Journal of Pharmacology and Experimental Therapeutics: 311 (1)

October 01, 2004; Volume 311,Issue 1

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Multiple Novel Nonsynonymous CYP2B6 Gene Polymorphisms in Caucasians: Demonstration of Phenotypic Null Alleles
Thomas Lang, Kathrin Klein, Tanja Richter, Arne Zibat, Reinhold Kerb, Michel Eichelbaum, Matthias Schwab and Ulrich M. Zanger

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 34-43; DOI: https://doi.org/10.1124/jpet.104.068973
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GHB (γ-Hydroxybutyrate) Carrier-Mediated Transport across the Blood-Brain Barrier
Indranil Bhattacharya and Kathleen M. K. Boje

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 92-98; DOI: https://doi.org/10.1124/jpet.104.069682
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Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans
Masaru Hirano, Kazuya Maeda, Yoshihisa Shitara and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 139-146; DOI: https://doi.org/10.1124/jpet.104.068056
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Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil
Yoshihisa Shitara, Masaru Hirano, Hitoshi Sato and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 228-236; DOI: https://doi.org/10.1124/jpet.104.068536
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Pharmacokinetics of Erythromycin in Rabbit Corneas after Single-Dose Infusion: Role of P-Glycoprotein as a Barrier to in Vivo Ocular Drug Absorption
Surajit Dey, Sriram Gunda and Ashim K. Mitra

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 246-255; DOI: https://doi.org/10.1124/jpet.104.069583
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Effect of Quinidine on the 10-Hydroxylation of R-Warfarin: Species Differences and Clearance Projection
Qing Chen, Eugene Tan, John R. Strauss, Zhoupeng Zhang, Judith E. Fenyk-Melody, Catherine Booth-Genthe, Thomas H. Rushmore, Ralph A. Stearns, David C. Evans, Thomas A. Baillie and Wei Tang

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 307-314; DOI: https://doi.org/10.1124/jpet.104.069955
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XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters
Kenneth C. Cundy, Russell Branch, Tania Chernov-Rogan, Tracy Dias, Toño Estrada, Karin Hold, Kerry Koller, Xiaoli Liu, Adam Mann, Matt Panuwat, Stephen P. Raillard, Shubhra Upadhyay, Quincey Q. Wu, Jia-Ning Xiang, Hui Yan, Noa Zerangue, Cindy X. Zhou, Ronald W. Barrett and Mark A. Gallop

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 315-323; DOI: https://doi.org/10.1124/jpet.104.067934
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XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: II. Improved Oral Bioavailability, Dose Proportionality, and Colonic Absorption Compared with Gabapentin in Rats and Monkeys
Kenneth C. Cundy, Thamil Annamalai, Lin Bu, Josephine De Vera, Jenny Estrela, Wendy Luo, Payal Shirsat, Allan Torneros, Fenmei Yao, Joan Zou, Ronald W. Barrett and Mark A. Gallop

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 324-333; DOI: https://doi.org/10.1124/jpet.104.067959

BEHAVIORAL PHARMACOLOGY

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Antiallodynic Effects of Loperamide and Fentanyl against Topical Capsaicin-Induced Allodynia in Unanesthetized Primates
Eduardo R. Butelman, Todd J. Harris and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 155-163; DOI: https://doi.org/10.1124/jpet.104.068411
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Antinociceptive Structure-Activity Studies with Enkephalin-Based Opioid Glycopeptides
Nura O. Elmagbari, Richard D. Egleton, Michael M. Palian, John J. Lowery, Wendi R. Schmid, Peg Davis, Edita Navratilova, Muthu Dhanasekaran, Charles M. Keyari, Henry I. Yamamura, Frank Porreca, Victor J. Hruby, Robin Polt and Edward J. Bilsky

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 290-297; DOI: https://doi.org/10.1124/jpet.104.069393

CARDIOVASCULAR

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N-Methyl-d-aspartate Receptor Blockade Inhibits Cardiac Inflammation in the Mg²+-Deficient Rat
M. Isabel Tejero-Taldo, Joanna J. Chmielinska, Grace Gonzalez, I. Tong Mak and William B. Weglicki

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 8-13; DOI: https://doi.org/10.1124/jpet.104.070003
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The Protective Effect of Superoxide Dismutase Mimetic M40401 on Balloon Injury-Related Neointima Formation: Role of the Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1
Carolina Muscoli, Iolanda Sacco, Wanessa Alecce, Ernesto Palma, Robert Nisticò, Nicola Costa, Fabrizio Clementi, Domenicantonio Rotiroti, Francesco Romeo, Daniela Salvemini, Jawahar L. Mehta and Vincenzo Mollace

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 44-50; DOI: https://doi.org/10.1124/jpet.104.068205
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Regulation of Gene Expression in Cardiomyocytes by Thyroid Hormone and Thyroid Hormone Analogs 3,5-Diiodothyropropionic Acid and CGS 23425 [N-[3,5-Dimethyl-4-(4′-hydroxy-3′-isopropylphenoxy)-phenyl]-oxamic Acid]
Cynthia Adamson, Niranjan Maitra, Joseph Bahl, Kevin Greer, Scott Klewer, James Hoying and Eugene Morkin

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 164-171; DOI: https://doi.org/10.1124/jpet.104.069153
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Pharmacology of the Urotensin-II Receptor Antagonist Palosuran (ACT-058362; 1-[2-(4-Benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea Sulfate Salt): First Demonstration of a Pathophysiological Role of the Urotensin System
Martine Clozel, Christoph Binkert, Magdalena Birker-Robaczewska, Céline Boukhadra, Shuang-Shuang Ding, Walter Fischli, Patrick Hess, Boris Mathys, Keith Morrison, Celia Müller, Claus Müller, Oliver Nayler, Changbin Qiu, Markus Rey, Michael W. Scherz, Jörg Velker, Thomas Weller, Jian-Fei Xi and Patrick Ziltener

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 204-212; DOI: https://doi.org/10.1124/jpet.104.068320
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Characterization of Cannabinoid Modulation of Sensory Neurotransmission in the Rat Isolated Mesenteric Arterial Bed
Marnie Duncan, David A. Kendall and Vera Ralevic

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 411-419; DOI: https://doi.org/10.1124/jpet.104.067587
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Effects of Pravastatin on the Expression of ATP-Binding Cassette Transporter A1
Hitoshi Ando, Shuichi Tsuruoka, Hisashi Yamamoto, Toshinari Takamura, Shuichi Kaneko and Akio Fujimura

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 420-425; DOI: https://doi.org/10.1124/jpet.104.068213

CELLULAR AND MOLECULAR

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p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride (TPT-CuCl₂): In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells
Naseruddin Höti, De-e Zhu, Zhiyin Song, Zhengsheng Wu, Sartaj Tabassum and Mian Wu

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 22-33; DOI: https://doi.org/10.1124/jpet.104.069104
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Identification of Amino Acid Residues Involved in the Inactivation of Cytochrome P450 2B1 by Two Acetylenic Compounds: The Role of Three Residues in Nonsubstrate Recognition Sites
Linda B. Von Weymarn, Chitra Sridar and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 71-79; DOI: https://doi.org/10.1124/jpet.104.069757
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Insulin Signaling Regulates γ-Glutamylcysteine Ligase Catalytic Subunit Expression in Primary Cultured Rat Hepatocytes
Sang K. Kim, Kimberley J. Woodcroft, Sarah S. Khodadadeh and Raymond F. Novak

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 99-108; DOI: https://doi.org/10.1124/jpet.104.070375
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Fenofibrate Impairs Rat Mitochondrial Function by Inhibition of Respiratory Complex I
Barbara Brunmair, Andrea Lest, Katrin Staniek, Florian Gras, Nicole Scharf, Michael Roden, Hans Nohl, Werner Waldhäusl and Clemens Fürnsinn

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 109-114; DOI: https://doi.org/10.1124/jpet.104.068312
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Domain Swapping in the Human Histamine H₁ Receptor
Remko A. Bakker, Guido Dees, Juan J. Carrillo, Raymond G. Booth, Juan F. López-Gimenez, Graeme Milligan, Philip G. Strange and Rob Leurs

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 131-138; DOI: https://doi.org/10.1124/jpet.104.067041
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Ligand-Directed Functional Heterogeneity of Histamine H₁ Receptors: Novel Dual-Function Ligands Selectively Activate and Block H₁-Mediated Phospholipase C and Adenylyl Cyclase Signaling
Nader H. Moniri, Dawn Covington-Strachan and Raymond G. Booth

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 274-281; DOI: https://doi.org/10.1124/jpet.104.070086

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Kaurene Diterpene Induces Apoptosis in Human Leukemia Cells Partly through a Caspase-8-Dependent Pathway
Masuo Kondoh, Ikue Suzuki, Masao Sato, Fumihiro Nagashima, Siro Simizu, Motoki Harada, Makiko Fujii, Hiroyuki Osada, Yoshinori Asakawa and Yoshiteru Watanabe

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 115-122; DOI: https://doi.org/10.1124/jpet.104.069690
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Intratumoral Administration of Methotrexate Bound to Activated Carbon Particles: Antitumor Effectiveness against Human Colon Carcinoma Xenografts and Acute Toxicity in Mice
Yuen Nakase, Akeo Hagiwara, Syuichi Kin, Ken-ichirou Fukuda, Tadao Ito, Tsuyoshi Takagi, Jyunshin Fujiyama, Chohei Sakakura, Eigo Otsuji and Hisakazu Yamagishi

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 382-387; DOI: https://doi.org/10.1124/jpet.104.069450

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Interleukin 1β-Induced Production of H₂O₂ Contributes to Reduced Sigmoid Colonic Circular Smooth Muscle Contractility in Ulcerative Colitis
Weibiao Cao, Matthew D. Vrees, Fabio M. Potenti, Karen M. Harnett, Claudio Fiocchi and Victor E. Pricolo

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 60-70; DOI: https://doi.org/10.1124/jpet.104.068023
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The Modulating Role of Nuclear Factor-κB in the Action of α7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
Yi N. Ye, Edgar S. L. Liu, Vivian Y. Shin, William K. K. Wu and Chi H. Cho

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 123-130; DOI: https://doi.org/10.1124/jpet.104.068031
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Effect of Omeprazole on Gastric Adenosine A₁ and A_2A Receptor Gene Expression and Function
Linda Yip, Henry Chi Hang Leung and Yin Nam Kwok

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 180-189; DOI: https://doi.org/10.1124/jpet.104.069708
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Effect of Prolyl Endopeptidase on Digestive-Resistant Gliadin Peptides in Vivo
Justin L. Piper, Gary M. Gray and Chaitan Khosla

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 213-219; DOI: https://doi.org/10.1124/jpet.104.068429
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Regulation of Rat Hepatocyte Function by P2Y Receptors: Focus on Control of Glycogen Phosphorylase and Cyclic AMP by 2-Methylthioadenosine 5′-Diphosphate
C. Jane Dixon, John F. Hall, Tania E. Webb and Michael R. Boarder

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 334-341; DOI: https://doi.org/10.1124/jpet.104.067744
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Submandibular Gland Acinar Cells Express Multiple α₁-Adrenoceptor Subtypes
Charles S. Bockman, Michael R. Bruchas, Wanyun Zeng, Kelly A. O'Connell, Peter W. Abel, Margaret A. Scofield and Frank J. Dowd

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 364-372; DOI: https://doi.org/10.1124/jpet.104.066399
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Angiotensin II-Induced Relaxation of Anococcygeus Smooth Muscle via Desensitization of AT₁ Receptor, and Activation of AT₂ Receptor Associated with Nitric-Oxide Synthase Pathway
Márcio A. F. de Godoy, Ana Maria de Oliveira and Satish Rattan

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 394-401; DOI: https://doi.org/10.1124/jpet.104.069856
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Proteinase-Activated Receptor-2-Mediated Relaxation in Mouse Tracheal and Bronchial Smooth Muscle: Signal Transduction Mechanisms and Distinct Agonist Sensitivity
Atsufumi Kawabata, Satoko Kubo, Tsuyoshi Ishiki, Naoyuki Kawao, Fumiko Sekiguchi, Ryotaro Kuroda, Morley D. Hollenberg, Toru Kanke and Naohiro Saito

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 402-410; DOI: https://doi.org/10.1124/jpet.104.068387

INFLAMMATION AND IMMUNOPHARMACOLOGY

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The Endocannabinoid 2-Arachidonylglycerol Decreases the Immunological Activation of Guinea Pig Mast Cells: Involvement of Nitric Oxide and Eicosanoids
Alfredo Vannacci, Lucia Giannini, Maria Beatrice Passani, Annamaria Di Felice, Simone Pierpaoli, Giovanni Zagli, Ornella Fantappiè, Roberto Mazzanti, Emanuela Masini and Pier Francesco Mannaioni

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 256-264; DOI: https://doi.org/10.1124/jpet.104.068635

NEUROPHARMACOLOGY

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Methamphetamine Neurotoxicity in Dopamine Nerve Endings of the Striatum Is Associated with Microglial Activation
David M. Thomas, Paul D. Walker, Joyce A. Benjamins, Timothy J. Geddes and Donald M. Kuhn

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 1-7; DOI: https://doi.org/10.1124/jpet.104.070961
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The N-Methyl-d-aspartate Receptor Inhibitory Potencies of Aromatic Inhaled Drugs of Abuse: Evidence for Modulation by Cation-π Interactions
Douglas E. Raines, Fredrick Gioia, Robert J. Claycomb and Renna J. Stevens

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 14-21; DOI: https://doi.org/10.1124/jpet.104.069930
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Serofendic Acid, a Sulfur-Containing Diterpenoid Derived from Fetal Calf Serum, Attenuates Reactive Oxygen Species-Induced Oxidative Stress in Cultured Striatal Neurons
Fumitaka Osakada, Yuka Kawato, Toshiaki Kume, Hiroshi Katsuki, Hachiro Sugimoto and Akinori Akaike

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 51-59; DOI: https://doi.org/10.1124/jpet.104.070334
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Electrophysiological, Pharmacological, and Molecular Evidence for α7-Nicotinic Acetylcholine Receptors in Rat Midbrain Dopamine Neurons
Jie Wu, Andrew A. George, Katherine M. Schroeder, Lin Xu, Syndia Marxer-Miller, Linda Lucero and Ronald J. Lukas

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 80-91; DOI: https://doi.org/10.1124/jpet.104.070417
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γ-Hydroxybutyrate Increases a Potassium Current and Decreases the H-Current in Hippocampal Neurons via GABA_B Receptors
Paul Schweitzer, Marisa Roberto, Samuel G. Madamba and George Robert Siggins

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 172-179; DOI: https://doi.org/10.1124/jpet.104.069534
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The Serotonin_1A Receptor Partial Agonist S15535 [4-(Benzodioxan-5-yl)1-(indan-2-yl)piperazine] Enhances Cholinergic Transmission and Cognitive Function in Rodents: A Combined Neurochemical and Behavioral Analysis
Mark J. Millan, Alain Gobert, Sylvain Roux, Roger Porsolt, Alfredo Meneses, Mirjana Carli, Benjamin Di Cara, Robert Jaffard, Jean-Michel Rivet, Pierre Lestage, Elisabeth Mocaer, Jean-Louis Peglion and Anne Dekeyne

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 190-203; DOI: https://doi.org/10.1124/jpet.104.069625
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Antiepileptic Drug Treatment of Nonconvulsive Seizures Induced by Experimental Focal Brain Ischemia
A. J. Williams, F. C. Tortella, X. M. Lu, J. E. Moreton and J. A. Hartings

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 220-227; DOI: https://doi.org/10.1124/jpet.104.069146
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β-Estradiol, Dehydroepiandrosterone, and Dehydroepiandrosterone Sulfate Protect against N-Methyl-d-aspartate-Induced Neurotoxicity in Rat Hippocampal Neurons by Different Mechanisms
Kenichi Kurata, Minoru Takebayashi, Shigeru Morinobu and Shigeto Yamawaki

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 237-245; DOI: https://doi.org/10.1124/jpet.104.067629
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Chronic Morphine Treatment Alters N-Methyl-d-aspartate Receptors in Freshly Isolated Neurons from Nucleus Accumbens
Gilles Martin, Ana Guadaño-Ferraz, Beatriz Morte, Serge Ahmed, George F. Koob, Luis de Lecea and George R. Siggins

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 265-273; DOI: https://doi.org/10.1124/jpet.104.067504
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Ethanol Suppression of Ventral Tegmental Area GABA Neuron Electrical Transmission Involves N-Methyl-d-aspartate Receptors
Sarah H. Stobbs, Allison J. Ohran, Matthew B. Lassen, David W. Allison, J. Elliott Brown and Scott C. Steffensen

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 282-289; DOI: https://doi.org/10.1124/jpet.104.071860
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Negative Feedback Regulation of Nigrostriatal Dopamine Release: Mediation by Striatal D1 Receptors
Sanjida S. Saklayen, Omar S. Mabrouk and Elizabeth A. Pehek

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 342-348; DOI: https://doi.org/10.1124/jpet.104.067991
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Short-Term Cocaine Treatment Causes Neuroadaptive Changes in Gα_q and Gα₁₁ Proteins in Rats Undergoing Withdrawal
Gonzalo A. Carrasco, Katerina J. Damjanoska, Deborah N. D'Souza, Yahong Zhang, Francisca Garcia, George Battaglia, Nancy A. Muma and Louis D. Van de Kar

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 349-355; DOI: https://doi.org/10.1124/jpet.104.069807
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Intrathecal Protease-Activated Receptor Stimulation Produces Thermal Hyperalgesia through Spinal Cyclooxygenase Activity
Lee Koetzner, Joshua A. Gregory and Tony L. Yaksh

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 356-363; DOI: https://doi.org/10.1124/jpet.104.069484
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Edaravone Protects against Hypoxia/Ischemia-Induced Endoplasmic Reticulum Dysfunction
Xin Qi, Yasunobu Okuma, Toru Hosoi and Yasuyuki Nomura

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 388-393; DOI: https://doi.org/10.1124/jpet.104.069088

TOXICOLOGY

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Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue
Kouichi Yoshinari, Takeshi Sato, Nao Okino, Junko Sugatani and Masao Miwa

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 147-154; DOI: https://doi.org/10.1124/jpet.104.067066
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Thioether Metabolites of 3,4-Methylenedioxyamphetamine and 3,4-Methylenedioxymethamphetamine Inhibit Human Serotonin Transporter (hSERT) Function and Simultaneously Stimulate Dopamine Uptake into hSERT-Expressing SK-N-MC Cells
Douglas C. Jones, Serrine S. Lau and Terrence J. Monks

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 298-306; DOI: https://doi.org/10.1124/jpet.104.069260
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Development of a Real-Time Polymerase Chain Reaction-Based Method for the Measurement of Relative Allelic Expression and Identification of CYP2A13 Alleles with Decreased Expression in Human Lung
Xiuling Zhang, Michele Caggana, Tracey L. Cutler and Xinxin Ding

Journal of Pharmacology and Experimental Therapeutics October 2004, 311 (1) 373-381; DOI: https://doi.org/10.1124/jpet.104.069872

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Table of Contents

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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