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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Avasimibe Induces CYP3A4 and Multiple Drug Resistance Protein 1 Gene Expression through Activation of the Pregnane X Receptor

Jasminder Sahi, Mark A. Milad, Xianxian Zheng, Kelly A. Rose, Hongbing Wang, Linda Stilgenbauer, Darryl Gilbert, Summer Jolley, Ralph H. Stern and Edward L. LeCluyse
Journal of Pharmacology and Experimental Therapeutics September 2003, 306 (3) 1027-1034; DOI: https://doi.org/10.1124/jpet.103.050526

Article Information

vol. 306 no. 3 1027-1034
DOI 
https://doi.org/10.1124/jpet.103.050526
PubMed 
12766253
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 14, 2003
  • Accepted May 22, 2003
  • Published online August 18, 2003.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jasminder Sahi,
  2. Mark A. Milad,
  3. Xianxian Zheng,
  4. Kelly A. Rose,
  5. Hongbing Wang,
  6. Linda Stilgenbauer,
  7. Darryl Gilbert,
  8. Summer Jolley,
  9. Ralph H. Stern and
  10. Edward L. LeCluyse
  1. Departments of Pharmacokinetics, Dynamics, and Metabolism (J.S., K.A.R., L.S.), Clinical Pharmacokinetics and Pharmacodynamics (M.A.M.), Molecular Biology (X.Z.), and Experimental Medicine (R.H.S.), Pfizer Global Research and Development, Ann Arbor, Michigan; and Division of Drug Delivery and Disposition (H.W., D.G., S.J., E.L.L.), School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
  1. Address correspondence to:
    Dr. Jasminder Sahi, Pfizer Global Research and Development, 2800 Plymouth Rd., Ann Arbor MI 48105. E-mail: jasminder.sahi{at}pfizer.com
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Avasimibe Induces CYP3A4 and Multiple Drug Resistance Protein 1 Gene Expression through Activation of the Pregnane X Receptor

Jasminder Sahi, Mark A. Milad, Xianxian Zheng, Kelly A. Rose, Hongbing Wang, Linda Stilgenbauer, Darryl Gilbert, Summer Jolley, Ralph H. Stern and Edward L. LeCluyse
Journal of Pharmacology and Experimental Therapeutics September 1, 2003, 306 (3) 1027-1034; DOI: https://doi.org/10.1124/jpet.103.050526
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