Abstract
A method for preparing colloidal tri-lead phosphate for intravenous theraapy is described.
Colloidal lead phosphate injected by vein is relatively non-toxic to rabbits and rats and does not affect the fragility of red cells in vitro. Ionic lead, buffered with serum containing enough phosphate to react completely with the lead, is also non-toxic. The rabbit excretes lead given as the phosphate at the same rate that it does lead administered in some other form.
The relative toxicities to rabbits of lead acetate, colloidal metallic lead and colloidal lead oxide are of the same order, taking the drop in the hemoglobin, following injection of a sublethal dose, as a criterion.
Metallic colloidal lead reacts similarly to lead acetate when added to blood in vitro, distributing itself between the serum and red cells. Its action upon the red cells can be demonstrated by Aub's fragility test.
Footnotes
- Received March 17, 1927.
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