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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1

Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

Article Information

vol. 310 no. 2 469-476
DOI 
https://doi.org/10.1124/jpet.104.067116
PubMed 
15082749
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 17, 2004
  • Accepted April 8, 2004
  • Published online July 16, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zejin Sun,
  2. Daryl J. Murry,
  3. Sonal P. Sanghani,
  4. Wilhelmina I. Davis,
  5. Natalia Y. Kedishvili,
  6. Qin Zou,
  7. Thomas D. Hurley and
  8. William F. Bosron
  1. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (Z.S., S.P.S., W.I.D., N.Y.K., Q.Z., T.D.H., W.F.B.); and Clinical and Administrative Pharmacy, University of Iowa College of Pharmacy, Iowa City, Iowa (D.J.M.)
  1. Address correspondence to:
    Dr. William F. Bosron, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 1345 W 16th St., L3–304, Indianapolis, IN 46202-2111. E-mail: wbosron{at}iupui.edu
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1

Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
Journal of Pharmacology and Experimental Therapeutics August 1, 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116
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