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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

July 01, 2004; Volume 310,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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    Phosphorylation and Regulation of Psychostimulant-Sensitive Neurotransmitter Transporters
    Roxanne A. Vaughan
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 1-7; DOI: https://doi.org/10.1124/jpet.103.052423

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Placental Handling of Fatty Acid Ethyl Esters: Perfusion and Subcellular Studies
    Daphne Chan, Brenda Knie, Rada Boskovic and Gideon Koren
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 75-82; DOI: https://doi.org/10.1124/jpet.104.066597
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    Blood-Brain Barrier Permeability of Novel [d-Arg2]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System
    Yoshiharu Deguchi, Yu Naito, Sumio Ohtsuki, Yusaku Miyakawa, Kazuhiro Morimoto, Ken-ichi Hosoya, Shinobu Sakurada and Tetsuya Terasaki
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 177-184; DOI: https://doi.org/10.1124/jpet.103.064006
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    Pharmacokinetic/Pharmacodynamic Analysis of Paradoxal Regulation of Erythropoietin Production in Acute Anemia
    N. H. Al-Huniti, J. A. Widness, R. L. Schmidt and P. Veng-Pedersen
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 202-208; DOI: https://doi.org/10.1124/jpet.104.066027
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    In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Sulforaphane in the Rat
    Rong Hu, Vidya Hebbar, Bok-Ryang Kim, Chi Chen, Bozena Winnik, Brian Buckley, Patricia Soteropoulos, Peter Tolias, Ronald P. Hart and A.-N. Tony Kong
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 263-271; DOI: https://doi.org/10.1124/jpet.103.064261
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    Novel Reversible Inactivation of Cytochrome P450 2E1 T303A by tert-Butyl Acetylene: The Role of Threonine 303 in Proton Delivery to the Active Site of Cytochrome P450 2E1
    Anna L. Blobaum, Ute M. Kent, William L. Alworth and Paul F. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 281-290; DOI: https://doi.org/10.1124/jpet.104.065508
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    HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
    Anshul Gupta, Yi Zhang, Jashvant D. Unadkat and Qingcheng Mao
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 334-341; DOI: https://doi.org/10.1124/jpet.104.065342
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    Differentiation of Gut and Hepatic First Pass Metabolism and Secretion of Saquinavir in Ported Rabbits
    Patrick J. Sinko, Jeevan R. Kunta, Helen H. Usansky and Barbara A. Perry
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 359-366; DOI: https://doi.org/10.1124/jpet.103.064394
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    Disposition Mechanisms of Raloxifene in the Human Intestinal Caco-2 Model
    Eun Ju Jeong, Huimin Lin and Ming Hu
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 376-385; DOI: https://doi.org/10.1124/jpet.103.063925

BEHAVIORAL PHARMACOLOGY

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    Effects of Opioids in Morphine-Treated Pigeons Trained to Discriminate among Morphine, the Low-Efficacy Agonist Nalbuphine, and Saline
    Ellen A. Walker, Mitchell J. Picker, Arthur Granger and Linda A. Dykstra
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 150-158; DOI: https://doi.org/10.1124/jpet.103.058503
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    The Role of Central μ Opioid Receptors in Opioid-Induced Itch in Primates
    M. C. H. Ko, M. S. Song, T. Edwards, H. Lee and N. N. Naughton
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 169-176; DOI: https://doi.org/10.1124/jpet.103.061101
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    Calcium-Permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/Kainate Receptors Mediate Development, but Not Maintenance, of Secondary Allodynia Evoked by First-Degree Burn in the Rat
    Toni L. Jones and Linda S. Sorkin
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 223-229; DOI: https://doi.org/10.1124/jpet.103.064741
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    FE200041 (d-Phe-d-Phe-d-Nle-d-Arg-NH2): A Peripheral Efficacious κ Opioid Agonist with Unprecedented Selectivity
    Todd W. Vanderah, Claudio D. Schteingart, Jerzy Trojnar, Jean-Louis Junien, Josephine Lai and Pierre J.-M. Riviere
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 326-333; DOI: https://doi.org/10.1124/jpet.104.065391
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    Cocaine-Like Discriminative Stimulus Effects of Heroin: Modulation by Selective Monoamine Transport Inhibitors
    James K. Rowlett, Donna M. Platt and Roger D. Spealman
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 342-348; DOI: https://doi.org/10.1124/jpet.104.065631

CARDIOVASCULAR

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    Obligatory Role for Endogenous Endothelin in Mediating the Hypertrophic Effects of Phenylephrine and Angiotensin II in Neonatal Rat Ventricular Myocytes: Evidence for Two Distinct Mechanisms for Endothelin Regulation
    Ying Xia and Morris Karmazyn
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 43-51; DOI: https://doi.org/10.1124/jpet.104.065185
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    Effects of Sodium-Calcium Exchange Inhibitors, KB-R7943 and SEA0400, on Aconitine-Induced Arrhythmias in Guinea Pigs in Vivo, in Vitro, and in Computer Simulation Studies
    Md. Shah Amran, Keitaro Hashimoto and Nobuo Homma
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 83-89; DOI: https://doi.org/10.1124/jpet.104.066951
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    Effect of Short-Term Phytoestrogen Treatment in Male Rats on Nitric Oxide-Mediated Responses of Carotid and Cerebral Arteries: Comparison with 17β-Estradiol
    Christopher G. Sobey, Jane M. Weiler, Mirna Boujaoude and Owen L. Woodman
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 135-140; DOI: https://doi.org/10.1124/jpet.103.063255
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    Mechanisms for the Inhibition of Genital Vascular Responses by Antidepressants in a Female Rabbit Model
    Javier Angulo, Pedro Cuevas, Begoña Cuevas, Sandeep Gupta and Iñigo Sáenz de Tejada
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 141-149; DOI: https://doi.org/10.1124/jpet.103.063362
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    Acute Aspirin Treatment Abolishes, whereas Acute Ibuprofen Treatment Enhances Morphine-Induced Cardioprotection: Role of 12-Lipoxygenase
    Eric R. Gross, Anna K. Hsu and Garrett J. Gross
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 185-191; DOI: https://doi.org/10.1124/jpet.103.064667
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    Urotensin-II-Converting Enzyme Activity of Furin and Trypsin in Human Cells in Vitro
    Fraser D. Russell, Philip Kearns, Istvan Toth and Peter Molenaar
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 209-214; DOI: https://doi.org/10.1124/jpet.104.065425
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    Isoproterenol Exacerbates a Long QT Phenotype in Kcnq1-Deficient Neonatal Mice: Possible Roles for Human-Like Kcnq1 Isoform 1 and Slow Delayed Rectifier K+ Current
    Bjorn C. Knollmann, Mathew C. Casimiro, Alexander N. Katchman, Syevda G. Sirenko, Tilmann Schober, Qi Rong, Karl Pfeifer and Steven N. Ebert
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 311-318; DOI: https://doi.org/10.1124/jpet.103.063743
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    Characterization of the Neutralizing Activity of Digoxin-Specific Fab toward Ouabain-Like Steroids
    Mark A. Pullen, David P Brooks and Richard M. Edwards
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 319-325; DOI: https://doi.org/10.1124/jpet.104.065250
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    Modulation of Cyclic AMP Production by Signal Transduction Pathways in Preglomerular Microvessels and Microvascular Smooth Muscle Cells
    Travis C. Jackson, Zaichuan Mi and Edwin K. Jackson
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 349-358; DOI: https://doi.org/10.1124/jpet.103.063081

CELLULAR AND MOLECULAR

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    Regulation of CXCR4 Receptor Dimerization by the Chemokine SDF-1α and the HIV-1 Coat Protein gp120: A Fluorescence Resonance Energy Transfer (FRET) Study
    Peter T. Toth, Dongjun Ren and Richard J. Miller
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 8-17; DOI: https://doi.org/10.1124/jpet.103.064956
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    The Expression and Functional Role of Nicotinic Acetylcholine Receptors in Rat Adipocytes
    Run-Hua Liu, Masanari Mizuta and Shigeru Matsukura
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 52-58; DOI: https://doi.org/10.1124/jpet.103.065037
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    Novel Regulatory Properties of Human Type 9 Adenylate Cyclase
    Medhane G. Cumbay and Val J. Watts
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 108-115; DOI: https://doi.org/10.1124/jpet.104.065748
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    Endogenous Regulator of G Protein Signaling Proteins Suppress Gαo-Dependent, μ-Opioid Agonist-Mediated Adenylyl Cyclase Supersensitization
    Mary J. Clark, Richard R. Neubig and John R. Traynor
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 215-222; DOI: https://doi.org/10.1124/jpet.103.064824
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    κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells
    Angel Y. F. Kam, Anthony S. L. Chan and Yung H. Wong
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 301-310; DOI: https://doi.org/10.1124/jpet.104.065078
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    Massive Cell Vacuolization Induced by Organic Amines Such as Procainamide
    Guillaume Morissette, Emmanuel Moreau, René C.-Gaudreault and François Marceau
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 395-406; DOI: https://doi.org/10.1124/jpet.104.066084

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Amiloride Kills Malignant Glioma Cells Independent of Its Inhibition of the Sodium-Hydrogen Exchanger
    Manu Hegde, Jane Roscoe, Peter Cala and Fredric Gorin
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 67-74; DOI: https://doi.org/10.1124/jpet.103.065029

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Involvement of Capsaicin-Sensitive Afferent Nerves and Cholecystokinin 2/Gastrin Receptors in Gastroprotection and Adaptation of Gastric Mucosa to Helicobacter pylori-Lipopolysaccharide
    Tomasz Brzozowski, Peter C. Konturek, Anthony P. Moran, Robert Pajdo, Slawomir Kwiecien, Stanislaw J. Konturek, Zbigniew Sliwowski, Danuta Drozdowicz, Wieslaw W. Pawlik and Eckhart G. Hahn
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 116-125; DOI: https://doi.org/10.1124/jpet.104.065128
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    Identification of Caspase-Independent Apoptosis in Epithelial and Cancer Cells
    Brian S. Cummings, Gilbert R. Kinsey, Laura J. C. Bolchoz and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 126-134; DOI: https://doi.org/10.1124/jpet.104.065862
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    A Nitric Oxide-Releasing Salbutamol Elicits Potent Relaxant and Anti-Inflammatory Activities
    Vincent Lagente, Emmanuel Naline, Isabelle Guenon, Marianne Corbel, Elisabeth Boichot, Jean-Luc Burgaud, Piero Del Soldato and Charles Advenier
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 367-375; DOI: https://doi.org/10.1124/jpet.103.061739

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Investigation into the Potential Anti-Inflammatory Effects of Endothelin Antagonists in a Murine Model of Experimental Monosodium Urate Peritonitis
    Stephen J. Getting, Clara Di Filippo, Connie W. Lam, Francesco Rossi and Michele D'Amico
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 90-97; DOI: https://doi.org/10.1124/jpet.104.065573
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    Regulation of Kinase Cascades and Transcription Factors by a Poly(ADP-Ribose) Polymerase-1 Inhibitor, 4-Hydroxyquinazoline, in Lipopolysaccharide-Induced Inflammation in Mice
    Balazs Veres, Balazs Radnai, Ferenc Gallyas, Gabor Varbiro, Zoltan Berente, Erzsebet Osz and Balazs Sumegi
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 247-255; DOI: https://doi.org/10.1124/jpet.104.065151
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    Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan
    Keisuke Takeshita, Kevin B. Bacon and Florian Gantner
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 272-280; DOI: https://doi.org/10.1124/jpet.103.063776
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    Cloning and Pharmacological Characterization of CXCR1 and CXCR2 from Macaca fascicularis
    R. William Hipkin, Gregory Deno, Jay Fine, Yongliang Sun, Brian Wilburn, Xuedong Fan, Waldemar Gonsiorek and Maria T. Wiekowski
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 291-300; DOI: https://doi.org/10.1124/jpet.103.063131

NEUROPHARMACOLOGY

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    AS601245 (1,3-Benzothiazol-2-yl (2-{[2-(3-pyridinyl) ethyl] amino}-4 pyrimidinyl) Acetonitrile): A c-Jun NH2-Terminal Protein Kinase Inhibitor with Neuroprotective Properties
    Sonia Carboni, Agnes Hiver, Cedric Szyndralewiez, Pascale Gaillard, Jean-Pierre Gotteland and Pierre-Alain Vitte
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 25-32; DOI: https://doi.org/10.1124/jpet.103.064246
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    Desensitization of 5-HT1A Receptors by 5-HT2A Receptors in Neuroendocrine Neurons in Vivo
    Yahong Zhang, Thackery S. Gray, Deborah N. D'Souza, Gonzalo A. Carrasco, Katerina J. Damjanoska, Bertalan Dudas, Francisca Garcia, Gina M. Zainelli, Nicole R. Sullivan Hanley, George Battaglia, Nancy A. Muma and Louis D. Van de Kar
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 59-66; DOI: https://doi.org/10.1124/jpet.103.062224
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    The Comparative Pharmacology and Up-Regulation of Rat Neuronal Nicotinic Receptor Subtype Binding Sites Stably Expressed in Transfected Mammalian Cells
    Yingxian Xiao and Kenneth J. Kellar
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 98-107; DOI: https://doi.org/10.1124/jpet.104.066787
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    KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] Enhances A-Type K+ Currents in Neurons of the Dorsal Root Ganglion of the Adult Rat
    Adrian Sculptoreanu, Naoki Yoshimura and William C. de Groat
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 159-168; DOI: https://doi.org/10.1124/jpet.104.065409
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    Fipronil Is a Potent Open Channel Blocker of Glutamate-Activated Chloride Channels in Cockroach Neurons
    Xilong Zhao, Jay Z. Yeh, Vincent L. Salgado and Toshio Narahashi
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 192-201; DOI: https://doi.org/10.1124/jpet.104.065516
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    Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice
    D. S. Reddy, D. C. Castaneda, B. W. O'Malley and M. A. Rogawski
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 230-239; DOI: https://doi.org/10.1124/jpet.104.065268
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    Nonopioidergic Mechanism Mediating Morphine-Induced Antianalgesia in the Mouse Spinal Cord
    Hsiang-En Wu, Jonathan Thompson, Han-Sen Sun, Randy J. Leitermann, James M. Fujimoto and Leon F. Tseng
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 240-246; DOI: https://doi.org/10.1124/jpet.104.065334
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    Dual Effects of DAMGO [d-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on Adenylyl Cyclase Activity: Implications for μ-Opioid Receptor Gs Coupling
    Mária Szücs, Krisztina Boda and Alan R. Gintzler
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 256-262; DOI: https://doi.org/10.1124/jpet.104.066837
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    Levetiracetam Potentiates the Antidyskinetic Action of Amantadine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Lesioned Primate Model of Parkinson's Disease
    Michael P. Hill, Paula Ravenscroft, Erwan Bezard, Alan R. Crossman, Jonathan M. Brotchie, Anne Michel, Renee Grimée and Henrik Klitgaard
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 386-394; DOI: https://doi.org/10.1124/jpet.104.066191
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    [3H]A-317491, a Novel High-Affinity Non-Nucleotide Antagonist That Specifically Labels Human P2X2/3 and P2X3 Receptors
    Michael F. Jarvis, Bruce Bianchi, John T. Uchic, Jayne Cartmell, Chih-Hung Lee, Michael Williams and Connie Faltynek
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 407-416; DOI: https://doi.org/10.1124/jpet.103.064907

TOXICOLOGY

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    The Nitric Oxide Donor, O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), Protects against Cadmium-Induced Hepatotoxicity in Mice
    Jie Liu, Wei Qu, Joseph E. Saavedra and Michael P. Waalkes
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 18-24; DOI: https://doi.org/10.1124/jpet.103.065003
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    Evidence That 1,1-Dichloroethylene Induces Apoptotic Cell Death in Murine Liver
    Erik J. Martin and Poh-Gek Forkert
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 33-42; DOI: https://doi.org/10.1124/jpet.104.066019
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    Alcoholic Liver Injury in the Rat Is Associated with Reduced Expression of Peroxisome Proliferator-α (PPARα)-Regulated Genes and Is Ameliorated by PPARα Activation
    Amin A. Nanji, Andrew J. Dannenberg, Kalle Jokelainen and Nathan M. Bass
    Journal of Pharmacology and Experimental Therapeutics July 2004, 310 (1) 417-424; DOI: https://doi.org/10.1124/jpet.103.064717
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Journal of Pharmacology and Experimental Therapeutics: 310 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 310, Issue 1
1 Jul 2004
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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