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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers

Ragini Vuppugalla and Reza Mehvar
Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 718-727; DOI: https://doi.org/10.1124/jpet.104.065557
Ragini Vuppugalla
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Reza Mehvar
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Article Information

vol. 310 no. 2 718-727
DOI 
https://doi.org/10.1124/jpet.104.065557
PubMed 
15051803

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 18, 2004
  • Accepted March 26, 2004
  • Published online July 16, 2004.

Article Versions

  • Earlier version (March 29, 2004 - 13:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ragini Vuppugalla and
  2. Reza Mehvar
  1. School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas
  1. Address correspondence to:
    Dr. Reza Mehvar, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S. Coulter, Amarillo, TX 79106. E-Mail: reza.mehvar{at}ttuhsc.edu
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Journal of Pharmacology and Experimental Therapeutics: 310 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 310, Issue 2
1 Aug 2004
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers

Ragini Vuppugalla and Reza Mehvar
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 718-727; DOI: https://doi.org/10.1124/jpet.104.065557

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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers

Ragini Vuppugalla and Reza Mehvar
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 718-727; DOI: https://doi.org/10.1124/jpet.104.065557
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