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Research ArticleBEHAVIORAL PHARMACOLOGY

Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines

John F. Cryan, Peter H. Kelly, Frederique Chaperon, Conrad Gentsch, Cedric Mombereau, Kurt Lingenhoehl, Wolfgang Froestl, Bernhard Bettler, Klemens Kaupmann and Will P. J. M. Spooren
Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 952-963; DOI: https://doi.org/10.1124/jpet.104.066753

Article Information

vol. 310 no. 3 952-963
DOI 
https://doi.org/10.1124/jpet.104.066753
PubMed 
15113848
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 11, 2004
  • Accepted April 26, 2004
  • Published online August 20, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. John F. Cryan,
  2. Peter H. Kelly,
  3. Frederique Chaperon,
  4. Conrad Gentsch,
  5. Cedric Mombereau1,
  6. Kurt Lingenhoehl,
  7. Wolfgang Froestl,
  8. Bernhard Bettler2,
  9. Klemens Kaupmann and
  10. Will P. J. M. Spooren3
  1. Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
  1. Address correspondence to:
    Dr. John F. Cryan, Psychiatry Program, Neuroscience Research, The Novartis Institutes for BioMedical Research WSJ 386.344, Novartis Pharma AG, Basel CH-4002, Switzerland. E-mail: john_f.cryan{at}pharma.novartis.com
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Research ArticleBEHAVIORAL PHARMACOLOGY

Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines

John F. Cryan, Peter H. Kelly, Frederique Chaperon, Conrad Gentsch, Cedric Mombereau, Kurt Lingenhoehl, Wolfgang Froestl, Bernhard Bettler, Klemens Kaupmann and Will P. J. M. Spooren
Journal of Pharmacology and Experimental Therapeutics September 1, 2004, 310 (3) 952-963; DOI: https://doi.org/10.1124/jpet.104.066753
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