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Research ArticlePERSPECTIVES IN PHARMACOLOGY

The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

A. V. Terry Jr and J. J. Buccafusco
Journal of Pharmacology and Experimental Therapeutics September 2003, 306 (3) 821-827; DOI: https://doi.org/10.1124/jpet.102.041616
A. V. Terry Jr
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J. J. Buccafusco
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Article Information

vol. 306 no. 3 821-827
DOI 
https://doi.org/10.1124/jpet.102.041616
PubMed 
12805474

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online August 18, 2003.

Article Versions

  • Earlier version (June 12, 2003 - 15:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. A. V. Terry, Jr and
  2. J. J. Buccafusco
  1. Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus) (A.V.T.), Small Animal Behavior Core (A.V.T.), and Alzheimer's Research Center and Department of Pharmacology and Toxicology (A.V.T., J.J.B.), Medical College of Georgia, Augusta, Georgia; and Department of Veterans Affairs Medical Center, Augusta, Georgia (A.V.T., J.J.B.)
  1. Address correspondence to:
    Dr. Alvin V. Terry Jr., UGA College of Pharmacy, CJ-1020, The Medical College of Georgia, Augusta, GA 30912-2450. E-mail: aterry{at}mail.mcg.edu
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Journal of Pharmacology and Experimental Therapeutics: 306 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 306, Issue 3
1 Sep 2003
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Research ArticlePERSPECTIVES IN PHARMACOLOGY

The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

A. V. Terry and J. J. Buccafusco
Journal of Pharmacology and Experimental Therapeutics September 1, 2003, 306 (3) 821-827; DOI: https://doi.org/10.1124/jpet.102.041616

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Research ArticlePERSPECTIVES IN PHARMACOLOGY

The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

A. V. Terry and J. J. Buccafusco
Journal of Pharmacology and Experimental Therapeutics September 1, 2003, 306 (3) 821-827; DOI: https://doi.org/10.1124/jpet.102.041616
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  • Article
    • Abstract
    • The Cholinergic Hypothesis
    • Challenges to the Cholinergic Hypothesis
    • Aging and Brain Cholinergic Neurons
    • Anticholinergic Drugs in Elderly Subjects and AD Patients
    • Amyloid and the Cholinergic System
    • Cholinergic-Based Therapeutic Strategies (Present and Future Considerations)
    • Concluding Remarks
    • Footnotes
    • References
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