Journal of Pharmacology and Experimental Therapeutics: 307 (2)

November 01, 2003; Volume 307,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking
Joann Trejo

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 437-442; DOI: https://doi.org/10.1124/jpet.103.052100

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Developmental Expression of the Major Human Hepatic CYP3A Enzymes
Jeffrey C. Stevens, Ronald N. Hines, Chungang Gu, Sevasti B. Koukouritaki, Jason R. Manro, Peter J. Tandler and Matthew J. Zaya

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 573-582; DOI: https://doi.org/10.1124/jpet.103.054841
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Altered Diurnal Rhythm of Intestinal Peptide Transporter by Fasting and Its Effects on the Pharmacokinetics of Ceftibuten
Xiaoyue Pan, Tomohiro Terada, Masahiro Okuda and Ken-Ichi Inui

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 626-632; DOI: https://doi.org/10.1124/jpet.103.055939
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Cellular Uptake and Efflux of the Tea Flavonoid (-)Epicatechin-3-gallate in the Human Intestinal Cell Line Caco-2
Jaya Bharathi Vaidyanathan and Thomas Walle

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 745-752; DOI: https://doi.org/10.1124/jpet.103.054296
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Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques
Sangeeta Raje, Jianjing Cao, Amy Hauck Newman, Huanling Gao and Natalie D. Eddington

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 801-808; DOI: https://doi.org/10.1124/jpet.103.053504
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Interaction of Imatinib Mesilate with Human P-Glycoprotein
Akinobu Hamada, Hideto Miyano, Hiroshi Watanabe and Hideyuki Saito

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 824-828; DOI: https://doi.org/10.1124/jpet.103.055574

BEHAVIORAL PHARMACOLOGY

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An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning
Mark D. Lindner, Donald B. Hodges, John B. Hogan, Anitra F. Orie, Jason A. Corsa, Donna M. Barten, Craig Polson, Barbara J. Robertson, Valerie L. Guss, Kevin W. Gillman, John E. Starrett and Valentin K. Gribkoff

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 682-691; DOI: https://doi.org/10.1124/jpet.103.056002
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The Competitive N-Methyl-d-aspartate Receptor Antagonist (-)-6-Phosphonomethyl-deca-hydroisoquinoline-3-carboxylic Acid (LY235959) Potentiates the Antinociceptive Effects of Opioids That Vary in Efficacy at the μ-Opioid Receptor
Richard M. Allen, Arthur L. Granger and Linda A. Dykstra

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 785-792; DOI: https://doi.org/10.1124/jpet.103.055319

CARDIOVASCULAR

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Semicarbazide-Sensitive Amine Oxidase Substrates Potentiate Hydralazine Hypotension: Possible Role of Hydrogen Peroxide
Horacio Vidrio, Martha Medina, Pilar González-Romo, Marte Lorenzana-Jiménez, Patricia Díaz-Arista and Alejandro Baeza

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 497-504; DOI: https://doi.org/10.1124/jpet.103.055350
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Hypothalamic Leptin Receptor and Signaling Molecule Expressions in Cafeteria Diet-Fed Rats
Charles Plut, Catherine Ribière, Yves Giudicelli and Jean-Pierre Dausse

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 544-549; DOI: https://doi.org/10.1124/jpet.103.054726
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A Subset of Highly Effective Propafenone-Type Multidrug Resistance Modulators Lacks Effects on Cardiac Action Potential and Mechanical Twitch Parameters of Rat Papillary Muscles
Diethart Schmid, Dawid L. Staudacher, Hans G. Loew, Paul G. Spieckermann, Gerhard F. Ecker, Stephan Kopp and Peter Chiba

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 589-596; DOI: https://doi.org/10.1124/jpet.103.052993
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Protective Effect of Amiodarone but Not N- Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition
Gabor Varbiro, Ambrus Toth, Antal Tapodi, Zita Bognar, Balazs Veres, Balazs Sumegi and Ferenc Gallyas

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 615-625; DOI: https://doi.org/10.1124/jpet.103.053553
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The Aminotetraline Derivative (±)-(R,S)-5,6-Dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene Hydrochloride (CHF-1024) Displays Cardioprotection in Postischemic Ventricular Dysfunction of the Rat Heart
Giuseppe Rossoni, Barbara Manfredi, Viviana Cavalca, Roberta Razzetti, Stefano Bongrani, Gian Luca Polvani and Ferruccio Berti

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 633-639; DOI: https://doi.org/10.1124/jpet.103.054700
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Up-Regulation of Endothelial Nitric-Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-Activated Protein Kinase and Protein Kinase C Signaling Pathways
Hong Wang, Li Lin, Jiangang Jiang, Yan Wang, Zai Ying Lu, J. Alyce Bradbury, Fred Bjørn Lih, Dao Wen Wang and Darryl C. Zeldin

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 753-764; DOI: https://doi.org/10.1124/jpet.103.052787
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Electrophysiological Safety of Sertindole in Dogs with Normal and Remodeled Hearts
Morten B. Thomsen, Paul G. A. Volders, Milan Stengl, Roel L. H. M. G. Späatjens, Jet D. M. Beekman, Ulrike Bischoff, Morten A. Kall, Kristen Frederiksen, Jørgen Matz and Marc A. Vos

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 776-784; DOI: https://doi.org/10.1124/jpet.103.052753

CELLULAR AND MOLECULAR

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Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans
Katherine G. Moss, Guy C. Toner, Julie M. Cherrington, Dirk B. Mendel and A. Douglas Laird

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 476-480; DOI: https://doi.org/10.1124/jpet.103.052530
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Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in Vivo
Susan R. George, Gordon Y. K. Ng, Samuel P. Lee, Theresa Fan, George Varghese, Chen Wang, Charles M. Deber, Philip Seeman and Brian F. O'Dowd

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 481-489; DOI: https://doi.org/10.1124/jpet.103.053843
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Peroxisome Proliferator-Activated Receptor-γ Activator 15-Deoxy-Δ^12,14-Prostaglandin J₂ Inhibits Neuroblastoma Cell Growth through Induction of Apoptosis: Association with Extracellular Signal-Regulated Kinase Signal Pathway
Eun Joung Kim, Ki Sook Park, Soo Youn Chung, Yhun Yhong Sheen, Dong Chuol Moon, Yeun Sook Song, Kyong Soon Kim, Sukgil Song, Yeo Pyo Yun, Myung Koo Lee, Ki Wan Oh, Do Young Yoon and Jin Tae Hong

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 505-517; DOI: https://doi.org/10.1124/jpet.103.053876
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Ca²⁺ Responses in Chinese Hamster Ovary-K1 Cells Demonstrate an Atypical Pattern of Ligand-Induced 5-HT_1A Receptor Activation
Petrus J. Pauwels and Francis C. Colpaert

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 608-614; DOI: https://doi.org/10.1124/jpet.103.055871
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Ca²⁺ Channel Blockers Enhance Neurotensin (NT) Binding and Inhibit NT-Induced Inositol Phosphate Formation in Prostate Cancer PC3 Cells
Robert E. Carraway, Xianyong Gui and David E. Cochrane

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 640-650; DOI: https://doi.org/10.1124/jpet.103.052688
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Cross Talk between P2Y₂ Nucleotide Receptors and CXC Chemokine Receptor 2 Resulting in Enhanced Ca²⁺ Signaling Involves Enhancement of Phospholipase C Activity and Is Enabled by Incremental Ca²⁺ Release in Human Embryonic Kidney Cells
Tim D. Werry, Graeme F. Wilkinson and Gary B. Willars

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 661-669; DOI: https://doi.org/10.1124/jpet.103.055632
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Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
Erding Hu, Edward Dul, Chiu-Mei Sung, Zunxuan Chen, Robert Kirkpatrick, Gui-Feng Zhang, Kyung Johanson, Ronggang Liu, Amparo Lago, Glenn Hofmann, Ricardo Macarron, Maite De Los Frailes, Paloma Perez, John Krawiec, James Winkler and Michael Jaye

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 720-728; DOI: https://doi.org/10.1124/jpet.103.055541
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Substrate-Induced Trafficking of the Dopamine Transporter in Heterologously Expressing Cells and in Rat Striatal Synaptosomal Preparations
Limen Chi and Maarten E. A. Reith

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 729-736; DOI: https://doi.org/10.1124/jpet.103.055095
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Cytotoxicity, DNA Damage, and Apoptosis Induced by New Fotemustine Analogs on Human Melanoma Cells in Relation to O⁶-Methylguanine DNA-Methyltransferase Expression
Isabelle Passagne, Alexandre Evrard, Jean-Yves Winum, Philippe Depeille, Pierre Cuq, Jean-Louis Montero, Didier Cupissol and Laurence Vian

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 816-823; DOI: https://doi.org/10.1124/jpet.103.051938

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Liposomal Delivery Enhances Short-Chain Ceramide-Induced Apoptosis of Breast Cancer Cells
Tom Stover and Mark Kester

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 468-475; DOI: https://doi.org/10.1124/jpet.103.054056

ENDOCRINE AND REPRODUCTIVE

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Glucagon-Like Peptide 1 Receptor Agonist ZP10A Increases Insulin mRNA Expression and Prevents Diabetic Progression in db/db Mice
Christian Thorkildsen, Søren Neve, Bjarne Due Larsen, Eddi Meier and Jørgen Søberg Petersen

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 490-496; DOI: https://doi.org/10.1124/jpet.103.051987

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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NAD⁺ Ameliorates Inflammation-Induced Epithelial Barrier Dysfunction in Cultured Enterocytes and Mouse Ileal Mucosa
Xiaonan Han, Takashi Uchiyama, Penny L. Sappington, Arino Yaguchi, Runkuan Yang, Mitchell P. Fink and Russell L. Delude

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 443-449; DOI: https://doi.org/10.1124/jpet.103.056556
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Neurotransmitters Mediating the Intestinal Peristaltic Reflex in the Mouse
John R. Grider

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 460-467; DOI: https://doi.org/10.1124/jpet.103.053512
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Importance of Amino Acids of the Central Portion of the Second Intracellular Loop of the Gastrin-Releasing Peptide Receptor for Phospholipase C Activation, Internalization, and Chronic Down-Regulation
Michael Schumann, Tomoo Nakagawa, Samuel A. Mantey, Kenji Tokita, David J. Venzon, Simon J. Hocart, Richard V. Benya and Robert T. Jensen

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 597-607; DOI: https://doi.org/10.1124/jpet.103.055087
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Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats
Jiing C. Luo, Vivian Y. Shin, Edgar S. L. Liu, Wallace H. L. So, Yi N. Ye, Full Y. Chang and Chi H. Cho

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 692-698; DOI: https://doi.org/10.1124/jpet.103.055202
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Cyclooxygenase Isozymes Involved in Adaptive Functional Responses in Rat Stomach after Barrier Disruption
Masanori Takeeda, Masanori Yamato, Shinichi Kato and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 713-719; DOI: https://doi.org/10.1124/jpet.103.054973

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D₂-Induced Eosinophilia in Rats
Michitaka Shichijo, Hiromi Sugimoto, Koichi Nagao, Hisayo Inbe, Jeffrey A. Encinas, Keisuke Takeshita, Kevin B. Bacon and Florian Gantner

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 518-525; DOI: https://doi.org/10.1124/jpet.103.055442
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TA-270 [4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an Anti-Asthmatic Agent, Inhibits Leukotriene Production Induced by IgE Receptor Stimulation in RBL-2H3 Cells
Mitsuteru Ishiwara, Yasuo Aoki, Hidetsugu Takagaki, Michio Ui and Fumikazu Okajima

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 583-588; DOI: https://doi.org/10.1124/jpet.103.055145
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Calf Intestinal Alkaline Phosphatase, a Novel Therapeutic Drug for Lipopolysaccharide (LPS)-Mediated Diseases, Attenuates LPS Toxicity in Mice and Piglets
Chantal Beumer, Marty Wulferink, Willem Raaben, Daniëlle Fiechter, Ruud Brands and Willem Seinen

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 737-744; DOI: https://doi.org/10.1124/jpet.103.056606
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Antagonism of N-Methyl-d-aspartate Receptors Reduces the Vulnerability of the Immune System to Stress after Chronic Morphine
Norma C. Alonzo and Barbara M. Bayer

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 793-800; DOI: https://doi.org/10.1124/jpet.103.053264

NEUROPHARMACOLOGY

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Discrete Cell Gene Profiling of Ventral Tegmental Dopamine Neurons after Acute and Chronic Cocaine Self-Administration
Eric Backes and Scott E. Hemby

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 450-459; DOI: https://doi.org/10.1124/jpet.103.054965
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Characterization of Spontaneous and Precipitated Nicotine Withdrawal in the Mouse
M. I. Damaj, W. Kao and B. R. Martin

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 526-534; DOI: https://doi.org/10.1124/jpet.103.054908
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Acetylcholinesterase Inhibitors Activate Septohippocampal GABAergic Neurons via Muscarinic but Not Nicotinic Receptors
Min Wu, Samuel S. Newton, Joshua B. Atkins, Changqing Xu, Ronald S. Duman and Meenakshi Alreja

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 535-543; DOI: https://doi.org/10.1124/jpet.103.052514
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Suppression of L-Type Voltage-Gated Calcium Channel-Dependent Synaptic Plasticity by Ethanol: Analysis of Miniature Synaptic Currents and Dendritic Calcium Transients
Adam W. Hendricson, Mark P. Thomas, Melanie J. Lippmann and Richard A. Morrisett

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 550-558; DOI: https://doi.org/10.1124/jpet.103.055137
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Neuropeptide Y Receptor-Mediated Sensitization of ATP-Stimulated Inositol Phosphate Formation
D. A. Drakulich, A. M. Walls, M. L. Toews and T. D. Hexum

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 559-565; DOI: https://doi.org/10.1124/jpet.103.053082
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Ethanol Withdrawal Reduces the Number of Spontaneously Active Ventral Tegmental Area Dopamine Neurons in Conscious Animals
Roh-Yu Shen

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 566-572; DOI: https://doi.org/10.1124/jpet.103.053371
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Effect of β-Amyloid Peptide 1-42 on the Cytoprotective Action Mediated by α7 Nicotinic Acetylcholine Receptors in Growth Factor-Deprived Differentiated PC-12 Cells
Xinyu D. Li and Jerry J. Buccafusco

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 670-675; DOI: https://doi.org/10.1124/jpet.103.053785
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Up-Regulation of Spinal Muscarinic Receptors and Increased Antinociceptive Effect of Intrathecal Muscarine in Diabetic Rats
Shao-Rui Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 676-681; DOI: https://doi.org/10.1124/jpet.103.055905
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Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice
Ronald J. Tallarida, Alan Cowan and Robert B. Raffa

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 699-704; DOI: https://doi.org/10.1124/jpet.103.054320
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Protein Kinase C-Dependent Potentiation of Intracellular Calcium Influx by σ₁ Receptor Agonists in Rat Hippocampal Neurons
F. P. Monnet, M. P. Morin-Surun, J. Leger and L. Combettes

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 705-712; DOI: https://doi.org/10.1124/jpet.103.053447
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Mechanism-Based Modeling of the Pharmacodynamic Interaction of Alphaxalone and Midazolam in Rats
S. A. G. Visser, D. R. H. Huntjens, P. H. van der Graaf, L. A. Peletier and M. Danhof

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 765-775; DOI: https://doi.org/10.1124/jpet.103.054510
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ATP Modulates Noradrenaline Release by Activation of Inhibitory P2Y Receptors and Facilitatory P2X Receptors in the Rat Vas Deferens
Glória Queiroz, Carlos Talaia and Jorge Gonçalves

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 809-815; DOI: https://doi.org/10.1124/jpet.103.054809

TOXICOLOGY

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Repeated Exposures to Heroin and/or Cadmium Alter the Rate of Formation of Morphine Glucuronides in the Rat
Letizia Antonilli, Carmen Suriano, Giovanna Paolone, Aldo Badiani and Paolo Nencini

Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 651-660; DOI: https://doi.org/10.1124/jpet.103.055467

Erratum

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Correction to “Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect”
Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 829;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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