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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

December 01, 2003; Volume 307,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Pharmacogenetic Considerations in Diseases of Cardiac Ion Channels
    Arun Anantharam, Steven M. Markowitz and Geoffrey W. Abbott
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 831-838; DOI: https://doi.org/10.1124/jpet.103.054569
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    Steroid Hormone Interactions with Target Cells: Cross Talk between Membrane and Nuclear Pathways
    Mary C. Farach-Carson and Paul J. Davis
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 839-845; DOI: https://doi.org/10.1124/jpet.103.055038

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore
    Ann-Charlotte Egnell, Cecilia Eriksson, Nan Albertson, Brian Houston and Scott Boyer
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 878-887; DOI: https://doi.org/10.1124/jpet.103.054999
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    Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression
    Vishal Lamba, Jatinder Lamba, Kazuto Yasuda, Stephen Strom, Julio Davila, Michael L. Hancock, James D. Fackenthal, Peter K. Rogan, Barbara Ring, Steven A. Wrighton and Erin G. Schuetz
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 906-922; DOI: https://doi.org/10.1124/jpet.103.054866
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    Simultaneous Modeling of Abciximab Plasma Concentrations and ex Vivo Pharmacodynamics in Patients Undergoing Coronary Angioplasty
    Donald E. Mager, Mary A. Mascelli, Neal S. Kleiman, Desmond J. Fitzgerald and Darrell R. Abernethy
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 969-976; DOI: https://doi.org/10.1124/jpet.103.057299
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    Stereoselective and Concentration-Dependent Polarized Epithelial Permeability of a Series of Phosphoramidate Triester Prodrugs of d4T: An in Vitro Study in Caco-2 and Madin-Darby Canine Kidney Cell Monolayers
    Dario Siccardi, Lana E. Kandalaft, Mark Gumbleton and Christopher McGuigan
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1112-1119; DOI: https://doi.org/10.1124/jpet.103.056135
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    Rapid Transcriptional Suppression of Rat Cytochrome P450 Genes by Endotoxin Treatment and Its Inhibition by Curcumin
    Po-Yung Cheng, Molin Wang and Edward T. Morgan
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1205-1212; DOI: https://doi.org/10.1124/jpet.103.057174
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    Evidence for the Involvement of a Pulmonary First-Pass Effect via Carboxylesterase in the Disposition of a Propranolol Ester Derivative after Intravenous Administration
    Teruko Imai, Yasushi Yoshigae, Masakiyo Hosokawa, Kan Chiba and Masaki Otagiri
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1234-1242; DOI: https://doi.org/10.1124/jpet.103.056499

BEHAVIORAL PHARMACOLOGY

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    Involvement of Adenosine A1 and A2A Receptors in the Adenosinergic Modulation of the Discriminative-Stimulus Effects of Cocaine and Methamphetamine in Rats
    Zuzana Justinova, Sergi Ferré, Pavan N. Segal, Katerina Antoniou, Marcello Solinas, Lara A. Pappas, Jena L. Highkin, Jörg Hockemeyer, Patrik Munzar and Steven R. Goldberg
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 977-986; DOI: https://doi.org/10.1124/jpet.103.056762
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    Intra-Accumbal Injection of CART (Cocaine-Amphetamine Regulated Transcript) Peptide Reduces Cocaine-Induced Locomotor Activity
    Jason N. Jaworski, Marie A. Kozel, Kelly B. Philpot and Michael J. Kuhar
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1038-1044; DOI: https://doi.org/10.1124/jpet.103.052332
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    Opioid Interactions in Rhesus Monkeys: Effects of δ + μ and δ + κ Agonists on Schedule-Controlled Responding and Thermal Nociception
    Glenn W. Stevenson, John E. Folk, David C. Linsenmayer, Kenner C. Rice and S. Stevens Negus
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1054-1064; DOI: https://doi.org/10.1124/jpet.103.056515

CARDIOVASCULAR

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    p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 1. p38 MAPK-Dependent Endothelial Dysfunction and Hypertension
    Haisong Ju, David J. Behm, Sandyha Nerurkar, Marianne E. Eybye, Robin E. Haimbach, Alan R. Olzinski, Stephen A. Douglas and Robert N. Willette
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 932-938; DOI: https://doi.org/10.1124/jpet.103.057422
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    Amiodarone Inhibits Sarcolemmal but Not Mitochondrial KATP Channels in Guinea Pig Ventricular Cells
    Toshiaki Sato, Taichi Takizawa, Tomoaki Saito, Satoru Kobayashi, Yukio Hara and Haruaki Nakaya
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 955-960; DOI: https://doi.org/10.1124/jpet.103.055863
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    Renal Extraction of Angiotensin II
    Edwin K. Jackson and William A. Herzer
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1001-1006; DOI: https://doi.org/10.1124/jpet.103.055236
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    Fructose-Fed Rats Are Protected against Ischemia/Reperfusion Injury
    James E. Jordan, Steven A. Simandle, Christina D. Tulbert, David W. Busija and Allison W. Miller
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1007-1011; DOI: https://doi.org/10.1124/jpet.103.055970
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    The Thromboxane Receptor Antagonist PBT-3, a Hepoxilin Stable Analog, Selectively Antagonizes the TPα Isoform in Transfected COS-7 Cells
    Na Qiao, Denis Reynaud, Peter Demin, Perry V. Halushka and Cecil R. Pace-Asciak
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1142-1147; DOI: https://doi.org/10.1124/jpet.103.056705
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    Inhibition of Platelet-Activating Factor (PAF) Acetylhydrolase by Methyl Arachidonyl Fluorophosphonate Potentiates PAF Synthesis in Thrombin-Stimulated Human Coronary Artery Endothelial Cells
    Pamela J. Kell, Michael H. Creer, Kimberley N. Crown, Karin Wirsig and Jane McHowat
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1163-1170; DOI: https://doi.org/10.1124/jpet.103.055392
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    Angiotensin Subtype 1 Receptor (AT1) Blockade Improves Vasorelaxation in Heart Failure by Up-Regulation of Endothelial Nitric-Oxide Synthase via Activation of the AT2 Receptor
    Hoang Thai, Jason Wollmuth, Steven Goldman and Mohamed Gaballa
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1171-1178; DOI: https://doi.org/10.1124/jpet.103.054916

CELLULAR AND MOLECULAR

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    Pumping of Drugs by P-Glycoprotein: A Two-Step Process?
    Thomas Litman, Torben Skovsgaard and Wilfred D. Stein
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 846-853; DOI: https://doi.org/10.1124/jpet.103.056960
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    Agonist-Dependent Internalization of the Human Melanocortin-4 Receptors in Human Embryonic Kidney 293 Cells
    Zhenhai Gao, Dachuan Lei, Julie Welch, Kathy Le, Jie Lin, Song Leng and David Duhl
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 870-877; DOI: https://doi.org/10.1124/jpet.103.055525
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    Tumor Necrosis Factor-α and Troglitazone Regulate Plasminogen Activator Inhibitor Type 1 Production through Extracellular Signal-Regulated Kinase- and Nuclear Factor-κB-Dependent Pathways in Cultured Human Umbilical Vein Endothelial Cells
    Erika Hamaguchi, Toshinari Takamura, Akiko Shimizu and Yukihiro Nagai
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 987-994; DOI: https://doi.org/10.1124/jpet.103.054346
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    Neuropeptide Y Y4 Receptor Homodimers Dissociate upon Agonist Stimulation
    Magnus M. Berglund, Douglas A. Schober, Michail A. Esterman and Donald R. Gehlert
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1120-1126; DOI: https://doi.org/10.1124/jpet.103.055673
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    Differential Effects of Agonists on Adenylyl Cyclase Superactivation Mediated by the κ Opioid Receptors: Adenylyl Cyclase Superactivation Is Independent of Agonist-Induced Phosphorylation, Desensitization, Internalization, and Down-Regulation
    Yulin Wang, Jian-Guo Li, Peng Huang, Wei Xu and Lee-Yuan Liu-Chen
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1127-1134; DOI: https://doi.org/10.1124/jpet.103.055814

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Repression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase-1 by Anthracyclines Contributes to Their Antiapoptotic Activation of p44/42-MAPK
    George W. Small, Sivagurunathan Somasundaram, Dominic T. Moore, Yue Y. Shi and Robert Z. Orlowski
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 861-869; DOI: https://doi.org/10.1124/jpet.103.055806

ENDOCRINE AND REPRODUCTIVE

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    Contrasting Metabolic Effects of Antihypertensive Agents
    Rodney A. Velliquette and Paul Ernsberger
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1104-1111; DOI: https://doi.org/10.1124/jpet.103.054221
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    Inhibition of Adrenal Cortical Steroid Formation by Procaine Is Mediated by Reduction of the cAMP-Induced 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Messenger Ribonucleic Acid Levels
    Jing Xu, Laurent Lecanu, Zeqiu Han, Zhixing Yao, Janet Greeson and Vassilios Papadopoulos
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1148-1157; DOI: https://doi.org/10.1124/jpet.103.055178
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    Mediation of β-Endorphin by Isoferulic Acid to Lower Plasma Glucose in Streptozotocin-Induced Diabetic Rats
    I-Min Liu, Wang-Chuan Chen and Juei-Tang Cheng
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1196-1204; DOI: https://doi.org/10.1124/jpet.103.053900

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Peroxisome Proliferator-Activated Receptor γ Agonist Provides Superior Renal Protection versus Angiotensin-Converting Enzyme Inhibition in a Rat Model of Type 2 Diabetes with Obesity
    Chris Baylis, Elke-Astrid Atzpodien, Gary Freshour and Kevin Engels
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 854-860; DOI: https://doi.org/10.1124/jpet.103.055616
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    Adenosine Biosynthesis in the Collecting Duct
    Edwin K. Jackson, Zaichuan Mi, Chongxue Zhu and Raghvendra K. Dubey
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 888-896; DOI: https://doi.org/10.1124/jpet.103.057166
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    p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 2. Improved Renal Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging
    Stephen C. Lenhard, Sandhya S. Nerurkar, Thomas R. Schaeffer, Rosanna C. Mirabile, Rogely W. Boyce, David F. Adams, Beat M. Jucker and Robert N. Willette
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 939-946; DOI: https://doi.org/10.1124/jpet.103.057398
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    Ginger Reduces Hyperglycemia-Evoked Gastric Dysrhythmias in Healthy Humans: Possible Role of Endogenous Prostaglandins
    Sutep Gonlachanvit, Yen Hsueh Chen, William L. Hasler, Wei Ming Sun and Chung Owyang
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1098-1103; DOI: https://doi.org/10.1124/jpet.103.053421

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Beneficial Effects of Heme Oxygenase-1 Up-Regulation in the Development of Experimental Inflammation Induced by Zymosan
    Ana María Vicente, María Isabel Guillén, Aüida Habib and María José Alcaraz
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1030-1037; DOI: https://doi.org/10.1124/jpet.103.057992
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    Gallium Arsenide Selectively Up-Regulates Inflammatory Cytokine Expression at Exposure Site
    Stephen M. Becker and Kathleen L. McCoy
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1045-1053; DOI: https://doi.org/10.1124/jpet.103.057919
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    Critical Role of Histamine H4 Receptor in Leukotriene B4 Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo
    Keisuke Takeshita, Katsuya Sakai, Kevin B. Bacon and Florian Gantner
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1072-1078; DOI: https://doi.org/10.1124/jpet.103.057489
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    Methylnaltrexone Antagonizes Opioid-Mediated Enhancement of HIV Infection of Human Blood Mononuclear Phagocytes
    Wen-Zhe Ho, Chang-Jiang Guo, Chun-Su Yuan, Steven D. Douglas and Jonathan Moss
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1158-1162; DOI: https://doi.org/10.1124/jpet.103.056697
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    Unique Regulation Profile of Prostaglandin E1 on Adhesion Molecule Expression and Cytokine Production in Human Peripheral Blood Mononuclear Cells
    Hideo Kohka Takahashi, Hiromi Iwagaki, Ryuji Tamura, Dong Xue, Masahiro Sano, Shuji Mori, Tadashi Yoshino, Noriaki Tanaka and Masahiro Nishibori
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1188-1195; DOI: https://doi.org/10.1124/jpet.103.056432
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    Induction of C-X-C Chemokines, Growth-Related Oncogene α Expression, and Epithelial Cell-Derived Neutrophil-Activating Protein-78 by ML-1 (Interleukin-17F) Involves Activation of Raf1-Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase 1/2 Pathway
    Mio Kawaguchi, Fumio Kokubu, Satoshi Matsukura, Koushi Ieki, Miho Odaka, Shin Watanabe, Shintaro Suzuki, Mitsuru Adachi and Shau-Ku Huang
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1213-1220; DOI: https://doi.org/10.1124/jpet.103.056341

NEUROPHARMACOLOGY

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    Identification of Critical Residues in the Amino Terminal Domain of the Human NR2B Subunit Involved in the RO 25-6981 Binding Pocket
    Pari Malherbe, Vincent Mutel, Clemens Broger, Florent Perin-Dureau, John A. Kemp, Jacques Neyton, Pierre Paoletti and James N. C. Kew
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 897-905; DOI: https://doi.org/10.1124/jpet.103.056291
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    Comparison of [Dmt1]DALDA and DAMGO in Binding and G Protein Activation at μ, δ, and κ Opioid Receptors
    Guo-Min Zhao, Xuanxuan Qian, Peter W. Schiller and Hazel H. Szeto
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 947-954; DOI: https://doi.org/10.1124/jpet.103.054775
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    A Novel Potent Radical Scavenger, 8-(4-Fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo[5,1-c] [1,2,4]triazine (FR210575), Prevents Neuronal Cell Death in Cultured Primary Neurons and Attenuates Brain Injury after Focal Ischemia in Rats
    Akinori Iwashita, Takuya Maemoto, Hirohisa Nakada, Ichiro Shima, Nobuya Matsuoka and Hiroshi Hisajima
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 961-968; DOI: https://doi.org/10.1124/jpet.103.056572
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    Site of Action of the General Anesthetic Propofol in Muscarinic M1 Receptor-Mediated Signal Transduction
    Osamu Murasaki, Muneshige Kaibara, Yoshihisa Nagase, Sayaka Mitarai, Yoshiyuki Doi, Koji Sumikawa and Kohtaro Taniyama
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 995-1000; DOI: https://doi.org/10.1124/jpet.103.055772
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    A Region-Specific Increase in Gαq And Gα11 Proteins in Brains of Rats during Cocaine Withdrawal
    Gonzalo A. Carrasco, Yahong Zhang, Katerina J. Damjanoska, Deborah N. D'Souza, Francisca Garcia, George Battaglia, Nancy A. Muma and Louis D. Van de Kar
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1012-1019; DOI: https://doi.org/10.1124/jpet.103.056978
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    Chronic Ethanol Ingestion Facilitates N-Methyl-d-aspartate Receptor Function and Expression in Rat Lateral/Basolateral Amygdala Neurons
    Donald W. Floyd, Ki-Yoon Jung and Brian A. McCool
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1020-1029; DOI: https://doi.org/10.1124/jpet.103.057505
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    Antiallodynic Effects of Intrathecal Orexins in a Rat Model of Postoperative Pain
    Jen-Kun Cheng, Robert Chang-Chih Chou, Ling-Ling Hwang and Lih-Chu Chiou
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1065-1071; DOI: https://doi.org/10.1124/jpet.103.056663
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    Evidence for a Selective Role of the δ-Opioid Agonist [8R-(4bS*,8aα,8aβ,12bβ)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline Hydrochloride (SB-235863) in Blocking Hyperalgesia Associated with Inflammatory and Neuropathic Pain Responses
    Paola Petrillo, Ornella Angelici, Sharon Bingham, Giovanna Ficalora, Martine Garnier, Paola F. Zaratin, Giuseppe Petrone, Ottorino Pozzi, Massimo Sbacchi, Tania O. Stean, Neil Upton, Guillio M. Dondio and Mark A. Scheideler
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1079-1089; DOI: https://doi.org/10.1124/jpet.103.055590
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    Subtype-Selective Up-Regulation by Chronic Nicotine of High-Affinity Nicotinic Receptors in Rat Brain Demonstrated by Receptor Autoradiography
    Henry N. Nguyen, Bruce A. Rasmussen and David C. Perry
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1090-1097; DOI: https://doi.org/10.1124/jpet.103.056408
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    Dynorphinergic Mechanism Mediating Endomorphin-2-Induced Antianalgesia in the Mouse Spinal Cord
    Hsiang-En Wu, Han-Sen Sun, Moses Darpolar, Randy J. Leitermann, John P. Kampine and Leon F. Tseng
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1135-1141; DOI: https://doi.org/10.1124/jpet.103.056242
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    DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A Mixed Opioid Agonist with Potent Antinociceptive Activity
    Peter J. Gengo, Hugh O. Pettit, Scott J. O'Neill, Ke Wei, Robert McNutt, Michael J. Bishop and Kwen-Jen Chang
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1221-1226; DOI: https://doi.org/10.1124/jpet.103.054361
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    DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A Mixed Opioid Agonist with Potent Antinociceptive Activity and Limited Effects on Respiratory Function
    Peter J. Gengo, Hugh O. Pettit, Scott J. O'Neill, Ying Fu Su, Robert McNutt and Kwen-Jen Chang
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1227-1233; DOI: https://doi.org/10.1124/jpet.103.054429

TOXICOLOGY

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    Neuronal and Astroglial Responses to the Serotonin and Norepinephrine Neurotoxin: 1-Methyl-4-(2′-aminophenyl)-1,2,3,6-tetrahydropyridine
    Beth A. Luellen, Diane B. Miller, Angela C. Chisnell, Dennis L. Murphy, James P. O'Callaghan and Anne Milasincic Andrews
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 923-931; DOI: https://doi.org/10.1124/jpet.103.055749
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    Pharmacokinetics and Pharmacodynamics of Methylecgonidine, a Crack Cocaine Pyrolyzate
    Karl B. Scheidweiler, Mark A. Plessinger, Jalil Shojaie, Ronald W. Wood and Tai C. Kwong
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1179-1187; DOI: https://doi.org/10.1124/jpet.103.055434

Errata

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    Correction to “Inhibitor Binding to Type 4 Phosphodiesterase (PDE4) Assessed Using [3H]Piclamilast and [3H]Rolipram”
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1243;
  • You have access
    Correction to “Cytochrome P450 2E1 (CYP2E1) Is the Principal Enzyme Responsible for Urethane Metabolism: Comparative Studies Using CYP2E1-Null and Wild-Type Mice”
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1243;
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    Correction to “Evidence That Nuclear Factor-{kappa}B Activation Is Critical in Oxidant-Induced Disruption of the Microtubule Cytoskeleton and Barrier Integrity and That Its Inactivation Is Essential in Epidermal Growth Factor-Mediated Protection of the Monolayers of Intestinal Epithelia”
    Journal of Pharmacology and Experimental Therapeutics December 2003, 307 (3) 1243;
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Journal of Pharmacology and Experimental Therapeutics: 307 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 307, Issue 3
1 Dec 2003
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Errata
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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