Journal of Pharmacology and Experimental Therapeutics: 309 (3)

June 01, 2004; Volume 309,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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Structures and Models of Transporter Proteins
Svein G. Dahl, Ingebrigt Sylte and Aina Westrheim Ravna

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 853-860; DOI: https://doi.org/10.1124/jpet.103.059972

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Pharmacokinetics, Safety, and Efficacy of a Liposome Encapsulated Thymidylate Synthase Inhibitor, OSI-7904L [(S)-2-[5-[(1,2-Dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric Acid] in Mice
John Desjardins, David L. Emerson, Dorothy B. Colagiovanni, Elizabeth Abbott, Eric N. Brown and Daniel W. Drolet

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 894-902; DOI: https://doi.org/10.1124/jpet.103.064725
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Benzylamine Exhibits Insulin-Like Effects on Glucose Disposal, Glucose Transport, and Fat Cell Lipolysis in Rabbits and Diabetic Mice
María Carmen Iglesias-Osma, Maria José Garcia-Barrado, Virgile Visentin, Maria Francisca Pastor-Mansilla, Sandy Bour, Danielle Prévot, Philippe Valet, Julio Moratinos and Christian Carpéné

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1020-1028; DOI: https://doi.org/10.1124/jpet.103.063636
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Cyclosporin A, but Not Tacrolimus, Inhibits the Biliary Excretion of Mycophenolic Acid Glucuronide Possibly Mediated by Multidrug Resistance-Associated Protein 2 in Rats
Mikako Kobayashi, Hiroshi Saitoh, Michiya Kobayashi, Koji Tadano, Yasushi Takahashi and Tetsuo Hirano

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1029-1035; DOI: https://doi.org/10.1124/jpet.103.063073
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Pharmacokinetics of Recombinant Human Leukemia Inhibitory Factor in Sheep
Alicia M. Segrave, Donald E. Mager, Susan A. Charman, Glenn A. Edwards and Christopher J. H. Porter

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1085-1092; DOI: https://doi.org/10.1124/jpet.103.063289
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2-Hydroxyestradiol Is a Prodrug of 2-Methoxyestradiol
Lefteris C. Zacharia, Claude A. Piché, Robert M. Fielding, Kathleen M. Holland, S. Dean Allison, Raghvendra K. Dubey and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1093-1097; DOI: https://doi.org/10.1124/jpet.103.062505
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Pharmacokinetics and Tissue Distribution of the Stereoisomers of 4-Methylaminorex in the Rat
Esa Meririnne, Satu Ellermaa, Aino Kankaanpää, Ali Bardy and Timo Seppälä

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1198-1205; DOI: https://doi.org/10.1124/jpet.103.060053
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Multidrug Resistance Protein (MRP) 4- and MRP 5-Mediated Efflux of 9-(2-Phosphonylmethoxyethyl)adenine by Microglia
Shannon Dallas, Lyanne Schlichter and Reina Bendayan

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1221-1229; DOI: https://doi.org/10.1124/jpet.103.063966
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Mouse Reduced in Osteosclerosis Transporter Functions as an Organic Anion Transporter 3 and Is Localized at Abluminal Membrane of Blood-Brain Barrier
Sumio Ohtsuki, Tazuru Kikkawa, Shinobu Mori, Satoko Hori, Hitomi Takanaga, Masaki Otagiri and Tetsuya Terasaki

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1273-1281; DOI: https://doi.org/10.1124/jpet.103.063370
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Isolation and Characterization of a New Major Intestinal CYP3A Form, CYP3A62, in the Rat
T. Matsubara, H. J. Kim, M. Miyata, M. Shimada, K. Nagata and Y. Yamazoe

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1282-1290; DOI: https://doi.org/10.1124/jpet.103.061671

BEHAVIORAL PHARMACOLOGY

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Deletion of the fyn-Kinase Gene Alters Sensitivity to GABAergic Drugs: Dependence on β2/β3 GABA_A Receptor Subunits
Stephen L. Boehm, Laura Peden, R. Adron Harris and Yuri A. Blednov

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1154-1159; DOI: https://doi.org/10.1124/jpet.103.064444
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Effects of Murine-Derived Anti-Methamphetamine Monoclonal Antibodies on (+)-Methamphetamine Self-Administration in the Rat
D. E. McMillan, W. C. Hardwick, M. Li, M. G. Gunnell, F. I. Carroll, P. Abraham and S. M. Owens

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1248-1255; DOI: https://doi.org/10.1124/jpet.103.061762

CARDIOVASCULAR

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Coadministration of a Liver X Receptor Agonist and a Peroxisome Proliferator Activator Receptor-α Agonist in Mice: Effects of Nuclear Receptor Interplay on High-Density Lipoprotein and Triglyceride Metabolism in Vivo
Thomas P. Beyer, Robert J. Schmidt, Patricia Foxworthy, Youyan Zhang, Jiannong Dai, William R. Bensch, Raymond F. Kauffman, Hong Gao, Timothy P. Ryan, Xian-Cheng Jiang, Sotirios K. Karathanasis, Patrick I. Eacho and Guoqing Cao

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 861-868; DOI: https://doi.org/10.1124/jpet.103.064535
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A Specific Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppresses Development of Abdominal Aortic Aneurysm in Hamsters
Koutaro Tsunemi, Shinji Takai, Masayoshi Nishimoto, Denan Jin, Masato Sakaguchi, Michiko Muramatsu, Atsushi Yuda, Shinjiro Sasaki and Mizuo Miyazaki

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 879-883; DOI: https://doi.org/10.1124/jpet.103.063974
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A Novel Selective Peroxisome Proliferator-Activated Receptor α Agonist, 2-Methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), Potently Decreases Plasma Triglyceride and Glucose Levels and Modifies Lipoprotein Profiles in KK-A^y Mice
Kenji Kuwabara, Kohji Murakami, Makoto Todo, Tomiyoshi Aoki, Tetsuo Asaki, Masatoshi Murai and Junichi Yano

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 970-977; DOI: https://doi.org/10.1124/jpet.103.064659
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Dual Regulation of Tumor Necrosis Factor-α-Induced CCL2/Monocyte Chemoattractant Protein-1 Expression in Vascular Smooth Muscle Cells by Nuclear Factor-κB and Activator Protein-1: Modulation by Type III Phosphodiesterase Inhibition
Yung-Ming Chen, Wen-Chih Chiang, Shuei-Liong Lin, Kwan-Dun Wu, Tun-Jun Tsai and Bor-Shen Hsieh

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 978-986; DOI: https://doi.org/10.1124/jpet.103.062620
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Rho/Rho Kinase and Phosphoinositide 3-Kinase Are Parallel Pathways in the Development of Spontaneous Arterial Tone in Deoxycorticosterone Acetate-Salt Hypertension
Erica A. Wehrwein, Carrie A. Northcott, Robert D. Loberg and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1011-1019; DOI: https://doi.org/10.1124/jpet.103.062265
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Ca²⁺-Activated K⁺ Channels Underlying the Impaired Acetylcholine-Induced Vasodilation in 2K-1C Hypertensive Rats
Glaucia E. Callera, Alvaro Yogi, Rita C. Tostes, Luciana V. Rossoni and Lusiane M. Bendhack

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1036-1042; DOI: https://doi.org/10.1124/jpet.103.062810
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Nitric Oxide Inhibits ATP Release from Erythrocytes
Jeffrey J. Olearczyk, Mary L. Ellsworth, Alan H. Stephenson, Andrew J. Lonigro and Randy S. Sprague

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1079-1084; DOI: https://doi.org/10.1124/jpet.103.064709
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2-Furoyl-LIGRLO-amide: A Potent and Selective Proteinase-Activated Receptor 2 Agonist
John J. McGuire, Mahmoud Saifeddine, Chris R. Triggle, Kimberly Sun and Morley D. Hollenberg

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1124-1131; DOI: https://doi.org/10.1124/jpet.103.064584
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Buspirone Raises Blood Pressure through Activation of Sympathetic Nervous System and by Direct Activation of α1-Adrenergic Receptors after Severe Hemorrhage
Patrick Osei-Owusu and Karie E. Scrogin

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1132-1140; DOI: https://doi.org/10.1124/jpet.103.064626
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The Effect of Acute Angiotensin-Converting Enzyme and Neutral Endopeptidase 24.11 Inhibition on Plasma Extravasation in the Rat
Anthony C. Sulpizio, Mark A. Pullen, Richard M. Edwards and David P. Brooks

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1141-1147; DOI: https://doi.org/10.1124/jpet.103.064105
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Potassium Canrenoate, an Aldosterone Receptor Antagonist, Reduces Isoprenaline-Induced Cardiac Fibrosis in the Rat
Romain Bos, Nathalie Mougenot, Odile Médiani, Paul M. Vanhoutte and Philippe Lechat

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1160-1166; DOI: https://doi.org/10.1124/jpet.103.063388
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The Tyrosine Phosphatase Inhibitor Bis(Maltolato)Oxovanadium Attenuates Myocardial Reperfusion Injury by Opening ATP-Sensitive Potassium Channels
David A. Liem, Coen C. Gho, Ben C. Gho, Shahla Kazim, Olivier C. Manintveld, Pieter D. Verdouw and Dirk J. Duncker

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1256-1262; DOI: https://doi.org/10.1124/jpet.103.062547
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Glucose-Dependent Enhancement of Spontaneous Phasic Contraction Is Suppressed in Diabetic Mouse Portal Vein: Association with Diacylglycerol-Protein Kinase C Pathway
Koji Nobe, Hikaru Suzuki, Yasushi Sakai, Hiromi Nobe, Richard J. Paul and Kazutaka Momose

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1263-1272; DOI: https://doi.org/10.1124/jpet.103.062802

CELLULAR AND MOLECULAR

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Anthraquinone Polyamines: Novel Channel Blockers to Study N-Methyl-d-Aspartate Receptors
Keiko Kashiwagi, Ikuko Tanaka, Maki Tamura, Hiromi Sugiyama, Tadashi Okawara, Masami Otsuka, Thomas N. Sabado, Keith Williams and Kazuei Igarashi

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 884-893; DOI: https://doi.org/10.1124/jpet.103.062042
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Potent and Metabolically Stable Agonists for Protease-Activated Receptor-2: Evaluation of Activity in Multiple Assay Systems in Vitro and in Vivo
Atsufumi Kawabata, Toru Kanke, Daiki Yonezawa, Tsuyoshi Ishiki, Masako Saka, Mototsugu Kabeya, Fumiko Sekiguchi, Satoko Kubo, Ryotaro Kuroda, Masahiro Iwaki, Kousaku Katsura and Robin Plevin

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1098-1107; DOI: https://doi.org/10.1124/jpet.103.061010
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The Synthetic Ligand of Peroxisome Proliferator-Activated Receptor-γ Ciglitazone Affects Human Glioblastoma Cell Lines
Nicol Strakova, Jiri Ehrmann, Petr Dzubak, Jan Bouchal and Zdenek Kolar

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1239-1247; DOI: https://doi.org/10.1124/jpet.103.063438

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Prodrug Modification Increases Potassium Tricyclo[5.2.1.0^2,6]-decan-8-yl Dithiocarbonate (D609) Chemical Stability and Cytotoxicity against U937 Leukemia Cells
Aiping Bai, G. Patrick Meier, Yong Wang, Chiara Luberto, Yusuf A. Hannun and Daohong Zhou

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1051-1059; DOI: https://doi.org/10.1124/jpet.103.064600

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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In Vivo Study on Cross Talk between Inducible Nitric-Oxide Synthase and Cyclooxygenase in Rat Gastric Mucosa: Effect of Cyclooxygenase Activity on Nitric Oxide Production
Kaname Uno, Yoshihito Iuchi, Junichi Fujii, Hideaki Sugata, Katsunori Iijima, Katsuaki Kato, Tooru Shimosegawa and Tetsuhiko Yoshimura

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 995-1002; DOI: https://doi.org/10.1124/jpet.103.061283
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Signal Transduction Underlying Carbachol-Induced Contraction of Human Urinary Bladder
Tim Schneider, Charlotte Fetscher, Susanne Krege and Martin C. Michel

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1148-1153; DOI: https://doi.org/10.1124/jpet.103.063735

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Ethanol Causes Inflammation in the Airways by a Neurogenic and TRPV1-Dependent Mechanism
Marcello Trevisani, David Gazzieri, Francesca Benvenuti, Barbara Campi, Q. Thai Dinh, David A. Groneberg, Michela Rigoni, Xavier Emonds-Alt, Christophe Creminon, Axel Fischer, Pierangelo Geppetti and Selena Harrison

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1167-1173; DOI: https://doi.org/10.1124/jpet.103.064162
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Cooperation between Aspirin-Triggered Lipoxin and Nitric Oxide (NO) Mediates Antiadhesive Properties of 2-(Acetyloxy)benzoic Acid 3-(Nitrooxymethyl)phenyl Ester (NCX-4016) (NO-Aspirin) on Neutrophil-Endothelial Cell Adherence
Stefano Fiorucci, Eleonora Distrutti, Andrea Mencarelli, Giovanni Rizzo, Anna Rita Di Lorenzo, Monia Baldoni, Piero del Soldato, Antonio Morelli and John L. Wallace

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1174-1182; DOI: https://doi.org/10.1124/jpet.103.063651
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E-Prostanoid (EP)2/EP4 Receptor-Dependent Maturation of Human Monocyte-Derived Dendritic Cells and Induction of Helper T2 Polarization
Shinichiro Kubo, Hideo Kohka Takahashi, Masao Takei, Hiromi Iwagaki, Tadashi Yoshino, Noriaki Tanaka, Shuji Mori and Masahiro Nishibori

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1213-1220; DOI: https://doi.org/10.1124/jpet.103.062646

NEUROPHARMACOLOGY

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A Newly Identified Role for Superoxide in Inflammatory Pain
Zhi-Qiang Wang, Frank Porreca, Salvatore Cuzzocrea, Karen Galen, Richard Lightfoot, Emanuela Masini, Carolina Muscoli, Vincenzo Mollace, Michael Ndengele, Harry Ischiropoulos and Daniela Salvemini

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 869-878; DOI: https://doi.org/10.1124/jpet.103.064154
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S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: I. Cellular, Electrophysiological, and Neurochemical Profile in Comparison with Ropinirole
Mark J. Millan, Didier Cussac, Alain Gobert, Françoise Lejeune, Jean-Michel Rivet, Clotilde Mannoury La Cour, Adrian Newman-Tancredi and Jean-Louis Peglion

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 903-920; DOI: https://doi.org/10.1124/jpet.103.062398
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S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: II. Actions in Rodent, Primate, and Cellular Models of Antiparkinsonian Activity in Comparison to Ropinirole
Mark J. Millan, Benjamin Di Cara, Michael Hill, Michael Jackson, Jeffrey N. Joyce, Jonathan Brotchie, Steve McGuire, Alan Crossman, Lance Smith, Peter Jenner, Alain Gobert, Jean-Louis Peglion and Mauricette Brocco

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 921-935; DOI: https://doi.org/10.1124/jpet.103.062414
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S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole
Mark J. Millan, Mauricette Brocco, Mariusz Papp, Florence Serres, Christophe Drieu La Rochelle, Trevor Sharp, Jean-Louis Peglion and Anne Dekeyne

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 936-950; DOI: https://doi.org/10.1124/jpet.103.062463
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Noncompetitive Metabotropic Glutamate₅ Receptor Antagonist (E)-2-Methyl-6-styryl-pyridine (SIB1893) Depresses Glutamate Release through Inhibition of Voltage-Dependent Ca²⁺ Entry in Rat Cerebrocortical Nerve Terminals (Synaptosomes)
Su-Jane Wang and Talvinder S. Sihra

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 951-958; DOI: https://doi.org/10.1124/jpet.103.064881
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Effects of Dopamine Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys: Relationship to Transporter Occupancy Determined by Positron Emission Tomography Neuroimaging
Kimberly P. Lindsey, Kristin M. Wilcox, John R. Votaw, Mark M. Goodman, Christophe Plisson, F. Ivy Carroll, Kenner C. Rice and Leonard L. Howell

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 959-969; DOI: https://doi.org/10.1124/jpet.103.060293
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Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na⁺ Channels
Munehiro Shiraishi and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 987-994; DOI: https://doi.org/10.1124/jpet.103.064063
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In Vitro Characterization of 5-Carboxyl-2,4-di-benzamidobenzoic Acid (NS3763), a Noncompetitive Antagonist of GLU_K5 Receptors
Jeppe K. Christensen, Thomas Varming, Philip K. Ahring, Tino D. Jørgensen and Elsebet Ø. Nielsen

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1003-1010; DOI: https://doi.org/10.1124/jpet.103.062794
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Agonist-Induced Serotonin 2A Receptor Desensitization in the Rat Frontal Cortex and Hypothalamus
K. J. Damjanoska, B. A. Heidenreich, G. H. Kindel, D. N. D'Souza, Y. Zhang, F. Garcia, G. Battaglia, W. A. Wolf, L. D. Van de Kar and N. A. Muma

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1043-1050; DOI: https://doi.org/10.1124/jpet.103.062067
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Naproxen Reduces Excitotoxic Neurodegeneration in Vivo with an Extended Therapeutic Window
Janna M. Silakova, James A. Hewett and Sandra J. Hewett

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1060-1066; DOI: https://doi.org/10.1124/jpet.103.063867
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Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in Mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson's Disease
Akinori Iwashita, Syunji Yamazaki, Kayoko Mihara, Kouji Hattori, Hirofumi Yamamoto, Junya Ishida, Nobuya Matsuoka and Seitaro Mutoh

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1067-1078; DOI: https://doi.org/10.1124/jpet.103.064642
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Structural Determinants of the Pharmacological Properties of the GABA_A Receptor α6 Subunit
Brandon C. Drafts and Janet L. Fisher

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1108-1115; DOI: https://doi.org/10.1124/jpet.103.064360
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Effects of Galantamine, a Nicotinic Allosteric Potentiating Ligand, on Nicotine-Induced Catecholamine Release in Hippocampus and Nucleus Accumbens of Rats
Burt M. Sharp, M. Yatsula and Yitong Fu

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1116-1123; DOI: https://doi.org/10.1124/jpet.103.063586
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Ethanol Antagonist Peptides: Structural Specificity without Stereospecificity
Michael F. Wilkemeyer, Shao-yu Chen, Carrie E. Menkari, Kathleen K. Sulik and Michael E. Charness

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1183-1189; DOI: https://doi.org/10.1124/jpet.103.063818
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Role of α7 Nicotinic Acetylcholine Receptors in the Pressor Response to Intracerebroventricular Injection of Choline: Blockade by Amyloid Peptide Aβ1-42
Xinyu D. Li and Jerry J. Buccafusco

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1206-1212; DOI: https://doi.org/10.1124/jpet.103.063321
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ReN-1869 [(R)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine Carboxylic Acid], a Novel Histamine H1 Receptor Antagonist, Produces Potent and Selective Antinociceptive Effects on Dorsal Horn Neurons after Inflammation and Neuropathy
R. Suzuki, M. Edwards and A. H. Dickenson

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1230-1238; DOI: https://doi.org/10.1124/jpet.103.063511

TOXICOLOGY

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Protective Peptides That Are Orally Active and Mechanistically Nonchiral
Douglas E. Brenneman, Catherine Y. Spong, Janet M. Hauser, Daniel Abebe, Albert Pinhasov, Tania Golian and Illana Gozes

Journal of Pharmacology and Experimental Therapeutics June 2004, 309 (3) 1190-1197; DOI: https://doi.org/10.1124/jpet.103.063891

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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