Journal of Pharmacology and Experimental Therapeutics: 310 (3)

September 01, 2004; Volume 310,Issue 3

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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CYP2C44, a New Murine CYP2C That Metabolizes Arachidonic Acid to Unique Stereospecific Products
Tracy C. DeLozier, Cheng-Chung Tsao, Sherry J. Coulter, Julie Foley, J. Alyce Bradbury, Darryl C. Zeldin and Joyce A. Goldstein

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 845-854; DOI: https://doi.org/10.1124/jpet.104.067819
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Metabolism of N,N′,N″-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms
Erin Harleton, Marie Webster, Namandjé N. Bumpus, Ute M. Kent, James M. Rae and Paul F. Hollenberg

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1011-1019; DOI: https://doi.org/10.1124/jpet.104.069112
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Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6
Zeruesenay Desta, Bryan A. Ward, Nadia V. Soukhova and David A. Flockhart

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1062-1075; DOI: https://doi.org/10.1124/jpet.104.065607
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Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Spin Probes in Mouse Blood
Ken-ichiro Matsumoto, Murali C. Krishna and James B. Mitchell

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1076-1083; DOI: https://doi.org/10.1124/jpet.104.066647
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Disposition of Flavonoids via Enteric Recycling: Enzyme-Transporter Coupling Affects Metabolism of Biochanin A and Formononetin and Excretion of Their Phase II Conjugates
Xiaobin Jia, Jun Chen, Huimin Lin and Ming Hu

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1103-1113; DOI: https://doi.org/10.1124/jpet.104.068403
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Multidrug Resistance Gene G1199A Polymorphism Alters Efflux Transport Activity of P-Glycoprotein
Erica L. Woodahl, Ziping Yang, Tot Bui, Danny D. Shen and Rodney J. Y. Ho

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1199-1207; DOI: https://doi.org/10.1124/jpet.104.065383
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Mentholated Cigarette Smoking Inhibits Nicotine Metabolism
Neal L. Benowitz, Brenda Herrera and Peyton Jacob

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1208-1215; DOI: https://doi.org/10.1124/jpet.104.066902

BEHAVIORAL PHARMACOLOGY

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Behavioral Characterization of the Novel GABA_B Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines
John F. Cryan, Peter H. Kelly, Frederique Chaperon, Conrad Gentsch, Cedric Mombereau, Kurt Lingenhoehl, Wolfgang Froestl, Bernhard Bettler, Klemens Kaupmann and Will P. J. M. Spooren

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 952-963; DOI: https://doi.org/10.1124/jpet.104.066753
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Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)₂ Agonist, and Ovine CRF, a CRF₁ Agonist, Differentially Alter Feeding and Motor Activity
Eric P. Zorrilla, Lindsay E. Reinhardt, Glenn R. Valdez, Koki Inoue, Jean E. Rivier, Wylie W. Vale and George F. Koob

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1027-1034; DOI: https://doi.org/10.1124/jpet.104.068676
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SL25.1131 [3(S),3a(S)-3-Methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a New, Reversible, and Mixed Inhibitor of Monoamine Oxidase-A and Monoamine Oxidase-B: Biochemical and Behavioral Profile
N. Aubin, P. Barneoud, C. Carter, D. Caille, N. Sontag, C. Marc, J. Lolivier, A. Gardes, C. Perron, A. Le Kim, T. Charieras, M. Pandini, P. Burnier, F. Puech, S. Jegham, P. George, B. Scatton and O. Curet

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1171-1182; DOI: https://doi.org/10.1124/jpet.103.064782
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Contribution of Serotonin (5-Hydroxytryptamine; 5-HT) 5-HT₂ Receptor Subtypes to the Hyperlocomotor Effects of Cocaine: Acute and Chronic Pharmacological Analyses
Malgorzata Filip, Marcy J. Bubar and Kathryn A. Cunningham

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1246-1254; DOI: https://doi.org/10.1124/jpet.104.068841
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Ethologically Based Resolution of D₂-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background
Rachel E. Nally, Anthony Kinsella, Orna Tighe, David T. Croke, Allen A. Fienberg, Paul Greengard and John L. Waddington

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1281-1287; DOI: https://doi.org/10.1124/jpet.104.068957

CARDIOVASCULAR

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Flavonoids from Artichoke (Cynara scolymus L.) Up-Regulate Endothelial-Type Nitric-Oxide Synthase Gene Expression in Human Endothelial Cells
Huige Li, Ning Xia, Isolde Brausch, Ying Yao and Ulrich Förstermann

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 926-932; DOI: https://doi.org/10.1124/jpet.104.066639
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Effect of BM-573 [N-Terbutyl-N′-[2-(4′-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist, in a Porcine Model of Acute Pulmonary Embolism
Alexandre Ghuysen, Bernard Lambermont, Jean-Michel Dogné, Philippe Kolh, Vincent Tchana-Sato, Philippe Morimont, David Magis, Julien Hanson, Patrick Segers and Vincent D'Orio

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 964-972; DOI: https://doi.org/10.1124/jpet.104.066852
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Identification of α-1L Adrenoceptor in Rabbit Ear Artery
Yasuko Hiraizumi-Hiraoka, Takashi Tanaka, Hatsumi Yamamoto, Fumiko Suzuki and Ikunobu Muramatsu

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 995-1002; DOI: https://doi.org/10.1124/jpet.104.066985
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The Distinct Alterations Produced in Cardiovascular Functions by Prednisolone and Nitro-prednisolone (NCX-1015) in the Rat Highlight a Causal Role for Endothelin-1
Clara Di Filippo, Francesco Rossi, Ennio Ongini, Piero Del Soldato, Mauro Perretti and Michele D'Amico

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1133-1141; DOI: https://doi.org/10.1124/jpet.104.068726
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Low Sodium Modifies the Vascular Effects of Angiotensin-Converting Enzyme Inhibitor Therapy in Healthy Rats
Menno J. A. Kocks, Simone Gschwend, Dick de Zeeuw, Gerjan Navis and Hendrik Buikema

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1183-1189; DOI: https://doi.org/10.1124/jpet.104.067272
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The Adenosine Transporter, mENT1, Is a Target for Adenosine Receptor Signaling and Protein Kinase Cϵ in Hypoxic and Pharmacological Preconditioning in the Mouse Cardiomyocyte Cell Line, HL-1
Naz Chaudary, Zlatina Naydenova, Irina Shuralyova and Imogen R. Coe

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1190-1198; DOI: https://doi.org/10.1124/jpet.104.067157
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Regional Hemodynamic Effects of the N-(2-Benzoylphenyl)-l-tyrosine Peroxisome Proliferator-Activated Receptor-γ Ligand, GI 262570 [(S)-2-(2-Benzoylphenylamino)-3-[4-[2-(5-methyl-2-phenyl-2-oxazol-4-yl)ethoxy]phenyl]propionic Acid], in Conscious Rats
Sheila M Gardiner, Derek J. R. Nunez, Philip G. Baer, Kathleen K. Brown and Terence Bennett

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1226-1233; DOI: https://doi.org/10.1124/jpet.104.068817

CELLULAR AND MOLECULAR

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Ligand Dependency of 5-Hydroxytryptamine 2C Receptor Internalization
Brian D. Schlag, Zhuangwei Lou, Myles Fennell and John Dunlop

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 865-870; DOI: https://doi.org/10.1124/jpet.104.067306
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In Vitro Internalization, Intracellular Transport, and Clearance of an Anti-CD11a Antibody (Raptiva) by Human T-Cells
G. P. Coffey, E. Stefanich, S. Palmieri, R. Eckert, J. Padilla-Eagar, P. J. Fielder and S. Pippig

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 896-904; DOI: https://doi.org/10.1124/jpet.104.067611
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Protein Cross-Linkage Induced by Formaldehyde Derived from Semicarbazide-Sensitive Amine Oxidase-Mediated Deamination of Methylamine
Diana Gubisne-Haberle, Wayne Hill, Mychaylo Kazachkov, J. Steven Richardson and Peter H. Yu

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1125-1132; DOI: https://doi.org/10.1124/jpet.104.068601
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Functional Selectivity of Muscarinic Receptor Antagonists for Inhibition of M₃-Mediated Phosphoinositide Responses in Guinea Pig Urinary Bladder and Submandibular Salivary Gland
Carl P. Nelson, Paul Gupta, Carolyn M. Napier, Stefan R. Nahorski and R. A. John Challiss

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1255-1265; DOI: https://doi.org/10.1124/jpet.104.067140
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Fenofibrate, Troglitazone, and 15-Deoxy-Δ^12,14-prostaglandin J₂ Close K_ATP Channels and Induce Insulin Secretion
Kenju Shimomura, Hiroyuki Shimizu, Mizuho Ikeda, Shuichi Okada, Masafumi Kakei, Shigeji Matsumoto and Masatomo Mori

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1273-1280; DOI: https://doi.org/10.1124/jpet.104.067249
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IC101 Induces Apoptosis by Akt Dephosphorylation via an Inhibition of Heat Shock Protein 90-ATP Binding Activity Accompanied by Preventing the Interaction with Akt in L1210 Cells
Hironori Fujiwara, Tohru Yamakuni, Mitsuhiro Ueno, Masaaki Ishizuka, Takashi Shinkawa, Toshiaki Isobe and Yasushi Ohizumi

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1288-1295; DOI: https://doi.org/10.1124/jpet.104.065979

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine 7-[{Dimethylcarbamoyl}oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH₂-Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-_XL
Margaret M. Mc Gee, Lisa M. Greene, Susan Ledwidge, Giuseppe Campiani, Vito Nacci, Mark Lawler, D. Clive Williams and Daniela M. Zisterer

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1084-1095; DOI: https://doi.org/10.1124/jpet.104.067561

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Development of Bombesin Analogs with Conformationally Restricted Amino Acid Substitutions with Enhanced Selectivity for the Orphan Receptor Human Bombesin Receptor Subtype 3
Samuel A. Mantey, David H. Coy, Laurence K. Entsuah and Robert T. Jensen

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1161-1170; DOI: https://doi.org/10.1124/jpet.104.066761
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Inhibition of Bladder Activity by 5-Hydroxytryptamine₁ Serotonin Receptor Agonists in Cats with Chronic Spinal Cord Injury
Baojun Gu, Kenneth J. Olejar, Jerome P. Reiter, Karl B. Thor and Paul C. Dolber

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1266-1272; DOI: https://doi.org/10.1124/jpet.103.063842

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats
Cristina Banfi, Luigi Sironi, Grazia De Simoni, Paolo Gelosa, Simona Barcella, Carlo Perego, Elisabetta Gianazza, Uliano Guerrini, Elena Tremoli and Luciana Mussoni

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 890-895; DOI: https://doi.org/10.1124/jpet.104.067090
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The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation
Gwen S. Scott, Rhonda B. Kean, Tatiana Mikheeva, Marzena J. Fabis, Jon G. Mabley, Csaba Szabó and D. Craig Hooper

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1053-1061; DOI: https://doi.org/10.1124/jpet.103.063214
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Enhanced Anti-Inflammatory Potency of a Nitric Oxide-Releasing Derivative of Flunisolide: Role of Nuclear Factor-κB
John L. Wallace, Gianni Rizzo, Giuseppe Cirino, Piero Del Soldato and Stefano Fiorucci

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1096-1102; DOI: https://doi.org/10.1124/jpet.104.067850

NEUROPHARMACOLOGY

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Epileptogenesis Causes Acute and Chronic Increases in GABA_A Receptor Endocytosis That Contributes to the Induction and Maintenance of Seizures in the Hippocampal Culture Model of Acquired Epilepsy
Robert E. Blair, Sompong Sombati, David C. Lawrence, Brendan D. McCay and Robert J. DeLorenzo

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 871-880; DOI: https://doi.org/10.1124/jpet.104.068478
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SR147778 [5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a New Potent and Selective Antagonist of the CB1 Cannabinoid Receptor: Biochemical and Pharmacological Characterization
Murielle Rinaldi-Carmona, Francis Barth, Christian Congy, Serge Martinez, Didier Oustric, Alain Pério, Martine Poncelet, Jeanne Maruani, Michèle Arnone, Olivier Finance, Philippe Soubrié and Gérard Le Fur

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 905-914; DOI: https://doi.org/10.1124/jpet.104.067884
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Analysis of the Effects of Cannabinoids on Synaptic Transmission between Basket and Purkinje Cells in the Cerebellar Cortex of the Rat
Bela Szabo, Marta Than, David Thorn and Ilka Wallmichrath

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 915-925; DOI: https://doi.org/10.1124/jpet.104.066670
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Mechanism of Action of Galantamine on N-Methyl-d-Aspartate Receptors in Rat Cortical Neurons
Shigeki Moriguchi, William Marszalec, Xilong Zhao, Jay Z. Yeh and Toshio Narahashi

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 933-942; DOI: https://doi.org/10.1124/jpet.104.067603
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Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist
Kimberly E. Vanover, Scott C. Harvey, Thomas Son, Stefania Risso Bradley, Henriette Kold, Malath Makhay, Isaac Veinbergs, Tracy A. Spalding, David M. Weiner, Carl Magnus Andersson, Bo-Ragnar Tolf, Mark R. Brann, Uli Hacksell and Robert E. Davis

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 943-951; DOI: https://doi.org/10.1124/jpet.104.066688
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P2X Receptor Activation Elicits Transporter-Mediated Noradrenaline Release from Rat Hippocampal Slices
Lilla Papp, Tamás Balázsa, Attila Köfalvi, Ferenc Erdélyi, Gábor Szabó, E. Sylvester Vizi and Beáta Sperlágh

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 973-980; DOI: https://doi.org/10.1124/jpet.104.066712
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Isobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles
Yury Grabovsky and Ronald J. Tallarida

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 981-986; DOI: https://doi.org/10.1124/jpet.104.067264
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ITH4012 (Ethyl 5-Amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a Novel Acetylcholinesterase Inhibitor with “Calcium Promotor” and Neuroprotective Properties
Camilo Orozco, Cristobal de los Rios, Esperanza Arias, Rafael León, Antonio G. García, Jose L. Marco, Mercedes Villarroya and Manuela G. López

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 987-994; DOI: https://doi.org/10.1124/jpet.104.068189
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Chronic Antidepressant Treatment Causes a Selective Reduction of μ-Opioid Receptor Binding and Functional Coupling to G Proteins in the Amygdala of Fawn-Hooded Rats
Feng Chen and Andrew J. Lawrence

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1020-1026; DOI: https://doi.org/10.1124/jpet.104.068692
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Lobeline Analogs with Enhanced Affinity and Selectivity for Plasmalemma and Vesicular Monoamine Transporters
Dennis K. Miller, Peter A. Crooks, Guangrong Zheng, Vladimir P. Grinevich, Seth D. Norrholm and Linda P. Dwoskin

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1035-1045; DOI: https://doi.org/10.1124/jpet.104.068098
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An Engineered Cocaine Hydrolase Blunts and Reverses Cardiovascular Responses to Cocaine in Rats
Yang Gao and Stephen Brimijoin

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1046-1052; DOI: https://doi.org/10.1124/jpet.104.068122
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A New Poly(ADP-Ribose) Polymerase Inhibitor, FR261529 [2-(4-Chlorophenyl)-5-quinoxalinecarboxamide], Ameliorates Methamphetamine-Induced Dopaminergic Neurotoxicity in Mice
Akinori Iwashita, Kayoko Mihara, Syunji Yamazaki, Shigeru Matsuura, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1114-1124; DOI: https://doi.org/10.1124/jpet.104.068932
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Effects of Methamphetamine and Lobeline on Vesicular Monoamine and Dopamine Transporter-Mediated Dopamine Release in a Cotransfected Model System
Clare J. Wilhelm, Robert A. Johnson, Paul G. Lysko, Amy J. Eshleman and Aaron Janowsky

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1142-1151; DOI: https://doi.org/10.1124/jpet.104.067314
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Differential Effects of Endogenous and Synthetic Cannabinoids on α₇-Nicotinic Acetylcholine Receptor-Mediated Responses in Xenopus Oocytes
Murat Oz, Li Zhang, Arippa Ravindran, Marisela Morales and Carl R. Lupica

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1152-1160; DOI: https://doi.org/10.1124/jpet.104.067751
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Brain-Derived Tumor Necrosis Factor-α and Its Involvement in Noradrenergic Neuron Functioning Involved in the Mechanism of Action of an Antidepressant
Jessica L. Reynolds, Tracey A. Ignatowski, Reeteka Sud and Robert N. Spengler

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1216-1225; DOI: https://doi.org/10.1124/jpet.104.067835
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Altered Pharmacology of Synaptic and Extrasynaptic GABA_A Receptors on CA1 Hippocampal Neurons Is Consistent with Subunit Changes in a Model of Alcohol Withdrawal and Dependence
Jing Liang, Elisabetta Cagetti, Richard W. Olsen and Igor Spigelman

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1234-1245; DOI: https://doi.org/10.1124/jpet.104.067983

TOXICOLOGY

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Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung
Andrea C. Simmonds, Burhan I. Ghanayem, Ashish Sharma, Christopher A. Reilly, Brandie Millen, Garold S. Yost and Poh-Gek Forkert

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 855-864; DOI: https://doi.org/10.1124/jpet.104.068171
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Botulinum Toxin Type A Targets RhoB to Inhibit Lysophosphatidic Acid-Stimulated Actin Reorganization and Acetylcholine Release in Nerve Growth Factor-Treated PC12 Cells
Hiroshi Ishida, Xieping Zhang, Kelly Erickson and Prabhati Ray

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 881-889; DOI: https://doi.org/10.1124/jpet.104.065318
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Strong Protein Adduct Trapping Accompanies Abolition of Acrolein-Mediated Hepatotoxicity by Hydralazine in Mice
Lisa M. Kaminskas, Simon M. Pyke and Philip C. Burcham

Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1003-1010; DOI: https://doi.org/10.1124/jpet.104.067330

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Table of Contents

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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