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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor

Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329
Dan E. Brobst
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Xunshan Ding
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Katrina L. Creech
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Bryan Goodwin
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Brian Kelley
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Jeff L. Staudinger
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Article Information

vol. 310 no. 2 528-535
DOI 
https://doi.org/10.1124/jpet.103.064329
PubMed 
15075359

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 12, 2003
  • Accepted April 1, 2004
  • Published online July 16, 2004.

Article Versions

  • Earlier version (April 1, 2004 - 13:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Dan E. Brobst,
  2. Xunshan Ding,
  3. Katrina L. Creech,
  4. Bryan Goodwin,
  5. Brian Kelley and
  6. Jeff L. Staudinger
  1. Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas (D.E.B., X.D., B.K., J.L.S.); and Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina (K.L.C., B.G.)
  1. Address correspondence to:
    Dr. Jeff L. Staudinger, Department of Pharmacology and Toxicology, University of Kansas, 5046 Malott Hall, Lawrence, KS 66045. E-mail: stauding{at}ku.edu
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Journal of Pharmacology and Experimental Therapeutics: 310 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 310, Issue 2
1 Aug 2004
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor

Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329

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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor

Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329
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