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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Blood-Brain Barrier Permeability of Novel [d-Arg2]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System

Yoshiharu Deguchi, Yu Naito, Sumio Ohtsuki, Yusaku Miyakawa, Kazuhiro Morimoto, Ken-ichi Hosoya, Shinobu Sakurada and Tetsuya Terasaki
Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 177-184; DOI: https://doi.org/10.1124/jpet.103.064006

Article Information

vol. 310 no. 1 177-184
DOI 
https://doi.org/10.1124/jpet.103.064006
PubMed 
15031301
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 8, 2003
  • Accepted March 18, 2004
  • Published online June 17, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshiharu Deguchi,
  2. Yu Naito,
  3. Sumio Ohtsuki,
  4. Yusaku Miyakawa,
  5. Kazuhiro Morimoto,
  6. Ken-ichi Hosoya,
  7. Shinobu Sakurada and
  8. Tetsuya Terasaki
  1. Department of Drug Disposition and Pharmacokinetics, School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan (Y.D.); Department of Biopharmaceutics, Hokkaido College of Pharmacy, Hokkaido, Japan (Y.N., Y.M., K.M.); New Industry Creation Hatchery Center and Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (S.O., T.T.); Department of Physiology and Anatomy, Tohoku Pharmaceutical University, Sendai, Japan (S.S.); Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan (K.H.); and CREST of Japan Science and Technology Agency, Hokkaido, Japan (S.O., K.H., T.T.)
  1. Address correspondence to:
    Dr. Yoshiharu Deguchi, Department of Drug Disposition and Pharmacokinetics, School of Pharmaceutical Sciences, Teikyo University, 1091-1 Suarashi, Sagamiko-machi, Tsukui-gun, Kanagawa 199-0195, Japan. E-mail: deguchi{at}pharm.teikyo-u.ac.jp
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Blood-Brain Barrier Permeability of Novel [d-Arg2]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System

Yoshiharu Deguchi, Yu Naito, Sumio Ohtsuki, Yusaku Miyakawa, Kazuhiro Morimoto, Ken-ichi Hosoya, Shinobu Sakurada and Tetsuya Terasaki
Journal of Pharmacology and Experimental Therapeutics July 1, 2004, 310 (1) 177-184; DOI: https://doi.org/10.1124/jpet.103.064006
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