Advertisement
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

Alexander Treiber, Ralph Schneiter, Stephane Delahaye and Martine Clozel
Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1121-1129; DOI: https://doi.org/10.1124/jpet.103.061614

Article Information

vol. 308 no. 3 1121-1129
DOI 
https://doi.org/10.1124/jpet.103.061614
PubMed 
14617681
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 14, 2003
  • Accepted November 10, 2003
  • Published online February 25, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Alexander Treiber,
  2. Ralph Schneiter,
  3. Stephane Delahaye and
  4. Martine Clozel
  1. Department of Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
  1. Address correspondence to:
    Dr. Alexander Treiber, Department of Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland. E-mail: alexander.treiber{at}actelion.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: November 2003 to May 2023

AbstractFullPdf
Nov 200315045
Dec 200314050
Jan 200431034
Feb 2004651188
Mar 200485102122
Apr 2004368384
May 2004308877
Jun 20046911855
Jul 2004538327
Aug 2004436929
Sep 2004276020
Oct 2004326449
Nov 2004245831
Dec 2004204025
Jan 2005285034
Feb 2005135134
Mar 2005283940
Apr 200583031
May 2005265935
Jun 2005177442
Jul 2005136945
Aug 200595118
Sep 2005103924
Oct 2005116142
Nov 2005163921
Dec 2005124527
Jan 2006195031
Feb 2006204842
Mar 2006113025
Apr 200683622
May 2006104635
Jun 200673122
Jul 200643330
Aug 200642317
Sep 2006172220
Oct 200664023
Nov 2006112316
Dec 20066168
Jan 200792723
Feb 200732420
Mar 200762926
Apr 200782218
May 2007103631
Jun 2007122424
Jul 2007125041
Aug 2007132818
Sep 2007121425
Oct 200713921
Nov 200762521
Dec 200752120
Jan 200872929
Feb 200892934
Mar 2008143932
Apr 2008121123
May 2008202322
Jun 2008181726
Jul 2008162526
Aug 2008132712
Sep 2008212331
Oct 2008202918
Nov 2008342327
Dec 2008141515
Jan 2009171930
Feb 2009181314
Mar 2009262026
Apr 200911912
May 2009111318
Jun 2009121729
Jul 20099911
Aug 2009848
Sep 2009231226
Oct 200935821
Nov 200927827
Dec 20098411
Jan 2010221720
Feb 2010271117
Mar 2010131015
Apr 2010141811
May 2010142011
Jun 2010231515
Jul 201091515
Aug 201010913
Sep 201082118
Oct 2010102021
Nov 201016135
Dec 201071217
Jan 2011131810
Feb 201181116
Mar 2011292718
Apr 2011232730
May 2011151713
Jun 2011122514
Jul 2011151117
Aug 201115820
Sep 2011182123
Oct 2011162527
Nov 2011183226
Dec 2011132322
Jan 2012142412
Feb 2012292722
Mar 2012201713
Apr 2012151820
May 2012181444
Jun 2012131720
Jul 2012131315
Aug 2012182015
Sep 2012171618
Oct 2012132421
Nov 2012111620
Dec 201272012
Jan 2013152228
Feb 2013142020
Mar 2013132827
Apr 2013201721
May 2013143321
Jun 201318208
Jul 2013111619
Aug 201391712
Sep 201381510
Oct 201312118
Nov 2013181517
Dec 201362512
Jan 2014102414
Feb 201462819
Mar 201473021
Apr 2014162931
May 201492015
Jun 2014111315
Jul 201419134
Aug 2014718
Sep 201441445
Oct 2014171011
Nov 2014774
Dec 20142913
Jan 20157721
Feb 2015647
Mar 201516108
Apr 201551014
May 2015111718
Jun 2015486
Jul 201532311
Aug 201512107
Sep 20159611
Oct 2015668
Nov 20151135
Dec 20151178
Jan 2016141212
Feb 20161356
Mar 201611814
Apr 20164917
May 20161411
Jun 20161487
Jul 20161178
Aug 20167512
Sep 20167614
Oct 201621812
Nov 201681011
Dec 2016122
Jan 20172129
Feb 2017296
Mar 201701412
Apr 20177239
May 201701413
Jun 20170165
Jul 201731314
Aug 201712118
Sep 201732012
Oct 20172137
Nov 20170243
Dec 2017382
Jan 20181187
Feb 20182158
Mar 20182144
Apr 20180225
May 20184239
Jun 20184244
Jul 201851711
Aug 20185107
Sep 20184187
Oct 20180176
Nov 20181107
Dec 2018111013
Jan 20191236
Feb 20191335
Mar 20192336
Apr 2019501
May 2019515
Jun 20191669
Jul 2019706
Aug 20192043
Sep 20191534
Oct 20191195
Nov 20191514
Dec 20191983
Jan 2020910
Feb 2020901
Mar 2020557
Apr 20201233
May 2020600
Jun 20201010
Jul 2020921
Aug 2020622
Sep 20201562
Oct 20201233
Nov 20201322
Dec 20201454
Jan 202114144
Feb 202113156
Mar 202124103
Apr 20212442
May 202114104
Jun 20219142
Jul 20212112
Aug 20218132
Sep 20211372
Oct 20211731
Nov 20211831
Dec 20213036
Jan 20221526
Feb 2022721
Mar 202210653
Apr 20221625
May 20221610
Jun 20221740
Jul 20221624
Aug 20222243
Sep 202218101
Oct 202215142
Nov 20221015
Dec 2022721
Jan 20231075
Feb 2023131
Mar 20231520
Apr 2023812
May 202316148

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

Alexander Treiber, Ralph Schneiter, Stephane Delahaye and Martine Clozel
Journal of Pharmacology and Experimental Therapeutics March 1, 2004, 308 (3) 1121-1129; DOI: https://doi.org/10.1124/jpet.103.061614
Reddit logo Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement