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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2003; Volume 307,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking
    Joann Trejo
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 437-442; DOI: https://doi.org/10.1124/jpet.103.052100

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Developmental Expression of the Major Human Hepatic CYP3A Enzymes
    Jeffrey C. Stevens, Ronald N. Hines, Chungang Gu, Sevasti B. Koukouritaki, Jason R. Manro, Peter J. Tandler and Matthew J. Zaya
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 573-582; DOI: https://doi.org/10.1124/jpet.103.054841
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    Altered Diurnal Rhythm of Intestinal Peptide Transporter by Fasting and Its Effects on the Pharmacokinetics of Ceftibuten
    Xiaoyue Pan, Tomohiro Terada, Masahiro Okuda and Ken-Ichi Inui
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 626-632; DOI: https://doi.org/10.1124/jpet.103.055939
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    Cellular Uptake and Efflux of the Tea Flavonoid (-)Epicatechin-3-gallate in the Human Intestinal Cell Line Caco-2
    Jaya Bharathi Vaidyanathan and Thomas Walle
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 745-752; DOI: https://doi.org/10.1124/jpet.103.054296
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    Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques
    Sangeeta Raje, Jianjing Cao, Amy Hauck Newman, Huanling Gao and Natalie D. Eddington
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 801-808; DOI: https://doi.org/10.1124/jpet.103.053504
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    Interaction of Imatinib Mesilate with Human P-Glycoprotein
    Akinobu Hamada, Hideto Miyano, Hiroshi Watanabe and Hideyuki Saito
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 824-828; DOI: https://doi.org/10.1124/jpet.103.055574

BEHAVIORAL PHARMACOLOGY

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    An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning
    Mark D. Lindner, Donald B. Hodges, John B. Hogan, Anitra F. Orie, Jason A. Corsa, Donna M. Barten, Craig Polson, Barbara J. Robertson, Valerie L. Guss, Kevin W. Gillman, John E. Starrett and Valentin K. Gribkoff
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 682-691; DOI: https://doi.org/10.1124/jpet.103.056002
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    The Competitive N-Methyl-d-aspartate Receptor Antagonist (-)-6-Phosphonomethyl-deca-hydroisoquinoline-3-carboxylic Acid (LY235959) Potentiates the Antinociceptive Effects of Opioids That Vary in Efficacy at the μ-Opioid Receptor
    Richard M. Allen, Arthur L. Granger and Linda A. Dykstra
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 785-792; DOI: https://doi.org/10.1124/jpet.103.055319

CARDIOVASCULAR

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    Semicarbazide-Sensitive Amine Oxidase Substrates Potentiate Hydralazine Hypotension: Possible Role of Hydrogen Peroxide
    Horacio Vidrio, Martha Medina, Pilar González-Romo, Marte Lorenzana-Jiménez, Patricia Díaz-Arista and Alejandro Baeza
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 497-504; DOI: https://doi.org/10.1124/jpet.103.055350
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    Hypothalamic Leptin Receptor and Signaling Molecule Expressions in Cafeteria Diet-Fed Rats
    Charles Plut, Catherine Ribière, Yves Giudicelli and Jean-Pierre Dausse
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 544-549; DOI: https://doi.org/10.1124/jpet.103.054726
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    A Subset of Highly Effective Propafenone-Type Multidrug Resistance Modulators Lacks Effects on Cardiac Action Potential and Mechanical Twitch Parameters of Rat Papillary Muscles
    Diethart Schmid, Dawid L. Staudacher, Hans G. Loew, Paul G. Spieckermann, Gerhard F. Ecker, Stephan Kopp and Peter Chiba
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 589-596; DOI: https://doi.org/10.1124/jpet.103.052993
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    Protective Effect of Amiodarone but Not N- Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition
    Gabor Varbiro, Ambrus Toth, Antal Tapodi, Zita Bognar, Balazs Veres, Balazs Sumegi and Ferenc Gallyas
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 615-625; DOI: https://doi.org/10.1124/jpet.103.053553
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    The Aminotetraline Derivative (±)-(R,S)-5,6-Dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene Hydrochloride (CHF-1024) Displays Cardioprotection in Postischemic Ventricular Dysfunction of the Rat Heart
    Giuseppe Rossoni, Barbara Manfredi, Viviana Cavalca, Roberta Razzetti, Stefano Bongrani, Gian Luca Polvani and Ferruccio Berti
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 633-639; DOI: https://doi.org/10.1124/jpet.103.054700
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    Up-Regulation of Endothelial Nitric-Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-Activated Protein Kinase and Protein Kinase C Signaling Pathways
    Hong Wang, Li Lin, Jiangang Jiang, Yan Wang, Zai Ying Lu, J. Alyce Bradbury, Fred Bjørn Lih, Dao Wen Wang and Darryl C. Zeldin
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 753-764; DOI: https://doi.org/10.1124/jpet.103.052787
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    Electrophysiological Safety of Sertindole in Dogs with Normal and Remodeled Hearts
    Morten B. Thomsen, Paul G. A. Volders, Milan Stengl, Roel L. H. M. G. Späatjens, Jet D. M. Beekman, Ulrike Bischoff, Morten A. Kall, Kristen Frederiksen, Jørgen Matz and Marc A. Vos
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 776-784; DOI: https://doi.org/10.1124/jpet.103.052753

CELLULAR AND MOLECULAR

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    Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans
    Katherine G. Moss, Guy C. Toner, Julie M. Cherrington, Dirk B. Mendel and A. Douglas Laird
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 476-480; DOI: https://doi.org/10.1124/jpet.103.052530
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    Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in Vivo
    Susan R. George, Gordon Y. K. Ng, Samuel P. Lee, Theresa Fan, George Varghese, Chen Wang, Charles M. Deber, Philip Seeman and Brian F. O'Dowd
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 481-489; DOI: https://doi.org/10.1124/jpet.103.053843
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    Peroxisome Proliferator-Activated Receptor-γ Activator 15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Neuroblastoma Cell Growth through Induction of Apoptosis: Association with Extracellular Signal-Regulated Kinase Signal Pathway
    Eun Joung Kim, Ki Sook Park, Soo Youn Chung, Yhun Yhong Sheen, Dong Chuol Moon, Yeun Sook Song, Kyong Soon Kim, Sukgil Song, Yeo Pyo Yun, Myung Koo Lee, Ki Wan Oh, Do Young Yoon and Jin Tae Hong
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 505-517; DOI: https://doi.org/10.1124/jpet.103.053876
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    Ca2+ Responses in Chinese Hamster Ovary-K1 Cells Demonstrate an Atypical Pattern of Ligand-Induced 5-HT1A Receptor Activation
    Petrus J. Pauwels and Francis C. Colpaert
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 608-614; DOI: https://doi.org/10.1124/jpet.103.055871
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    Ca2+ Channel Blockers Enhance Neurotensin (NT) Binding and Inhibit NT-Induced Inositol Phosphate Formation in Prostate Cancer PC3 Cells
    Robert E. Carraway, Xianyong Gui and David E. Cochrane
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 640-650; DOI: https://doi.org/10.1124/jpet.103.052688
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    Cross Talk between P2Y2 Nucleotide Receptors and CXC Chemokine Receptor 2 Resulting in Enhanced Ca2+ Signaling Involves Enhancement of Phospholipase C Activity and Is Enabled by Incremental Ca2+ Release in Human Embryonic Kidney Cells
    Tim D. Werry, Graeme F. Wilkinson and Gary B. Willars
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 661-669; DOI: https://doi.org/10.1124/jpet.103.055632
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    Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
    Erding Hu, Edward Dul, Chiu-Mei Sung, Zunxuan Chen, Robert Kirkpatrick, Gui-Feng Zhang, Kyung Johanson, Ronggang Liu, Amparo Lago, Glenn Hofmann, Ricardo Macarron, Maite De Los Frailes, Paloma Perez, John Krawiec, James Winkler and Michael Jaye
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 720-728; DOI: https://doi.org/10.1124/jpet.103.055541
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    Substrate-Induced Trafficking of the Dopamine Transporter in Heterologously Expressing Cells and in Rat Striatal Synaptosomal Preparations
    Limen Chi and Maarten E. A. Reith
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 729-736; DOI: https://doi.org/10.1124/jpet.103.055095
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    Cytotoxicity, DNA Damage, and Apoptosis Induced by New Fotemustine Analogs on Human Melanoma Cells in Relation to O6-Methylguanine DNA-Methyltransferase Expression
    Isabelle Passagne, Alexandre Evrard, Jean-Yves Winum, Philippe Depeille, Pierre Cuq, Jean-Louis Montero, Didier Cupissol and Laurence Vian
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 816-823; DOI: https://doi.org/10.1124/jpet.103.051938

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Liposomal Delivery Enhances Short-Chain Ceramide-Induced Apoptosis of Breast Cancer Cells
    Tom Stover and Mark Kester
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 468-475; DOI: https://doi.org/10.1124/jpet.103.054056

ENDOCRINE AND REPRODUCTIVE

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    Glucagon-Like Peptide 1 Receptor Agonist ZP10A Increases Insulin mRNA Expression and Prevents Diabetic Progression in db/db Mice
    Christian Thorkildsen, Søren Neve, Bjarne Due Larsen, Eddi Meier and Jørgen Søberg Petersen
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 490-496; DOI: https://doi.org/10.1124/jpet.103.051987

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    NAD+ Ameliorates Inflammation-Induced Epithelial Barrier Dysfunction in Cultured Enterocytes and Mouse Ileal Mucosa
    Xiaonan Han, Takashi Uchiyama, Penny L. Sappington, Arino Yaguchi, Runkuan Yang, Mitchell P. Fink and Russell L. Delude
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 443-449; DOI: https://doi.org/10.1124/jpet.103.056556
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    Neurotransmitters Mediating the Intestinal Peristaltic Reflex in the Mouse
    John R. Grider
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 460-467; DOI: https://doi.org/10.1124/jpet.103.053512
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    Importance of Amino Acids of the Central Portion of the Second Intracellular Loop of the Gastrin-Releasing Peptide Receptor for Phospholipase C Activation, Internalization, and Chronic Down-Regulation
    Michael Schumann, Tomoo Nakagawa, Samuel A. Mantey, Kenji Tokita, David J. Venzon, Simon J. Hocart, Richard V. Benya and Robert T. Jensen
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 597-607; DOI: https://doi.org/10.1124/jpet.103.055087
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    Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats
    Jiing C. Luo, Vivian Y. Shin, Edgar S. L. Liu, Wallace H. L. So, Yi N. Ye, Full Y. Chang and Chi H. Cho
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 692-698; DOI: https://doi.org/10.1124/jpet.103.055202
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    Cyclooxygenase Isozymes Involved in Adaptive Functional Responses in Rat Stomach after Barrier Disruption
    Masanori Takeeda, Masanori Yamato, Shinichi Kato and Koji Takeuchi
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 713-719; DOI: https://doi.org/10.1124/jpet.103.054973

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D2-Induced Eosinophilia in Rats
    Michitaka Shichijo, Hiromi Sugimoto, Koichi Nagao, Hisayo Inbe, Jeffrey A. Encinas, Keisuke Takeshita, Kevin B. Bacon and Florian Gantner
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 518-525; DOI: https://doi.org/10.1124/jpet.103.055442
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    TA-270 [4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an Anti-Asthmatic Agent, Inhibits Leukotriene Production Induced by IgE Receptor Stimulation in RBL-2H3 Cells
    Mitsuteru Ishiwara, Yasuo Aoki, Hidetsugu Takagaki, Michio Ui and Fumikazu Okajima
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 583-588; DOI: https://doi.org/10.1124/jpet.103.055145
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    Calf Intestinal Alkaline Phosphatase, a Novel Therapeutic Drug for Lipopolysaccharide (LPS)-Mediated Diseases, Attenuates LPS Toxicity in Mice and Piglets
    Chantal Beumer, Marty Wulferink, Willem Raaben, Daniëlle Fiechter, Ruud Brands and Willem Seinen
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 737-744; DOI: https://doi.org/10.1124/jpet.103.056606
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    Antagonism of N-Methyl-d-aspartate Receptors Reduces the Vulnerability of the Immune System to Stress after Chronic Morphine
    Norma C. Alonzo and Barbara M. Bayer
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 793-800; DOI: https://doi.org/10.1124/jpet.103.053264

NEUROPHARMACOLOGY

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    Discrete Cell Gene Profiling of Ventral Tegmental Dopamine Neurons after Acute and Chronic Cocaine Self-Administration
    Eric Backes and Scott E. Hemby
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 450-459; DOI: https://doi.org/10.1124/jpet.103.054965
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    Characterization of Spontaneous and Precipitated Nicotine Withdrawal in the Mouse
    M. I. Damaj, W. Kao and B. R. Martin
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 526-534; DOI: https://doi.org/10.1124/jpet.103.054908
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    Acetylcholinesterase Inhibitors Activate Septohippocampal GABAergic Neurons via Muscarinic but Not Nicotinic Receptors
    Min Wu, Samuel S. Newton, Joshua B. Atkins, Changqing Xu, Ronald S. Duman and Meenakshi Alreja
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 535-543; DOI: https://doi.org/10.1124/jpet.103.052514
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    Suppression of L-Type Voltage-Gated Calcium Channel-Dependent Synaptic Plasticity by Ethanol: Analysis of Miniature Synaptic Currents and Dendritic Calcium Transients
    Adam W. Hendricson, Mark P. Thomas, Melanie J. Lippmann and Richard A. Morrisett
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 550-558; DOI: https://doi.org/10.1124/jpet.103.055137
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    Neuropeptide Y Receptor-Mediated Sensitization of ATP-Stimulated Inositol Phosphate Formation
    D. A. Drakulich, A. M. Walls, M. L. Toews and T. D. Hexum
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 559-565; DOI: https://doi.org/10.1124/jpet.103.053082
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    Ethanol Withdrawal Reduces the Number of Spontaneously Active Ventral Tegmental Area Dopamine Neurons in Conscious Animals
    Roh-Yu Shen
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 566-572; DOI: https://doi.org/10.1124/jpet.103.053371
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    Effect of β-Amyloid Peptide 1-42 on the Cytoprotective Action Mediated by α7 Nicotinic Acetylcholine Receptors in Growth Factor-Deprived Differentiated PC-12 Cells
    Xinyu D. Li and Jerry J. Buccafusco
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 670-675; DOI: https://doi.org/10.1124/jpet.103.053785
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    Up-Regulation of Spinal Muscarinic Receptors and Increased Antinociceptive Effect of Intrathecal Muscarine in Diabetic Rats
    Shao-Rui Chen and Hui-Lin Pan
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 676-681; DOI: https://doi.org/10.1124/jpet.103.055905
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    Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice
    Ronald J. Tallarida, Alan Cowan and Robert B. Raffa
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 699-704; DOI: https://doi.org/10.1124/jpet.103.054320
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    Protein Kinase C-Dependent Potentiation of Intracellular Calcium Influx by σ1 Receptor Agonists in Rat Hippocampal Neurons
    F. P. Monnet, M. P. Morin-Surun, J. Leger and L. Combettes
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 705-712; DOI: https://doi.org/10.1124/jpet.103.053447
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    Mechanism-Based Modeling of the Pharmacodynamic Interaction of Alphaxalone and Midazolam in Rats
    S. A. G. Visser, D. R. H. Huntjens, P. H. van der Graaf, L. A. Peletier and M. Danhof
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 765-775; DOI: https://doi.org/10.1124/jpet.103.054510
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    ATP Modulates Noradrenaline Release by Activation of Inhibitory P2Y Receptors and Facilitatory P2X Receptors in the Rat Vas Deferens
    Glória Queiroz, Carlos Talaia and Jorge Gonçalves
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 809-815; DOI: https://doi.org/10.1124/jpet.103.054809

TOXICOLOGY

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    Repeated Exposures to Heroin and/or Cadmium Alter the Rate of Formation of Morphine Glucuronides in the Rat
    Letizia Antonilli, Carmen Suriano, Giovanna Paolone, Aldo Badiani and Paolo Nencini
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 651-660; DOI: https://doi.org/10.1124/jpet.103.055467

Erratum

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    Correction to “Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect”
    Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 829;
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Journal of Pharmacology and Experimental Therapeutics: 307 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 307, Issue 2
1 Nov 2003
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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