Journal of Pharmacology and Experimental Therapeutics: 308 (1)

January 01, 2004; Volume 308,Issue 1

EDITORIAL

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Editorial
Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 1; DOI: https://doi.org/10.1124/jpet.103.062497

PERSPECTIVES IN PHARMACOLOGY

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Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3)
Johan W. Jonker and Alfred H. Schinkel

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 2-9; DOI: https://doi.org/10.1124/jpet.103.053298

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse
Hiroko Kawaguchi, Yumi Matsui, Yoshihiko Watanabe and Yoshinobu Takakura

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 91-96; DOI: https://doi.org/10.1124/jpet.103.057521
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CYP3A4-Transfected Caco-2 Cells as a Tool for Understanding Biochemical Absorption Barriers: Studies with Sirolimus and Midazolam
Carolyn L. Cummins, Wolfgang Jacobsen, Uwe Christians and Leslie Z. Benet

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 143-155; DOI: https://doi.org/10.1124/jpet.103.058065
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Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine
Tanja Richter, Thomas E. Mürdter, Georg Heinkele, Jürgen Pleiss, Stephan Tatzel, Matthias Schwab, Michel Eichelbaum and Ulrich M. Zanger

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 189-197; DOI: https://doi.org/10.1124/jpet.103.056127
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Ion-Trapping, Microsomal Binding, and Unbound Drug Distribution in the Hepatic Retention of Basic Drugs
Gerhard A. Siebert, Daniel Y. Hung, Ping Chang and Michael S. Roberts

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 228-235; DOI: https://doi.org/10.1124/jpet.103.056770
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Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes
Norie Murayama, Akiko Soyama, Yoshiro Saito, Yukiko Nakajima, Kazuo Komamura, Kazuyuki Ueno, Shiro Kamakura, Masafumi Kitakaze, Hideo Kimura, Yu-ichi Goto, Osamu Saitoh, Masaaki Katoh, Teiichi Ohnuma, Mitsuru Kawai, Kenji Sugai, Taisuke Ohtsuki, Chieko Suzuki, Narihiro Minami, Shogo Ozawa and Jun-ichi Sawada

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 300-306; DOI: https://doi.org/10.1124/jpet.103.055798

BEHAVIORAL PHARMACOLOGY

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Cocaine and Other Indirect-Acting Monoamine Agonists Differentially Attenuate a Naltrexone Discriminative Stimulus in Morphine-Treated Rhesus Monkeys
Lance R. McMahon, Stacy L. Sell and Charles P. France

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 111-119; DOI: https://doi.org/10.1124/jpet.103.058917
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Effects of γ-Hydroxybutyrate (GHB) on Schedule-Controlled Responding in Rats: Role of GHB and GABA_B Receptors
Lawrence P. Carter, Huifang Wu, Weibin Chen, Christopher M. Cruz, R. J. Lamb, Wouter Koek, Andy Coop and Charles P. France

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 182-188; DOI: https://doi.org/10.1124/jpet.103.058909
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Modification by Dopaminergic Drugs of Choice Behavior under Concurrent Schedules of Intravenous Saline and Food Delivery in Monkeys
Maciej Gasior, Carol A. Paronis and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 249-259; DOI: https://doi.org/10.1124/jpet.103.052795
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Antinociceptive Effects of Novel A_2B Adenosine Receptor Antagonists
Osama M. Abo-Salem, Alaa M. Hayallah, Andras Bilkei-Gorzo, Barbara Filipek, Andreas Zimmer and Christa E. Müller

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 358-366; DOI: https://doi.org/10.1124/jpet.103.056036

CARDIOVASCULAR

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Propafenone and Its Metabolites Preferentially Inhibit I_Krin Rabbit Ventricular Myocytes
Sean A. Cahill and Gil J. Gross

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 59-65; DOI: https://doi.org/10.1124/jpet.103.057844
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Cardiovascular Effects of Nicotine, Chlorisondamine, and Mecamylamine in the Pigeon
Kathryn K. Chadman and James H. Woods

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 73-78; DOI: https://doi.org/10.1124/jpet.103.057307
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Synthetic High-Density Lipoproteins Exert Cardioprotective Effects in Myocardial Ischemia/Reperfusion Injury
Giuseppe Rossoni, Monica Gomaraschi, Ferruccio Berti, Cesare R. Sirtori, Guido Franceschini and Laura Calabresi

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 79-84; DOI: https://doi.org/10.1124/jpet.103.057141
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Potent Antioxidant Properties of 4-Hydroxyl-propranolol
I. Tong Mak and William B. Weglicki

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 85-90; DOI: https://doi.org/10.1124/jpet.103.058032
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Inhibition of G Protein-Coupled and ATP-Sensitive Potassium Currents by 2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015), an Amiodarone Derivative
B. Brandts, R. Borchard, R. Macianskiene, V. Gendviliene, D. Dirkmann, M. Van Bracht, M. Prull, M. Meine, I. Wickenbrock, K. Mubagwa and H.-J. Trappe

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 134-142; DOI: https://doi.org/10.1124/jpet.103.057646
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A Physiologically Based Approach for the Estimation of Recirculatory Parameters
Vangelis Karalis, Aristides Dokoumetzidis and Panos Macheras

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 198-205; DOI: https://doi.org/10.1124/jpet.103.058941
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Effect of Graded Heart Rate Reduction with Ivabradine on Myocardial Oxygen Consumption and Diastolic Time in Exercising Dogs
Patrice Colin, Bijan Ghaleh, Xavier Monnet, Luc Hittinger and Alain Berdeaux

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 236-240; DOI: https://doi.org/10.1124/jpet.103.059717
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Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin
G. Abou-Mohamed, J. A. Johnson, L. Jin, A. B. El-Remessy, K. Do, W. H. Kaesemeyer, R. B. Caldwell and R. W. Caldwell

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 289-299; DOI: https://doi.org/10.1124/jpet.103.056119
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Saxitoxin Blocks L-Type I_Ca
Zhi Su, Michael Sheets, Hideyuki Ishida, Fenghua Li and William H. Barry

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 324-329; DOI: https://doi.org/10.1124/jpet.103.056564
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Increased Reactivity of Murine Mesenteric Veins to Adrenergic Agonists: Functional Evidence Supporting Increased α₁-Adrenoceptor Reserve in Veins Compared with Arteries
Alex A. Pérez-Rivera, Gregory D. Fink and James J. Galligan

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 350-357; DOI: https://doi.org/10.1124/jpet.103.056184

CELLULAR AND MOLECULAR

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Cilostazol Enhances Casein Kinase 2 Phosphorylation and Suppresses Tumor Necrosis Factor-α-Induced Increased Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation and Apoptotic Cell Death in SK-N-SH Cells
Ki Young Kim, Hwa Kyoung Shin, Jeong Hyun Lee, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim, Yung Woo Shin and Ki Whan Hong

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 97-104; DOI: https://doi.org/10.1124/jpet.103.058768
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Role of Receptor Protein and Membrane Lipids in Xanomeline Wash-Resistant Binding to Muscarinic M₁ Receptors
Jan Jakubík, Stanislav Tuček and Esam E. El-Fakahany

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 105-110; DOI: https://doi.org/10.1124/jpet.103.058594
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Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates Glutathione S-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity
Pamela K. Smitherman, Alan J. Townsend, Timothy E. Kute and Charles S. Morrow

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 260-267; DOI: https://doi.org/10.1124/jpet.103.057729
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Roles of Catalase and Hydrogen Peroxide in Green Tea Polyphenol-Induced Chemopreventive Effects
Tetsuya Yamamoto, Jill Lewis, John Wataha, Douglas Dickinson, Baldev Singh, Wendy B. Bollag, Eisaku Ueta, Tokio Osaki, Mohammad Athar, George Schuster and Stephen Hsu

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 317-323; DOI: https://doi.org/10.1124/jpet.103.058891
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Muscarinic Agonist-Mediated Heterologous Desensitization in Isolated Ileum Requires Activation of Both Muscarinic M₂ and M₃ Receptors
Michael T. Griffin, Minoru Matsui, Darakhshanda Shehnaz, Khurram Z. Ansari, Makoto M. Taketo, Toshiya Manabe and Frederick J. Ehlert

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 339-349; DOI: https://doi.org/10.1124/jpet.103.055327

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect
Takanori Akagi, Kazami Ushinohama, Shoko Ikesue, Eiji Yukawa, Shun Higuchi, Kenji Hamase, Kiyoshi Zaitsu and Shigehiro Ohdo

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 378-384; DOI: https://doi.org/10.1124/jpet.103.055657

ENDOCRINE AND REPRODUCTIVE

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Ovarian Steroid Hormone Modulation of the Acute Effects of Cocaine on Luteinizing Hormone and Prolactin Levels in Ovariectomized Rhesus Monkeys
Nancy K. Mello, Jack H. Mendelson, S. Stevens Negus and Maureen Kelly

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 156-167; DOI: https://doi.org/10.1124/jpet.103.057216

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Hyperosmolar Solution Effects in Guinea Pig Airways. I. Mechanical Responses to Relative Changes in Osmolarity
Jeffrey S. Fedan, Janet A. Dowdy, Richard A. Johnston and Michael R. Van Scott

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 10-18; DOI: https://doi.org/10.1124/jpet.103.051607
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Hyperosmolar Solution Effects in Guinea Pig Airways. II. Epithelial Bioelectric Responses to Relative Changes in Osmolarity
David X.-Y. Wu, Richard A. Johnston, Appavoo Rengasamy, Michael R. Van Scott and Jeffrey S. Fedan

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 19-29; DOI: https://doi.org/10.1124/jpet.103.051615
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Hyperosmolar Solution Effects in Guinea Pig Airways. III. Studies on the Identity of Epithelium-Derived Relaxing Factor in Isolated Perfused Trachea Using Pharmacological Agents
Jeffrey S. Fedan, Janet A. Dowdy, Michael R. Van Scott, David X.-Y. Wu and Richard A. Johnston

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 30-36; DOI: https://doi.org/10.1124/jpet.103.051664
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Hyperosmolar Solution Effects in Guinea Pig Airways. IV. Lipopolysaccharide-Induced Alterations in Airway Reactivity and Epithelial Bioelectric Responses to Methacholine and Hyperosmolarity
Richard A. Johnston, Michael R. Van Scott, Choudari Kommineni, Lyndell L. Millecchia, Juanita Dortch-Carnes and Jeffrey S. Fedan

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 37-46; DOI: https://doi.org/10.1124/jpet.103.051672
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Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. I. Phospholipases and Ca²⁺ Sources
Tim Schneider, Peter Hein and Martin C. Michel

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 47-53; DOI: https://doi.org/10.1124/jpet.103.058248
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Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. II. Protein Kinases
Marina Fleichman, Tim Schneider, Charlotte Fetscher and Martin C. Michel

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 54-58; DOI: https://doi.org/10.1124/jpet.103.058255
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Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway
Yi N. Ye, Edgar S. L. Liu, Vivian Y. Shin, William K. K. Wu, Jiing C. Luo and Chi H. Cho

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 66-72; DOI: https://doi.org/10.1124/jpet.103.058321
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Antitumor Effect of a Splenic Injection of 5-Fluorouracil on Metastatic Liver Cancer in Mice
Kenichi Kanoh, Tatsuo Shimura, Hideki Suzuki, Kenichi Nomoto, Takayuki Asao and Hiroyuki Kuwano

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 168-174; DOI: https://doi.org/10.1124/jpet.103.057547
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Oral Treatment with Recombinant Human Interleukin-11 Improves Mucosal Transport in the Colon of Human Leukocyte Antigen-B27 Transgenic Rats
Kalina Venkova, James C. Keith and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 206-213; DOI: https://doi.org/10.1124/jpet.103.058701
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The Inhibitory Effect of Adrenomedullin in the Rat Ileum: Cross-Talk with β₃-Adrenoceptor in the Serotonin-Induced Muscle Contraction
Gennadi M. Kravtsov, Isabel S. S. Hwang and Fai Tang

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 241-248; DOI: https://doi.org/10.1124/jpet.103.057612
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Interaction of Cyclooxygenase Isoenzymes, Nitric Oxide, and Afferent Neurons in Gastric Mucosal Defense in Rats
Karlheinz Ehrlich, Christa Sicking, Michael Respondek and Brigitta M. Peskar

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 277-283; DOI: https://doi.org/10.1124/jpet.103.057752
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Characterization of Specific Opioid Binding Sites in Neural Membranes from the Myenteric Plexus of Porcine Small Intestine
DeWayne Townsend, Philip S. Portoghese and David R. Brown

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 385-393; DOI: https://doi.org/10.1124/jpet.103.058016

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia
Melvyn Lynn, Y. Nancy Wong, Janice L. Wheeler, Richard J. Kao, Carlos A. Perdomo, Robert Noveck, Ramon Vargas, Tony D'Angelo, Sandra Gotzkowsky, F. Gilbert McMahon, Kishor M. Wasan and Daniel P. Rossignol

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 175-181; DOI: https://doi.org/10.1124/jpet.103.056531
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Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor
Robin L. Thurmond, Siquan Sun, Clark A. Sehon, Sherry M. Baker, Hui Cai, Yin Gu, Wen Jiang, Jason P. Riley, Kacy N. Williams, James P. Edwards and Lars Karlsson

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 268-276; DOI: https://doi.org/10.1124/jpet.103.056879
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Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 Cells
Mingchen Song, John A. Kellum, Hoda Kaldas and Mitchell P. Fink

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 307-316; DOI: https://doi.org/10.1124/jpet.103.056622

NEUROPHARMACOLOGY

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Modulation of Ca²⁺Channel Currents by a Novel Antidementia DrugN-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960) in Rat Hippocampal Neurons
Feng Wang, Nobuya Matsuoka, Seitaro Mutoh and Shuji Kaneko

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 120-126; DOI: https://doi.org/10.1124/jpet.103.057687
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Effects of 2-[N-(4-Chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an Orally Active α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist, in Models of Generalized Epileptic Seizure in Mice and Rats
Hiroshi Yamashita, Kazushige Ohno, Yoko Amada, Hanae Hattori, Yukiko Ozawa-Funatsu, Takashi Toya, Hiroshi Inami, Jun-Ichi Shishikura, Shuichi Sakamoto, Masamichi Okada and Tokio Yamaguchi

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 127-133; DOI: https://doi.org/10.1124/jpet.103.058495
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An Electrophysiological Model of Spinal Transmission Deficits in Mouse Experimental Autoimmune Encephalomyelitis
Susan E. Hanak, Erin M. Reilly, Jill Wotanis, Bin Zhu, Claudine Pulicicchio, Kathleen McMonagle-Strucko, Joseph G. Wettstein and Mark D. Black

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 214-220; DOI: https://doi.org/10.1124/jpet.103.056994
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Sensitization of Neuronal A_2A Adenosine Receptors after Persistent D₂ Dopamine Receptor Activation
Timothy A. Vortherms and Val J. Watts

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 221-227; DOI: https://doi.org/10.1124/jpet.103.057083
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Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine
Gin C. Hsieh, Peter R. Hollingsworth, Brenda Martino, Renjie Chang, Marc A. Terranova, Alyssa B. O'Neill, James J. Lynch, Robert B. Moreland, Diana L. Donnelly-Roberts, Teodozyi Kolasa, Joseph P. Mikusa, Jill M. McVey, Kennan C. Marsh, James P. Sullivan and Jorge D. Brioni

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 330-338; DOI: https://doi.org/10.1124/jpet.103.057455
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Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex
Lisa S. Middleton, Wayne A. Cass and Linda P. Dwoskin

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 367-377; DOI: https://doi.org/10.1124/jpet.103.055335

TOXICOLOGY

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Suppression of Cytochrome P450 2E1 Promoter Activity by Interferon-γ and Loss of Response Due to the -71G>T Nucleotide Polymorphism of the CYP2E1^*7B Allele
Ling O. Qiu, Mark W. Linder, Deborah M. Antonino-Green and Roland Valdes

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 284-288; DOI: https://doi.org/10.1124/jpet.103.057208
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In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress
F. Pouzaud, K. Bernard-Beaubois, M. Thevenin, J.-M. Warnet, G. Hayem and P. Rat

Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 394-402; DOI: https://doi.org/10.1124/jpet.103.057984

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Table of Contents

EDITORIAL

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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