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Research ArticleNEUROPHARMACOLOGY

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

Article Information

vol. 310 no. 2 783-792
DOI 
https://doi.org/10.1124/jpet.103.063313
PubMed 
15054115
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Accepted March 29, 2004
  • Received December 15, 2003
  • Published online July 16, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kenneth J. Valenzano,
  2. Wendy Miller,
  3. Zhengming Chen,
  4. Shen Shan,
  5. Gregg Crumley,
  6. Sam F. Victory,
  7. Ellen Davies,
  8. Jin-Cheng Huang,
  9. Nezima Allie,
  10. Scott J. Nolan,
  11. Yakov Rotshteyn,
  12. Donald J. Kyle and
  13. Kevin Broglé
  1. Departments of Molecular Pharmacology (K.J.V., W.M., S.S., G.C.) and Computational, Combinatorial, and Medicinal Chemistry (Z.C., S.F.V., E.D., J.-C.H., D.J.K., K.B.), Purdue Pharma Discovery Research, Cranbury, New Jersey; and Discovery Support, Purdue Pharma, Ardsley, New York (N.A., S.J.N., Y.R.)
  1. Address correspondence to:
    Kenneth J. Valenzano, 6 Cedarbrook Drive, Cranbury, NJ 08512. E-mail: ken.valenzano{at}pharma.com
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Research ArticleNEUROPHARMACOLOGY

DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313
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