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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2004; Volume 308,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Emerging Pharmacologic Approaches for the Treatment of Lower Urinary Tract Disorders
    Robert B. Moreland, Jorge D. Brioni and James P. Sullivan
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 797-804; DOI: https://doi.org/10.1124/jpet.102.034991

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Effect of Age on in Vitro Triazolam Biotransformation in Male Human Liver Microsomes
    Kiran C. Patki, Lisa L. von Moltke, Jerold S. Harmatz, Leah M. Hesse, Michael H. Court and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 874-879; DOI: https://doi.org/10.1124/jpet.103.059311
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    Contributions of CYP3A4, P-glycoprotein, and Serum Protein Binding to the Intestinal First-Pass Extraction of Saquinavir
    Stéphane J. Mouly, Mary F. Paine and Paul B. Watkins
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 941-948; DOI: https://doi.org/10.1124/jpet.103.056390
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    Developmental Expression of Human Hepatic CYP2C9 and CYP2C19
    Sevasti B. Koukouritaki, Jason R. Manro, Sandra A. Marsh, Jeffrey C. Stevens, Allan E. Rettie, D. Gail McCarver and Ronald N. Hines
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 965-974; DOI: https://doi.org/10.1124/jpet.103.060137
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    Functional and Pharmacological Characterization of the Natriuretic Peptide-Dependent Lipolytic Pathway in Human Fat Cells
    Cedric Moro, Jean Galitzky, Coralie Sengenes, François Crampes, Max Lafontan and Michel Berlan
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 984-992; DOI: https://doi.org/10.1124/jpet.103.060913
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    Ex Situ Inhibition of Hepatic Uptake and Efflux Significantly Changes Metabolism: Hepatic Enzyme-Transporter Interplay
    Yvonne Y. Lau, Chi-Yuan Wu, Hideaki Okochi and Leslie Z. Benet
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1040-1045; DOI: https://doi.org/10.1124/jpet.103.061770
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    Pharmacokinetics and Biodistribution of the Antitumor Immunoconjugate, Cantuzumab Mertansine (huC242-DM1), and Its Two Components in Mice
    Hongsheng Xie, Charlene Audette, Mary Hoffee, John M. Lambert and Walter A. Blättler
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1073-1082; DOI: https://doi.org/10.1124/jpet.103.060533
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    Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat
    Alexander Treiber, Ralph Schneiter, Stephane Delahaye and Martine Clozel
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1121-1129; DOI: https://doi.org/10.1124/jpet.103.061614
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    Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery
    Takahiro Hatanaka, Masayuki Haramura, You-Jun Fei, Seiji Miyauchi, Christy C. Bridges, Preethi S. Ganapathy, Sylvia B. Smith, Vadivel Ganapathy and Malliga E. Ganapathy
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1138-1147; DOI: https://doi.org/10.1124/jpet.103.057109
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    ABCC2-Mediated Biliary Transport of 4-Glutathionylcyclophosphamide and Its Contribution to Elimination of 4-Hydroxycyclophosphamide in Rat
    Ruolun Qiu, Thomas F. Kalhorn and John T. Slattery
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1204-1212; DOI: https://doi.org/10.1124/jpet.103.059105

BEHAVIORAL PHARMACOLOGY

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    Discriminative Stimulus Effects of γ-Hydroxybutyrate in Pigeons: Role of Diazepam-Sensitive and -Insensitive GABAA and GABAB Receptors
    Wouter Koek, Lauren R. Flores, Lawrence P. Carter, R. J. Lamb, Weibin Chen, Huifang Wu, Andrew Coop and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 904-911; DOI: https://doi.org/10.1124/jpet.103.056093

CARDIOVASCULAR

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    Comparison of Three Different A1 Adenosine Receptor Antagonists on Infarct Size and Multiple Cycle Ischemic Preconditioning in Anesthetized Dogs
    John A. Auchampach, Xiaowei Jin, Jeannine Moore, Tina C. Wan, Laura M. Kreckler, Zhi-Dong Ge, Jayashree Narayanan, Eric Whalley, William Kiesman, Barry Ticho, Glenn Smits and Garrett J. Gross
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 846-856; DOI: https://doi.org/10.1124/jpet.103.057943
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    Catalytic Activity and Isoform-Specific Inhibition of Rat Cytochrome P450 4F Enzymes
    Fengyun Xu, John R. Falck, Paul R. Ortiz de Montellano and Deanna L. Kroetz
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 887-895; DOI: https://doi.org/10.1124/jpet.103.059626
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    Cardiac Ion Channel Effects of Tolterodine
    Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, William Reynolds, Sungtaek Lim, James Hendrix and David Rampe
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 935-940; DOI: https://doi.org/10.1124/jpet.103.062182
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    Reversibility versus Persistence of GPIIb/IIIa Blocker-Induced Conformational Change of GPIIb/IIIa (αIIbβ3, CD41/CD61)
    Meike Schwarz, Yasuhiro Katagiri, Masaharu Kotani, Nicole Bassler, Christoph Loeffler, Christoph Bode and Karlheinz Peter
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1002-1011; DOI: https://doi.org/10.1124/jpet.103.058883
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    Loss of Sodium Modulation of Plasma Kinins in Human Hypertension
    Laine J. Murphey, Wendy K. Eccles, Gordon H. Williams and Nancy J. Brown
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1046-1052; DOI: https://doi.org/10.1124/jpet.103.059337
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    Acute Cardiovascular Effects of Sibutramine in Conscious Rats
    Jeanette Woolard, Terence Bennett, William R. Dunn, David J. Heal, Susan Aspley and Sheila M. Gardiner
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1102-1110; DOI: https://doi.org/10.1124/jpet.103.061259
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    Tamoxifen Is a Potent Inhibitor of Cholesterol Esterification and Prevents the Formation of Foam Cells
    Philippe de Medina, Bruno L. Payré, José Bernad, Isabelle Bosser, Bernard Pipy, Sandrine Silvente-Poirot, Gilles Favre, Jean-Charles Faye and Marc Poirot
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1165-1173; DOI: https://doi.org/10.1124/jpet.103.060426
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    Ouabain Increases Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes
    Manabu Nishio, Stuart W. Ruch, James E. Kelly, Gary L. Aistrup, Katherine Sheehan and J. Andrew Wasserstrom
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1181-1190; DOI: https://doi.org/10.1124/jpet.103.060004
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    Interactions of Carbon Monoxide and Metabotropic Glutamate Receptor Groups in the Nucleus Tractus Solitarii of Rats
    Chia-Hui Lin, Wan-Chen Lo, Michael Hsiao, Che-Se Tung and Ching-Jiunn Tseng
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1213-1218; DOI: https://doi.org/10.1124/jpet.103.060186

CELLULAR AND MOLECULAR

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    Xylocydine, a Novel Inhibitor of Cyclin-Dependent Kinases, Prevents the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptotic Cell Death of SK-HEP-1 Cells
    Young-Mi Ham, Kyoung-Jin Choi, Sun-Yong Song, Ying-Hua Jin, Moon-Woo Chun and Seung-Ki Lee
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 814-819; DOI: https://doi.org/10.1124/jpet.103.059568
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    Investigation of the Interaction of a Putative Allosteric Modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) Methanamine Hydrobromide (SCH-202676), with M1 Muscarinic Acetylcholine Receptors
    Alfred Lanzafame and Arthur Christopoulos
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 830-837; DOI: https://doi.org/10.1124/jpet.103.060590
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    Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
    Paola Massi, Angelo Vaccani, Stefania Ceruti, Arianna Colombo, Maria P. Abbracchio and Daniela Parolaro
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 838-845; DOI: https://doi.org/10.1124/jpet.103.061002
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    Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells
    Diana L. Donnelly-Roberts, Marian T. Namovic, Connie R. Faltynek and Michael F. Jarvis
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1053-1061; DOI: https://doi.org/10.1124/jpet.103.059600
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    Application of a Kinetic Model to the Apparently Complex Behavior of Negative and Positive Allosteric Modulators of Muscarinic Acetylcholine Receptors
    Vimesh Avlani, Lauren T. May, Patrick M. Sexton and Arthur Christopoulos
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1062-1072; DOI: https://doi.org/10.1124/jpet.103.059840
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    Interaction of the Novel Adenosine Uptake Inhibitor 3-[1-(6,7-Diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazolinedione Hydrochloride (KF24345) with the es and ei Subtypes of Equilibrative Nucleoside Transporters
    James R. Hammond and Richard G. E. Archer
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1083-1093; DOI: https://doi.org/10.1124/jpet.103.060434

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Inhibition of Cyclooxygenase-2 by Celecoxib Reverses Tumor-Induced Wasting
    Thomas W. Davis, Ben S. Zweifel, Janet M. O'Neal, Deborah M. Heuvelman, Ann L. Abegg, Todd O. Hendrich and Jaime L. Masferrer
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 929-934; DOI: https://doi.org/10.1124/jpet.103.063099

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Reduced Expression of Organic Cation Transporters rOCT1 and rOCT2 in Experimental Diabetes
    Brett Grover, Donna Buckley, Arthur R. Buckley and William Cacini
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 949-956; DOI: https://doi.org/10.1124/jpet.103.058388
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    Interactions of Human Organic Anion Transporters with Diuretics
    Habib Hasannejad, Michio Takeda, Kentarou Taki, Ho Jung Shin, Ellappan Babu, Promsuk Jutabha, Suparat Khamdang, Mahmoud Aleboyeh, Maristela Lika Onozato, Akihiro Tojo, Atsushi Enomoto, Naohiko Anzai, Shinichi Narikawa, Xiu-Lin Huang, Toshimitsu Niwa and Hitoshi Endou
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1021-1029; DOI: https://doi.org/10.1124/jpet.103.059139
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    Role of Adenylate and Guanylate Cyclases in β1-, β2-, and β3-Adrenoceptor-Mediated Relaxation of Internal Anal Sphincter Smooth Muscle
    Fangxia Li, Márcio De Godoy and Satish Rattan
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1111-1120; DOI: https://doi.org/10.1124/jpet.103.060145
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    Neurokinin-1 Receptor Antagonists Protect Mice from CD95- and Tumor Necrosis Factor-α-Mediated Apoptotic Liver Damage
    Renate Bang, Markus Biburger, Winfried L. Neuhuber and Gisa Tiegs
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1174-1180; DOI: https://doi.org/10.1124/jpet.103.059329
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    The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse
    Ali Canbay, Ariel Feldstein, Edwina Baskin-Bey, Steven F. Bronk and Gregory J. Gores
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1191-1196; DOI: https://doi.org/10.1124/jpet.103.060129

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Selective Inhibition of Endothelial and Monocyte Redox-Sensitive Genes by AGI-1067: A Novel Antioxidant and Anti-Inflammatory Agent
    Charles Kunsch, Jayraz Luchoomun, Janice Y. Grey, Lynda K. Olliff, Leigh B. Saint, Richard F. Arrendale, Martin A. Wasserman, Uday Saxena and Russell M. Medford
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 820-829; DOI: https://doi.org/10.1124/jpet.103.059733
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    The Effect of Central Injection of Angiotensin-Converting Enzyme Inhibitor and the Angiotensin Type 1 Receptor Antagonist on the Induction by Lipopolysaccharide of Fever and Brain Interleukin-1β Response in Rats
    Hideki Shimizu, Michio Miyoshi, Kenji Matsumoto, Osamu Goto, Toshiaki Imoto and Tatsuo Watanabe
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 865-873; DOI: https://doi.org/10.1124/jpet.103.060392
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    Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-κB Transcription Factors
    Nieves Márquez, Rocío Sancho, Antonio Macho, Marco A. Calzado, Bernd L. Fiebich and Eduardo Muñoz
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 993-1001; DOI: https://doi.org/10.1124/jpet.103.060673

NEUROPHARMACOLOGY

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    Mammalian Voltage-Gated Calcium Channels Are Potently Blocked by the Pyrethroid Insecticide Allethrin
    Michael E. Hildebrand, John E. McRory, Terrance P. Snutch and Anthony Stea
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 805-813; DOI: https://doi.org/10.1124/jpet.103.058792
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    D2 Dopamine Receptors Modulate Gα-Subunit Coupling of the CB1 Cannabinoid Receptor
    A. Jarrahian, V. J. Watts and E. L. Barker
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 880-886; DOI: https://doi.org/10.1124/jpet.103.057620
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    Cilostazol Prevents Focal Cerebral Ischemic Injury by Enhancing Casein Kinase 2 Phosphorylation and Suppression of Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation in Rats
    Jeong Hyun Lee, Ki Young Kim, Yong-Kyu Lee, So Youn Park, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim and Ki Whan Hong
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 896-903; DOI: https://doi.org/10.1124/jpet.103.061853
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    The Distribution of the HIV Protease Inhibitor, Ritonavir, to the Brain, Cerebrospinal Fluid, and Choroid Plexuses of the Guinea Pig
    C. Anthonypillai, R. N. Sanderson, J. E. Gibbs and S. A. Thomas
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 912-920; DOI: https://doi.org/10.1124/jpet.103.060210
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    Protection against Cocaine Toxicity in Mice by the Dopamine D3/D2 Agonist R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD 128,907]
    J. M. Witkin, D. Dijkstra, B. Levant, H. C. Akunne, A. Zapata, S. Peters, H. E. Shannon and M. Gasior
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 957-964; DOI: https://doi.org/10.1124/jpet.103.059980
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    Andrographolide Reduces Inflammation-Mediated Dopaminergic Neurodegeneration in Mesencephalic Neuron-Glia Cultures by Inhibiting Microglial Activation
    Tongguang Wang, Bin Liu, Wei Zhang, Belinda Wilson and Jau-Shyong Hong
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 975-983; DOI: https://doi.org/10.1124/jpet.103.059683
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    Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of 5-HT1A Receptor Agonists: Estimation of in Vivo Affinity and Intrinsic Efficacy on Body Temperature in Rats
    Klaas P. Zuideveld, Piet H. Van der Graaf, Donald Newgreen, Richard Thurlow, Nicola Petty, Paul Jordan, Lambertus A. Peletier and Meindert Danhof
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1012-1020; DOI: https://doi.org/10.1124/jpet.103.059030
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    Opioid Partial Agonist Effects of 3-O-Methylnaltrexone in Rhesus Monkeys
    Donna M. Platt, James K. Rowlett, Sari Izenwasser and Roger D. Spealman
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1030-1039; DOI: https://doi.org/10.1124/jpet.103.060962
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    Antithrombotic Effects of FK419, a Novel Nonpeptide Platelet GPIIb/IIIa Antagonist, in a Guinea Pig Photochemically Induced Middle Cerebral Artery Thrombosis Model: Comparison with Ozagrel and Argatroban
    Akira Moriguchi, Toshiaki Aoki, Kayoko Mihara, Nobuteru Tojo, Nobuya Matsuoka and Seitaro Mutoh
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1094-1101; DOI: https://doi.org/10.1124/jpet.103.058073
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    Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a Small Molecule Antagonist of the Neuropeptide Y Y2 Receptor
    Pascal Bonaventure, Diane Nepomuceno, Curt Mazur, Brian Lord, Dale A. Rudolph, Jill A. Jablonowski, Nicholas I. Carruthers and Timothy W. Lovenberg
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1130-1137; DOI: https://doi.org/10.1124/jpet.103.060459
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    GABA Modulates Presynaptic Signalling Mediated by Dinucleotides on Rat Synaptic Terminals
    R. Gómez-Villafuertes, J. Pintor, J. Gualix and M. T. Miras-Portugal
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1148-1157; DOI: https://doi.org/10.1124/jpet.103.061564
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    Switching of Bradykinin-Mediated Nociception Following Partial Sciatic Nerve Injury in Mice
    Md Harunor Rashid, Makoto Inoue, Misaki Matsumoto and Hiroshi Ueda
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1158-1164; DOI: https://doi.org/10.1124/jpet.103.060335
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    Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious κ-Opioid Receptor Agonist: Structural and Functional Considerations
    Charles Chavkin, Sumit Sud, Wenzhen Jin, Jeremy Stewart, Jordan K. Zjawiony, Daniel J. Siebert, Beth Ann Toth, Sandra J. Hufeisen and Bryan L. Roth
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1197-1203; DOI: https://doi.org/10.1124/jpet.103.059394

TOXICOLOGY

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    The Role of the Interchain Disulfide Bond in Governing the Pharmacological Actions of Botulinum Toxin
    Lance L. Simpson, Andrew B. Maksymowych, Jong-Beak Park and Roop S. Bora
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 857-864; DOI: https://doi.org/10.1124/jpet.103.058149
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    Role of an Endoplasmic Reticulum Ca2+-Independent Phospholipase A2 in Cisplatin-Induced Renal Cell Apoptosis
    Brian S. Cummings, Jane McHowat and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 921-928; DOI: https://doi.org/10.1124/jpet.103.060541

Erratum

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    Correction to “Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes”
    Journal of Pharmacology and Experimental Therapeutics March 2004, 308 (3) 1219;
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Journal of Pharmacology and Experimental Therapeutics: 308 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 308, Issue 3
1 Mar 2004
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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