Journal of Pharmacology and Experimental Therapeutics: 307 (1)

October 01, 2003; Volume 307,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Inflammation and Drug Idiosyncrasy—Is There a Connection?
Robert A. Roth, James P. Luyendyk, Jane F. Maddox and Patricia E. Ganey

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 1-8; DOI: https://doi.org/10.1124/jpet.102.041624

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and Flavopiridol Anticancer Drugs
Lyne Villeneuve, Hugo Girard, Louis-Charles Fortier, Jean-Francois Gagné and Chantal Guillemette

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 117-128; DOI: https://doi.org/10.1124/jpet.103.054072
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Functional Expression of the Multidrug Resistance Protein 1 in Microglia
Shannon Dallas, Xiaoping Zhu, Sylvain Baruchel, Lyanne Schlichter and Reina Bendayan

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 282-290; DOI: https://doi.org/10.1124/jpet.103.054304
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Metabolism of Flavonoids via Enteric Recycling: Mechanistic Studies of Disposition of Apigenin in the Caco-2 Cell Culture Model
Ming Hu, June Chen and Huimin Lin

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 314-321; DOI: https://doi.org/10.1124/jpet.103.053496
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Human Hepatic CYP2E1 Expression during Development
Elizabeth K. Johnsrud, Sevasti B. Koukouritaki, Karthika Divakaran, Laura L. Brunengraber, Ronald N. Hines and D. Gail McCarver

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 402-407; DOI: https://doi.org/10.1124/jpet.103.053124

BEHAVIORAL PHARMACOLOGY

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Capsaicin-Induced Hyperalgesia and μ-Opioid-Induced Antihyperalgesia in Male and Female Fischer 344 Rats
Andrew C. Barrett, Eric S. Smith and Mitchell J. Picker

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 237-245; DOI: https://doi.org/10.1124/jpet.103.054478
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Effects of Intravenous Cocaine and Cigarette Smoking on Luteinizing Hormone, Testosterone, and Prolactin in Men
Jack H. Mendelson, Michelle B. Sholar, Nicole H. Mutschler, Maria Jaszyna-Gasior, Nathalie V. Goletiani, Arthur J. Siegel and Nancy K. Mello

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 339-348; DOI: https://doi.org/10.1124/jpet.103.052928
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The Reinforcing Efficacy of Psychostimulants in Rhesus Monkeys: The Role of Pharmacokinetics and Pharmacodynamics
Joshua A. Lile, Zhixia Wang, William L. Woolverton, Jessica E. France, Timothy C. Gregg, Huw M. L. Davies and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 356-366; DOI: https://doi.org/10.1124/jpet.103.049825
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Wake-Promoting Actions of Dopamine D1 and D2 Receptor Stimulation
Stuart O. Isaac and Craig W. Berridge

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 386-394; DOI: https://doi.org/10.1124/jpet.103.053918

CARDIOVASCULAR

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S-Nitrosating Nitric Oxide Donors Induce Long-Lasting Inhibition of Contraction in Isolated Arteries
Jacicarlos L. Alencar, Irina Lobysheva, Karel Chalupsky, Michel Geffard, Françoise Nepveu, Jean-Claude Stoclet and Bernard Muller

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 152-159; DOI: https://doi.org/10.1124/jpet.103.052605
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Investigation of the Effects of Naratriptan, Rizatriptan, and Sumatriptan on Jugular Venous Oxygen Saturation in Anesthetized Pigs: Implications for Their Mechanism of Acute Antimigraine Action
Robert Létienne, Yvan Verscheure and Gareth W. John

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 168-174; DOI: https://doi.org/10.1124/jpet.103.054940
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Contractions to Histamine in Pulmonary and Mesenteric Arteries from Endotoxemic Rabbits: Modulation by Vascular Expressions of Inducible Nitric-Oxide Synthase and Histamine H₁-Receptors
Naoyuki Matsuda, Yuichi Hattori, Xiao-Hong Zhang, Hiroyuki Fukui, Osamu Kemmotsu and Satoshi Gando

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 175-181; DOI: https://doi.org/10.1124/jpet.103.054163
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Comparative Profile of Vasodilation by CVT-3146, a Novel A_2A Receptor Agonist, and Adenosine in Conscious Dogs
Gong Zhao, Axel Linke, Xiaobin Xu, Manuel Ochoa, Francis Belloni, Luiz Belardinelli and Thomas H. Hintze

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 182-189; DOI: https://doi.org/10.1124/jpet.103.053306
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Inhibitors of 20-Hydroxyeicosatetraenoic Acid Reduce Renal Vasoconstrictor Responsiveness
J. Quilley, Y. Qiu and J. Hirt

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 223-229; DOI: https://doi.org/10.1124/jpet.103.051995
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17β-Estradiol as a Receptor-Mediated Cardioprotective Agent
Erin A. Booth, Marta Marchesi, Edward J. Kilbourne and Benedict R. Lucchesi

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 395-401; DOI: https://doi.org/10.1124/jpet.103.054205
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Effect of Cardiac Glycosides on Action Potential Characteristics and Contractility in Cat Ventricular Myocytes: Role of Calcium Overload
Stuart R. Ruch, Manabu Nishio and J Andrew Wasserstrom

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 419-428; DOI: https://doi.org/10.1124/jpet.103.049189

CELLULAR AND MOLECULAR

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Molecular Mechanism of Citalopram and Cocaine Interactions with Neurotransmitter Transporters
Aina Westrheim Ravna, Ingebrigt Sylte and Svein G. Dahl

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 34-41; DOI: https://doi.org/10.1124/jpet.103.054593
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ζ Isoform of Protein Kinase C Prevents Oxidant-Induced Nuclear Factor-κB Activation and I-κBα Degradation: A Fundamental Mechanism for Epidermal Growth Factor Protection of the Microtubule Cytoskeleton and Intestinal Barrier Integrity
A. Banan, J. Z. Fields, L. J. Zhang, M. Shaikh, A. Farhadi and A. Keshavarzian

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 53-66; DOI: https://doi.org/10.1124/jpet.103.053835
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Functional Analysis of Three Genetic Polymorphisms in the Glucocorticoid Receptor Gene
Satoru Koyano, Yoshiro Saito, Michiyo Nagano, Keiko Maekawa, Yutaka Kikuchi, Norie Murayama, Tomofumi Fujino, Shogo Ozawa, Toshiharu Nakajima, Kenji Matsumoto, Hirohisa Saito and Jun-Ichi Sawada

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 110-116; DOI: https://doi.org/10.1124/jpet.103.054155
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Neuronal Necrosis Inhibition by Insulin through Protein Kinase C Activation
Wakako Hamabe, Ryousuke Fujita and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 205-212; DOI: https://doi.org/10.1124/jpet.103.053033
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Generation and Characterization of Highly Constitutive Active Histamine H3 Receptors
Kazuhiko Takahashi, Shigeru Tokita and Hidehito Kotani

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 213-218; DOI: https://doi.org/10.1124/jpet.103.053249
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Green Tea Polyphenol Causes Differential Oxidative Environments in Tumor versus Normal Epithelial Cells
Tetsuya Yamamoto, Stephen Hsu, Jill Lewis, John Wataha, Douglas Dickinson, Baldev Singh, Wendy B. Bollag, Petra Lockwood, Eisaku Ueta, Tokio Osaki and George Schuster

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 230-236; DOI: https://doi.org/10.1124/jpet.103.054676
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A Natural Product Ligand of the Oxysterol Receptor, Liver X Receptor
Kelli S. Bramlett, Keith A. Houck, Kristen M. Borchert, Michele S. Dowless, Palaniappan Kulanthaivel, Youyan Zhang, Thomas P. Beyer, Robert Schmidt, Jeffrey S. Thomas, Laura F. Michael, Robert Barr, Chahrzad Montrose, Patrick I. Eacho, Guoqing Cao and Thomas P. Burris

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 291-296; DOI: https://doi.org/10.1124/jpet.103.052852

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Antisense Oligonucleotide Inhibition of Bcl-xL and Bid Expression in Liver Regulates Responses in a Mouse Model of Fas-Induced Fulminant Hepatitis
Hong Zhang, Jennifer Taylor, Doreen Luther, Joe Johnston, Susan Murray, Jacqueline R. Wyatt, Andrew T. Watt, Seongjoon Koo, Cathie York-DeFalco, Kimberly Stecker and Nicholas M. Dean

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 24-33; DOI: https://doi.org/10.1124/jpet.103.050435
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Edaravone, a Novel Free Radical Scavenger, Prevents Liver Injury and Mortality in Rats Administered Endotoxin
Hiroshi Kono, Masami Asakawa, Hideki Fujii, Akira Maki, Hidetake Amemiya, Masayuki Yamamoto, Masanori Matsuda and Yoshiro Matsumoto

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 74-82; DOI: https://doi.org/10.1124/jpet.103.053595
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Hepatocyte Growth Factor Facilitates Colonic Mucosal Repair in Experimental Ulcerative Colitis in Rats
Yoshihiro Tahara, Akio Ido, Shojiro Yamamoto, Yoshifumi Miyata, Hirofumi Uto, Takeshi Hori, Katsuhiro Hayashi and Hirohito Tsubouchi

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 146-151; DOI: https://doi.org/10.1124/jpet.103.054106
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Biliary Secretion of Glutathione in Estradiol 17β-d-Glucuronide-Induced Cholestasis
Aldo D. Mottino, Luis M. Veggi, Marcie Wood, Joyce M. Vélez Román and Mary Vore

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 306-313; DOI: https://doi.org/10.1124/jpet.103.054544
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Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice
Kazuharu Furutani, Takeshi Aihara, Eiji Nakamura, Satoshi Tanaka, Atsushi Ichikawa, Hiroshi Ohtsu and Susumu Okabe

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 331-338; DOI: https://doi.org/10.1124/jpet.103.052019
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Interactions among Three Classes of Mediators Explain Antigen-Induced Bronchoconstriction in the Isolated Perfused and Ventilated Guinea Pig Lung
Ewa Sundström, Lena Låstbom, Åke Ryrfeldt and Sven-Erik Dahlén

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 408-418; DOI: https://doi.org/10.1124/jpet.103.053546

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Candesartan, an Angiotensin II Receptor Antagonist, Suppresses Pancreatic Inflammation and Fibrosis in Rats
Tamaki Yamada, Atsushi Kuno, Kazuhiko Masuda, Kumiko Ogawa, Mitsue Sogawa, Soichi Nakamura, Tomoaki Ando, Hitoshi Sano, Takahiro Nakazawa, Hirotaka Ohara, Tomoyuki Nomura, Takashi Joh and Makoto Itoh

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 17-23; DOI: https://doi.org/10.1124/jpet.103.053322
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Potency and Specificity of the Pharmacological Action of a New, Antiasthmatic, Topically Administered Soft Steroid, Etiprednol Dicloacetate (BNP-166)
István Kurucz, Szilveszter Tóth, Klára Németh, Katalin Török, Viola Csillik-Perczel, Ágnes Pataki, Cecilia Salamon, Zoltán Nagy, József I. Székely, Katalin Horváth and Nicholas Bodor

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 83-92; DOI: https://doi.org/10.1124/jpet.103.053652
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Modeling of Corticosteroid Pharmacogenomics in Rat Liver Using Gene Microarrays
Jin Y. Jin, Richard R. Almon, Debra C. DuBois and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 93-109; DOI: https://doi.org/10.1124/jpet.103.053256
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Anti-Inflammatory Actions of St. John's Wort: Inhibition of Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1α (STAT-1α) Activation
Elisa Tedeschi, Marta Menegazzi, Daniela Margotto, Hisanori Suzuki, Ulrich Förstermann and Hartmut Kleinert

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 254-261; DOI: https://doi.org/10.1124/jpet.103.054460
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Angiotensin Inhibition Reduces Glomerular Damage and Renal Chemokine Expression in MRL/lpr Mice
Guillermo Pérez de Lema, Cor de Wit, Clemens D. Cohen, Elena Nieto, Ana Molina, Bernhard Banas, Bruno Luckow, Ana B. Vicente, Francisco Mampaso and Detlef Schlöndorff

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 275-281; DOI: https://doi.org/10.1124/jpet.103.053678
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Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma
Rakesh K. Kumar, Cristan Herbert, Paul S. Thomas, Lutz Wollin, Rolf Beume, Ming Yang, Dianne C. Webb and Paul S. Foster

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 349-355; DOI: https://doi.org/10.1124/jpet.103.053819
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In Vivo Efficacy in Airway Disease Models of N-(3,5-Dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), a Selective Phosphodiesterase 4 Inhibitor for Inhaled Administration
H. Kuss, N. Hoefgen, S. Johanssen, T. Kronbach and C. Rundfeldt

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 373-385; DOI: https://doi.org/10.1124/jpet.103.053942
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Nitric Oxide and Cyclic GMP Increase the Expression of Matrix Metalloproteinase-9 in Vascular Smooth Muscle
Marcelo Marcet-Palacios, Kathryn Graham, Carol Cass, A. Dean Befus, Irvin Mayers and Marek W. Radomski

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 429-436; DOI: https://doi.org/10.1124/jpet.103.050385

NEUROPHARMACOLOGY

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Sites of Excitatory and Inhibitory Actions of Alcohols on Neuronal α2β4 Nicotinic Acetylcholine Receptors
Cecilia M. Borghese, L. Ashley Henderson, Virginia Bleck, James R. Trudell and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 42-52; DOI: https://doi.org/10.1124/jpet.103.053710
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The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
Melisa J. Wallace, Robert E. Blair, Katherine W. Falenski, Billy R. Martin and Robert J. DeLorenzo

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 129-137; DOI: https://doi.org/10.1124/jpet.103.051920
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In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates
Richard B. Rothman, Nga Vu, John S. Partilla, Bryan L. Roth, Sandra J. Hufeisen, Beth A. Compton-Toth, Jon Birkes, Richard Young and Richard A. Glennon

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 138-145; DOI: https://doi.org/10.1124/jpet.103.053975
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Potentiation of N-Methyl-d-aspartate-Induced Currents by the Nootropic Drug Nefiracetam in Rat Cortical Neurons
Shigeki Moriguchi, William Marszalec, Xilong Zhao, Jay Z. Yeh and Toshio Narahashi

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 160-167; DOI: https://doi.org/10.1124/jpet.103.050823
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Ethanol Influences on Native T-Type Calcium Current in Thalamic Sleep Circuitry
Jian Mu, W. Breckinridge Carden, Nuwan C. Kurukulasuriya, Georgia M. Alexander and Dwayne W. Godwin

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 197-204; DOI: https://doi.org/10.1124/jpet.103.053272
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Role of the Nitric-Oxide Synthase Isoforms during Morphine-Induced Hyperthermia in Rats
Khalid Benamar, Menachem Z. Yondorf, David Kon, Ellen B. Geller and Martin W. Adler

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 219-222; DOI: https://doi.org/10.1124/jpet.103.053181
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Antidepressant-Induced Increase in High-Affinity Rolipram Binding Sites in Rat Brain: Dependence on Noradrenergic and Serotonergic Function
Yu Zhao, Han-Ting Zhang and James M. O'Donnell

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 246-253; DOI: https://doi.org/10.1124/jpet.103.053215
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Interaction of Antiepileptic Drugs with Human P-Glycoprotein in Vitro
Johanna Weiss, Christian Johannes Kerpen, Heike Lindenmaier, Sven-Maria Gregor Dormann and Walter Emil Haefeli

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 262-267; DOI: https://doi.org/10.1124/jpet.103.054197
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Evidence for an Involvement of Supraspinal δ- and Spinal μ-Opioid Receptors in the Antihyperalgesic Effect of Chronically Administered Clomipramine in Mononeuropathic Rats
F. Marchand, D. Ardid, E. Chapuy, A. Alloui, D. Jourdan and A. Eschalier

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 268-274; DOI: https://doi.org/10.1124/jpet.103.052613
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Chronic Elevation of Brain-Derived Neurotrophic Factor by Ampakines
Julie C. Lauterborn, Giang S. Truong, Michel Baudry, Xiaoning Bi, Gary Lynch and Christine M. Gall

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 297-305; DOI: https://doi.org/10.1124/jpet.103.053694
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N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and Structurally Related Compounds: Novel Allosteric Enhancers of γ-Aminobutyric Acid_B Receptor Function
Stephan Urwyler, Mario F. Pozza, Kurt Lingenhoehl, Johannes Mosbacher, Christina Lampert, Wolfgang Froestl, Manuel Koller and Klemens Kaupmann

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 322-330; DOI: https://doi.org/10.1124/jpet.103.053074
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Arylacetamide κ-Opioid Receptor Agonists Produce a Tonic- and Use-Dependent Block of Tetrodotoxin-Sensitive and -Resistant Sodium Currents in Colon Sensory Neurons
S. K. Joshi, Kenneth Lamb, K. Bielefeldt and G. F. Gebhart

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 367-372; DOI: https://doi.org/10.1124/jpet.103.052829

TOXICOLOGY

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Ranitidine Treatment during a Modest Inflammatory Response Precipitates Idiosyncrasy-Like Liver Injury in Rats
James P. Luyendyk, Jane F. Maddox, Gregory N. Cosma, Patricia E. Ganey, Gary L. Cockerell and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 9-16; DOI: https://doi.org/10.1124/jpet.103.054288
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Scavenging Peroxynitrite with Glutathione Promotes Regeneration and Enhances Survival during Acetaminophen-Induced Liver Injury in Mice
Mary Lynn Bajt, Tamara R. Knight, Anwar Farhood and Hartmut Jaeschke

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 67-73; DOI: https://doi.org/10.1124/jpet.103.052506
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Cholinesterase Reactivation in Vivo with a Novel Bis-Oxime Optimized by Computer-Aided Design
P. I. Hammond, C. Kern, F. Hong, T. M. Kollmeyer, Y.-P. Pang and S. Brimijoin

Journal of Pharmacology and Experimental Therapeutics October 2003, 307 (1) 190-196; DOI: https://doi.org/10.1124/jpet.103.053405

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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