DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Kenneth J. Valenzano; Wendy Miller; Zhengming Chen; Shen Shan; Gregg Crumley; Sam F. Victory; Ellen Davies; Jin-Cheng Huang; Nezima Allie; Scott J. Nolan; Yakov Rotshteyn; Donald J. Kyle; Kevin Broglé

doi:10.1124/jpet.103.063313

Research ArticleNEUROPHARMACOLOGY

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé

Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

Kenneth J. Valenzano

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Wendy Miller

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Zhengming Chen

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Shen Shan

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Gregg Crumley

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Sam F. Victory

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Ellen Davies

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Jin-Cheng Huang

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Nezima Allie

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Scott J. Nolan

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Yakov Rotshteyn

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Donald J. Kyle

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Kevin Broglé

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Journal of Pharmacology and Experimental Therapeutics

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Research ArticleNEUROPHARMACOLOGY

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

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Research ArticleNEUROPHARMACOLOGY

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

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DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

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DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

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