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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

Alexander Treiber, Ralph Schneiter, Stephane Delahaye and Martine Clozel
Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1121-1129; DOI: https://doi.org/10.1124/jpet.103.061614

Article Information

vol. 308 no. 3 1121-1129
DOI 
https://doi.org/10.1124/jpet.103.061614
PubMed 
14617681
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 14, 2003
  • Accepted November 10, 2003
  • Published online February 25, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Alexander Treiber,
  2. Ralph Schneiter,
  3. Stephane Delahaye and
  4. Martine Clozel
  1. Department of Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
  1. Address correspondence to:
    Dr. Alexander Treiber, Department of Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland. E-mail: alexander.treiber{at}actelion.com
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

Alexander Treiber, Ralph Schneiter, Stephane Delahaye and Martine Clozel
Journal of Pharmacology and Experimental Therapeutics March 1, 2004, 308 (3) 1121-1129; DOI: https://doi.org/10.1124/jpet.103.061614
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