Induction of Drug Metabolism Enzymes and MDR1 Using a Novel Human Hepatocyte Cell Line

Exploratory Medicinal Sciences (J.B.M, S.M.F.de M.), Pfizer Global Research and Development, Groton Laboratories, Groton, Connecticut; and Department of Pharmacokinetics, Dynamics, and Metabolism (K.A.R., N.S., J.S.), Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, Michigan

Address correspondence to:
Dr. Sonia M. F. de Morais, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Rd., Groton, CT 06340. E-mail: demoraissm{at}groton.pfizer.com

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: January 2004 to May 2021

	Abstract	Full	Pdf
Jan 2004	165	0	115
Feb 2004	63	0	92
Mar 2004	160	41	170
Apr 2004	148	161	195
May 2004	82	133	135
Jun 2004	80	146	92
Jul 2004	111	110	99
Aug 2004	83	95	60
Sep 2004	84	84	57
Oct 2004	66	126	59
Nov 2004	52	74	51
Dec 2004	79	79	48
Jan 2005	40	98	43
Feb 2005	42	75	47
Mar 2005	40	63	37
Apr 2005	24	123	55
May 2005	19	72	40
Jun 2005	25	119	38
Jul 2005	20	69	38
Aug 2005	12	84	64
Sep 2005	8	73	41
Oct 2005	29	62	60
Nov 2005	25	54	35
Dec 2005	26	41	36
Jan 2006	27	85	45
Feb 2006	24	59	33
Mar 2006	33	62	38
Apr 2006	20	67	40
May 2006	20	47	26
Jun 2006	19	34	30
Jul 2006	10	37	19
Aug 2006	18	31	26
Sep 2006	26	51	42
Oct 2006	26	57	45
Nov 2006	21	47	45
Dec 2006	22	45	27
Jan 2007	27	178	53
Feb 2007	9	31	38
Mar 2007	26	24	44
Apr 2007	25	37	42
May 2007	22	29	48
Jun 2007	25	32	33
Jul 2007	20	35	34
Aug 2007	20	37	28
Sep 2007	12	36	31
Oct 2007	27	56	50
Nov 2007	17	38	35
Dec 2007	12	15	17
Jan 2008	25	35	40
Feb 2008	16	25	19
Mar 2008	30	35	35
Apr 2008	19	24	34
May 2008	27	44	38
Jun 2008	22	32	26
Jul 2008	29	31	37
Aug 2008	36	23	26
Sep 2008	21	17	17
Oct 2008	21	26	29
Nov 2008	46	22	20
Dec 2008	19	20	30
Jan 2009	28	30	35
Feb 2009	22	30	21
Mar 2009	20	23	16
Apr 2009	11	17	24
May 2009	16	15	14
Jun 2009	20	16	27
Jul 2009	13	18	9
Aug 2009	19	9	13
Sep 2009	22	14	16
Oct 2009	28	12	20
Nov 2009	15	14	16
Dec 2009	25	10	18
Jan 2010	17	21	19
Feb 2010	16	20	14
Mar 2010	13	19	16
Apr 2010	26	23	14
May 2010	32	26	13
Jun 2010	24	21	13
Jul 2010	34	29	24
Aug 2010	33	28	19
Sep 2010	27	35	24
Oct 2010	25	39	14
Nov 2010	17	42	12
Dec 2010	21	29	12
Jan 2011	22	27	20
Feb 2011	14	46	12
Mar 2011	18	35	24
Apr 2011	17	36	17
May 2011	32	41	28
Jun 2011	20	18	20
Jul 2011	24	21	18
Aug 2011	20	17	22
Sep 2011	20	27	11
Oct 2011	29	36	16
Nov 2011	21	23	11
Dec 2011	29	49	25
Jan 2012	29	25	22
Feb 2012	29	35	19
Mar 2012	33	27	15
Apr 2012	25	37	29
May 2012	15	28	15
Jun 2012	14	17	20
Jul 2012	13	38	21
Aug 2012	10	35	17
Sep 2012	23	45	15
Oct 2012	20	34	18
Nov 2012	11	34	21
Dec 2012	9	28	8
Jan 2013	16	23	12
Feb 2013	37	32	19
Mar 2013	25	28	18
Apr 2013	21	33	12
May 2013	13	31	21
Jun 2013	12	22	12
Jul 2013	14	31	10
Aug 2013	18	19	8
Sep 2013	8	9	8
Oct 2013	26	26	21
Nov 2013	6	14	14
Dec 2013	12	15	10
Jan 2014	17	19	14
Feb 2014	10	13	12
Mar 2014	18	20	12
Apr 2014	21	13	13
May 2014	10	49	18
Jun 2014	9	22	14
Jul 2014	41	19	5
Aug 2014	16	11	24
Sep 2014	8	12	14
Oct 2014	20	10	17
Nov 2014	19	14	17
Dec 2014	10	7	7
Jan 2015	6	4	10
Feb 2015	8	6	6
Mar 2015	16	10	9
Apr 2015	17	11	8
May 2015	7	16	5
Jun 2015	8	13	14
Jul 2015	11	8	13
Aug 2015	5	18	23
Sep 2015	9	8	12
Oct 2015	10	8	6
Nov 2015	10	11	10
Dec 2015	18	2	7
Jan 2016	14	12	7
Feb 2016	7	14	9
Mar 2016	12	31	12
Apr 2016	17	12	12
May 2016	9	9	14
Jun 2016	12	9	12
Jul 2016	6	6	12
Aug 2016	7	15	58
Sep 2016	12	11	11
Oct 2016	7	24	20
Nov 2016	4	13	11
Dec 2016	4	9	1
Jan 2017	6	15	5
Feb 2017	7	13	8
Mar 2017	10	12	9
Apr 2017	4	18	9
May 2017	3	6	7
Jun 2017	3	16	6
Jul 2017	2	26	9
Aug 2017	4	14	11
Sep 2017	8	17	12
Oct 2017	6	10	23
Nov 2017	3	21	13
Dec 2017	2	12	26
Jan 2018	2	16	3
Feb 2018	3	21	6
Mar 2018	2	20	13
Apr 2018	3	33	16
May 2018	1	9	8
Jun 2018	3	20	11
Jul 2018	2	11	4
Aug 2018	7	13	4
Sep 2018	0	13	7
Oct 2018	2	16	8
Nov 2018	0	11	9
Dec 2018	15	5	6
Jan 2019	12	1	4
Feb 2019	12	2	1
Mar 2019	14	7	1
Apr 2019	31	1	2
May 2019	23	3	2
Jun 2019	18	1	8
Jul 2019	17	1	2
Aug 2019	24	6	1
Sep 2019	23	6	2
Oct 2019	12	3	2
Nov 2019	23	1	1
Dec 2019	5	8	3
Jan 2020	9	1	0
Feb 2020	26	4	3
Mar 2020	14	5	4
Apr 2020	18	2	2
May 2020	11	0	0
Jun 2020	19	3	2
Jul 2020	8	1	0
Aug 2020	2	1	2
Sep 2020	23	3	1
Oct 2020	29	1	4
Nov 2020	19	2	3
Dec 2020	31	3	5
Jan 2021	17	19	4
Feb 2021	11	19	6
Mar 2021	19	3	2
Apr 2021	11	5	3
May 2021	4	0	0