Abstract
1. Samples of powdered digitalis A, B and standard C have been administered 219 times to 122 patients by the massive dose method. The subjects included cases of auricular fibrillation, other types of heart disease, and a number with no cardiac involvement.
2. In the absence of auricular fibrillation the drug produced inconstant and usually comparatively slight results.
3. When the results were analyzed remarkable uniformity was observed in the reaction of cases of auricular fibrillation.
4. The amount of pulse slowing was found to bear a relation to the rate of the heart at the time the drug was given.
5. Clinical comparison of the strength of the three samples showed their relative values to be A 64.3, B 88.9 and C 100.
Footnotes
- Received February 25, 1927.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.