and Ashim K. Mitra

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 659-667; DOI: https://doi.org/10.1124/jpet.104.069997
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Estrogen Regulation of the Cytochrome P450 3A Subfamily in Humans
Eric T. Williams, Malgorzata Leyk, Steven A. Wrighton, Peter J. A. Davies, David S. Loose, Gregory L. Shipley and Henry W. Strobel

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 728-735; DOI: https://doi.org/10.1124/jpet.104.068908
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Expression of Constitutive Androstane Receptor Splice Variants in Human Tissues and Their Functional Consequences
Jatinder K. Lamba, Vishal Lamba, Kazuto Yasuda, Yvonne S. Lin, Mahfoud Assem, Emma Thompson, Stephen Strom and Erin Schuetz

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 811-821; DOI: https://doi.org/10.1124/jpet.104.069310

BEHAVIORAL PHARMACOLOGY

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Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity
Aron H. Lichtman, Donmienne Leung, Christopher C. Shelton, Alan Saghatelian, Christophe Hardouin, Dale L. Boger and Benjamin F. Cravatt

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 441-448; DOI: https://doi.org/10.1124/jpet.104.069401
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The NR2B-Selective N-Methyl-D-aspartate Receptor Antagonist Ro 25-6981 [(±)-(R*,S*)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine Propanol] Potentiates the Effect of Nicotine on Locomotor Activity and Dopamine Release in the Nucleus Accumbens
Alexander R. Kosowski and Sture Liljequist

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 560-567; DOI: https://doi.org/10.1124/jpet.104.070235
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The Opioid Receptor Like-1 Receptor Agonist Ro 64-6198 (1S,3aS-8-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one) Produces a Discriminative Stimulus in Rats Distinct from That of a μ, κ, and δ Opioid Receptor Agonist Cue
Matthew D. Recker and Guy A. Higgins

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 652-658; DOI: https://doi.org/10.1124/jpet.104.071423
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Memantine Improves Spatial Learning in a Transgenic Mouse Model of Alzheimer's Disease
Rimante Minkeviciene, Pradeep Banerjee and Heikki Tanila

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 677-682; DOI: https://doi.org/10.1124/jpet.104.071027
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Drug Discrimination in Methamphetamine-Trained Monkeys: Effects of Monoamine Transporter Inhibitors
Paul W. Czoty, Chinnasamy R. Ramanathan, Nicole H. Mutschler, Alexandros Makriyannis and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 720-727; DOI: https://doi.org/10.1124/jpet.104.071035
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Effect of the D3 Dopamine Receptor Partial Agonist BP897 [N-[4-(4-(2-Methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on l-3,4-Dihydroxyphenylalanine-Induced Dyskinesias and Parkinsonism in Squirrel Monkeys
Albert Hsu, Daniel M. Togasaki, Erwan Bezard, Pierre Sokoloff, J. William Langston, Donato A. Di Monte and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 770-777; DOI: https://doi.org/10.1124/jpet.104.071142

CARDIOVASCULAR

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Human Adipocyte Fatty Acid-Binding Protein (aP2) Gene Promoter-Driven Reporter Assay Discriminates Nonlipogenic Peroxisome Proliferator-Activated Receptor γ Ligands
Yves Rival, Aline Stennevin, Laurence Puech, Anne Rouquette, Claudie Cathala, Fabrice Lestienne, Elisabeth Dupont-Passelaigue, Jean-François Patoiseau, Thierry Wurch and Didier Junquéro

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 467-475; DOI: https://doi.org/10.1124/jpet.104.068254
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A New, Potent Poly(ADP-ribose) Polymerase Inhibitor Improves Cardiac and Vascular Dysfunction Associated with Advanced Aging
Pál Pacher, Anne Vaslin, Rita Benkő, Jon G. Mabley, Lucas Liaudet, György Haskó, Anita Marton, Sándor Bátkai, Márk Kollai and Csaba Szabó

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 485-491; DOI: https://doi.org/10.1124/jpet.104.069658
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The Preparation and Characterization of Novel Peptide Antagonists to Thrombin and Factor VIIa and Activation of Protease-Activated Receptor 1
Marvin T. Nieman, Mark Warnock, Ahmed A. K. Hasan, Fakhri Mahdi, Benedict R. Lucchesi, Nancy J. Brown, Laine J. Murphey and Alvin H. Schmaier

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 492-501; DOI: https://doi.org/10.1124/jpet.104.069229
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Role of Prostaglandins in Mediating Differences in Human Internal Mammary and Radial Artery Relaxation Elicited by Hypoxia
Sachin A. Gupte, Elias A. Zias, Mohan R. Sarabu and Michael S. Wolin

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 510-518; DOI: https://doi.org/10.1124/jpet.104.070995
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Perillyl Alcohol Is an Angiogenesis Inhibitor
Heleni Loutrari, Maria Hatziapostolou, Vassoula Skouridou, Evangelia Papadimitriou, Charis Roussos, Fragiskos N. Kolisis and Andreas Papapetropoulos

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 568-575; DOI: https://doi.org/10.1124/jpet.104.070516
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Role of Protein Kinase Cδ in Endothelin-Induced Type I Collagen Expression in Cardiac Myofibroblasts Isolated from the Site of Myocardial Infarction
Vishnu Chintalgattu and Laxmansa C. Katwa

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 691-699; DOI: https://doi.org/10.1124/jpet.104.070151
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Changes in Phospholipid Content and Myocardial Calcium-Independent Phospholipase A₂ Activity during Chronic Anthracycline Administration
Jane McHowat, Luther M. Swift, Kimberly N. Crown and Narine A. Sarvazyan

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 736-741; DOI: https://doi.org/10.1124/jpet.104.069419
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The Role of Rho Kinase and Extracellular Regulated Kinase-Mitogen-Activated Protein Kinase in α₂-Adrenoceptor-Mediated Vasoconstriction in the Porcine Palmar Lateral Vein
Richard E. Roberts

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 742-747; DOI: https://doi.org/10.1124/jpet.104.071100
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Inhibitory Profile of SEA0400 [2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline] Assessed on the Cardiac Na⁺-Ca²⁺ Exchanger, NCX1.1
Candace Lee, Neeraj S. Visen, Naranjan S. Dhalla, Hoa Dinh Le, Michael Isaac, Platon Choptiany, Gil Gross, Alexander Omelchenko, Toshio Matsuda, Akemichi Baba, Kenzo Takahashi, Mark Hnatowich and Larry V. Hryshko

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 748-757; DOI: https://doi.org/10.1124/jpet.104.070805

CELLULAR AND MOLECULAR

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Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion
Atsushi Fukunari, Ken Okamoto, Takeshi Nishino, Bryan T. Eger, Emil F. Pai, Miho Kamezawa, Ichimaro Yamada and Norihisa Kato

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 519-528; DOI: https://doi.org/10.1124/jpet.104.070433
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Compounds Exhibiting Selective Efficacy for Different β Subunits of Human Recombinant γ-Aminobutyric Acid_A Receptors
Alison J. Smith, Beth Oxley, Sallie Malpas, Gopalan V. Pillai and Peter B. Simpson

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 601-609; DOI: https://doi.org/10.1124/jpet.104.070342
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N-Butyryl Glucosamine Increases Matrix Gene Expression by Chondrocytes
Mark W. Poustie, John Carran, Kevin McEleney, S. Jeffrey Dixon, Tassos P. Anastassiades and Suzanne M. Bernier

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 610-616; DOI: https://doi.org/10.1124/jpet.104.067769
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Signaling Mechanisms Involved in Protease-Activated Receptor-1-Mediated Interleukin-6 Production by Human Gingival Fibroblasts
Nobuhisa Tanaka, Takao Morita, Akihiro Nezu, Akihiko Tanimura, Itaru Mizoguchi and Yosuke Tojyo

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 778-786; DOI: https://doi.org/10.1124/jpet.104.068569
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LY-294002 [2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] Affects Calcium Signaling in Airway Smooth Muscle Cells Independently of Phosphoinositide 3-Kinase Inhibition
Barbara Tolloczko, Petra Turkewitsch, Mustafa Al-Chalabi and James G. Martin

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 787-793; DOI: https://doi.org/10.1124/jpet.104.069013
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Simultaneous α_2B- and β₂-Adrenoceptor Activation Sensitizes the α_2B-Adrenoceptor for Agonist-Induced Down-Regulation
Aarti N. Desai, Kelly M. Standifer and Douglas C. Eikenburg

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 794-802; DOI: https://doi.org/10.1124/jpet.104.069674

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Inhibition of Epidermal Growth Factor Receptor Activity by Two Pyrimidopyrimidine Derivatives
Flavio F. Solca, Anke Baum, Elke Langkopf, Georg Dahmann, Karl-Heinz Heider, Frank Himmelsbach and Jacques C. A. van Meel

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 502-509; DOI: https://doi.org/10.1124/jpet.104.069138
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Inhibition of O⁶-Methylguanine-DNA Methyltransferase by Glucose-Conjugated Inhibitors: Comparison with Nonconjugated Inhibitors and Effect on Fotemustine and Temozolomide-Induced Cell Death
Bernd Kaina, Ute Mühlhausen, Andrea Piee-Staffa, Markus Christmann, Regine Garcia Boy, Frank Rösch and Ralf Schirrmacher

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 585-593; DOI: https://doi.org/10.1124/jpet.104.071316

ENDOCRINE AND REPRODUCTIVE

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Exendin-4 Pharmacodynamics: Insights from the Hyperglycemic Clamp Technique
Donald E. Mager, Darrell R. Abernethy, Josephine M. Egan and Dariush Elahi

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 830-835; DOI: https://doi.org/10.1124/jpet.104.069765

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Azathioprine Acts upon Rat Hepatocyte Mitochondria and Stress-Activated Protein Kinases Leading to Necrosis: Protective Role of N-Acetyl-L-cysteine
César Menor, María D. Fernández-Moreno, Jesús A. Fueyo, Oscar Escribano, Tomás Olleros, Encarna Arriaza, Carlos Cara, Michele Lorusso, Marco Di Paola, Irene D. Román and Luis G. Guijarro

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 668-676; DOI: https://doi.org/10.1124/jpet.104.069286
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Disposition Kinetics of Propranolol Isomers in the Perfused Rat Liver
Daniel Y. Hung, Gerhard A. Siebert, Ping Chang, Yuri G. Anissimov and Michael S. Roberts

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 822-829; DOI: https://doi.org/10.1124/jpet.104.070011

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Nitric Oxide as a Noninvasive Biomarker of Lipopolysaccharide-Induced Airway Inflammation: Possible Role in Lung Neutrophilia
Kerryn McCluskie, Mark A. Birrell, Sissie Wong and Maria G. Belvisi

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 625-633; DOI: https://doi.org/10.1124/jpet.104.068890
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A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes
Cheryl E. Rockwell and Norbert E. Kaminski

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 683-690; DOI: https://doi.org/10.1124/jpet.104.065524
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Nicotine Activates Nuclear Factor of Activated T Cells c2 (NFATc2) and Prevents Cell Cycle Entry in T Cells
Ashley A. Frazer-Abel, Shairaz Baksh, Susan P. Fosmire, Derall Willis, Angela M. Pierce, Heather Meylemans, Darwin S. Linthicum, Steven J. Burakoff, Teresa Coons, Donald Bellgrau and Jaime F. Modiano

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 758-769; DOI: https://doi.org/10.1124/jpet.104.070060

NEUROPHARMACOLOGY

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Competitive Inhibition of the Capsaicin Receptor-Mediated Current by Dehydroepiandrosterone in Rat Dorsal Root Ganglion Neurons
Shu-Cheng Chen, Tsui-Jung Chang and Fong-Sen Wu

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 529-536; DOI: https://doi.org/10.1124/jpet.104.069096
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Characterization of the Interaction of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic, with the GABA_A Receptor
Susan K. Sullivan, Robert E. Petroski, Gail Verge, Raymond S. Gross, Alan C. Foster and Dimitri E. Grigoriadis

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 537-546; DOI: https://doi.org/10.1124/jpet.104.071282
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In Vivo Pharmacological Characterization of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic
Alan C. Foster, Mary Ann Pelleymounter, Mary Jane Cullen, Dacie Lewis, Margaret Joppa, Ta Kung Chen, Haig P. Bozigian, Raymond S. Gross and Kathleen R. Gogas

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 547-559; DOI: https://doi.org/10.1124/jpet.103.063487
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Efficacy of Duloxetine, a Potent and Balanced Serotonin-Norepinephrine Reuptake Inhibitor in Persistent Pain Models in Rats
Smriti Iyengar, Amy A. Webster, Susan K. Hemrick-Luecke, Jimmy Yu Xu and Rosa Maria A. Simmons

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 576-584; DOI: https://doi.org/10.1124/jpet.104.070656
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Bupropion (Zyban, Wellbutrin) Inhibits Nicotine-Induced Viral Reactivation in Herpes Simplex Virus Type 1 Latent Rabbits
Marvin E. Myles, Ann M. Azcuy, Ngoc T. Nguyen, Eric R. Reisch, Steven A. Barker, Hilary W. Thompson and James M. Hill

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 640-644; DOI: https://doi.org/10.1124/jpet.104.070862
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Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] Acts Differently from Nociceptin/Orphanin FQ in Rat Periaqueductal Gray Slices
Lih-Chu Chiou, Kuang-Chieh Chuang, Juergen Wichmann and Geo Adam

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 645-651; DOI: https://doi.org/10.1124/jpet.104.070219
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Serotonin_1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels
L. E. O'Dell and L. H. Parsons

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 711-719; DOI: https://doi.org/10.1124/jpet.104.069278
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The Role of 5-Hydroxytryptamine₃ Receptors in the Vagal Afferent Activation-Induced Inhibition of the First Cervical Dorsal Horn Spinal Neurons Projected from Tooth Pulp in the Rat
Takeshi Tanimoto, Mamoru Takeda, Toshimi Nishikawa and Shigeji Matsumoto

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 803-810; DOI: https://doi.org/10.1124/jpet.104.070300
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Endogenous d-Serine Is Involved in Induction of Neuronal Death by N-Methyl-d-aspartate and Simulated Ischemia in Rat Cerebrocortical Slices
Hiroshi Katsuki, Miki Nonaka, Hisashi Shirakawa, Toshiaki Kume and Akinori Akaike

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 836-844; DOI: https://doi.org/10.1124/jpet.104.070912
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The Bile Acid Tauroursodeoxycholic Acid Modulates Phosphorylation and Translocation of Bad via Phosphatidylinositol 3-Kinase in Glutamate-Induced Apoptosis of Rat Cortical Neurons
Rui E. Castro, Susana Solá, Rita M. Ramalho, Clifford J. Steer and Cecília M. P. Rodrigues

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 845-852; DOI: https://doi.org/10.1124/jpet.104.070532

TOXICOLOGY

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Influence of Feeding Schedule on 24-h Rhythm of Hepatotoxicity Induced by Acetaminophen in Mice
Naoya Matsunaga, Naomi Nakamura, Noriyo Yoneda, Tian Qin, Hideyuki Terazono, Hideto To, Shun Higuchi and Shigehiro Ohdo

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 594-600; DOI: https://doi.org/10.1124/jpet.104.069062
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Interaction between Ascorbate and Light-Exposed Riboflavin Induces Lung Remodeling
Jean-Claude Lavoie, Thérèse Rouleau and Philippe Chessex

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 634-639; DOI: https://doi.org/10.1124/jpet.104.070755
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Pb²⁺ via Protein Kinase C Inhibits Nicotinic Cholinergic Modulation of Synaptic Transmission in the Hippocampus
Maria F. M. Braga, Edna F. R. Pereira, Arpad Mike and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 700-710; DOI: https://doi.org/10.1124/jpet.104.070466

Erratum

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Correction to “Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung”
Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 853;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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