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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice

Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201
Hiroyuki Sasabe
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Yukio Kato
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Takashi Suzuki
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Minoru Itose
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Gohachiro Miyamoto
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Yuichi Sugiyama
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Article Information

vol. 310 no. 2 648-655
DOI 
https://doi.org/10.1124/jpet.104.065201
PubMed 
15131241

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 14, 2004
  • Accepted April 30, 2004
  • Published online July 16, 2004.

Article Versions

  • Earlier version (May 6, 2004 - 13:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hiroyuki Sasabe,
  2. Yukio Kato,
  3. Takashi Suzuki,
  4. Minoru Itose,
  5. Gohachiro Miyamoto and
  6. Yuichi Sugiyama
  1. Department of Drug Metabolism, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan (H.S., T.S., M.I., G.M.); Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan (Y.K., Y.S.); and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation (Y.K., Y.S.)
  1. Address correspondence to:
    Prof. Yuichi Sugiyama, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Journal of Pharmacology and Experimental Therapeutics: 310 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 310, Issue 2
1 Aug 2004
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice

Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201

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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice

Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201
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