XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

	Abstract	Full	Pdf
May 2004	68	0	111
Jun 2004	124	0	132
Jul 2004	152	0	164
Aug 2004	149	0	128
Sep 2004	190	35	143
Oct 2004	164	105	110
Nov 2004	123	79	47
Dec 2004	102	52	23
Jan 2005	97	67	24
Feb 2005	87	60	33
Mar 2005	60	81	26
Apr 2005	34	79	41
May 2005	31	69	29
Jun 2005	45	67	20
Jul 2005	41	63	19
Aug 2005	40	46	41
Sep 2005	17	39	35
Oct 2005	27	59	38
Nov 2005	28	78	31
Dec 2005	33	82	46
Jan 2006	33	65	31
Feb 2006	34	57	34
Mar 2006	28	59	41
Apr 2006	24	45	19
May 2006	29	40	32
Jun 2006	16	45	31
Jul 2006	23	48	40
Aug 2006	17	43	30
Sep 2006	29	37	62
Oct 2006	22	39	51
Nov 2006	30	53	60
Dec 2006	28	36	42
Jan 2007	34	50	76
Feb 2007	30	45	56
Mar 2007	30	53	77
Apr 2007	52	43	90
May 2007	44	41	68
Jun 2007	29	27	55
Jul 2007	30	37	52
Aug 2007	31	51	57
Sep 2007	29	35	51
Oct 2007	41	31	74
Nov 2007	35	28	70
Dec 2007	29	31	72
Jan 2008	43	31	75
Feb 2008	42	31	61
Mar 2008	34	24	62
Apr 2008	39	29	75
May 2008	51	24	83
Jun 2008	43	24	42
Jul 2008	39	36	67
Aug 2008	38	32	57
Sep 2008	37	35	65
Oct 2008	54	41	65
Nov 2008	66	44	68
Dec 2008	36	26	55
Jan 2009	36	17	51
Feb 2009	71	36	64
Mar 2009	68	38	64
Apr 2009	50	32	59
May 2009	32	32	58
Jun 2009	45	20	57
Jul 2009	52	25	44
Aug 2009	59	23	71
Sep 2009	55	33	67
Oct 2009	74	34	68
Nov 2009	54	27	58
Dec 2009	53	16	47
Jan 2010	71	21	53
Feb 2010	81	15	53
Mar 2010	75	30	57
Apr 2010	45	26	32
May 2010	48	22	39
Jun 2010	55	16	36
Jul 2010	32	24	31
Aug 2010	34	31	38
Sep 2010	38	32	37
Oct 2010	39	27	47
Nov 2010	56	40	61
Dec 2010	32	47	49
Jan 2011	26	16	21
Feb 2011	47	13	33
Mar 2011	57	30	46
Apr 2011	80	26	71
May 2011	39	42	67
Jun 2011	61	25	69
Jul 2011	79	22	78
Aug 2011	78	25	99
Sep 2011	50	29	68
Oct 2011	77	43	73
Nov 2011	70	34	60
Dec 2011	55	41	59
Jan 2012	82	20	86
Feb 2012	75	32	68
Mar 2012	53	21	54
Apr 2012	53	23	57
May 2012	51	31	59
Jun 2012	51	25	67
Jul 2012	61	36	72
Aug 2012	43	33	82
Sep 2012	44	46	59
Oct 2012	50	44	80
Nov 2012	37	32	64
Dec 2012	41	35	55
Jan 2013	49	33	77
Feb 2013	70	24	68
Mar 2013	78	30	64
Apr 2013	86	20	88
May 2013	47	26	56
Jun 2013	36	8	28
Jul 2013	42	22	43
Aug 2013	35	13	20
Sep 2013	40	17	29
Oct 2013	35	19	38
Nov 2013	68	21	35
Dec 2013	12	15	25
Jan 2014	32	9	28
Feb 2014	38	16	25
Mar 2014	43	14	30
Apr 2014	41	18	30
May 2014	53	30	29
Jun 2014	22	19	23
Jul 2014	46	29	36
Aug 2014	26	45	21
Sep 2014	37	30	35
Oct 2014	30	8	55
Nov 2014	37	10	22
Dec 2014	27	6	16
Jan 2015	58	18	35
Feb 2015	40	21	31
Mar 2015	43	18	32
Apr 2015	43	30	35
May 2015	31	18	40
Jun 2015	31	19	32
Jul 2015	39	27	51
Aug 2015	27	13	40
Sep 2015	48	24	39
Oct 2015	18	19	35
Nov 2015	33	15	22
Dec 2015	51	23	26
Jan 2016	31	21	37
Feb 2016	28	12	22
Mar 2016	27	18	30
Apr 2016	8	20	26
May 2016	12	14	31
Jun 2016	28	16	46
Jul 2016	20	17	58
Aug 2016	24	19	63
Sep 2016	12	15	36
Oct 2016	14	38	39
Nov 2016	14	30	42
Dec 2016	5	21	21
Jan 2017	5	27	19
Feb 2017	4	28	17
Mar 2017	6	34	20
Apr 2017	10	29	14
May 2017	5	34	28
Jun 2017	5	26	24
Jul 2017	8	33	15
Aug 2017	2	30	32
Sep 2017	2	39	20
Oct 2017	5	34	13
Nov 2017	3	38	41
Dec 2017	2	43	27
Jan 2018	5	25	15
Feb 2018	1	35	26
Mar 2018	5	43	35
Apr 2018	6	46	34
May 2018	5	82	39
Jun 2018	2	76	32
Jul 2018	1	42	45
Aug 2018	3	44	30
Sep 2018	2	39	32
Oct 2018	4	29	49
Nov 2018	7	35	53
Dec 2018	58	17	26
Jan 2019	33	8	15
Feb 2019	42	7	15
Mar 2019	40	6	14
Apr 2019	56	9	23
May 2019	40	5	24
Jun 2019	32	3	27
Jul 2019	100	9	33
Aug 2019	54	5	31
Sep 2019	75	5	22
Oct 2019	58	3	13
Nov 2019	58	2	14
Dec 2019	65	3	16
Jan 2020	70	9	15
Feb 2020	76	5	17
Mar 2020	51	4	13
Apr 2020	36	4	9
May 2020	36	2	11
Jun 2020	38	8	10
Jul 2020	53	6	6
Aug 2020	27	4	8
Sep 2020	27	1	5
Oct 2020	39	5	17
Nov 2020	34	8	19
Dec 2020	70	11	23
Jan 2021	55	9	32
Feb 2021	29	7	12
Mar 2021	67	5	27
Apr 2021	30	4	18
May 2021	25	8	16
Jun 2021	46	13	13
Jul 2021	42	6	19
Aug 2021	30	4	12
Sep 2021	49	6	13
Oct 2021	24	6	19
Nov 2021	35	9	18
Dec 2021	49	6	29
Jan 2022	66	5	25
Feb 2022	31	17	15
Mar 2022	92	14	13
Apr 2022	131	4	14
May 2022	71	1	14
Jun 2022	50	5	12
Jul 2022	42	21	14
Aug 2022	49	3	16
Sep 2022	57	10	15
Oct 2022	39	13	25
Nov 2022	51	9	23
Dec 2022	36	4	2
Jan 2023	41	13	15
Feb 2023	57	6	7
Mar 2023	73	7	6