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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

Kenneth C. Cundy, Russell Branch, Tania Chernov-Rogan, Tracy Dias, Toño Estrada, Karin Hold, Kerry Koller, Xiaoli Liu, Adam Mann, Matt Panuwat, Stephen P. Raillard, Shubhra Upadhyay, Quincey Q. Wu, Jia-Ning Xiang, Hui Yan, Noa Zerangue, Cindy X. Zhou, Ronald W. Barrett and Mark A. Gallop
Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 315-323; DOI: https://doi.org/10.1124/jpet.104.067934

Article Information

vol. 311 no. 1 315-323
DOI 
https://doi.org/10.1124/jpet.104.067934
PubMed 
15146028
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 5, 2004
  • Accepted May 14, 2004
  • Published online September 16, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kenneth C. Cundy,
  2. Russell Branch,
  3. Tania Chernov-Rogan,
  4. Tracy Dias,
  5. Toño Estrada,
  6. Karin Hold,
  7. Kerry Koller,
  8. Xiaoli Liu,
  9. Adam Mann,
  10. Matt Panuwat,
  11. Stephen P. Raillard,
  12. Shubhra Upadhyay,
  13. Quincey Q. Wu,
  14. Jia-Ning Xiang,
  15. Hui Yan,
  16. Noa Zerangue,
  17. Cindy X. Zhou,
  18. Ronald W. Barrett and
  19. Mark A. Gallop
  1. XenoPort, Inc., Santa Clara, California
  1. Address correspondence to:
    Dr. Kenneth C. Cundy, XenoPort, Inc., 3410 Central Expressway, Santa Clara, CA 95051. E-mail: kcundy{at}xenoport.com
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

Kenneth C. Cundy, Russell Branch, Tania Chernov-Rogan, Tracy Dias, Toño Estrada, Karin Hold, Kerry Koller, Xiaoli Liu, Adam Mann, Matt Panuwat, Stephen P. Raillard, Shubhra Upadhyay, Quincey Q. Wu, Jia-Ning Xiang, Hui Yan, Noa Zerangue, Cindy X. Zhou, Ronald W. Barrett and Mark A. Gallop
Journal of Pharmacology and Experimental Therapeutics October 1, 2004, 311 (1) 315-323; DOI: https://doi.org/10.1124/jpet.104.067934
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