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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2004; Volume 310,Issue 3

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    CYP2C44, a New Murine CYP2C That Metabolizes Arachidonic Acid to Unique Stereospecific Products
    Tracy C. DeLozier, Cheng-Chung Tsao, Sherry J. Coulter, Julie Foley, J. Alyce Bradbury, Darryl C. Zeldin and Joyce A. Goldstein
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 845-854; DOI: https://doi.org/10.1124/jpet.104.067819
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    Metabolism of N,N′,N″-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms
    Erin Harleton, Marie Webster, Namandjé N. Bumpus, Ute M. Kent, James M. Rae and Paul F. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1011-1019; DOI: https://doi.org/10.1124/jpet.104.069112
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    Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6
    Zeruesenay Desta, Bryan A. Ward, Nadia V. Soukhova and David A. Flockhart
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1062-1075; DOI: https://doi.org/10.1124/jpet.104.065607
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    Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Spin Probes in Mouse Blood
    Ken-ichiro Matsumoto, Murali C. Krishna and James B. Mitchell
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1076-1083; DOI: https://doi.org/10.1124/jpet.104.066647
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    Disposition of Flavonoids via Enteric Recycling: Enzyme-Transporter Coupling Affects Metabolism of Biochanin A and Formononetin and Excretion of Their Phase II Conjugates
    Xiaobin Jia, Jun Chen, Huimin Lin and Ming Hu
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1103-1113; DOI: https://doi.org/10.1124/jpet.104.068403
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    Multidrug Resistance Gene G1199A Polymorphism Alters Efflux Transport Activity of P-Glycoprotein
    Erica L. Woodahl, Ziping Yang, Tot Bui, Danny D. Shen and Rodney J. Y. Ho
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1199-1207; DOI: https://doi.org/10.1124/jpet.104.065383
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    Mentholated Cigarette Smoking Inhibits Nicotine Metabolism
    Neal L. Benowitz, Brenda Herrera and Peyton Jacob
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1208-1215; DOI: https://doi.org/10.1124/jpet.104.066902

BEHAVIORAL PHARMACOLOGY

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    Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines
    John F. Cryan, Peter H. Kelly, Frederique Chaperon, Conrad Gentsch, Cedric Mombereau, Kurt Lingenhoehl, Wolfgang Froestl, Bernhard Bettler, Klemens Kaupmann and Will P. J. M. Spooren
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 952-963; DOI: https://doi.org/10.1124/jpet.104.066753
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    Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2 Agonist, and Ovine CRF, a CRF1 Agonist, Differentially Alter Feeding and Motor Activity
    Eric P. Zorrilla, Lindsay E. Reinhardt, Glenn R. Valdez, Koki Inoue, Jean E. Rivier, Wylie W. Vale and George F. Koob
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1027-1034; DOI: https://doi.org/10.1124/jpet.104.068676
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    SL25.1131 [3(S),3a(S)-3-Methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a New, Reversible, and Mixed Inhibitor of Monoamine Oxidase-A and Monoamine Oxidase-B: Biochemical and Behavioral Profile
    N. Aubin, P. Barneoud, C. Carter, D. Caille, N. Sontag, C. Marc, J. Lolivier, A. Gardes, C. Perron, A. Le Kim, T. Charieras, M. Pandini, P. Burnier, F. Puech, S. Jegham, P. George, B. Scatton and O. Curet
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1171-1182; DOI: https://doi.org/10.1124/jpet.103.064782
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    Contribution of Serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2 Receptor Subtypes to the Hyperlocomotor Effects of Cocaine: Acute and Chronic Pharmacological Analyses
    Malgorzata Filip, Marcy J. Bubar and Kathryn A. Cunningham
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1246-1254; DOI: https://doi.org/10.1124/jpet.104.068841
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    Ethologically Based Resolution of D2-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background
    Rachel E. Nally, Anthony Kinsella, Orna Tighe, David T. Croke, Allen A. Fienberg, Paul Greengard and John L. Waddington
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1281-1287; DOI: https://doi.org/10.1124/jpet.104.068957

CARDIOVASCULAR

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    Flavonoids from Artichoke (Cynara scolymus L.) Up-Regulate Endothelial-Type Nitric-Oxide Synthase Gene Expression in Human Endothelial Cells
    Huige Li, Ning Xia, Isolde Brausch, Ying Yao and Ulrich Förstermann
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 926-932; DOI: https://doi.org/10.1124/jpet.104.066639
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    Effect of BM-573 [N-Terbutyl-N′-[2-(4′-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist, in a Porcine Model of Acute Pulmonary Embolism
    Alexandre Ghuysen, Bernard Lambermont, Jean-Michel Dogné, Philippe Kolh, Vincent Tchana-Sato, Philippe Morimont, David Magis, Julien Hanson, Patrick Segers and Vincent D'Orio
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 964-972; DOI: https://doi.org/10.1124/jpet.104.066852
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    Identification of α-1L Adrenoceptor in Rabbit Ear Artery
    Yasuko Hiraizumi-Hiraoka, Takashi Tanaka, Hatsumi Yamamoto, Fumiko Suzuki and Ikunobu Muramatsu
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 995-1002; DOI: https://doi.org/10.1124/jpet.104.066985
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    The Distinct Alterations Produced in Cardiovascular Functions by Prednisolone and Nitro-prednisolone (NCX-1015) in the Rat Highlight a Causal Role for Endothelin-1
    Clara Di Filippo, Francesco Rossi, Ennio Ongini, Piero Del Soldato, Mauro Perretti and Michele D'Amico
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1133-1141; DOI: https://doi.org/10.1124/jpet.104.068726
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    Low Sodium Modifies the Vascular Effects of Angiotensin-Converting Enzyme Inhibitor Therapy in Healthy Rats
    Menno J. A. Kocks, Simone Gschwend, Dick de Zeeuw, Gerjan Navis and Hendrik Buikema
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1183-1189; DOI: https://doi.org/10.1124/jpet.104.067272
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    The Adenosine Transporter, mENT1, Is a Target for Adenosine Receptor Signaling and Protein Kinase Cϵ in Hypoxic and Pharmacological Preconditioning in the Mouse Cardiomyocyte Cell Line, HL-1
    Naz Chaudary, Zlatina Naydenova, Irina Shuralyova and Imogen R. Coe
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1190-1198; DOI: https://doi.org/10.1124/jpet.104.067157
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    Regional Hemodynamic Effects of the N-(2-Benzoylphenyl)-l-tyrosine Peroxisome Proliferator-Activated Receptor-γ Ligand, GI 262570 [(S)-2-(2-Benzoylphenylamino)-3-[4-[2-(5-methyl-2-phenyl-2-oxazol-4-yl)ethoxy]phenyl]propionic Acid], in Conscious Rats
    Sheila M Gardiner, Derek J. R. Nunez, Philip G. Baer, Kathleen K. Brown and Terence Bennett
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1226-1233; DOI: https://doi.org/10.1124/jpet.104.068817

CELLULAR AND MOLECULAR

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    Ligand Dependency of 5-Hydroxytryptamine 2C Receptor Internalization
    Brian D. Schlag, Zhuangwei Lou, Myles Fennell and John Dunlop
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 865-870; DOI: https://doi.org/10.1124/jpet.104.067306
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    In Vitro Internalization, Intracellular Transport, and Clearance of an Anti-CD11a Antibody (Raptiva) by Human T-Cells
    G. P. Coffey, E. Stefanich, S. Palmieri, R. Eckert, J. Padilla-Eagar, P. J. Fielder and S. Pippig
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 896-904; DOI: https://doi.org/10.1124/jpet.104.067611
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    Protein Cross-Linkage Induced by Formaldehyde Derived from Semicarbazide-Sensitive Amine Oxidase-Mediated Deamination of Methylamine
    Diana Gubisne-Haberle, Wayne Hill, Mychaylo Kazachkov, J. Steven Richardson and Peter H. Yu
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1125-1132; DOI: https://doi.org/10.1124/jpet.104.068601
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    Functional Selectivity of Muscarinic Receptor Antagonists for Inhibition of M3-Mediated Phosphoinositide Responses in Guinea Pig Urinary Bladder and Submandibular Salivary Gland
    Carl P. Nelson, Paul Gupta, Carolyn M. Napier, Stefan R. Nahorski and R. A. John Challiss
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1255-1265; DOI: https://doi.org/10.1124/jpet.104.067140
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    Fenofibrate, Troglitazone, and 15-Deoxy-Δ12,14-prostaglandin J2 Close KATP Channels and Induce Insulin Secretion
    Kenju Shimomura, Hiroyuki Shimizu, Mizuho Ikeda, Shuichi Okada, Masafumi Kakei, Shigeji Matsumoto and Masatomo Mori
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1273-1280; DOI: https://doi.org/10.1124/jpet.104.067249
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    IC101 Induces Apoptosis by Akt Dephosphorylation via an Inhibition of Heat Shock Protein 90-ATP Binding Activity Accompanied by Preventing the Interaction with Akt in L1210 Cells
    Hironori Fujiwara, Tohru Yamakuni, Mitsuhiro Ueno, Masaaki Ishizuka, Takashi Shinkawa, Toshiaki Isobe and Yasushi Ohizumi
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1288-1295; DOI: https://doi.org/10.1124/jpet.104.065979

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine 7-[{Dimethylcarbamoyl}oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH2-Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-XL
    Margaret M. Mc Gee, Lisa M. Greene, Susan Ledwidge, Giuseppe Campiani, Vito Nacci, Mark Lawler, D. Clive Williams and Daniela M. Zisterer
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1084-1095; DOI: https://doi.org/10.1124/jpet.104.067561

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Development of Bombesin Analogs with Conformationally Restricted Amino Acid Substitutions with Enhanced Selectivity for the Orphan Receptor Human Bombesin Receptor Subtype 3
    Samuel A. Mantey, David H. Coy, Laurence K. Entsuah and Robert T. Jensen
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1161-1170; DOI: https://doi.org/10.1124/jpet.104.066761
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    Inhibition of Bladder Activity by 5-Hydroxytryptamine1 Serotonin Receptor Agonists in Cats with Chronic Spinal Cord Injury
    Baojun Gu, Kenneth J. Olejar, Jerome P. Reiter, Karl B. Thor and Paul C. Dolber
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1266-1272; DOI: https://doi.org/10.1124/jpet.103.063842

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats
    Cristina Banfi, Luigi Sironi, Grazia De Simoni, Paolo Gelosa, Simona Barcella, Carlo Perego, Elisabetta Gianazza, Uliano Guerrini, Elena Tremoli and Luciana Mussoni
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 890-895; DOI: https://doi.org/10.1124/jpet.104.067090
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    The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation
    Gwen S. Scott, Rhonda B. Kean, Tatiana Mikheeva, Marzena J. Fabis, Jon G. Mabley, Csaba Szabó and D. Craig Hooper
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1053-1061; DOI: https://doi.org/10.1124/jpet.103.063214
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    Enhanced Anti-Inflammatory Potency of a Nitric Oxide-Releasing Derivative of Flunisolide: Role of Nuclear Factor-κB
    John L. Wallace, Gianni Rizzo, Giuseppe Cirino, Piero Del Soldato and Stefano Fiorucci
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1096-1102; DOI: https://doi.org/10.1124/jpet.104.067850

NEUROPHARMACOLOGY

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    Epileptogenesis Causes Acute and Chronic Increases in GABAA Receptor Endocytosis That Contributes to the Induction and Maintenance of Seizures in the Hippocampal Culture Model of Acquired Epilepsy
    Robert E. Blair, Sompong Sombati, David C. Lawrence, Brendan D. McCay and Robert J. DeLorenzo
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 871-880; DOI: https://doi.org/10.1124/jpet.104.068478
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    SR147778 [5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a New Potent and Selective Antagonist of the CB1 Cannabinoid Receptor: Biochemical and Pharmacological Characterization
    Murielle Rinaldi-Carmona, Francis Barth, Christian Congy, Serge Martinez, Didier Oustric, Alain Pério, Martine Poncelet, Jeanne Maruani, Michèle Arnone, Olivier Finance, Philippe Soubrié and Gérard Le Fur
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 905-914; DOI: https://doi.org/10.1124/jpet.104.067884
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    Analysis of the Effects of Cannabinoids on Synaptic Transmission between Basket and Purkinje Cells in the Cerebellar Cortex of the Rat
    Bela Szabo, Marta Than, David Thorn and Ilka Wallmichrath
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 915-925; DOI: https://doi.org/10.1124/jpet.104.066670
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    Mechanism of Action of Galantamine on N-Methyl-d-Aspartate Receptors in Rat Cortical Neurons
    Shigeki Moriguchi, William Marszalec, Xilong Zhao, Jay Z. Yeh and Toshio Narahashi
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 933-942; DOI: https://doi.org/10.1124/jpet.104.067603
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    Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist
    Kimberly E. Vanover, Scott C. Harvey, Thomas Son, Stefania Risso Bradley, Henriette Kold, Malath Makhay, Isaac Veinbergs, Tracy A. Spalding, David M. Weiner, Carl Magnus Andersson, Bo-Ragnar Tolf, Mark R. Brann, Uli Hacksell and Robert E. Davis
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 943-951; DOI: https://doi.org/10.1124/jpet.104.066688
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    P2X Receptor Activation Elicits Transporter-Mediated Noradrenaline Release from Rat Hippocampal Slices
    Lilla Papp, Tamás Balázsa, Attila Köfalvi, Ferenc Erdélyi, Gábor Szabó, E. Sylvester Vizi and Beáta Sperlágh
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 973-980; DOI: https://doi.org/10.1124/jpet.104.066712
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    Isobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles
    Yury Grabovsky and Ronald J. Tallarida
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 981-986; DOI: https://doi.org/10.1124/jpet.104.067264
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    ITH4012 (Ethyl 5-Amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a Novel Acetylcholinesterase Inhibitor with “Calcium Promotor” and Neuroprotective Properties
    Camilo Orozco, Cristobal de los Rios, Esperanza Arias, Rafael León, Antonio G. García, Jose L. Marco, Mercedes Villarroya and Manuela G. López
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 987-994; DOI: https://doi.org/10.1124/jpet.104.068189
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    Chronic Antidepressant Treatment Causes a Selective Reduction of μ-Opioid Receptor Binding and Functional Coupling to G Proteins in the Amygdala of Fawn-Hooded Rats
    Feng Chen and Andrew J. Lawrence
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1020-1026; DOI: https://doi.org/10.1124/jpet.104.068692
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    Lobeline Analogs with Enhanced Affinity and Selectivity for Plasmalemma and Vesicular Monoamine Transporters
    Dennis K. Miller, Peter A. Crooks, Guangrong Zheng, Vladimir P. Grinevich, Seth D. Norrholm and Linda P. Dwoskin
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1035-1045; DOI: https://doi.org/10.1124/jpet.104.068098
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    An Engineered Cocaine Hydrolase Blunts and Reverses Cardiovascular Responses to Cocaine in Rats
    Yang Gao and Stephen Brimijoin
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1046-1052; DOI: https://doi.org/10.1124/jpet.104.068122
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    A New Poly(ADP-Ribose) Polymerase Inhibitor, FR261529 [2-(4-Chlorophenyl)-5-quinoxalinecarboxamide], Ameliorates Methamphetamine-Induced Dopaminergic Neurotoxicity in Mice
    Akinori Iwashita, Kayoko Mihara, Syunji Yamazaki, Shigeru Matsuura, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1114-1124; DOI: https://doi.org/10.1124/jpet.104.068932
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    Effects of Methamphetamine and Lobeline on Vesicular Monoamine and Dopamine Transporter-Mediated Dopamine Release in a Cotransfected Model System
    Clare J. Wilhelm, Robert A. Johnson, Paul G. Lysko, Amy J. Eshleman and Aaron Janowsky
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1142-1151; DOI: https://doi.org/10.1124/jpet.104.067314
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    Differential Effects of Endogenous and Synthetic Cannabinoids on α7-Nicotinic Acetylcholine Receptor-Mediated Responses in Xenopus Oocytes
    Murat Oz, Li Zhang, Arippa Ravindran, Marisela Morales and Carl R. Lupica
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1152-1160; DOI: https://doi.org/10.1124/jpet.104.067751
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    Brain-Derived Tumor Necrosis Factor-α and Its Involvement in Noradrenergic Neuron Functioning Involved in the Mechanism of Action of an Antidepressant
    Jessica L. Reynolds, Tracey A. Ignatowski, Reeteka Sud and Robert N. Spengler
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1216-1225; DOI: https://doi.org/10.1124/jpet.104.067835
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    Altered Pharmacology of Synaptic and Extrasynaptic GABAA Receptors on CA1 Hippocampal Neurons Is Consistent with Subunit Changes in a Model of Alcohol Withdrawal and Dependence
    Jing Liang, Elisabetta Cagetti, Richard W. Olsen and Igor Spigelman
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1234-1245; DOI: https://doi.org/10.1124/jpet.104.067983

TOXICOLOGY

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    Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung
    Andrea C. Simmonds, Burhan I. Ghanayem, Ashish Sharma, Christopher A. Reilly, Brandie Millen, Garold S. Yost and Poh-Gek Forkert
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 855-864; DOI: https://doi.org/10.1124/jpet.104.068171
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    Botulinum Toxin Type A Targets RhoB to Inhibit Lysophosphatidic Acid-Stimulated Actin Reorganization and Acetylcholine Release in Nerve Growth Factor-Treated PC12 Cells
    Hiroshi Ishida, Xieping Zhang, Kelly Erickson and Prabhati Ray
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 881-889; DOI: https://doi.org/10.1124/jpet.104.065318
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    Strong Protein Adduct Trapping Accompanies Abolition of Acrolein-Mediated Hepatotoxicity by Hydralazine in Mice
    Lisa M. Kaminskas, Simon M. Pyke and Philip C. Burcham
    Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1003-1010; DOI: https://doi.org/10.1124/jpet.104.067330
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Journal of Pharmacology and Experimental Therapeutics: 310 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 310, Issue 3
1 Sep 2004
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  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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