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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2004; Volume 308,Issue 1

EDITORIAL

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    Editorial
    Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 1; DOI: https://doi.org/10.1124/jpet.103.062497

PERSPECTIVES IN PHARMACOLOGY

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    Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3)
    Johan W. Jonker and Alfred H. Schinkel
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 2-9; DOI: https://doi.org/10.1124/jpet.103.053298

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse
    Hiroko Kawaguchi, Yumi Matsui, Yoshihiko Watanabe and Yoshinobu Takakura
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 91-96; DOI: https://doi.org/10.1124/jpet.103.057521
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    CYP3A4-Transfected Caco-2 Cells as a Tool for Understanding Biochemical Absorption Barriers: Studies with Sirolimus and Midazolam
    Carolyn L. Cummins, Wolfgang Jacobsen, Uwe Christians and Leslie Z. Benet
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 143-155; DOI: https://doi.org/10.1124/jpet.103.058065
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    Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine
    Tanja Richter, Thomas E. Mürdter, Georg Heinkele, Jürgen Pleiss, Stephan Tatzel, Matthias Schwab, Michel Eichelbaum and Ulrich M. Zanger
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 189-197; DOI: https://doi.org/10.1124/jpet.103.056127
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    Ion-Trapping, Microsomal Binding, and Unbound Drug Distribution in the Hepatic Retention of Basic Drugs
    Gerhard A. Siebert, Daniel Y. Hung, Ping Chang and Michael S. Roberts
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 228-235; DOI: https://doi.org/10.1124/jpet.103.056770
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    Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes
    Norie Murayama, Akiko Soyama, Yoshiro Saito, Yukiko Nakajima, Kazuo Komamura, Kazuyuki Ueno, Shiro Kamakura, Masafumi Kitakaze, Hideo Kimura, Yu-ichi Goto, Osamu Saitoh, Masaaki Katoh, Teiichi Ohnuma, Mitsuru Kawai, Kenji Sugai, Taisuke Ohtsuki, Chieko Suzuki, Narihiro Minami, Shogo Ozawa and Jun-ichi Sawada
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 300-306; DOI: https://doi.org/10.1124/jpet.103.055798

BEHAVIORAL PHARMACOLOGY

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    Cocaine and Other Indirect-Acting Monoamine Agonists Differentially Attenuate a Naltrexone Discriminative Stimulus in Morphine-Treated Rhesus Monkeys
    Lance R. McMahon, Stacy L. Sell and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 111-119; DOI: https://doi.org/10.1124/jpet.103.058917
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    Effects of γ-Hydroxybutyrate (GHB) on Schedule-Controlled Responding in Rats: Role of GHB and GABAB Receptors
    Lawrence P. Carter, Huifang Wu, Weibin Chen, Christopher M. Cruz, R. J. Lamb, Wouter Koek, Andy Coop and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 182-188; DOI: https://doi.org/10.1124/jpet.103.058909
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    Modification by Dopaminergic Drugs of Choice Behavior under Concurrent Schedules of Intravenous Saline and Food Delivery in Monkeys
    Maciej Gasior, Carol A. Paronis and Jack Bergman
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 249-259; DOI: https://doi.org/10.1124/jpet.103.052795
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    Antinociceptive Effects of Novel A2B Adenosine Receptor Antagonists
    Osama M. Abo-Salem, Alaa M. Hayallah, Andras Bilkei-Gorzo, Barbara Filipek, Andreas Zimmer and Christa E. Müller
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 358-366; DOI: https://doi.org/10.1124/jpet.103.056036

CARDIOVASCULAR

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    Propafenone and Its Metabolites Preferentially Inhibit IKrin Rabbit Ventricular Myocytes
    Sean A. Cahill and Gil J. Gross
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 59-65; DOI: https://doi.org/10.1124/jpet.103.057844
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    Cardiovascular Effects of Nicotine, Chlorisondamine, and Mecamylamine in the Pigeon
    Kathryn K. Chadman and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 73-78; DOI: https://doi.org/10.1124/jpet.103.057307
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    Synthetic High-Density Lipoproteins Exert Cardioprotective Effects in Myocardial Ischemia/Reperfusion Injury
    Giuseppe Rossoni, Monica Gomaraschi, Ferruccio Berti, Cesare R. Sirtori, Guido Franceschini and Laura Calabresi
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 79-84; DOI: https://doi.org/10.1124/jpet.103.057141
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    Potent Antioxidant Properties of 4-Hydroxyl-propranolol
    I. Tong Mak and William B. Weglicki
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 85-90; DOI: https://doi.org/10.1124/jpet.103.058032
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    Inhibition of G Protein-Coupled and ATP-Sensitive Potassium Currents by 2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015), an Amiodarone Derivative
    B. Brandts, R. Borchard, R. Macianskiene, V. Gendviliene, D. Dirkmann, M. Van Bracht, M. Prull, M. Meine, I. Wickenbrock, K. Mubagwa and H.-J. Trappe
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 134-142; DOI: https://doi.org/10.1124/jpet.103.057646
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    A Physiologically Based Approach for the Estimation of Recirculatory Parameters
    Vangelis Karalis, Aristides Dokoumetzidis and Panos Macheras
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 198-205; DOI: https://doi.org/10.1124/jpet.103.058941
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    Effect of Graded Heart Rate Reduction with Ivabradine on Myocardial Oxygen Consumption and Diastolic Time in Exercising Dogs
    Patrice Colin, Bijan Ghaleh, Xavier Monnet, Luc Hittinger and Alain Berdeaux
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 236-240; DOI: https://doi.org/10.1124/jpet.103.059717
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    Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin
    G. Abou-Mohamed, J. A. Johnson, L. Jin, A. B. El-Remessy, K. Do, W. H. Kaesemeyer, R. B. Caldwell and R. W. Caldwell
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 289-299; DOI: https://doi.org/10.1124/jpet.103.056119
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    Saxitoxin Blocks L-Type ICa
    Zhi Su, Michael Sheets, Hideyuki Ishida, Fenghua Li and William H. Barry
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 324-329; DOI: https://doi.org/10.1124/jpet.103.056564
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    Increased Reactivity of Murine Mesenteric Veins to Adrenergic Agonists: Functional Evidence Supporting Increased α1-Adrenoceptor Reserve in Veins Compared with Arteries
    Alex A. Pérez-Rivera, Gregory D. Fink and James J. Galligan
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 350-357; DOI: https://doi.org/10.1124/jpet.103.056184

CELLULAR AND MOLECULAR

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    Cilostazol Enhances Casein Kinase 2 Phosphorylation and Suppresses Tumor Necrosis Factor-α-Induced Increased Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation and Apoptotic Cell Death in SK-N-SH Cells
    Ki Young Kim, Hwa Kyoung Shin, Jeong Hyun Lee, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim, Yung Woo Shin and Ki Whan Hong
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 97-104; DOI: https://doi.org/10.1124/jpet.103.058768
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    Role of Receptor Protein and Membrane Lipids in Xanomeline Wash-Resistant Binding to Muscarinic M1 Receptors
    Jan Jakubík, Stanislav Tuček and Esam E. El-Fakahany
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 105-110; DOI: https://doi.org/10.1124/jpet.103.058594
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    Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates Glutathione S-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity
    Pamela K. Smitherman, Alan J. Townsend, Timothy E. Kute and Charles S. Morrow
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 260-267; DOI: https://doi.org/10.1124/jpet.103.057729
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    Roles of Catalase and Hydrogen Peroxide in Green Tea Polyphenol-Induced Chemopreventive Effects
    Tetsuya Yamamoto, Jill Lewis, John Wataha, Douglas Dickinson, Baldev Singh, Wendy B. Bollag, Eisaku Ueta, Tokio Osaki, Mohammad Athar, George Schuster and Stephen Hsu
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 317-323; DOI: https://doi.org/10.1124/jpet.103.058891
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    Muscarinic Agonist-Mediated Heterologous Desensitization in Isolated Ileum Requires Activation of Both Muscarinic M2 and M3 Receptors
    Michael T. Griffin, Minoru Matsui, Darakhshanda Shehnaz, Khurram Z. Ansari, Makoto M. Taketo, Toshiya Manabe and Frederick J. Ehlert
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 339-349; DOI: https://doi.org/10.1124/jpet.103.055327

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect
    Takanori Akagi, Kazami Ushinohama, Shoko Ikesue, Eiji Yukawa, Shun Higuchi, Kenji Hamase, Kiyoshi Zaitsu and Shigehiro Ohdo
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 378-384; DOI: https://doi.org/10.1124/jpet.103.055657

ENDOCRINE AND REPRODUCTIVE

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    Ovarian Steroid Hormone Modulation of the Acute Effects of Cocaine on Luteinizing Hormone and Prolactin Levels in Ovariectomized Rhesus Monkeys
    Nancy K. Mello, Jack H. Mendelson, S. Stevens Negus and Maureen Kelly
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 156-167; DOI: https://doi.org/10.1124/jpet.103.057216

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Hyperosmolar Solution Effects in Guinea Pig Airways. I. Mechanical Responses to Relative Changes in Osmolarity
    Jeffrey S. Fedan, Janet A. Dowdy, Richard A. Johnston and Michael R. Van Scott
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 10-18; DOI: https://doi.org/10.1124/jpet.103.051607
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    Hyperosmolar Solution Effects in Guinea Pig Airways. II. Epithelial Bioelectric Responses to Relative Changes in Osmolarity
    David X.-Y. Wu, Richard A. Johnston, Appavoo Rengasamy, Michael R. Van Scott and Jeffrey S. Fedan
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 19-29; DOI: https://doi.org/10.1124/jpet.103.051615
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    Hyperosmolar Solution Effects in Guinea Pig Airways. III. Studies on the Identity of Epithelium-Derived Relaxing Factor in Isolated Perfused Trachea Using Pharmacological Agents
    Jeffrey S. Fedan, Janet A. Dowdy, Michael R. Van Scott, David X.-Y. Wu and Richard A. Johnston
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 30-36; DOI: https://doi.org/10.1124/jpet.103.051664
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    Hyperosmolar Solution Effects in Guinea Pig Airways. IV. Lipopolysaccharide-Induced Alterations in Airway Reactivity and Epithelial Bioelectric Responses to Methacholine and Hyperosmolarity
    Richard A. Johnston, Michael R. Van Scott, Choudari Kommineni, Lyndell L. Millecchia, Juanita Dortch-Carnes and Jeffrey S. Fedan
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 37-46; DOI: https://doi.org/10.1124/jpet.103.051672
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    Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. I. Phospholipases and Ca2+ Sources
    Tim Schneider, Peter Hein and Martin C. Michel
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 47-53; DOI: https://doi.org/10.1124/jpet.103.058248
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    Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. II. Protein Kinases
    Marina Fleichman, Tim Schneider, Charlotte Fetscher and Martin C. Michel
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 54-58; DOI: https://doi.org/10.1124/jpet.103.058255
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    Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway
    Yi N. Ye, Edgar S. L. Liu, Vivian Y. Shin, William K. K. Wu, Jiing C. Luo and Chi H. Cho
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 66-72; DOI: https://doi.org/10.1124/jpet.103.058321
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    Antitumor Effect of a Splenic Injection of 5-Fluorouracil on Metastatic Liver Cancer in Mice
    Kenichi Kanoh, Tatsuo Shimura, Hideki Suzuki, Kenichi Nomoto, Takayuki Asao and Hiroyuki Kuwano
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 168-174; DOI: https://doi.org/10.1124/jpet.103.057547
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    Oral Treatment with Recombinant Human Interleukin-11 Improves Mucosal Transport in the Colon of Human Leukocyte Antigen-B27 Transgenic Rats
    Kalina Venkova, James C. Keith and Beverley Greenwood-Van Meerveld
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 206-213; DOI: https://doi.org/10.1124/jpet.103.058701
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    The Inhibitory Effect of Adrenomedullin in the Rat Ileum: Cross-Talk with β3-Adrenoceptor in the Serotonin-Induced Muscle Contraction
    Gennadi M. Kravtsov, Isabel S. S. Hwang and Fai Tang
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 241-248; DOI: https://doi.org/10.1124/jpet.103.057612
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    Interaction of Cyclooxygenase Isoenzymes, Nitric Oxide, and Afferent Neurons in Gastric Mucosal Defense in Rats
    Karlheinz Ehrlich, Christa Sicking, Michael Respondek and Brigitta M. Peskar
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 277-283; DOI: https://doi.org/10.1124/jpet.103.057752
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    Characterization of Specific Opioid Binding Sites in Neural Membranes from the Myenteric Plexus of Porcine Small Intestine
    DeWayne Townsend, Philip S. Portoghese and David R. Brown
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 385-393; DOI: https://doi.org/10.1124/jpet.103.058016

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia
    Melvyn Lynn, Y. Nancy Wong, Janice L. Wheeler, Richard J. Kao, Carlos A. Perdomo, Robert Noveck, Ramon Vargas, Tony D'Angelo, Sandra Gotzkowsky, F. Gilbert McMahon, Kishor M. Wasan and Daniel P. Rossignol
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 175-181; DOI: https://doi.org/10.1124/jpet.103.056531
  • You have access
    Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor
    Robin L. Thurmond, Siquan Sun, Clark A. Sehon, Sherry M. Baker, Hui Cai, Yin Gu, Wen Jiang, Jason P. Riley, Kacy N. Williams, James P. Edwards and Lars Karlsson
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 268-276; DOI: https://doi.org/10.1124/jpet.103.056879
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    Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 Cells
    Mingchen Song, John A. Kellum, Hoda Kaldas and Mitchell P. Fink
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 307-316; DOI: https://doi.org/10.1124/jpet.103.056622

NEUROPHARMACOLOGY

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    Modulation of Ca2+Channel Currents by a Novel Antidementia DrugN-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960) in Rat Hippocampal Neurons
    Feng Wang, Nobuya Matsuoka, Seitaro Mutoh and Shuji Kaneko
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 120-126; DOI: https://doi.org/10.1124/jpet.103.057687
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    Effects of 2-[N-(4-Chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an Orally Active α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist, in Models of Generalized Epileptic Seizure in Mice and Rats
    Hiroshi Yamashita, Kazushige Ohno, Yoko Amada, Hanae Hattori, Yukiko Ozawa-Funatsu, Takashi Toya, Hiroshi Inami, Jun-Ichi Shishikura, Shuichi Sakamoto, Masamichi Okada and Tokio Yamaguchi
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 127-133; DOI: https://doi.org/10.1124/jpet.103.058495
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    An Electrophysiological Model of Spinal Transmission Deficits in Mouse Experimental Autoimmune Encephalomyelitis
    Susan E. Hanak, Erin M. Reilly, Jill Wotanis, Bin Zhu, Claudine Pulicicchio, Kathleen McMonagle-Strucko, Joseph G. Wettstein and Mark D. Black
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 214-220; DOI: https://doi.org/10.1124/jpet.103.056994
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    Sensitization of Neuronal A2A Adenosine Receptors after Persistent D2 Dopamine Receptor Activation
    Timothy A. Vortherms and Val J. Watts
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 221-227; DOI: https://doi.org/10.1124/jpet.103.057083
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    Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine
    Gin C. Hsieh, Peter R. Hollingsworth, Brenda Martino, Renjie Chang, Marc A. Terranova, Alyssa B. O'Neill, James J. Lynch, Robert B. Moreland, Diana L. Donnelly-Roberts, Teodozyi Kolasa, Joseph P. Mikusa, Jill M. McVey, Kennan C. Marsh, James P. Sullivan and Jorge D. Brioni
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 330-338; DOI: https://doi.org/10.1124/jpet.103.057455
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    Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex
    Lisa S. Middleton, Wayne A. Cass and Linda P. Dwoskin
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 367-377; DOI: https://doi.org/10.1124/jpet.103.055335

TOXICOLOGY

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    Suppression of Cytochrome P450 2E1 Promoter Activity by Interferon-γ and Loss of Response Due to the -71G>T Nucleotide Polymorphism of the CYP2E1*7B Allele
    Ling O. Qiu, Mark W. Linder, Deborah M. Antonino-Green and Roland Valdes
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 284-288; DOI: https://doi.org/10.1124/jpet.103.057208
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    In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress
    F. Pouzaud, K. Bernard-Beaubois, M. Thevenin, J.-M. Warnet, G. Hayem and P. Rat
    Journal of Pharmacology and Experimental Therapeutics January 2004, 308 (1) 394-402; DOI: https://doi.org/10.1124/jpet.103.057984
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Journal of Pharmacology and Experimental Therapeutics: 308 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 308, Issue 1
1 Jan 2004
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  • EDITORIAL
  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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