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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Effect of Quinidine on the 10-Hydroxylation of R-Warfarin: Species Differences and Clearance Projection

Qing Chen, Eugene Tan, John R. Strauss, Zhoupeng Zhang, Judith E. Fenyk-Melody, Catherine Booth-Genthe, Thomas H. Rushmore, Ralph A. Stearns, David C. Evans, Thomas A. Baillie and Wei Tang
Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 307-314; DOI: https://doi.org/10.1124/jpet.104.069955
Qing Chen
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Eugene Tan
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John R. Strauss
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Zhoupeng Zhang
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Judith E. Fenyk-Melody
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Catherine Booth-Genthe
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Thomas H. Rushmore
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Ralph A. Stearns
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David C. Evans
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Thomas A. Baillie
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Wei Tang
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Article Information

vol. 311 no. 1 307-314
DOI 
https://doi.org/10.1124/jpet.104.069955
PubMed 
15163679

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 13, 2004
  • Accepted May 26, 2004
  • Published online September 16, 2004.

Article Versions

  • Earlier version (May 26, 2004 - 13:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Qing Chen1,
  2. Eugene Tan1,
  3. John R. Strauss,
  4. Zhoupeng Zhang,
  5. Judith E. Fenyk-Melody,
  6. Catherine Booth-Genthe,
  7. Thomas H. Rushmore,
  8. Ralph A. Stearns,
  9. David C. Evans,
  10. Thomas A. Baillie and
  11. Wei Tang
  1. Departments of Drug Metabolism and Comparative Medicine, Merck Research Labs, Rahway, New Jersey (Q.C., E.T., J.R.S., Z.Z., J.E.F.-M., R.A.S., D.C.E., T.A.B., W.T.); and Department of Drug Metabolism, Merck Research Labs, West Point, Pennsylvania (C.B.-G., T.A.B., T.H.R.)
  1. Address correspondence to:
    Dr. Wei Tang, Department of Drug Metabolism, Merck and Co., P.O. Box 2000, RY800-B211, Rahway, NJ 07065. E-mail: wei_tang{at}merck.com
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Journal of Pharmacology and Experimental Therapeutics: 311 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 311, Issue 1
1 Oct 2004
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Effect of Quinidine on the 10-Hydroxylation of R-Warfarin: Species Differences and Clearance Projection

Qing Chen, Eugene Tan, John R. Strauss, Zhoupeng Zhang, Judith E. Fenyk-Melody, Catherine Booth-Genthe, Thomas H. Rushmore, Ralph A. Stearns, David C. Evans, Thomas A. Baillie and Wei Tang
Journal of Pharmacology and Experimental Therapeutics October 1, 2004, 311 (1) 307-314; DOI: https://doi.org/10.1124/jpet.104.069955

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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Effect of Quinidine on the 10-Hydroxylation of R-Warfarin: Species Differences and Clearance Projection

Qing Chen, Eugene Tan, John R. Strauss, Zhoupeng Zhang, Judith E. Fenyk-Melody, Catherine Booth-Genthe, Thomas H. Rushmore, Ralph A. Stearns, David C. Evans, Thomas A. Baillie and Wei Tang
Journal of Pharmacology and Experimental Therapeutics October 1, 2004, 311 (1) 307-314; DOI: https://doi.org/10.1124/jpet.104.069955
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