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Index by author

August 01, 2004; Volume 310,Issue 2

A

  1. Abbruscato, Thomas J.

    1. Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter through Phosphorylation during in Vitro Stroke Conditions and Nicotine Exposure
      Thomas J. Abbruscato, Steve P. Lopez, Karen Roder and Jennifer R. Paulson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 459-468; DOI: https://doi.org/10.1124/jpet.104.066274

  2. Abdelmegeed, Mohamed A.

    1. Acetoacetate Activation of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in Primary Cultured Rat Hepatocytes: Role of Oxidative Stress
      Mohamed A. Abdelmegeed, Sang K. Kim, Kimberley J. Woodcroft and Raymond F. Novak
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 728-736; DOI: https://doi.org/10.1124/jpet.104.066522

  3. Al-Rohaimi, Abdul

    1. UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
      Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke and David J. Greenblatt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 656-665; DOI: https://doi.org/10.1124/jpet.104.067660

  4. Allie, Nezima

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  5. Allouche, S.

    1. Different Regulation of Human δ-Opioid Receptors by SNC-80 [(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Endogenous Enkephalins
      I. Lecoq, N. Marie, Ph. Jauzac and S. Allouche
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 666-677; DOI: https://doi.org/10.1124/jpet.103.063958

  6. Antony, Smitha

    1. ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
      Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey and Yves Pommier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 836-842; DOI: https://doi.org/10.1124/jpet.103.063149

  7. Antzelevitch, Charles

    1. Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
      Lin Wu, John C. Shryock, Yejia Song, Yuan Li, Charles Antzelevitch and Luiz Belardinelli
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 599-605; DOI: https://doi.org/10.1124/jpet.104.066100

  8. Apparsundaram, Subbu

    1. Regulation of Choline Transporter Surface Expression and Phosphorylation by Protein Kinase C and Protein Phosphatase 1/2A
      Jeremiah Gates, Shawn M. Ferguson, Randy D. Blakely and Subbu Apparsundaram
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 536-545; DOI: https://doi.org/10.1124/jpet.104.066795

  9. Avery, Stephen E.

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  10. Azzarano, Leonard M.

    1. Preclinical Pharmacokinetic Properties of the P-Glycoprotein Inhibitor GF120918A (HCl salt of GF120918, 9,10-Dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the Mouse, Rat, Dog, and Monkey
      Keith W. Ward and Leonard M. Azzarano
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 703-709; DOI: https://doi.org/10.1124/jpet.104.068288

B

  1. Bacac, Marina

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  2. Baguley, Bruce C.

    1. Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
      Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell and Lai-Ming Ching
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 571-577; DOI: https://doi.org/10.1124/jpet.104.067793

  3. Barrios, Roberto

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  4. Bartus, Raymond T.

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  5. Basile, Anthony S.

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  6. Bates, Susan E.

    1. ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
      Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey and Yves Pommier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 836-842; DOI: https://doi.org/10.1124/jpet.103.063149

  7. Baudy, Reinhardt

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

  8. Bekaii-Saab, Tanios

    1. UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
      Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke and David J. Greenblatt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 656-665; DOI: https://doi.org/10.1124/jpet.104.067660

  9. Belardinelli, Luiz

    1. Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
      Lin Wu, John C. Shryock, Yejia Song, Yuan Li, Charles Antzelevitch and Luiz Belardinelli
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 599-605; DOI: https://doi.org/10.1124/jpet.104.066100

  10. Bermack, Jordanna E.

    1. Effects of the Potential Antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone Monomethanesulfonate] a Combined σ and 5-HT1A Ligand: Modulation of Neuronal Activity in the Dorsal Raphe Nucleus
      Jordanna E. Bermack, Nasser Haddjeri and Guy Debonnel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 578-583; DOI: https://doi.org/10.1124/jpet.104.066472

  11. Berti, Ferruccio

    1. The Nitric Oxide-Releasing Naproxen Derivative Displays Cardioprotection in Perfused Rabbit Heart Submitted to Ischemia-Reperfusion
      Giuseppe Rossoni, Barbara Manfredi, Piero Del Soldato and Ferruccio Berti
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 555-562; DOI: https://doi.org/10.1124/jpet.104.067397

  12. Bishop, Christopher

    1. Serotonin 5-HT2A Receptors Underlie Increased Motor Behaviors Induced in Dopamine-Depleted Rats by Intrastriatal 5-HT2A/2C Agonism
      Christopher Bishop, Jennifer L. Tessmer, Thomas Ullrich, Kenner C. Rice and Paul D. Walker
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 687-694; DOI: https://doi.org/10.1124/jpet.104.066365

  13. Bishop-Bailey, David

    1. Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues
      Timothy D. Warner, Ivana Vojnovic, Francesco Giuliano, Rosario Jiménez, David Bishop-Bailey and Jane A. Mitchell
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 642-647; DOI: https://doi.org/10.1124/jpet.103.063875

  14. Blakely, Randy D.

    1. Regulation of Choline Transporter Surface Expression and Phosphorylation by Protein Kinase C and Protein Phosphatase 1/2A
      Jeremiah Gates, Shawn M. Ferguson, Randy D. Blakely and Subbu Apparsundaram
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 536-545; DOI: https://doi.org/10.1124/jpet.104.066795

  15. Bock, Mark G.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  16. Boland, Bridget

    1. Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques
      Bridget Boland, Ching Yu Lin, Dexter Morin, Lisa Miller, Charles Plopper and Alan Buckpitt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 546-554; DOI: https://doi.org/10.1124/jpet.103.063669

  17. Bosron, William F.

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

  18. Bricout, H.

    1. Behavior of α-, β-, and γ-Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier
      V. Monnaert, S. Tilloy, H. Bricout, L. Fenart, R. Cecchelli and E. Monflier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 745-751; DOI: https://doi.org/10.1124/jpet.104.067512

  19. Brobst, Dan E.

    1. Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor
      Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329

  20. Broglé, Kevin

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  21. Broglé, Kevin C.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  22. Buckpitt, Alan

    1. Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques
      Bridget Boland, Ching Yu Lin, Dexter Morin, Lisa Miller, Charles Plopper and Alan Buckpitt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 546-554; DOI: https://doi.org/10.1124/jpet.103.063669

  23. Butcher, Heather L.

    1. Metallothionein Mediates the Level and Activity of Nuclear Factor ΚB in Murine Fibroblasts
      Heather L. Butcher, Wendy A. Kennette, Olga Collins, Rudolfs K. Zalups and James Koropatnick
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 589-598; DOI: https://doi.org/10.1124/jpet.104.066126

C

  1. Castellarin, Anna

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  2. Cecchelli, R.

    1. Behavior of α-, β-, and γ-Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier
      V. Monnaert, S. Tilloy, H. Bricout, L. Fenart, R. Cecchelli and E. Monflier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 745-751; DOI: https://doi.org/10.1124/jpet.104.067512

  3. Chang, Raymond S. L.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  4. Chen, Mai

    1. Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or κ-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
      Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu and Tak Ming Wong
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 606-613; DOI: https://doi.org/10.1124/jpet.104.067926

  5. Chen, Min

    1. Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor
      Chun-Yang Xiao, Min Chen, Zsuzsanna Zsengellér and Csaba Szabó
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 498-504; DOI: https://doi.org/10.1124/jpet.104.066803

  6. Chen, S. L.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  7. Chen, Tsing-Bau

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  8. Chen, Zhengming

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313
    2. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  9. Ching, Lai-Ming

    1. Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
      Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell and Lai-Ming Ching
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 571-577; DOI: https://doi.org/10.1124/jpet.104.067793

  10. Chiu, Doreen

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

  11. Claveau, D.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  12. Cocchietto, Moreno

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  13. Collins, Olga

    1. Metallothionein Mediates the Level and Activity of Nuclear Factor ΚB in Murine Fibroblasts
      Heather L. Butcher, Wendy A. Kennette, Olga Collins, Rudolfs K. Zalups and James Koropatnick
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 589-598; DOI: https://doi.org/10.1124/jpet.104.066126

  14. Colquhoun, Amy

    1. Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75NTR Interactions in the Presence of TrkA
      Amy Colquhoun, Gail M. Lawrance, Igor L. Shamovsky, Richard J. Riopelle and Gregory M. Ross
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 505-511; DOI: https://doi.org/10.1124/jpet.104.066225

  15. Cooper, Thomas

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  16. Couroucli, Xanthi I.

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  17. Court, Michael H.

    1. UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
      Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke and David J. Greenblatt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 656-665; DOI: https://doi.org/10.1124/jpet.104.067660

  18. Creech, Katrina L.

    1. Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor
      Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329

  19. Crumley, Gregg

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  20. Cunha, Fernando Q.

    1. Interleukin-18 Induces Mechanical Hypernociception in Rats via Endothelin Acting on ETB Receptors in a Morphine-Sensitive Manner
      Waldiceu A. Verri, Ieda R. S. Schivo, Thiago M. Cunha, Foo Y. Liew, Sergio H. Ferreira and Fernando Q. Cunha
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 710-717; DOI: https://doi.org/10.1124/jpet.103.063990

  21. Cunha, Thiago M.

    1. Interleukin-18 Induces Mechanical Hypernociception in Rats via Endothelin Acting on ETB Receptors in a Morphine-Sensitive Manner
      Waldiceu A. Verri, Ieda R. S. Schivo, Thiago M. Cunha, Foo Y. Liew, Sergio H. Ferreira and Fernando Q. Cunha
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 710-717; DOI: https://doi.org/10.1124/jpet.103.063990

D

  1. Daniel, Hannelore

    1. A Rapid in Vitro Screening for Delivery of Peptide-Derived Peptidase Inhibitors as Potential Drug Candidates via Epithelial Peptide Transporters
      Martin Foltz, Antje Meyer, Stephan Theis, Hans-Ulrich Demuth and Hannelore Daniel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 695-702; DOI: https://doi.org/10.1124/jpet.104.066480

  2. Davies, Ellen

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  3. Davis, Wilhelmina I.

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

  4. Debonnel, Guy

    1. Effects of the Potential Antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone Monomethanesulfonate] a Combined σ and 5-HT1A Ligand: Modulation of Neuronal Activity in the Dorsal Raphe Nucleus
      Jordanna E. Bermack, Nasser Haddjeri and Guy Debonnel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 578-583; DOI: https://doi.org/10.1124/jpet.104.066472

  5. Del Soldato, Piero

    1. The Nitric Oxide-Releasing Naproxen Derivative Displays Cardioprotection in Perfused Rabbit Heart Submitted to Ischemia-Reperfusion
      Giuseppe Rossoni, Barbara Manfredi, Piero Del Soldato and Ferruccio Berti
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 555-562; DOI: https://doi.org/10.1124/jpet.104.067397

  6. Demuth, Hans-Ulrich

    1. A Rapid in Vitro Screening for Delivery of Peptide-Derived Peptidase Inhibitors as Potential Drug Candidates via Epithelial Peptide Transporters
      Martin Foltz, Antje Meyer, Stephan Theis, Hans-Ulrich Demuth and Hannelore Daniel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 695-702; DOI: https://doi.org/10.1124/jpet.104.066480

  7. Denzer, Dirk

    1. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
      Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier and Frank Mauler
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 620-632; DOI: https://doi.org/10.1124/jpet.103.062836

  8. De Vry, Jean

    1. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
      Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier and Frank Mauler
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 620-632; DOI: https://doi.org/10.1124/jpet.103.062836

  9. Dickinson, Ronald G.

    1. Abolition of Valproate-Derived Choleresis in the Mrp2 Transporter-Deficient Rat
      Andrew W. E. Wright and Ronald G. Dickinson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 584-588; DOI: https://doi.org/10.1124/jpet.103.064220

  10. Ding, Xunshan

    1. Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor
      Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329

  11. DiPardo, Robert M.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  12. Dohi, Toshihiro

    1. Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP+)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP+ in PC12 Cells
      Norimitsu Morioka, Kei Kumagai, Katsuya Morita, Shigeo Kitayama and Toshihiro Dohi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 800-807; DOI: https://doi.org/10.1124/jpet.104.065300

E

  1. Eijckenboom, Maud

    1. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
      Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier and Frank Mauler
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 620-632; DOI: https://doi.org/10.1124/jpet.103.062836

  2. El-Ayoubi, Rouwayda

    1. Imidazoline Receptors but Not α2-Adrenoceptors Are Regulated in Spontaneously Hypertensive Rat Heart by Chronic Moxonidine Treatment
      Rouwayda El-Ayoubi, Ahmed Menaouar, Jolanta Gutkowska and Suhayla Mukaddam-Daher
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 446-451; DOI: https://doi.org/10.1124/jpet.104.067595

  3. Emerich, Dwaine

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

F

  1. Fenart, L.

    1. Behavior of α-, β-, and γ-Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier
      V. Monnaert, S. Tilloy, H. Bricout, L. Fenart, R. Cecchelli and E. Monflier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 745-751; DOI: https://doi.org/10.1124/jpet.104.067512

  2. Ferguson, Shawn M.

    1. Regulation of Choline Transporter Surface Expression and Phosphorylation by Protein Kinase C and Protein Phosphatase 1/2A
      Jeremiah Gates, Shawn M. Ferguson, Randy D. Blakely and Subbu Apparsundaram
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 536-545; DOI: https://doi.org/10.1124/jpet.104.066795

  3. Ferreira, Sergio H.

    1. Interleukin-18 Induces Mechanical Hypernociception in Rats via Endothelin Acting on ETB Receptors in a Morphine-Sensitive Manner
      Waldiceu A. Verri, Ieda R. S. Schivo, Thiago M. Cunha, Foo Y. Liew, Sergio H. Ferreira and Fernando Q. Cunha
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 710-717; DOI: https://doi.org/10.1124/jpet.103.063990

  4. Ferrier, Gregory R.

    1. Diminished Inotropic Response to Amrinone in Ventricular Myocytes from Myopathic Hamsters Is Linked to Depression of High-Gain Ca2+-Induced Ca2+ Release
      Wei Xiong, Gregory R. Ferrier and Susan E. Howlett
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 761-773; DOI: https://doi.org/10.1124/jpet.103.064873

  5. Foltz, Martin

    1. A Rapid in Vitro Screening for Delivery of Peptide-Derived Peptidase Inhibitors as Potential Drug Candidates via Epithelial Peptide Transporters
      Martin Foltz, Antje Meyer, Stephan Theis, Hans-Ulrich Demuth and Hannelore Daniel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 695-702; DOI: https://doi.org/10.1124/jpet.104.066480

  6. Fu, Dong-Jing

    1. Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro586
      Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton and Kathleen M. Hillgren
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 437-445; DOI: https://doi.org/10.1124/jpet.104.065912

  7. Fu, Karen

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

G

  1. Gates, Jeremiah

    1. Regulation of Choline Transporter Surface Expression and Phosphorylation by Protein Kinase C and Protein Phosphatase 1/2A
      Jeremiah Gates, Shawn M. Ferguson, Randy D. Blakely and Subbu Apparsundaram
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 536-545; DOI: https://doi.org/10.1124/jpet.104.066795

  2. Gava, Barbara

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  3. Gibson, Raymond E.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  4. Giuliano, Francesco

    1. Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues
      Timothy D. Warner, Ivana Vojnovic, Francesco Giuliano, Rosario Jiménez, David Bishop-Bailey and Jane A. Mitchell
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 642-647; DOI: https://doi.org/10.1124/jpet.103.063875

  5. Goodwin, Bryan

    1. Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor
      Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329

  6. Gould, Robert J.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  7. Green, A. Chris

    1. A Guinea Pig Hippocampal Slice Model of Organophosphate-Induced Seizure Activity
      Patrick K. Harrison, Robert D. Sheridan, A. Chris Green, Iain R. Scott and John E. H. Tattersall
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 678-686; DOI: https://doi.org/10.1124/jpet.104.065433

  8. Greenblatt, David J.

    1. UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
      Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke and David J. Greenblatt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 656-665; DOI: https://doi.org/10.1124/jpet.104.067660

  9. Gutkowska, Jolanta

    1. Imidazoline Receptors but Not α2-Adrenoceptors Are Regulated in Spontaneously Hypertensive Rat Heart by Chronic Moxonidine Treatment
      Rouwayda El-Ayoubi, Ahmed Menaouar, Jolanta Gutkowska and Suhayla Mukaddam-Daher
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 446-451; DOI: https://doi.org/10.1124/jpet.104.067595

H

  1. Haddjeri, Nasser

    1. Effects of the Potential Antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone Monomethanesulfonate] a Combined σ and 5-HT1A Ligand: Modulation of Neuronal Activity in the Dorsal Raphe Nucleus
      Jordanna E. Bermack, Nasser Haddjeri and Guy Debonnel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 578-583; DOI: https://doi.org/10.1124/jpet.104.066472

  2. Hao, Qin

    1. UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
      Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke and David J. Greenblatt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 656-665; DOI: https://doi.org/10.1124/jpet.104.067660

  3. Harrell, Charles M.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  4. Harrison, James E.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  5. Harrison, Patrick K.

    1. A Guinea Pig Hippocampal Slice Model of Organophosphate-Induced Seizure Activity
      Patrick K. Harrison, Robert D. Sheridan, A. Chris Green, Iain R. Scott and John E. H. Tattersall
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 678-686; DOI: https://doi.org/10.1124/jpet.104.065433

  6. Hattori, Kouji

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  7. Heil, Markus

    1. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
      Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier and Frank Mauler
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 620-632; DOI: https://doi.org/10.1124/jpet.103.062836

  8. Helsby, Nuala

    1. Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
      Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell and Lai-Ming Ching
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 571-577; DOI: https://doi.org/10.1124/jpet.104.067793

  9. Hess, J. Fred

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  10. Hey, Patricia J.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  11. Hillgren, Kathleen M.

    1. Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro586
      Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton and Kathleen M. Hillgren
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 437-445; DOI: https://doi.org/10.1124/jpet.104.065912

  12. Honma, Wataru

    1. Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism
      Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata and Yasushi Yamazoe
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 808-814; DOI: https://doi.org/10.1124/jpet.104.065532

  13. Howlett, Susan E.

    1. Diminished Inotropic Response to Amrinone in Ventricular Myocytes from Myopathic Hamsters Is Linked to Depression of High-Gain Ca2+-Induced Ca2+ Release
      Wei Xiong, Gregory R. Ferrier and Susan E. Howlett
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 761-773; DOI: https://doi.org/10.1124/jpet.103.064873

  14. Huang, Jin-Cheng

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  15. Huang, Z.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  16. Hurley, Thomas D.

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

I

  1. Inoue, Takashi

    1. Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
      Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki and Isao Tanaka
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 614-619; DOI: https://doi.org/10.1124/jpet.103.064964

  2. Ishida, Junya

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  3. Itose, Minoru

    1. Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
      Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201

  4. Iwashita, Akinori

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

J

  1. Jauzac, Ph.

    1. Different Regulation of Human δ-Opioid Receptors by SNC-80 [(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Endogenous Enkephalins
      I. Lecoq, N. Marie, Ph. Jauzac and S. Allouche
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 666-677; DOI: https://doi.org/10.1124/jpet.103.063958

  2. Jiang, Weiwu

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  3. Jiménez, Rosario

    1. Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues
      Timothy D. Warner, Ivana Vojnovic, Francesco Giuliano, Rosario Jiménez, David Bishop-Bailey and Jane A. Mitchell
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 642-647; DOI: https://doi.org/10.1124/jpet.103.063875

K

  1. Kam, Kenneth W. L.

    1. Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or κ-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
      Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu and Tak Ming Wong
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 606-613; DOI: https://doi.org/10.1124/jpet.104.067926

  2. Kamijo, Kazunori

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  3. Kamiyama, Yoshiteru

    1. Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism
      Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata and Yasushi Yamazoe
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 808-814; DOI: https://doi.org/10.1124/jpet.104.065532

  4. Kang, Walter S.

    1. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
      Walter S. Kang, Frank J. Tamarkin, Marcia A. Wheeler and Robert M. Weiss
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 452-458; DOI: https://doi.org/10.1124/jpet.104.066506

  5. Kato, Yukio

    1. Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
      Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201

  6. Kedishvili, Natalia Y.

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

  7. Kelley, Brian

    1. Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor
      Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329

  8. Kennette, Wendy A.

    1. Metallothionein Mediates the Level and Activity of Nuclear Factor ΚB in Murine Fibroblasts
      Heather L. Butcher, Wendy A. Kennette, Olga Collins, Rudolfs K. Zalups and James Koropatnick
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 589-598; DOI: https://doi.org/10.1124/jpet.104.066126

  9. Kestell, Philip

    1. Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
      Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell and Lai-Ming Ching
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 571-577; DOI: https://doi.org/10.1124/jpet.104.067793

  10. Kikuta, Kazuhiro

    1. A c-Jun NH2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells
      Atsushi Masamune, Kazuhiro Kikuta, Noriaki Suzuki, Masahiro Satoh, Kennichi Satoh and Tooru Shimosegawa
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 520-527; DOI: https://doi.org/10.1124/jpet.104.067280

  11. Kim, Sang K.

    1. Acetoacetate Activation of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in Primary Cultured Rat Hepatocytes: Role of Oxidative Stress
      Mohamed A. Abdelmegeed, Sang K. Kim, Kimberley J. Woodcroft and Raymond F. Novak
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 728-736; DOI: https://doi.org/10.1124/jpet.104.066522

  12. Kira, Kazunobu

    1. Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
      Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki and Isao Tanaka
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 614-619; DOI: https://doi.org/10.1124/jpet.103.064964

  13. Kitayama, Shigeo

    1. Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP+)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP+ in PC12 Cells
      Norimitsu Morioka, Kei Kumagai, Katsuya Morita, Shigeo Kitayama and Toshihiro Dohi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 800-807; DOI: https://doi.org/10.1124/jpet.104.065300

  14. Kohlhagen, Glenda

    1. ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
      Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey and Yves Pommier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 836-842; DOI: https://doi.org/10.1124/jpet.103.063149

  15. Kondraganti, Sudha R.

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  16. Koropatnick, James

    1. Metallothionein Mediates the Level and Activity of Nuclear Factor ΚB in Murine Fibroblasts
      Heather L. Butcher, Wendy A. Kennette, Olga Collins, Rudolfs K. Zalups and James Koropatnick
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 589-598; DOI: https://doi.org/10.1124/jpet.104.066126

  17. Kowal, Dianne

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

  18. Krishnaswamy, Soundararajan

    1. UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
      Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke and David J. Greenblatt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 656-665; DOI: https://doi.org/10.1124/jpet.104.067660

  19. Kumagai, Kei

    1. Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP+)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP+ in PC12 Cells
      Norimitsu Morioka, Kei Kumagai, Katsuya Morita, Shigeo Kitayama and Toshihiro Dohi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 800-807; DOI: https://doi.org/10.1124/jpet.104.065300

  20. Kwok, Yin Nam

    1. Role of Adenosine A1 Receptor in the Regulation of Gastrin Release
      Linda Yip, Henry Chi Hang Leung and Yin Nam Kwok
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 477-487; DOI: https://doi.org/10.1124/jpet.104.066654

  21. Kyle, Donald J.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

L

  1. Lafreniere, Denise

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  2. Lawrance, Gail M.

    1. Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75NTR Interactions in the Presence of TrkA
      Amy Colquhoun, Gail M. Lawrance, Igor L. Shamovsky, Richard J. Riopelle and Gregory M. Ross
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 505-511; DOI: https://doi.org/10.1124/jpet.104.066225

  3. Lecoq, I.

    1. Different Regulation of Human δ-Opioid Receptors by SNC-80 [(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Endogenous Enkephalins
      I. Lecoq, N. Marie, Ph. Jauzac and S. Allouche
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 666-677; DOI: https://doi.org/10.1124/jpet.103.063958

  4. Leung, Henry Chi Hang

    1. Role of Adenosine A1 Receptor in the Regulation of Gastrin Release
      Linda Yip, Henry Chi Hang Leung and Yin Nam Kwok
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 477-487; DOI: https://doi.org/10.1124/jpet.104.066654

  5. Lewis, Mark W.

    1. Inorganic Lead Exposure in the Rat Activates Striatal cFOS Expression at Lower Blood Levels and Inhibits Amphetamine-Induced cFOS Expression at Higher Blood Levels
      Mark W. Lewis and David K. Pitts
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 815-820; DOI: https://doi.org/10.1124/jpet.103.063941

  6. Li, Yuan

    1. Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
      Lin Wu, John C. Shryock, Yejia Song, Yuan Li, Charles Antzelevitch and Luiz Belardinelli
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 599-605; DOI: https://doi.org/10.1124/jpet.104.066100

  7. Liew, Foo Y.

    1. Interleukin-18 Induces Mechanical Hypernociception in Rats via Endothelin Acting on ETB Receptors in a Morphine-Sensitive Manner
      Waldiceu A. Verri, Ieda R. S. Schivo, Thiago M. Cunha, Foo Y. Liew, Sergio H. Ferreira and Fernando Q. Cunha
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 710-717; DOI: https://doi.org/10.1124/jpet.103.063990

  8. Lin, Ching Yu

    1. Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques
      Bridget Boland, Ching Yu Lin, Dexter Morin, Lisa Miller, Charles Plopper and Alan Buckpitt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 546-554; DOI: https://doi.org/10.1124/jpet.103.063669

  9. Lin, Stephen

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

  10. Lis, Edward

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  11. Liu, Jing

    1. Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or κ-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
      Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu and Tak Ming Wong
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 606-613; DOI: https://doi.org/10.1124/jpet.104.067926

  12. Liu, S.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  13. Lo, Ee-Sing

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  14. Lopez, Steve P.

    1. Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter through Phosphorylation during in Vitro Stroke Conditions and Nicotine Exposure
      Thomas J. Abbruscato, Steve P. Lopez, Karen Roder and Jennifer R. Paulson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 459-468; DOI: https://doi.org/10.1124/jpet.104.066274

  15. Lu, Jun

    1. Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
      Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell and Lai-Ming Ching
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 571-577; DOI: https://doi.org/10.1124/jpet.104.067793

M

  1. Maksymowych, Andrew B.

    1. Structural Features of the Botulinum Neurotoxin Molecule That Govern Binding and Transcytosis across Polarized Human Intestinal Epithelial Cells
      Andrew B. Maksymowych and Lance L. Simpson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 633-641; DOI: https://doi.org/10.1124/jpet.104.066845

  2. Mancini, J. A.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  3. Manfredi, Barbara

    1. The Nitric Oxide-Releasing Naproxen Derivative Displays Cardioprotection in Perfused Rabbit Heart Submitted to Ischemia-Reperfusion
      Giuseppe Rossoni, Barbara Manfredi, Piero Del Soldato and Ferruccio Berti
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 555-562; DOI: https://doi.org/10.1124/jpet.104.067397

  4. Marie, N.

    1. Different Regulation of Human δ-Opioid Receptors by SNC-80 [(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Endogenous Enkephalins
      I. Lecoq, N. Marie, Ph. Jauzac and S. Allouche
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 666-677; DOI: https://doi.org/10.1124/jpet.103.063958

  5. Mark, Lilly

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  6. Markowitz, M. Kristine

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  7. Masamune, Atsushi

    1. A c-Jun NH2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells
      Atsushi Masamune, Kazuhiro Kikuta, Noriaki Suzuki, Masahiro Satoh, Kennichi Satoh and Tooru Shimosegawa
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 520-527; DOI: https://doi.org/10.1124/jpet.104.067280

  8. Matsuoka, Nobuya

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  9. Matsuura, Shigeru

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  10. Mauler, Frank

    1. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
      Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier and Frank Mauler
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 620-632; DOI: https://doi.org/10.1124/jpet.103.062836

  11. Medina-Pérez, Wilma Y.

    1. ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
      Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey and Yves Pommier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 836-842; DOI: https://doi.org/10.1124/jpet.103.063149

  12. Mehvar, Reza

    1. Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers
      Ragini Vuppugalla and Reza Mehvar
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 718-727; DOI: https://doi.org/10.1124/jpet.104.065557

  13. Meier, Heinrich

    1. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
      Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier and Frank Mauler
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 620-632; DOI: https://doi.org/10.1124/jpet.103.062836

  14. Menaouar, Ahmed

    1. Imidazoline Receptors but Not α2-Adrenoceptors Are Regulated in Spontaneously Hypertensive Rat Heart by Chronic Moxonidine Treatment
      Rouwayda El-Ayoubi, Ahmed Menaouar, Jolanta Gutkowska and Suhayla Mukaddam-Daher
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 446-451; DOI: https://doi.org/10.1124/jpet.104.067595

  15. Meyer, Antje

    1. A Rapid in Vitro Screening for Delivery of Peptide-Derived Peptidase Inhibitors as Potential Drug Candidates via Epithelial Peptide Transporters
      Martin Foltz, Antje Meyer, Stephan Theis, Hans-Ulrich Demuth and Hannelore Daniel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 695-702; DOI: https://doi.org/10.1124/jpet.104.066480

  16. Miller, Lisa

    1. Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques
      Bridget Boland, Ching Yu Lin, Dexter Morin, Lisa Miller, Charles Plopper and Alan Buckpitt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 546-554; DOI: https://doi.org/10.1124/jpet.103.063669

  17. Miller, Patricia J.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  18. Miller, Wendy

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  19. Mitchell, Jane A.

    1. Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues
      Timothy D. Warner, Ivana Vojnovic, Francesco Giuliano, Rosario Jiménez, David Bishop-Bailey and Jane A. Mitchell
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 642-647; DOI: https://doi.org/10.1124/jpet.103.063875

  20. Miyamoto, Gohachiro

    1. Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
      Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201

  21. Monflier, E.

    1. Behavior of α-, β-, and γ-Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier
      V. Monnaert, S. Tilloy, H. Bricout, L. Fenart, R. Cecchelli and E. Monflier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 745-751; DOI: https://doi.org/10.1124/jpet.104.067512

  22. Monnaert, V.

    1. Behavior of α-, β-, and γ-Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier
      V. Monnaert, S. Tilloy, H. Bricout, L. Fenart, R. Cecchelli and E. Monflier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 745-751; DOI: https://doi.org/10.1124/jpet.104.067512

  23. Moorthy, Bhagavatula

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  24. Morin, Dexter

    1. Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques
      Bridget Boland, Ching Yu Lin, Dexter Morin, Lisa Miller, Charles Plopper and Alan Buckpitt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 546-554; DOI: https://doi.org/10.1124/jpet.103.063669

  25. Morioka, Norimitsu

    1. Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP+)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP+ in PC12 Cells
      Norimitsu Morioka, Kei Kumagai, Katsuya Morita, Shigeo Kitayama and Toshihiro Dohi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 800-807; DOI: https://doi.org/10.1124/jpet.104.065300

  26. Morita, Katsuya

    1. Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP+)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP+ in PC12 Cells
      Norimitsu Morioka, Kei Kumagai, Katsuya Morita, Shigeo Kitayama and Toshihiro Dohi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 800-807; DOI: https://doi.org/10.1124/jpet.104.065300

  27. Mukaddam-Daher, Suhayla

    1. Imidazoline Receptors but Not α2-Adrenoceptors Are Regulated in Spontaneously Hypertensive Rat Heart by Chronic Moxonidine Treatment
      Rouwayda El-Ayoubi, Ahmed Menaouar, Jolanta Gutkowska and Suhayla Mukaddam-Daher
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 446-451; DOI: https://doi.org/10.1124/jpet.104.067595

  28. Mukhopadhyay, Nitai

    1. Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro586
      Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton and Kathleen M. Hillgren
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 437-445; DOI: https://doi.org/10.1124/jpet.104.065912

  29. Muller, Daniella L.

    1. In Vivo Regulation of Extracellular Signal-Regulated Protein Kinase (ERK) and Protein Kinase B (Akt) Phosphorylation by Acute and Chronic Morphine
      Daniella L. Muller and Ellen M. Unterwald
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 774-782; DOI: https://doi.org/10.1124/jpet.104.066548

  30. Murphy, Kathryn L.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  31. Murry, Daryl J.

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

  32. Muthiah, Kathirvel

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  33. Mutoh, Seitaro

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

N

  1. Nadjem, Tim

    1. ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
      Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey and Yves Pommier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 836-842; DOI: https://doi.org/10.1124/jpet.103.063149

  2. Nagakura, Tadashi

    1. Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
      Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki and Isao Tanaka
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 614-619; DOI: https://doi.org/10.1124/jpet.103.064964

  3. Nagata, Kiyoshi

    1. Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism
      Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata and Yasushi Yamazoe
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 808-814; DOI: https://doi.org/10.1124/jpet.104.065532

  4. Nicholson, D. W.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  5. Nolan, Scott J.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  6. Novak, Leah

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  7. Novak, Raymond F.

    1. Acetoacetate Activation of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in Primary Cultured Rat Hepatocytes: Role of Oxidative Stress
      Mohamed A. Abdelmegeed, Sang K. Kim, Kimberley J. Woodcroft and Raymond F. Novak
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 728-736; DOI: https://doi.org/10.1124/jpet.104.066522

O

  1. O'Keefe, S.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  2. Ohno, Ryoko

    1. Induction of Small Intestinal Damage in Rats Following Combined Treatment with Cyclooxygenase-2 and Nitric-Oxide Synthase Inhibitors
      Ryoko Ohno, Aya Yokota, Akiko Tanaka and Koji Takeuchi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 821-827; DOI: https://doi.org/10.1124/jpet.104.065961

  3. Olney, John

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

P

  1. Pacor, Sabrina

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  2. Pak, Youngeen A.

    1. Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro586
      Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton and Kathleen M. Hillgren
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 437-445; DOI: https://doi.org/10.1124/jpet.104.065912

  3. Palmer, Brian D.

    1. Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
      Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell and Lai-Ming Ching
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 571-577; DOI: https://doi.org/10.1124/jpet.104.067793

  4. Paulson, Jennifer R.

    1. Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter through Phosphorylation during in Vitro Stroke Conditions and Nicotine Exposure
      Thomas J. Abbruscato, Steve P. Lopez, Karen Roder and Jennifer R. Paulson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 459-468; DOI: https://doi.org/10.1124/jpet.104.066274

  5. Pearson, Michelle S.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  6. Pettibone, Douglas J.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  7. Pitts, David K.

    1. Inorganic Lead Exposure in the Rat Activates Striatal cFOS Expression at Lower Blood Levels and Inhibits Amphetamine-Induced cFOS Expression at Higher Blood Levels
      Mark W. Lewis and David K. Pitts
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 815-820; DOI: https://doi.org/10.1124/jpet.103.063941

  8. Plopper, Charles

    1. Site-Specific Metabolism of Naphthalene and 1-Nitronaphthalene in Dissected Airways of Rhesus Macaques
      Bridget Boland, Ching Yu Lin, Dexter Morin, Lisa Miller, Charles Plopper and Alan Buckpitt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 546-554; DOI: https://doi.org/10.1124/jpet.103.063669

  9. Pommier, Yves

    1. ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
      Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey and Yves Pommier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 836-842; DOI: https://doi.org/10.1124/jpet.103.063149

  10. Pomonis, James D.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

R

  1. Ransom, Richard W.

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  2. Reiss, Duane

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  3. Reissmueller, Elke

    1. 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A Novel Cannabinoid CB1/CB2 Receptor Partial Agonist with Antihyperalgesic and Antiallodynic Effects
      Jean De Vry, Dirk Denzer, Elke Reissmueller, Maud Eijckenboom, Markus Heil, Heinrich Meier and Frank Mauler
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 620-632; DOI: https://doi.org/10.1124/jpet.103.062836

  4. Rice, Kenner C.

    1. Serotonin 5-HT2A Receptors Underlie Increased Motor Behaviors Induced in Dopamine-Depleted Rats by Intrastriatal 5-HT2A/2C Agonism
      Christopher Bishop, Jennifer L. Tessmer, Thomas Ullrich, Kenner C. Rice and Paul D. Walker
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 687-694; DOI: https://doi.org/10.1124/jpet.104.066365

  5. Riopelle, Richard J.

    1. Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75NTR Interactions in the Presence of TrkA
      Amy Colquhoun, Gail M. Lawrance, Igor L. Shamovsky, Richard J. Riopelle and Gregory M. Ross
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 505-511; DOI: https://doi.org/10.1124/jpet.104.066225

  6. Robey, Robert W.

    1. ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
      Susan E. Bates, Wilma Y. Medina-Pérez, Glenda Kohlhagen, Smitha Antony, Tim Nadjem, Robert W. Robey and Yves Pommier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 836-842; DOI: https://doi.org/10.1124/jpet.103.063149

  7. Roder, Karen

    1. Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter through Phosphorylation during in Vitro Stroke Conditions and Nicotine Exposure
      Thomas J. Abbruscato, Steve P. Lopez, Karen Roder and Jennifer R. Paulson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 459-468; DOI: https://doi.org/10.1124/jpet.104.066274

  8. Ross, Gregory M.

    1. Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75NTR Interactions in the Presence of TrkA
      Amy Colquhoun, Gail M. Lawrance, Igor L. Shamovsky, Richard J. Riopelle and Gregory M. Ross
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 505-511; DOI: https://doi.org/10.1124/jpet.104.066225

  9. Rossoni, Giuseppe

    1. The Nitric Oxide-Releasing Naproxen Derivative Displays Cardioprotection in Perfused Rabbit Heart Submitted to Ischemia-Reperfusion
      Giuseppe Rossoni, Barbara Manfredi, Piero Del Soldato and Ferruccio Berti
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 555-562; DOI: https://doi.org/10.1124/jpet.104.067397

  10. Rotshteyn, Yakov

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313
    2. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

S

  1. Saeki, Takao

    1. Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
      Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki and Isao Tanaka
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 614-619; DOI: https://doi.org/10.1124/jpet.103.064964

  2. Salzberg-Brenhouse, Heather

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  3. Sanghani, Sonal P.

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

  4. Sasabe, Hiroyuki

    1. Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
      Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201

  5. Satoh, Kennichi

    1. A c-Jun NH2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells
      Atsushi Masamune, Kazuhiro Kikuta, Noriaki Suzuki, Masahiro Satoh, Kennichi Satoh and Tooru Shimosegawa
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 520-527; DOI: https://doi.org/10.1124/jpet.104.067280

  6. Satoh, Masahiro

    1. A c-Jun NH2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells
      Atsushi Masamune, Kazuhiro Kikuta, Noriaki Suzuki, Masahiro Satoh, Kennichi Satoh and Tooru Shimosegawa
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 520-527; DOI: https://doi.org/10.1124/jpet.104.067280

  7. Sava, Gianni

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  8. Schivo, Ieda R. S.

    1. Interleukin-18 Induces Mechanical Hypernociception in Rats via Endothelin Acting on ETB Receptors in a Morphine-Sensitive Manner
      Waldiceu A. Verri, Ieda R. S. Schivo, Thiago M. Cunha, Foo Y. Liew, Sergio H. Ferreira and Fernando Q. Cunha
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 710-717; DOI: https://doi.org/10.1124/jpet.103.063990

  9. Scott, Iain R.

    1. A Guinea Pig Hippocampal Slice Model of Organophosphate-Induced Seizure Activity
      Patrick K. Harrison, Robert D. Sheridan, A. Chris Green, Iain R. Scott and John E. H. Tattersall
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 678-686; DOI: https://doi.org/10.1124/jpet.104.065433

  10. Shamovsky, Igor L.

    1. Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75NTR Interactions in the Presence of TrkA
      Amy Colquhoun, Gail M. Lawrance, Igor L. Shamovsky, Richard J. Riopelle and Gregory M. Ross
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 505-511; DOI: https://doi.org/10.1124/jpet.104.066225

  11. Shan, Shen

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  12. Sheridan, Robert D.

    1. A Guinea Pig Hippocampal Slice Model of Organophosphate-Induced Seizure Activity
      Patrick K. Harrison, Robert D. Sheridan, A. Chris Green, Iain R. Scott and John E. H. Tattersall
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 678-686; DOI: https://doi.org/10.1124/jpet.104.065433

  13. Shimada, Miki

    1. Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism
      Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata and Yasushi Yamazoe
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 808-814; DOI: https://doi.org/10.1124/jpet.104.065532

  14. Shimosegawa, Tooru

    1. A c-Jun NH2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells
      Atsushi Masamune, Kazuhiro Kikuta, Noriaki Suzuki, Masahiro Satoh, Kennichi Satoh and Tooru Shimosegawa
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 520-527; DOI: https://doi.org/10.1124/jpet.104.067280

  15. Shryock, John C.

    1. Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
      Lin Wu, John C. Shryock, Yejia Song, Yuan Li, Charles Antzelevitch and Luiz Belardinelli
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 599-605; DOI: https://doi.org/10.1124/jpet.104.066100

  16. Simon, Rachelle

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

  17. Simpson, Lance L.

    1. Structural Features of the Botulinum Neurotoxin Molecule That Govern Binding and Transcytosis across Polarized Human Intestinal Epithelial Cells
      Andrew B. Maksymowych and Lance L. Simpson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 633-641; DOI: https://doi.org/10.1124/jpet.104.066845

  18. Smeyne, Michelle

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

  19. Snodgrass-Belt, Pam

    1. A Pulmonary Formulation of l-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease
      Raymond T. Bartus, Dwaine Emerich, Pam Snodgrass-Belt, Karen Fu, Heather Salzberg-Brenhouse, Denise Lafreniere, Leah Novak, Ee-Sing Lo, Thomas Cooper and Anthony S. Basile
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 828-835; DOI: https://doi.org/10.1124/jpet.103.064121

  20. Song, Yejia

    1. Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
      Lin Wu, John C. Shryock, Yejia Song, Yuan Li, Charles Antzelevitch and Luiz Belardinelli
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 599-605; DOI: https://doi.org/10.1124/jpet.104.066100

  21. Staudinger, Jeff L.

    1. Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor
      Dan E. Brobst, Xunshan Ding, Katrina L. Creech, Bryan Goodwin, Brian Kelley and Jeff L. Staudinger
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 528-535; DOI: https://doi.org/10.1124/jpet.103.064329

  22. Stewart, Trent

    1. Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro586
      Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton and Kathleen M. Hillgren
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 437-445; DOI: https://doi.org/10.1124/jpet.104.065912

  23. Styhler, A.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  24. Su, Dai-Shi

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  25. Sugiyama, Yuichi

    1. Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
      Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201

  26. Sun, Lucy

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092

  27. Sun, Zejin

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

  28. Suzuki, Noriaki

    1. A c-Jun NH2-Terminal Kinase Inhibitor SP600125 (Anthra[1,9-cd]pyrazole-6 (2H)-one) Blocks Activation of Pancreatic Stellate Cells
      Atsushi Masamune, Kazuhiro Kikuta, Noriaki Suzuki, Masahiro Satoh, Kennichi Satoh and Tooru Shimosegawa
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 520-527; DOI: https://doi.org/10.1124/jpet.104.067280

  29. Suzuki, Takashi

    1. Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice
      Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 648-655; DOI: https://doi.org/10.1124/jpet.104.065201

  30. Szabó, Csaba

    1. Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor
      Chun-Yang Xiao, Min Chen, Zsuzsanna Zsengellér and Csaba Szabó
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 498-504; DOI: https://doi.org/10.1124/jpet.104.066803

T

  1. Takeuchi, Koji

    1. Induction of Small Intestinal Damage in Rats Following Combined Treatment with Cyclooxygenase-2 and Nitric-Oxide Synthase Inhibitors
      Ryoko Ohno, Aya Yokota, Akiko Tanaka and Koji Takeuchi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 821-827; DOI: https://doi.org/10.1124/jpet.104.065961

  2. Tamarkin, Frank J.

    1. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
      Walter S. Kang, Frank J. Tamarkin, Marcia A. Wheeler and Robert M. Weiss
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 452-458; DOI: https://doi.org/10.1124/jpet.104.066506

  3. Tanaka, Akiko

    1. Induction of Small Intestinal Damage in Rats Following Combined Treatment with Cyclooxygenase-2 and Nitric-Oxide Synthase Inhibitors
      Ryoko Ohno, Aya Yokota, Akiko Tanaka and Koji Takeuchi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 821-827; DOI: https://doi.org/10.1124/jpet.104.065961

  4. Tanaka, Isao

    1. Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
      Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki and Isao Tanaka
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 614-619; DOI: https://doi.org/10.1124/jpet.103.064964

  5. Tattersall, John E. H.

    1. A Guinea Pig Hippocampal Slice Model of Organophosphate-Induced Seizure Activity
      Patrick K. Harrison, Robert D. Sheridan, A. Chris Green, Iain R. Scott and John E. H. Tattersall
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 678-686; DOI: https://doi.org/10.1124/jpet.104.065433

  6. Terazawa, Reiko

    1. Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism
      Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata and Yasushi Yamazoe
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 808-814; DOI: https://doi.org/10.1124/jpet.104.065532

  7. Tessmer, Jennifer L.

    1. Serotonin 5-HT2A Receptors Underlie Increased Motor Behaviors Induced in Dopamine-Depleted Rats by Intrastriatal 5-HT2A/2C Agonism
      Christopher Bishop, Jennifer L. Tessmer, Thomas Ullrich, Kenner C. Rice and Paul D. Walker
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 687-694; DOI: https://doi.org/10.1124/jpet.104.066365

  8. Theis, Stephan

    1. A Rapid in Vitro Screening for Delivery of Peptide-Derived Peptidase Inhibitors as Potential Drug Candidates via Epithelial Peptide Transporters
      Martin Foltz, Antje Meyer, Stephan Theis, Hans-Ulrich Demuth and Hannelore Daniel
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 695-702; DOI: https://doi.org/10.1124/jpet.104.066480

  9. Tilloy, S.

    1. Behavior of α-, β-, and γ-Cyclodextrins and Their Derivatives on an in Vitro Model of Blood-Brain Barrier
      V. Monnaert, S. Tilloy, H. Bricout, L. Fenart, R. Cecchelli and E. Monflier
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 745-751; DOI: https://doi.org/10.1124/jpet.104.067512

  10. Tingle, Malcolm

    1. Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans
      Jun Lu, Nuala Helsby, Brian D. Palmer, Malcolm Tingle, Bruce C. Baguley, Philip Kestell and Lai-Ming Ching
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 571-577; DOI: https://doi.org/10.1124/jpet.104.067793

  11. Tojo, Nobuteru

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  12. Turchin, Paul I.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  13. Turrin, Claudia

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

U

  1. Ullrich, Thomas

    1. Serotonin 5-HT2A Receptors Underlie Increased Motor Behaviors Induced in Dopamine-Depleted Rats by Intrastriatal 5-HT2A/2C Agonism
      Christopher Bishop, Jennifer L. Tessmer, Thomas Ullrich, Kenner C. Rice and Paul D. Walker
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 687-694; DOI: https://doi.org/10.1124/jpet.104.066365

  2. Unterwald, Ellen M.

    1. In Vivo Regulation of Extracellular Signal-Regulated Protein Kinase (ERK) and Protein Kinase B (Akt) Phosphorylation by Acute and Chronic Morphine
      Daniella L. Muller and Ellen M. Unterwald
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 774-782; DOI: https://doi.org/10.1124/jpet.104.066548

V

  1. Vadori, Marta

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  2. Valenzano, Kenneth J.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  3. Verri, Waldiceu A.

    1. Interleukin-18 Induces Mechanical Hypernociception in Rats via Endothelin Acting on ETB Receptors in a Morphine-Sensitive Manner
      Waldiceu A. Verri, Ieda R. S. Schivo, Thiago M. Cunha, Foo Y. Liew, Sergio H. Ferreira and Fernando Q. Cunha
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 710-717; DOI: https://doi.org/10.1124/jpet.103.063990

  4. Victory, Sam F.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties
      Kenneth J. Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Sam F. Victory, Ellen Davies, Jin-Cheng Huang, Nezima Allie, Scott J. Nolan, Yakov Rotshteyn, Donald J. Kyle and Kevin Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 783-792; DOI: https://doi.org/10.1124/jpet.103.063313

  5. Vojnovic, Ivana

    1. Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues
      Timothy D. Warner, Ivana Vojnovic, Francesco Giuliano, Rosario Jiménez, David Bishop-Bailey and Jane A. Mitchell
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 642-647; DOI: https://doi.org/10.1124/jpet.103.063875

  6. von Moltke, Lisa L.

    1. UDP-Glucuronosyltransferase (UGT) 2B15 Pharmacogenetics: UGT2B15 D85Y Genotype and Gender Are Major Determinants of Oxazepam Glucuronidation by Human Liver
      Michael H. Court, Qin Hao, Soundararajan Krishnaswamy, Tanios Bekaii-Saab, Abdul Al-Rohaimi, Lisa L. von Moltke and David J. Greenblatt
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 656-665; DOI: https://doi.org/10.1124/jpet.104.067660

  7. Vuppugalla, Ragini

    1. Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers
      Ragini Vuppugalla and Reza Mehvar
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 718-727; DOI: https://doi.org/10.1124/jpet.104.065557

W

  1. Walker, Katharine

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  2. Walker, Paul D.

    1. Serotonin 5-HT2A Receptors Underlie Increased Motor Behaviors Induced in Dopamine-Depleted Rats by Intrastriatal 5-HT2A/2C Agonism
      Christopher Bishop, Jennifer L. Tessmer, Thomas Ullrich, Kenner C. Rice and Paul D. Walker
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 687-694; DOI: https://doi.org/10.1124/jpet.104.066365

  3. Ward, Keith W.

    1. Preclinical Pharmacokinetic Properties of the P-Glycoprotein Inhibitor GF120918A (HCl salt of GF120918, 9,10-Dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the Mouse, Rat, Dog, and Monkey
      Keith W. Ward and Leonard M. Azzarano
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 703-709; DOI: https://doi.org/10.1124/jpet.104.068288

  4. Warner, Timothy D.

    1. Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues
      Timothy D. Warner, Ivana Vojnovic, Francesco Giuliano, Rosario Jiménez, David Bishop-Bailey and Jane A. Mitchell
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 642-647; DOI: https://doi.org/10.1124/jpet.103.063875

  5. Warren, Lee

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  6. Weiss, Robert M.

    1. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
      Walter S. Kang, Frank J. Tamarkin, Marcia A. Wheeler and Robert M. Weiss
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 452-458; DOI: https://doi.org/10.1124/jpet.104.066506

  7. Welty, Stephen E.

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

  8. Wheeler, Marcia A.

    1. Rapid Up-Regulation of Endothelial Nitric-Oxide Synthase in a Mouse Model of Escherichia coli Lipopolysaccharide-Induced Bladder Inflammation
      Walter S. Kang, Frank J. Tamarkin, Marcia A. Wheeler and Robert M. Weiss
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 452-458; DOI: https://doi.org/10.1124/jpet.104.066506

  9. Whiteside, Garth T.

    1. DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat
      Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine Walker and Kevin C. Broglé
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 793-799; DOI: https://doi.org/10.1124/jpet.103.063560

  10. Wong, Tak Ming

    1. Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or κ-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
      Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu and Tak Ming Wong
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 606-613; DOI: https://doi.org/10.1124/jpet.104.067926

  11. Woodcroft, Kimberley J.

    1. Acetoacetate Activation of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in Primary Cultured Rat Hepatocytes: Role of Oxidative Stress
      Mohamed A. Abdelmegeed, Sang K. Kim, Kimberley J. Woodcroft and Raymond F. Novak
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 728-736; DOI: https://doi.org/10.1124/jpet.104.066522

  12. Wright, Andrew W. E.

    1. Abolition of Valproate-Derived Choleresis in the Mrp2 Transporter-Deficient Rat
      Andrew W. E. Wright and Ronald G. Dickinson
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 584-588; DOI: https://doi.org/10.1124/jpet.103.064220

  13. Wrighton, Steven A.

    1. Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro586
      Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton and Kathleen M. Hillgren
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 437-445; DOI: https://doi.org/10.1124/jpet.104.065912

  14. Wu, Lin

    1. Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome
      Lin Wu, John C. Shryock, Yejia Song, Yuan Li, Charles Antzelevitch and Luiz Belardinelli
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 599-605; DOI: https://doi.org/10.1124/jpet.104.066100

  15. Wu, Song

    1. Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or κ-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
      Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu and Tak Ming Wong
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 606-613; DOI: https://doi.org/10.1124/jpet.104.067926

X

  1. Xiao, Chun-Yang

    1. Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor
      Chun-Yang Xiao, Min Chen, Zsuzsanna Zsengellér and Csaba Szabó
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 498-504; DOI: https://doi.org/10.1124/jpet.104.066803

  2. Xiong, Wei

    1. Diminished Inotropic Response to Amrinone in Ventricular Myocytes from Myopathic Hamsters Is Linked to Depression of High-Gain Ca2+-Induced Ca2+ Release
      Wei Xiong, Gregory R. Ferrier and Susan E. Howlett
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 761-773; DOI: https://doi.org/10.1124/jpet.103.064873

Y

  1. Yamamoto, Hirofumi

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  2. Yamazaki, Kazuto

    1. Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
      Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki and Isao Tanaka
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 614-619; DOI: https://doi.org/10.1124/jpet.103.064964

  3. Yamazaki, Syunji

    1. A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
      Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka and Seitaro Mutoh
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 425-436; DOI: https://doi.org/10.1124/jpet.104.066944

  4. Yamazoe, Yasushi

    1. Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism
      Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata and Yasushi Yamazoe
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 808-814; DOI: https://doi.org/10.1124/jpet.104.065532

  5. Yan, Wing-Yi

    1. Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or κ-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
      Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu and Tak Ming Wong
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 606-613; DOI: https://doi.org/10.1124/jpet.104.067926

  6. Yasuda, Nobuyuki

    1. Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
      Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki and Isao Tanaka
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 614-619; DOI: https://doi.org/10.1124/jpet.103.064964

  7. Yip, Linda

    1. Role of Adenosine A1 Receptor in the Regulation of Gastrin Release
      Linda Yip, Henry Chi Hang Leung and Yin Nam Kwok
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 477-487; DOI: https://doi.org/10.1124/jpet.104.066654

  8. Yokota, Aya

    1. Induction of Small Intestinal Damage in Rats Following Combined Treatment with Cyclooxygenase-2 and Nitric-Oxide Synthase Inhibitors
      Ryoko Ohno, Aya Yokota, Akiko Tanaka and Koji Takeuchi
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 821-827; DOI: https://doi.org/10.1124/jpet.104.065961

  9. Yu, Ling

    1. Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury
      Weiwu Jiang, Stephen E. Welty, Xanthi I. Couroucli, Roberto Barrios, Sudha R. Kondraganti, Kathirvel Muthiah, Ling Yu, Stephen E. Avery and Bhagavatula Moorthy
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 512-519; DOI: https://doi.org/10.1124/jpet.103.059766

Z

  1. Zaller, D. M.

    1. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
      D. Claveau, S. L. Chen, S. O'Keefe, D. M. Zaller, A. Styhler, S. Liu, Z. Huang, D. W. Nicholson and J. A. Mancini
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 752-760; DOI: https://doi.org/10.1124/jpet.103.064691

  2. Zalups, Rudolfs K.

    1. Metallothionein Mediates the Level and Activity of Nuclear Factor ΚB in Murine Fibroblasts
      Heather L. Butcher, Wendy A. Kennette, Olga Collins, Rudolfs K. Zalups and James Koropatnick
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 589-598; DOI: https://doi.org/10.1124/jpet.104.066126

  3. Zeng, Zhizhen

    1. Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
      J. Fred Hess, Richard W. Ransom, Zhizhen Zeng, Raymond S. L. Chang, Patricia J. Hey, Lee Warren, Charles M. Harrell, Kathryn L. Murphy, Tsing-Bau Chen, Patricia J. Miller, Edward Lis, Duane Reiss, Raymond E. Gibson, M. Kristine Markowitz, Robert M. DiPardo, Dai-Shi Su, Mark G. Bock, Robert J. Gould and Douglas J. Pettibone
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 488-497; DOI: https://doi.org/10.1124/jpet.104.066886

  4. Zhang, Eric Y.

    1. Genetic Polymorphisms in Human Proton-Dependent Dipeptide Transporter PEPT1: Implications for the Functional Role of Pro586
      Eric Y. Zhang, Dong-Jing Fu, Youngeen A. Pak, Trent Stewart, Nitai Mukhopadhyay, Steven A. Wrighton and Kathleen M. Hillgren
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 437-445; DOI: https://doi.org/10.1124/jpet.104.065912

  5. Zhou, Jing-Jun

    1. Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or κ-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults
      Jing Liu, Kenneth W. L. Kam, Jing-Jun Zhou, Wing-Yi Yan, Mai Chen, Song Wu and Tak Ming Wong
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 606-613; DOI: https://doi.org/10.1124/jpet.104.067926

  6. Zorzet, Sonia

    1. Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
      Sabrina Pacor, Sonia Zorzet, Moreno Cocchietto, Marina Bacac, Marta Vadori, Claudia Turrin, Barbara Gava, Anna Castellarin and Gianni Sava
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 737-744; DOI: https://doi.org/10.1124/jpet.104.066175

  7. Zou, Qin

    1. Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1
      Zejin Sun, Daryl J. Murry, Sonal P. Sanghani, Wilhelmina I. Davis, Natalia Y. Kedishvili, Qin Zou, Thomas D. Hurley and William F. Bosron
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 469-476; DOI: https://doi.org/10.1124/jpet.104.067116

  8. Zsengellér, Zsuzsanna

    1. Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor
      Chun-Yang Xiao, Min Chen, Zsuzsanna Zsengellér and Csaba Szabó
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 498-504; DOI: https://doi.org/10.1124/jpet.104.066803

  9. Zukin, R. Suzanne

    1. Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)
      Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R. Suzanne Zukin, John Olney, Reinhardt Baudy and Stephen Lin
      Journal of Pharmacology and Experimental Therapeutics August 2004, 310 (2) 563-570; DOI: https://doi.org/10.1124/jpet.104.066092
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